Table 1. Mouth Disintegrating portion of Formulation
Ingredients (mg) F1 F2 F3 F4 F5 F6
TLM 40 40 40 40 40 40
Pre-gelatinize Starch 16 - 12 08 04 -
Kyron T134 - 16 04 08 12 -
Mg-Stearate 04 04 04 04 04 04
Talc 04 04 04 04 04 04
Lactose 77 77 77 77 77 93
Orange Flavor 05 05 05 05 05 05
Saccharine Sodium 04 04 04 04 04 04
Total Weight(mg) 150 150 150 150 150 150
Table 2. Extended release portion of Formulation
Ingredients (mg) F1 F2 F3 F4 F5 F6
TLM 40 40 40 40 40 40
CMC 20 - - 20 20 -
Chitosan - 20 - 20 20 20
PVP - - 20 - -20
Mg-Stearate 04 04 04 04 04 04
Talc 04 04 04 04 04 04
Lactose 82 82 82 82 82 82
Total Weight(mg) 150 150 150 150 150 150
Table 3. Results of Hardness, Weight variation, Thickness, Friability, Disintegration time and Wetting time
Parameters
Code Wt.
variat ion (mg)
Hardn ess Kg/cm
2
Thickn ess (mm)
Friabili ty*
(%)
Disintegr ation*
Time (Sec)
Wetting*
Time(Sec)
F1 298.6
8 4.2 4.12 0.718±
0.02 76±2.00 90±1.50
F2 295.9
0 3.9 3.94 0.587±
0.00 42±0.60 52±1.30
F3 299.2
5 3.8 4.15 0.591±
0.02 67±1.50 58±1.50
F4 300.2
0 4.1 4.10 0.782±
0.01 56±0.30 69±0.83
F5 298.5
0 3.9 4.25 0.769±
0.02 49±2.00 61±1.50
F6 299.5
5 5.0 4.16 0.642±
0.01 Up to hrs No much
wetting
Table 4. Results of. Dispersion time, Wetting volume ,pH of Tablet solution and Water absorption ratio.
Parameters Formulation Wettin
g*
volume (ml)
Dispersi on* time (Sec)
pH of
Tablet Sol Water*
absorptio n ratio
F1 25±0.5
0 68±1.00 6,8 0.90±0.15
F2 17±1.5
0 44±1.15 6.7 1.30±0.20
F3 24±0.5
0 61±1.00 7.3 1.00±0.10
F4 22±1.5
0 57±1.53 6.8 1.10±0.03
F5 20±0.5
0 51±1.00 6.6 1.20±0.10
F6 No such
absorpti on
Up to hrs 7.3 No such
absorption
Table 5. Results of Angle of Repose, Bulk density, Tapped density, Hausner’s Ratio and Carr’s Index.
Code Bulk Density Tapped Density Angle of Repose Hausner’s Ratio Carr’s Index
(g/ml) (g/ml) (ϴ)
%
F1 0.623 0.749 22.5 1.20 18.35
F2 0.613 0.729 21.6 1.18 19.50
F3 0.617 0.721 23.5 1.16 18.25
F4 0.627 0.735 22.9 1.17 17.55
F5 0.621 0.727 23.5 1.17 18.75
F6 0.623 0.739 24.5 1.18 17.60
