Supplemental Table 1. The performance of IVUS in the diagnosis of lipid plaques, TCFA, and plaque rupture using OCT as a gold standard
IVUS=intravascular ultrasound, OCT=optical coherence tomography, TCFA=thin cap fibroatheroma, PPV = positive predictive value, NPV = negative predictive value
OCT lipidic plaque (+) OCT lipidic plaque (-) Total Sensitivity 52.3%
IVUS superficial attenuated plaque (+) 347 8 355 Specificity 20.5%
IVUS superficial attenuated plaque (-) 317 31 348 PPV 2.3%
Total 664 39 703 NPV 8.9%
Accuracy 53.8%
OCT TCFA (+) OCT TCFA (-) Total Sensitivity 68.4%
IVUS superficial attenuated plaque (+) 158 196 354 Specificity 41.9%
IVUS superficial attenuated plaque (-) 73 272 345 PPV 55.4%
Total 231 468 699 NPV 78.8%
Accuracy 61.5%
OCT plaque rupture (+) OCT plaque rupture (-) Total Sensitivity 52.2%
IVUS plaque rupture (+) 119 23 142 Specificity 4.8%
IVUS plaque rupture (-) 109 452 561 PPV 16.2%
Total 228 475 703 NPV 80.6%
Accuracy 81.2%
Supplemental Figure 1. Multivariable Logistic and Linear Regression Analysis for Clinical Features and Plaque Morphology in the Acute Coronary Syndrome Population (n=313)
(A) Male sex was related to thrombus formation with plaque rupture. (B) Female sex was related to thrombus formation without plaque rupture (presumably erosion). (C) The absence of risk factors was related to thin-cap fibroatheroma (TCFA). (D) Diabetes mellitus was related to a greater lipid volume index.
(E) Hypertension was related to a greater macrophage volume index, and age was related to a less
macrophage volume index. (F) Current smoking was related to less calcium. (G) The absence of risk factors was related to plaque burden at the minimal lumen area (MLA) site. (H) DM treated with insulin was related to more negative remodeling, and statin pre-admission was related to less negative remodeling. (I) DM with insulin was related to less positive remodeling, and statin pre-admission was related to more positive
remodeling. eGFR = estimated glomerular filtration rate, DM=diabetes mellitus.
Supplemental Figure 2. Multivariable Logistic and Linear Regression Analysis for Clinical Features and Plaque Morphology in the Stable Angina Pectoris Population (n=391)
(A) The absence of risk factors was related to thrombus formation with plaque rupture. (B) The absence of risk factors was related to thrombus formation without plaque rupture (presumably erosion). (C) The
absence of risk factors was related to thin-cap fibroatheroma (TCFA). (D) Diabetes mellitus was related to a greater lipid volume index. (E) Satin pre-admission was related to a greater macrophage volume index, and age was related to a less macrophage volume index. (F) Aging and diabetes mellitus were related to more calcium. (G) Diabetes mellitus was related to more plaque burden at the minimal lumen area (MLA) site.
(H)The absence of risk factors was related to negative remodeling. (I)The absence of risk factors was related to positive remodeling. eGFR = estimated glomerular filtration rate, DM=diabetes mellitus.
Supplemental Figure 3. Multivariable Logistic and Linear Regression Analysis for Clinical Features and Plaque Morphology in Patients Without Chronic Statin Usage (n=595)
(A) Acute coronary syndromes (ACS) presentation and male sex were related to thrombus formation with plaque rupture. (B) Female sex, diabetes mellitus, and ACS presentation were related to thrombus formation without plaque rupture (presumably erosion). (C) ACS was significantly related to thin-cap fibroatheroma (TCFA). (D) Diabetes mellitus and ACS presentation were related to a greater lipid volume index. (E) Hypertension and ACS presentation were related to a greater macrophage volume index, while age was related to a less macrophage volume index. (F) Older patient age was associated with more calcium in the plaque, while smoking was related to less calcium. (G) Diabetes mellitus and ACS presentation were related to more plaque burden at the minimal lumen area (MLA) site. (H) ACS presentation was related to a less negative remodeling. (I) DM treated with insulin was related to less positive remodeling, and ACS presentation was related to more positive remodeling. eGFR = estimated glomerular filtration rate, DM=diabetes mellitus.
