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Supplemental Content 3: Critical appraisal assessing risk of bias and applicability concerns based on QUADAS-2Author, year
Risk of bias Applicability concerns
Overall risk Patient
selection
Index test
Reference standard
Flow and timing
Patient selection
Index test
Reference standard
1. Ederveen (2020) Low Low Low Low Low Low Low Low
2. Ederveen (2018a) a. ES + FU b. ES
Low Low
Low Low
Low High
Low Low
Low Low
Low Low
Low Unclear
Low Low 3. Ederveen (2018b)
a. ES + FU b. ES
Low Low
Low Low
Low High
Low Low
Low Low
Low Low
Low Unclear
Low Low 4. Frøkjær (2018)
a. ES + FU b. ES
Low Low
Low Low
Low High
Low Low
Low Low
Low Low
Low Unclear
Low Low 5. Agaba (2008)
a. ES + FU b. ES
Low Low
Low Low
Low High
Low Low
Low Low
Unclear Unclear
Low Unclear
Low Low
6. Al-Saeed (2013) Low Low Low Unclear Low Low Low Low
7. Torensma (2020) Low Low Low Unclear Low Unclear Low Low
8. Bordonaro (2020) Low Low Low High Low Low Low Low
9. Karila-Cohen (2017) Low Low Low High Low Low Low Low
10. Goudsmedt (2015) Low Low High Unclear Low Low Unclear Low
11. Ahmed (2009) Low Unclear High Unclear Low Low Unclear Low
12. Obeid (2014) Low Low High Unclear Low Unclear Unclear Low
13. Iannuccilli (2009) Unclear Low High Unclear Low Low Unclear Moderate
14. Dilauro (2017)* Unclear Low Low Low Unclear Low Low Moderate
15. Altieri (2015) Low Low High Unclear Unclear Low Unclear Moderate
16. Parakh (2007) Low Low High Unclear Unclear Unclear Unclear Moderate
17. Lockhart (2007) Unclear Low High Unclear Low Low Unclear Moderate
18. Farukhi (2017) Low Low High Unclear Unclear Unclear Unclear Moderate
19. Al-Mansour (2015) Low Unclear High Unclear Low Unclear Unclear Moderate
20. Reddy (2007) Unclear High High Low Low Low Unclear Moderate
21. Hongo (2010) High Unclear High Unclear Low Low Unclear High
22. Park (2016) Low High High High Low Low Unclear High
23. Geubbels (2016) Low Unclear High Low Low High Unclear High
24. Kristensen (2016) Low High Unclear Unclear Low Unclear Unclear High
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25. Maier (2017) High Low Low High High Low Low High
26. Sandvik (2018) Low High Low High Low Unclear Low High
27. Altinoz (2020) Low Unclear High High Low Unclear Unclear High
28. Van Berckel (2020) Low Unclear Unclear High Low Unclear High High
29. Giudicelli (2020) Low Low Low High Low Unclear Unclear High
* Reasonable risk of bias for overall diagnostic value of CT; missing data for diagnostic value of specific CT-signs.
ES explorative surgery, FU follow up. Supplementary table 1 presents a rubric for the critical appraisal.
