Supplemental Digital Content 3: Results of case control analysis (matched and unmatched)
Variable Case
(N=4)
Unmatched Case Control (N=743) analysis
Matched Case Control (N=28) Analysis
N (%) N(%) p N(%) p
Maternal age
<30 yrs
≥30 yrs
3 (75) 1 (25)
602 (81.5) 137 (18.5)
0.7 25 (10.7)
3 (89.3)
0.9
Socio economic status Lower Middle Upper Middle
1 (25) 3 (75)
73 (9.8) 670 (90.2)
0.3 2 (7.1)
26 (92.9)
0.9 Gravidity
Primi Multi
3 (75) 1 (25)
417 (56.1) 326 (43.9)
0.4 18 (64.3)
10 (35.7)
0.9 Previous history of adverse
pregnancy outcome Yes
No
0 4 (100)
143 (19.3) 600 (80.7)
0.3 5 (17.9)
23 (82.1)
0.9
Gestational age Preterm Term
1 (25) 3 (75)
69 (9.3) 674 (90.7)
0.3 3 (10.7)
25 (89.3)
0.9 Birth weight
<2500g
≥2500g
1 (25) 3 (75)
115 (15.5) 628 (84.5)
0.5 24 (85.7)
4 (14.3)
0.9 NICU Stay
Yes No
1 (25) 3 (75)
24 (3.2) 719 (96.7)
0.015* 2 (7.1) 26 (92.9)
0.2 Sex
Male Female
2 (50%) 2 (50%)
393 (52.9) 350 (47.1)
0.9
Sex Matched
