Conner SN, Bedell V, Lipsey K, Macones GA, Cahill AG, Tuuli MG. Maternal marijuana use and adverse neonatal outcomes: a systematic review and meta‐analysis. Obstet Gynecol 2016; 128.
The authors provided this information as a supplement to their article.
©2016 American College of Obstetricians and Gynecologists. Page 1 of 4
NOTE: Weights are from random effects analysis
Overall (I−squared = 35.6%, p = 0.199) van Gelder (2010)
ID Study
Bada (2005)
Conner (2015) Shiono (1995)
1.60 (1.40, 1.84) 1.07 (0.56, 2.05) RR (95% CI)
1.73 (1.57, 1.91)
1.67 (1.28, 2.18) 1.42 (1.15, 1.76)
466/2498 9/185 Marijuana Events,
309/811
58/680 90/822
2858/27275 243/5343 Control Events,
1723/7826
380/7458 512/6648
100.00 4.11 Weight
%
51.15
19.01 25.73
1.60 (1.40, 1.84) 1.07 (0.56, 2.05) RR (95% CI)
1.73 (1.57, 1.91)
1.67 (1.28, 2.18) 1.42 (1.15, 1.76)
466/2498 9/185 Marijuana Events,
309/811
58/680 90/822
1
.1 1 10
Lower Risk for LBW Higher Risk for LBW
A
Appendix 1. Forest plot unadjusted estimates for marijuana use among studies who also reported adjusted estimates. A) low birth weight <2500g; B) preterm delivery. ES, effect size; CI, confidence interval; LBW, low birth weight.
Conner SN, Bedell V, Lipsey K, Macones GA, Cahill AG, Tuuli MG. Maternal marijuana use and adverse neonatal outcomes: a systematic review and meta‐analysis. Obstet Gynecol 2016; 128.
The authors provided this information as a supplement to their article.
©2016 American College of Obstetricians and Gynecologists. Page 2 of 4
NOTE: Weights are from random effects analysis
Overall (I−squared = 81.6%, p = 0.001) Study
van Gelder (2010) ID
Saurel−Cubizolles (2014) Shiono (1995)
Bada (2005)
1.47 (1.12, 1.94) 1.27 (0.81, 1.99) RR (95% CI)
2.06 (1.31, 3.24) 1.13 (0.94, 1.37)
1.68 (1.52, 1.84)
460/1974 Events,
18/185 Marijuana
17/156 110/822
315/811
3714/33165 Events,
410/5343 Control
707/13348 784/6648
1813/7826
100.00
%
18.17 Weight
17.94 30.24
33.65
1.47 (1.12, 1.94) 1.27 (0.81, 1.99) RR (95% CI)
2.06 (1.31, 3.24) 1.13 (0.94, 1.37)
1.68 (1.52, 1.84)
460/1974 Events,
18/185 Marijuana
17/156 110/822
315/811
1
.1 1 10
Lower Risk for PTD Higher Risk for PTD
B
Conner SN, Bedell V, Lipsey K, Macones GA, Cahill AG, Tuuli MG. Maternal marijuana use and adverse neonatal outcomes: a systematic review and meta‐analysis. Obstet Gynecol 2016; 128.
The authors provided this information as a supplement to their article.
©2016 American College of Obstetricians and Gynecologists. Page 3 of 4
Harbord’s p = 0.24
0.2.4.6.81se(logRR)
−2 −1 0 1 2
logRR
LBW Funnel plot with pseudo 95% confidence limits
A
Appendix 2. Funnel plot and publication bias. A) low birth weight <2500g; B) preterm delivery. ES, effect size; CI, confidence interval; PTD, preterm delivery.
Conner SN, Bedell V, Lipsey K, Macones GA, Cahill AG, Tuuli MG. Maternal marijuana use and adverse neonatal outcomes: a systematic review and meta‐analysis. Obstet Gynecol 2016; 128.
The authors provided this information as a supplement to their article.
©2016 American College of Obstetricians and Gynecologists. Page 4 of 4
Harbord’s p = 0.67
0.511.5se(logRR)
−4 −2 0 2 4
logRR
PTD Funnel plot with pseudo 95% confidence limits
