Supplemental digital content 4 - Optimization results of loading and maintenance phase doses
Optimization results of loading and maintenance phase doses. (A) PTA results (solid line: target within 150-250 μg/L; dashed line: target > 300 μg/L; 95%
confidence intervals of the estimates are shaded in grey) in the end of a 3-hour loading dose. (B) Objective function scores for loading doses. (C) PTA results (solid line: target within 150-250 μg/L; dashed line: target > 300 μg/L; 95%
confidence intervals of the estimates are shaded in grey.) of the maintenance dose preceded by a preliminary 3-h loading dose of 0.5 μg/kg/min followed by 21-h maintenance infusion estimated as the average of subject proportions at times 3-h, 9-h, 15-h and 21-h post maintenance infusion start. (D) Objective function scores for maintenance doses.
0 25 50 75 100
0.25 0.50 0.75 1.00 1.25
Loading dose (µg/kg/min)
Probability of target attainment (%)
Target 150−250
>300 A
−100
−50 0 50 100
0.25 0.50 0.75 1.00 1.25
Loading dose (µg/kg/min)
Objective value
B
0 25 50 75 100
0.0 0.2 0.4 0.6
Maintenance dose (µg/kg/min)
Probability of target attainment (%)
Target 150−250
>300 C
−50 0 50
0.0 0.2 0.4 0.6
Maintenance dose (µg/kg/min)
Objective value
D
