Supplemental Digital Content 1 (SDC)
SEASONAL BLOOD PRESSURE VARIATION ASSESSED BY DIFFERENT MEASUREMENT METHODS: SYSTEMATIC REVIEW AND META-ANALYSIS
Anastasios Kollias, Konstantinos G. Kyriakoulis, Emelina Stambolliu, Angeliki Ntineri, Ioannis Anagnostopoulos, George S. Stergiou
Hypertension Center STRIDE-7, National and Kapodistrian University of Athens, School of Medicine, Third Department of Medicine, Sotiria Hospital, Athens, Greece
Correspondence: Professor George S. Stergiou, MD, FRCP Hypertension Center STRIDE-7,
National and Kapodistrian University of Athens, School of Medicine,
Third Department of Medicine,
Sotiria Hospital, 152 Mesogion Avenue,
Athens 11527, Greece
Tel: +30 2107763117, Fax: +30 2107719981
Email: [email protected]
Supplementary Table 1. Quality assessment tool used for evaluation of the included studies
CRITERIA YES
(2 points)
UNCLEAR/INDIRECTLY CALCULATED (1 point)
NO (0 points)
Objective
Was the research question/objective in the study clearly stated regarding seasonal BP change?
Methodology Design
Was the study prospective?
Were the same subjects followed-up in different seasons?
Was the antihypertensive treatment stable throughout the study?
Sample
Was the study population clearly specified and defined?
Was the participation rate of eligible persons at least 50%?
Was the total sample> 100 subjects for prospective studies using the same subjects or > 500 for cross- sectional ones?
Did the study include at least 30% of each gender?
Blood pressure measurement
Was the BP device and BP measurement method reported?
Were the international guidelines followed regarding BP measurements?
Outcome reporting
Was the seasonal systolic/diastolic BP difference reported based on averaged per season BP values?
Supplementary Table 2. Quality score of the included studies
Study, publication year Objective Prospective design
Same subjects
Stable treatment
Sample description
Participation rate
Sample size n>100/500
Gender distribution
BP measurements
Guidelines Outcome report
Total score
Schneider 1972 2 2 2 1 1 1 0 2 1 0 1 13
Hata 1982 2 2 2 2 1 1 0 0 1 0 1 12
Giaconi 1989 2 2 2 2 1 1 0 0 2 1 1 14
James 1990 1 0 0 2 2 1 0 2 2 1 1 12
Woodhouse 1993 2 2 2 1 1 2 0 2 1 1 1 15
Fujiwara 1995 2 2 2 2 2 2 0 2 2 1 1 18
Tsuchihashi 1995 2 2 2 2 1 1 0 0 1 1 1 13
Kristal-Boneh 1996 2 2 2 2 2 2 2 0 2 2 1 19
Minami 1996 2 2 2 2 2 1 0 2 2 1 2 18
Winnicki 1996 2 0 0 0 2 1 0 0 2 1 1 9
Sega 1998 2 0 0 0 2 2 2 2 2 1 1 14
Brueren 1998 2 2 2 2 2 1 0 2 2 1 2 18
Minami 1998 2 2 2 1 2 1 2 2 2 1 1 18
Shahar 1999 1 2 2 1 1 1 0 0 1 1 1 11
Kristal-Boneh 2000 1 2 2 2 1 2 2 0 1 1 1 15
Nakajima 2000 2 2 2 2 2 2 0 2 2 1 1 18
Goodwin 2001 (young) 2 2 2 1 1 2 0 1 2 1 1 15
Jehn 2002 2 0 0 0 2 1 0 2 2 2 1 12
Charach 2004 2 2 2 2 2 2 2 2 1 1 2 20
Madsen 2006 2 0 0 0 1 0 2 2 1 1 1 10
Perez-Lloret 2006 2 0 0 2 2 2 2 2 2 2 1 17
Youn 2007 1 2 2 2 1 1 0 2 1 1 2 15
Modesti 2006 2 0 0 0 2 2 2 2 2 2 1 15
Chen 2008 2 2 0 1 1 1 2 2 1 1 1 14
Alperovitch 2009 2 0 0 0 2 1 2 2 2 1 1 13
Radke 2010 1 2 2 2 1 1 0 0 2 2 1 14
Dasgupta 2010 1 2 2 1 1 2 2 2 1 1 2 17
Sinha 2010 2 2 2 2 2 2 2 0 1 1 1 17
Kamezaki 2010 2 2 2 2 2 1 2 0 1 1 1 16
Iwabu 2010 2 2 2 2 2 1 0 2 1 2 1 17
Kimura 2010 2 2 2 2 2 1 0 2 1 1 1 16
Hozawa 2011 2 2 2 1 1 0 0 2 2 1 1 14
Lewington 2012 2 0 0 0 1 1 2 2 2 2 1 13
Fedecostante 2012 2 0 0 0 2 1 2 2 2 1 1 13
Modesti 2013 2 0 0 0 2 2 2 2 2 2 1 15
Cois 2015 2 2 0 1 1 1 2 2 1 1 1 14
Stergiou 2015 2 2 2 2 2 2 0 2 2 2 2 20
Martinez-Nicolas 2015 1 2 2 2 2 1 0 0 2 2 1 15
Wong 2016 1 0 0 0 2 1 0 2 2 2 1 11
Hanazawa 2017 2 2 2 0 2 1 2 2 2 1 0 16
Nishizawa 2017 1 2 2 0 2 1 2 2 2 1 0 15
Wang 2017 2 0 0 0 1 1 2 2 1 1 1 11
Iwahori 2018 2 0 0 0 2 1 2 0 1 1 1 10
Supplementary Figure 1.
Geographical origin of studies reporting seasonal blood pressure differences (countries in black)
Supplementary Figure 2. Begg's funnel plots for identification of publication bias
Standard Error of seasonal BP difference (mmHg)
Begg's funnel plot with pseudo 95% confidence limits
S-W OSBP
s.e. of: S-W OSBP
0 2 4 6
-30 -20 -10 0 10
Office SBP
Office DBP
Begg's funnel plot with pseudo 95% confidence limits
S-W ODBP
s.e. of: S-W ODBP
0 1 2 3
-15 -10 -5 0 5
Begg's funnel plot with pseudo 95% confidence limits
S-W D-SBP
s.e. of: S-W D-SBP
0 1 2 3
-10 -5 0 5
Daytime ambulatory SBP
Begg's funnel plot with pseudo 95% confidence limits
S-W D-DBP
s.e. of: S-W D-DBP
0 .5 1 1.5 2
-10 -5 0
Daytime ambulatory DBP
Begg's funnel plot with pseudo 95% confidence limits
S-W SHBP
s.e. of: S-W SHBP
0 1 2 3
-15 -10 -5 0
Seaso n al B P d iff e ren ce (mmH g )
Home SBP
Home DBP
Begg's funnel plot with pseudo 95% confidence limits
S-W DHBP
s.e. of: S-W DHBP
0 1 2 3
-10 -5 0 5
