0 6 12 18 24 30 36 42 48 54 60 66 72 0
20 20 25 30 35 40
*
* ** ** ** *
Time after AP (Hours)
Body Temperature [°C]
0 6 12 18 24 30 36 42 48 54 60 66 72 0
2 4 6 8 10
** *
*
**
BL/6 AP OT-II AP
Time after AP (Hours)
Severity Score
survivors
0 6 12 18 24 30 36 42 48 54 60 66 72 0
20 20 25 30 35 40
*
Time after AP (Hours)
Body Temperature [°C]
0 6 12 18 24 30 36 42 48 54 60 66 72 0
2 4 6 8 10
Time after AP (Hours)
Severity Score
non-survivors
A B
C D
Supplemental Digital Content 3
Prolonged recovery phase in septic OTII mice compared to WT.
OTII mice and C57BL/6 WT mice were subjected to AP or left untreated. Body temperature was measured at close intervals and is depicted separately for surviving (A) and non-surviving (B) mice. Additionally, sepsis severity was determined as described in Materials and Methods. It is shown separately for surviving (C) and non-surviving (D) mice, respectively. Sample sizes were 11 WT, 4 OTII/group for surviving and 11 WT, 26 OTII/group for non-surviving animals. Data are expressed as the mean ± SEM. Septic OTII and WT mice were compared using the Mann-Whitney test.*,P ≤ 0.05; **, P≤ 0.01
