1
Appendix 1: Adherence to the Mediterranean diet and risk of ulcerative colitis and Crohn’s disease Mediterranean score (0-9) Cases, N (%) Unadjusted
*
IRR (95% CI) Adjusted**
IRR (95% CI)UC
0-2 74 (29) 1.00 1.00
3 50 (19) 1.20 (0.78-1.83) 1.19 (0.77-1.82)
4 59 (23) 1.45 (0.95-2.22) 1.45 (0.94-2.23)
5-6 48 (19) 1.22 (0.81-1.85) 1.19 (0.78-1.81)
7-9 25 (10) 0.83 (0.50-1.36) 0.79 (0.48-1.32)
Ptrend=0.54 Ptrend=0.41
CD
0-2 46 (39) 1.00 1.00
3 21 (18) 0.86 (0.47-1.57) 0.95 (0.51-1.74)
4 23 (20) 1.19 (0.67-2.10) 1.26 (0.70-2.25)
5-6 13 (11) 0.63 (0.32-1.27) 0.61 (0.30-1.24)
7-9 14 (12) 0.88 (0.46-1.71) 0.90 (0.45-1.77)
Ptrend=0.62 Ptrend=0.67
Abbreviations: CD: Crohn’s disease CI: confidence interval, IRR: Incidence rate ratio, UC: ulcerative colitis.
*
Matched on age, sex, center and date of recruitment into EPIC**
Matched on age, sex , center and date of recruitment into EPIC, and adjusted for daily energy intake (kcal/day), body mass index (kg/m2), and smoking status (never/past/current smoker) .2
Appendix 2: Intakes of macronutrients according to adherence to the a “Sugar and Soft drink pattern” in UC case and controls( n=1278)
Mean daily
(g/day), SD Quintile 1 Quintile 2 Quintile 3 Quintile 4 Quintile 5 Carbohydrates 235.8
(74.2)
234.4 (69.0))
228.0 (75.2)
226.7 (69.3)
254.0 (82.9)
Fat 24.3
(17.8)
27.6 (16.2)
27.4 (19.4)
29.3 (19.3)
31.1 (20.8) Animal protein 58.6
(24.9)
53.7 (21.4)
51.3 (20.5)
49.3 (20.2)
47.8 (21.4)
Fibers 25.7
(8.3)
22.8 (6.8)
21.7 (7.0)
20.5 (6.7)
21.6 (7.9)
