Supplement materials:

Supplement materials:

Table S1: ICD-9 codes used to define prevalent comorbid conditions and incident conditions

Comorbid condition ICD-9 code

Hypertension 401-405

Diabetes mellitus 250.x

Myocardial infarction 410-410.9, 412

Angina 411, 413

CAD 414.0, 414.8, 414.9

PCI 36.03, 36.04, 36.06, 36.07, 36.09

CABG 36.10-36.17, 36.19

CHF 428-428.9

Peripheral arterial disease 440.0-440.9, 443, 443.x, 38.0, 38.1, 39.50, 39.22, 39.24, 39.25, 39.26, 39.28

Cerebrovascular disease 430-438

Chronic lung disease 490-496, 500-505, 506.4

Dementia 290-290.9

Rheumatologic disease 710.0, 710.1, 710.4, 714.0-714.2, 714.81, 725

Peptic ulcer disease 531-534.9, 531.4-531.7, 532.4-532.7,

533.4-533.7, 534.4-534.7

Liver disease 571.x, 572.x, 456.0-456.21

Malignancy 140-172.9, 174-195.8, 200-208.9, 196-199.1 HIV/AIDS 042, V08, 795.71

Depression 296.x

Abbreviations: CAD: coronary artery disease; PCI: percutaneous coronary intervention;

CABG: coronary artery bypass grafting; CHF: congestive heart failure

Table S2: ICD9 codes used to define incident clinical events

Incident event ICD9 code

Acute myocardial infarction 410.x

PCI 36.03, 36.04, 36.06, 36.07, 36.09

CABG 36.10-36.17, 36.19

Ischemic stroke 433.x, 434.x, 436.x

Abbreviations: PCI: percutaneous coronary intervention; CABG: coronary artery bypass

grafting

Table S3: Procedure (CPT) codes used to define coronary interventions

Coronary intervention CPT code PCI 92980 92981 92982 92984 92985 92986 92987

92988 92989 92990 92991 92992 92993 92994 92995 92996

CABG 33510 33511 33512 33513 33514 33515 33516 33517 33518 33519 33521 33522 33523 33533 33534 33535 33536

Abbreviations: PCI: percutaneous coronary intervention; CABG: coronary artery bypass grafting

Table S4A. Multivariable adjusted risk of all-cause mortality across categories of A1c and systolic blood pressure.

Systolic Blood Pressure, mmHg HbA1c, %

<100 100-119 120-139 140-159 160-179 >180

<6.5

1.67 (1.58-1.77)* 1.28 (1.25-1.31)* 1.15 (1.13-1.17)* 1.15 (1.13-1.18)* 1.23 (1.20-1.27)* 1.42 (1.36-1.49)*

6.5-6.9

1.51 (1.38-1.65)* 1.15 (1.11-1.18)* 1.00 1.04 (1.01-1.07)* 1.16 (1.12-1.21)* 1.20 (1.13-1.28)*

7.0-7.9

1.62 (1.50-1.75)* 1.17 (1.13-1.20)* 1.05 (1.02-1.07)* 1.05 (1.02-1.08)* 1.17 (1.13-1.21)* 1.34 (1.28-1.42)*

8.0-8.9

1.72 (1.55-1.91)* 1.31 (1.25-1.36)* 1.16 (1.13-1.20)* 1.21 (1.17-1.24)* 1.36 (1.40-1.42)* 1.52 (1.42-1.63)*

9.0-9.9

2.24 (1.96-2.56)* 1.45 (1.37-1.53)* 1.28 (1.23-1.32)* 1.32 (1.27-1.37)* 1.54 (1.45-1.62)* 1.67 (1.50-1.81)*

>10.0

2.27 (1.99-2.56)* 1.70 (1.61-1.78)* 1.56 (1.50-1.61)* 1.60 (1.54-1.66)* 1.74 (1.64-1.82)* 2.05 (1.90-2.21)*

Data is presented as HR (hazard ratio) with 95% CI (confidence interval). * - P<0.001, ¶ - p<0.05. A1c of 6.5-6.9% and

SBP 120-139 mmHg group served as a reference group for all analyzes.

Table S4B. Multivariable adjusted risk of CVD across categories of A1c and systolic blood pressure.

Systolic Blood Pressure, mmHg HbA1c, %

<100 100-119 120-139 140-159 160-179 >180

<6.5

1.01 (0.83-1.23) 0.91 (0.84-0.99)¶ 0.89 (0.83-0.95)* 1.00 (0.93-1.06) 1.22 (1.12-1.33)* 1.42 (1.25-1.61)*

6.5-6.9

0.96 (0.71-1.29) 1.02 (0.92-1.13) 1.00 1.16 (1.07-1.25)* 1.14 (1.03-1.27)¶ 1.68 (1.44-1.96)*

7.0-7.9

1.14 (0.91-1.44) 1.18 (1.08-1.28)* 1.14 (1.07-1.22)* 1.26 (1.17-1.35)* 1.43 (1.31-1.56)* 1.84 (1.63-2.01)*

8.0-8.9

1.37 (1.03-1.81)¶ 1.45 (1.31-1.60)* 1.41 (1.32-1.52)* 1.51 (1.40-1.63)* 1.66 (1.50-1.85)* 2.03 (1.74-2.37)*

9.0-9.9

2.38 (1.73-2.27)* 1.45 (1.27-1.65)* 1.49 (1.37-1.63)* 1.69 (1.54-1.85)* 1.77 (1.56-2.02)* 1.81 (1.47-2.22)*

>10.0

1.72 (1.27-2.33)* 1.75 (1.56-1.95)* 1.62 (1.50-1.76)* 1.87 (1.72-2.04)* 2.12 (1.89-2.38)* 2.49 (2.11-2.94)*

Data is presented as HR (hazard ratio) with 95% CI (confidence interval). * - P<0.001, ¶ - p<0.05. A1c of 6.5-6.9% and

SBP 120-139 mmHg group served as a reference group for all analyzes.

Table S4C. Multivariable adjusted risk of stroke across categories of A1c and systolic blood pressure.

Systolic Blood Pressure, mmHg

¶

HbA1c, %

<100 100-119 120-139 140-159 160-179 >180

<6.5

1.18 (0.97-1.43) 1.02 (0.94-1.11) 1.03 (0.96-1.10) 1.15 (1.08-1.23)* 1.36 (1.24-1.48)* 1.60 (1.42-1.81)*

6.5-6.9

1.07 (0.78-1.45) 0.98 (0.88-1.09) 1.00 1.17 (1.08-1.27)* 1.25 (1.12-1.39) 1.59 (1.36-1.86)*

7.0-7.9

1.21 (0.94-1.55) 1.11 (1.01-1.22)¶ 1.15 (1.07-1.23)* 1.29 (1.20-1.39)* 1.59 (1.45-1.74)* 1.73 (1.52-1.97)*

8.0-8.9

1.49 (1.10-2.02)¶ 1.34 (1.20-1.50)* 1.26 (1.16-1.36)* 1.52 (1.40-1.65)* 1.59 (1.42-1.78)* 1.88 (1.59-2.22)*

9.0-9.9

1.20 (0.73-1.96) 1.55 (1.35-1.77)* 1.50 (1.36-1.65)* 1.57 (1.42-1.74)* 2.05 (1.80-2.33)* 2.64 (2.19-3.18)*

>10.0

1.88 (1.35-2.63)* 1.65 (1.45-1.86)* 1.69 (1.55-1.84)* 2.18 (2.00-2.38)* 2.49 (2.22-2.79)* 2.99 (2.58-3.48)*

Data is presented as HR (hazard ratio) with 95% CI (confidence interval). * - P<0.001, ¶ - p<0.05. A1c of 6.5-6.9% and

SBP 120-139 mmHg group served as a reference group for all analyzes.

Table S4D. Multivariable adjusted risk of incident chronic kidney disease across categories of A1c and systolic blood pressure.

Systolic Blood Pressure, mmHg

¶

HbA1c, %

<100 100-119 120-139 140-159 160-179 >180

<6.5

0.84 (0.72-0.98)¶ 0.85 (0.81-0.90) 0.88 (0.84-0.92) 1.07 (1.02-1.12)* 1.25 (1.18-1.32)* 1.46 (1.34-1.59)*

6.5-6.9

1.02 (0.83-1.26) 0.92 (0.86-0.99)¶ 1.00 1.11 (1.05-1.17)* 1.30 (1.22-1.40) 1.54 (1.38-1.72)*

7.0-7.9

1.19 (1.01-1.41)¶ 1.02 (0.96-1.09) 1.11 (1.07-1.16)* 1.28 (1.22-1.34)* 1.60 (1.51-1.70)* 1.85 (1.69-2.03)*

8.0-8.9

1.27 (1.01-1.59)¶ 1.08 (0.99-1.17) 1.16 (1.10-1.22)* 1.47 (1.39-1.55)* 1.76 (1.63-1.89)* 1.94 (1.72-2.18)*

9.0-9.9

1.55 (1.16-2.07)* 1.21 (1.09-1.34)* 1.26 (1.18-1.34)* 1.54 (1.44-1.64)* 1.94 (1.77-2.13)* 2.02 (1.72-2.36)*

>10.0

1.62 (1.26-2.10)* 1.50 (1.37-1.64)* 1.46 (1.38-1.55)* 1.72 (1.61-1.83)* 2.05 (21.88-2.23)* 2.70 (2.39-3.06)*

Data is presented as HR (hazard ratio) with 95% CI (confidence interval). * - P<0.001, ¶ - p<0.05. A1c of 6.5-6.9% and

SBP 120-139 mmHg group served as a reference group for all analyzes.

Figure Legends

Supplementary Figure 1: Hazard ratios of the association of blood pressure and A1c categories and the risk of mortality based on age (Panel A) or ethnicity (Panel B).

The associations of the categories with mortality risk were estimated from Cox proportional hazards models. Risk estimates were adjusted for the following factors at baseline: age, gender, race/ethnicity, baseline eGFR, various socio-economic parameters, service connection, adherence to medical interventions, comorbidities, body mass index and statin treatment. The adjusted hazard ratios are

compared to the reference category of systolic blood pressure of 120-139mmHg and A1c of 6.5-7.0% taken as 1.0.

Supplementary Figure 2: Hazard ratios of the association of blood pressure and A1c categories on the risk of cardiovascular disease based on age (Panel A) and ethnicity (Panel B).

The associations of the categories with risk of incident cardiovascular disease were estimated from Cox proportional hazards models. Risk estimates were adjusted for the following factors at baseline: age, gender, race/ethnicity, baseline eGFR, various socio-economic parameters, service connection, adherence to medical interventions, comorbidities, body mass index and statin treatment. The adjusted hazard ratios are compared to the reference category of systolic blood pressure of 120-139mmHg and A1c of 6.5-7.0%

taken as 1.0.

Supplementary Figure 3: Hazard ratios of the association of blood pressure and A1c categories on the risk of stroke based on age (Panel A) and ethnicity (Panel B).

The associations of the categories with risk of incident stroke were estimated from Cox proportional hazards models. Risk estimates were adjusted for the following factors at baseline: age, gender, race/ethnicity, baseline eGFR, various socio-economic parameters, service connection, adherence to

compared to the reference category of systolic blood pressure of 120-139mmHg and A1c of 6.5-7.0% taken as 1.0.

Supplementary Figure 4: Hazard ratios of the associations of blood pressure and A1c categories on the risk of chronic kidney disease based on age (Panel A) and ethnicity (Panel B).

The effects of the categories on the risk of incident chronic kidney disease were estimated from Cox proportional hazards models. Risk estimates were adjusted for the following factors at baseline: age, gender, race/ethnicity, baseline eGFR, various socio-economic parameters, service connection, adherence to medical interventions, comorbidities, body mass index and statin treatment. The adjusted hazard ratios are compared to the reference category of systolic blood pressure of 120-139mmHg and A1c of 6.5-7.0%

taken as 1.0.

Supplementary Figure 1 Panel A:

Supplementary Figure 1 Panel B:

Supplementary Figure 2 Panel A:

CHD

Supplementary Figure 2 Panel B:

CHD

Supplementary Figure 3 Panel A:

Supplementary Figure 3 Panel B:

Supplementary Figure 4 Panel A:

Supplementary Figure 4 Panel B: