Supplemental Digital Content 5-expression_decrease_16h

(1)

SKI_chr1_+_2160134_2241652 ERRFI1_chr1_‐_8071779_8086393 RERE_chr1_‐_8412464_8877699 PIK3CD_chr1_+_9711790_9789172 SNORA59A_chr1_+_12567300_12567451 SNORA59B_chr1_+_12567300_12567451 AGMAT_chr1_‐_15898194_15911605 RSC1A1_chr1_+_15986364_15988217 SPEN_chr1_+_16174359_16266950 EPHA2_chr1_‐_16450832_16482582 C1orf144_chr1_+_16693583_16724640 ATP13A2_chr1_‐_17312453_17338423 ID3_chr1_‐_23884421_23886285 TCEB3_chr1_+_24069856_24088549 C1orf201_chr1_‐_24683489_24741587 NIPAL3_chr1_+_24742245_24799473 CLIC4_chr1_+_25071760_25170815 RPS6KA1_chr1_+_26856249_26901520 ARID1A_chr1_+_27022522_27108601 RCC1_chr1_+_28832455_28865708 MYCBP_chr1_‐_39328162_39339050 GJA9‐MYCBP_chr1_‐_39328162_39347298 ZNF643_chr1_+_40916337_40929390 ZSWIM5_chr1_‐_45482076_45672250 KIAA0494_chr1_‐_47140831_47184736 CMPK1_chr1_+_47799469_47844511 RAB3B_chr1_‐_52373628_52456436 PDE4B_chr1_+_66258193_66840262 GNG12_chr1_‐_68167149_68299155 NEXN_chr1_+_78354200_78409578 ELTD1_chr1_‐_79355449_79472495 BCL10_chr1_‐_85731460_85742587 SH3GLB1_chr1_+_87170253_87213867 LRRC8C_chr1_+_90098644_90185094 EVI5_chr1_‐_92974253_93257961 BCAR3_chr1_‐_94027343_94312706 CNN3_chr1_‐_95362507_95392735 SLC30A7_chr1_+_101361632_101447311 PRMT6_chr1_+_107599267_107601916 NTNG1_chr1_+_107682629_108024475 MAGI3_chr1_+_113933475_114228545 RSBN1_chr1_‐_114304454_114355070 NRAS_chr1_‐_115247085_115259515 GDAP2_chr1_‐_118406107_118472302 ZNF697_chr1_‐_120162000_120190390 NBPF7_chr1_‐_120377388_120387779 EMBP1_chr1_+_121260910_121313686

(2)

TXNIP_chr1_+_145438462_145442628 HIST2H2BC_chr1_‐_149821759_149822340 RPRD2_chr1_+_150336990_150449041 LCE3D_chr1_‐_152551860_152552980 PRR9_chr1_+_153190060_153191793 MIR765_chr1_‐_156905923_156906036 TOMM40L_chr1_+_161195833_161200407 UHMK1_chr1_+_162466964_162499419 UAP1_chr1_+_162531296_162569633 BLZF1_chr1_+_169337194_169365780 C1orf9_chr1_+_172502260_172580973 SNORD81_chr1_‐_173833313_173833355 SNORD78_chr1_‐_173834771_173834824 LAMC2_chr1_+_183155174_183214262 PDC_chr1_‐_186412698_186430239 ZBTB41_chr1_‐_197122814_197169672 ZNF281_chr1_‐_200375420_200379166 CAMSAP2_chr1_+_200708686_200829831 RPS10P7_chr1_+_201489032_201489720 NAV1_chr1_+_201617450_201796102 MIR1231_chr1_+_201777739_201777830 ADIPOR1_chr1_‐_202909960_202927700 ZBED6_chr1_+_203766651_203769590 TMCC2_chr1_+_205197038_205242471 ELK4_chr1_‐_205577071_205602000 PLXNA2_chr1_‐_208195588_208417665 G0S2_chr1_+_209848670_209849735 DIEXF_chr1_+_210001312_210030910 PTPN14_chr1_‐_214522039_214725024 KCNK2_chr1_+_215178885_215410436 FBXO28_chr1_+_224301789_224349749 MBOAT2_chr2_‐_8996701_9143876 RHOB_chr2_+_20646835_20649201 C2orf44_chr2_‐_24252206_24270296 ASXL2_chr2_‐_25962253_26101312 RAB10_chr2_+_26256729_26360323 GPN1_chr2_+_27851515_27873713 EHD3_chr2_+_31456880_31491260 SLC30A6_chr2_+_32390910_32449181 EIF2AK2_chr2_‐_37332284_37384190 SOCS5_chr2_+_46926099_46989927 C2orf61_chr2_‐_47314130_47382517 FOXN2_chr2_+_48541795_48606434 PSME4_chr2_‐_54091204_54197977 PNPT1_chr2_‐_55861198_55921011 CCDC85A_chr2_+_56411258_56613309 REL_chr2_+_61108752_61150178

(3)

PEX13_chr2_+_61244812_61279125 KIAA1841_chr2_+_61293006_61365169 MEIS1_chr2_+_66662532_66799891 APLF_chr2_+_68694691_68807294 ANTXR1_chr2_+_69240276_69476459 C2orf42_chr2_‐_70377017_70418151 ATOH8_chr2_+_85980909_86018506 LOC284950_chr2_+_86042253_86053911 ST3GAL5_chr2_‐_86066271_86116157 TMEM131_chr2_‐_98372801_98612354 LYG1_chr2_‐_99900701_99917639 FHL2_chr2_‐_105977283_106055230 UXS1_chr2_‐_106709759_106810795

LOC100287216_chr2_‐_109743784_109746575 ZC3H6_chr2_+_113033178_113097640

TTL_chr2_+_113239743_113290222 SLC20A1_chr2_+_113403434_113421400 PSD4_chr2_+_113931560_113960677 RABL2A_chr2_+_114384817_114400975 CCDC93_chr2_‐_118673054_118771739 RALB_chr2_+_121010414_121052286 MAP3K2_chr2_‐_128056245_128100805 LOC401010_chr2_‐_132199734_132202467 R3HDM1_chr2_+_136289083_136482839 EPC2_chr2_+_149402560_149545136 RND3_chr2_‐_151324707_151344209 GPD2_chr2_+_157291965_157442915 MARCH7_chr2_+_160569010_160625084 PSMD14_chr2_+_162164786_162268228 GRB14_chr2_‐_165349323_165478360 STK39_chr2_‐_168810530_169104105 HAT1_chr2_+_172778935_172848600 AGPS_chr2_+_178257471_178408564 NCKAP1_chr2_‐_183789605_183903229 MYO1B_chr2_+_192110107_192290115 HECW2_chr2_‐_197063977_197457335 PGAP1_chr2_‐_197697728_197791454 MARS2_chr2_+_198570028_198573114 SATB2_chr2_‐_200134223_200335989 MARCH4_chr2_‐_217122585_217236750 USP37_chr2_‐_219314974_219433084 EPHA4_chr2_‐_222282747_222437010 AP1S3_chr2_‐_224620047_224702319 DOCK10_chr2_‐_225629807_225907330 IRS1_chr2_‐_227596033_227663506 TRIP12_chr2_‐_230631930_230786655 SP100_chr2_+_231280871_231410317

(4)

SH3BP4_chr2_+_235860628_235964358 LRRFIP1_chr2_+_238536224_238690290 ANKMY1_chr2_‐_241418839_241497405 BOK_chr2_+_242498146_242513553 BHLHE40_chr3_+_5021097_5026865 OXTR_chr3_‐_8792095_8811300 IRAK2_chr3_+_10206563_10285427 DPH3_chr3_‐_16298568_16306496 PLCL2_chr3_+_16926452_17132098 RAB5A_chr3_+_19988572_20026667 NEK10_chr3_‐_27257097_27410912 GPD1L_chr3_+_32148003_32210207 CMTM6_chr3_‐_32522804_32544403 DYNC1LI1_chr3_‐_32567463_32612366 SUSD5_chr3_‐_33191537_33260707 PDCD6IP_chr3_+_33840063_33911199 OXSR1_chr3_+_38207026_38296979 ABHD5_chr3_+_43732375_43764217 C3orf23_chr3_+_44379611_44450940 COL7A1_chr3_‐_48601506_48632593 PRKAR2A_chr3_‐_48788093_48885270 QRICH1_chr3_‐_49067142_49131504 NAT6_chr3_‐_50333833_50336852 ALAS1_chr3_+_52232099_52248343 PBRM1_chr3_‐_52579368_52719866 ERC2‐IT1_chr3_‐_55691243_55693497 FAM208A_chr3_‐_56654160_56717135 PRICKLE2_chr3_‐_64079526_64211131 MAGI1_chr3_‐_65339906_66024509 LRIG1_chr3_‐_66429221_66550845 KBTBD8_chr3_+_67048727_67061632 FRMD4B_chr3_‐_69219146_69435430 SHQ1_chr3_‐_72798428_72897598 PPP4R2_chr3_+_73046119_73115011 PDZRN3_chr3_‐_73431652_73674072 ZNF717_chr3_‐_75786029_75834255 ROBO1_chr3_‐_78646388_79817059 GBE1_chr3_‐_81538850_81810950 CGGBP1_chr3_‐_88101100_88199016 ARL6_chr3_+_97483595_97517373 DCBLD2_chr3_‐_98514814_98620533 COL8A1_chr3_+_99357440_99515577 TMEM45A_chr3_+_100211463_100296285 ZBTB11_chr3_‐_101368283_101395988 NFKBIZ_chr3_+_101546834_101579869 CBLB_chr3_‐_105377109_105587887 ZDHHC23_chr3_+_113666748_113681827

(5)

ARHGAP31_chr3_+_119013220_119138323 GSK3B_chr3_‐_119540802_119813264 PTPLB_chr3_‐_123213363_123303924 ZNF148_chr3_‐_124944513_125094198 MGLL_chr3_‐_127407905_127542093 PPP2R3A_chr3_+_135684515_135866752 ZBTB38_chr3_+_141043055_141168632 RASA2_chr3_+_141205926_141331197 XRN1_chr3_‐_142025449_142166853 SIAH2_chr3_‐_150458910_150481263 SSR3_chr3_‐_156257929_156272973 VEPH1_chr3_‐_156977532_157221415 KPNA4_chr3_‐_160212783_160283376 SCARNA7_chr3_‐_160232695_160233024 TMEM212_chr3_+_171561139_171577108 ECT2_chr3_+_172468475_172539264 PIK3CA_chr3_+_178866311_178952497 ETV5_chr3_‐_185764106_185826901 TBCCD1_chr3_‐_186263856_186288332 CCDC50_chr3_+_191046874_191116459 UBXN7_chr3_‐_196080369_196159345 RNF168_chr3_‐_196195657_196230639 PAK2_chr3_+_196466728_196559518 SENP5_chr3_+_196594727_196661584 SLIT2_chr4_+_20255235_20620788 SLIT2‐IT1_chr4_+_20393812_20396479 STIM2_chr4_+_26862313_27027003 PGM2_chr4_+_37828282_37864559 PDS5A_chr4_‐_39824483_39979576 NFXL1_chr4_‐_47849258_47916633 CHIC2_chr4_‐_54875958_54930815 CLOCK_chr4_‐_56298660_56412997 AASDH_chr4_‐_57204457_57253638 REST_chr4_+_57774042_57802010 UBA6_chr4_‐_68481479_68566889 MOB1B_chr4_+_71768057_71853891 SLC4A4_chr4_+_72053003_72437804 MTHFD2L_chr4_+_75023829_75168814 EPGN_chr4_+_75174204_75179307 PAQR3_chr4_‐_79839094_79860582 LIN54_chr4_‐_83845756_83934040 HELQ_chr4_‐_84328499_84377025 AFF1_chr4_+_87856154_88062206 KLHL8_chr4_‐_88082214_88141674 HSP90AB3P_chr4_+_88812995_88815167 PKD2_chr4_+_88928799_88998931 PDLIM5_chr4_+_95373008_95589378

(6)

TET2_chr4_+_106067032_106200960 GSTCD_chr4_+_106629941_106768882 USP53_chr4_+_120133782_120216673 LOC645513_chr4_+_120375938_120420747 FGF2_chr4_+_123747863_123819390 CCRN4L_chr4_+_139936943_139967095 NAA15_chr4_+_140222676_140311935 INPP4B_chr4_‐_142949182_143767604 USP38_chr4_+_144106070_144143141 SH3D19_chr4_‐_152041433_152149182 PDGFC_chr4_‐_157682763_157892546 RXFP1_chr4_+_159442866_159574521 SH3RF1_chr4_‐_170015407_170192249 NEK1_chr4_‐_170314421_170533778 MFAP3L_chr4_‐_170907748_170947429 VEGFC_chr4_‐_177604691_177713895 SNX25_chr4_+_186131284_186285120 CLPTM1L_chr5_‐_1318000_1345002 MTRR_chr5_+_7869217_7901235 MARCH6_chr5_+_10353828_10435491 TRIO_chr5_+_14143829_14509458 FBXL7_chr5_+_15500305_15939900 DROSHA_chr5_‐_31400602_31532282 GDNF_chr5_‐_37812779_37839782 RICTOR_chr5_‐_38938022_39074501 CARD6_chr5_+_40841410_40855456 ZNF131_chr5_+_43121642_43175823 FST_chr5_+_52776264_52782304 ARL15_chr5_‐_53180614_53606403 LRRC70_chr5_+_61874562_61877275 RNF180_chr5_+_63461671_63668696 SREK1IP1_chr5_‐_64013978_64064496 ADAMTS6_chr5_‐_64444563_64777704 TRIM23_chr5_‐_64885507_64920187 SGTB_chr5_‐_64961755_65017941 NLN_chr5_+_65018023_65125111 ERBB2IP_chr5_+_65222382_65376851 MAST4_chr5_+_65892176_66465423 PTCD2_chr5_+_71616200_71655180 TMEM171_chr5_+_72416388_72427644 ENC1_chr5_‐_73923231_73937249 HMGCR_chr5_+_74632993_74657926 POC5_chr5_‐_74970024_75013313 SCAMP1_chr5_+_77656339_77776562 HOMER1_chr5_‐_78669786_78809700 MTX3_chr5_‐_79272539_79287088 SERINC5_chr5_‐_79407050_79551898

(7)

POLR3G_chr5_+_89770681_89810369 ELL2_chr5_‐_95220802_95297775

LOC100289230_chr5_+_98264838_98266713 C5orf30_chr5_+_102594442_102614361 STARD4_chr5_‐_110834022_110848157 APC_chr5_+_112043202_112181936

TMED7‐TICAM2_chr5_‐_114914339_114961876 PRR16_chr5_+_119800019_120022964

SNX24_chr5_+_122181160_122344902 CSNK1G3_chr5_+_122847793_122952464 GRAMD3_chr5_+_125695788_125829853 RAD50_chr5_+_131892616_131980313 AFF4_chr5_‐_132211071_132299354 SMAD5_chr5_+_135468536_135518422 PURA_chr5_+_139493708_139499001 HBEGF_chr5_‐_139712428_139726188 WDR55_chr5_+_140044384_140050553 PCDHB13_chr5_+_140593509_140596993 RBM27_chr5_+_145583163_145668784 GALNT10_chr5_+_153570295_153800543 LSM11_chr5_+_157170755_157183746 PANK3_chr5_‐_167982628_168006614 CCDC99_chr5_+_169010638_169031781 DOCK2_chr5_+_169064251_169510386 FAM196B_chr5_‐_169290719_169407744 KIAA1191_chr5_‐_175773066_175788809 ARL10_chr5_+_175792502_175800503 RMND5B_chr5_+_177558028_177575479 ZNF354A_chr5_‐_178138522_178157703 ZNF879_chr5_+_178450776_178461388 MAPK9_chr5_‐_179660595_179719071 CNOT6_chr5_+_179921417_180005353 SLC22A23_chr6_‐_3269207_3456793 SSR1_chr6_‐_7281288_7313541 DSP_chr6_+_7541870_7586946 PIP5K1P1_chr6_+_7986335_7990577 CD83_chr6_+_14117487_14137148 HIST1H1T_chr6_‐_26107640_26108364 ZNF187_chr6_+_28234788_28245980 PGBD1_chr6_+_28249314_28270326 PPP1R10_chr6_‐_30568182_30585020 ZBTB12_chr6_‐_31867394_31869769 HLA‐DMB_chr6_‐_32902406_32908847 SRPK1_chr6_‐_35800811_35888957 PPIL1_chr6_‐_36822606_36842800 PI16_chr6_+_36916039_36932613 NFYA_chr6_+_41040707_41070146

(8)

GUCA1B_chr6_‐_42151022_42162694 KIAA0240_chr6_+_42788794_42836296 ZNF318_chr6_‐_43303808_43337181 CD2AP_chr6_+_47445525_47594996 PTCHD4_chr6_‐_47845764_48036425 BEND6_chr6_+_56819773_56892142 KIAA1586_chr6_+_56911384_56920023 ZNF451_chr6_+_56954808_57035098 BAG2_chr6_+_57037104_57050012 PTP4A1_chr6_+_64281920_64293489 RIMS1_chr6_+_72596406_73112845 KCNQ5_chr6_+_73331571_73908573 TMEM30A_chr6_‐_75962638_75994632 LOC100288198_chr6_+_79943391_79946517 UBE2J1_chr6_‐_90036344_90062619

CASP8AP2_chr6_+_90539619_90584155 MANEA_chr6_+_96025373_96057328 OSTM1_chr6_‐_108362613_108395941 KPNA5_chr6_+_117002367_117063030 DCBLD1_chr6_+_117803820_117891020 ARHGAP18_chr6_‐_129898240_130031370 ENPP1_chr6_+_132129156_132216295 SGK1_chr6_‐_134490384_134639196 AHI1_chr6_‐_135605110_135818903 MAP3K5_chr6_‐_136878187_137113656 CITED2_chr6_‐_139693392_139695787 VTA1_chr6_+_142468410_142542085 HIVEP2_chr6_‐_143072604_143266338 LATS1_chr6_‐_149982051_150039392 SYNE1_chr6_‐_152442819_152958534 C6orf99_chr6_+_159309619_159331385 SOD2_chr6_‐_160100149_160114353 FGFR1OP_chr6_+_167412816_167454066 ADAP1_chr7_‐_937537_994289

USP42_chr7_+_6144550_6201195 KDELR2_chr7_‐_6500712_6523849 ZNF853_chr7_+_6655527_6663921 STEAP1B_chr7_‐_22459063_22539901 MALSU1_chr7_+_23338940_23349180 IGF2BP3_chr7_‐_23349828_23509995 OSBPL3_chr7_‐_24836164_25019760 BMPER_chr7_+_33944523_34195484 DPY19L1_chr7_‐_34968493_35077653 STK17A_chr7_+_43622692_43666978 RASA4P_chr7_‐_44068486_44080222 MIR4649_chr7_+_44150448_44150511 MIR4657_chr7_‐_44921347_44921399

(9)

FIGNL1_chr7_‐_50511832_50518088 ZNF680_chr7_‐_63980255_64023505 ZNF92_chr7_+_64838768_64865998 VKORC1L1_chr7_+_65338257_65419800 FZD9_chr7_+_72848109_72850450 LIMK1_chr7_+_73498107_73536855 RSBN1L_chr7_+_77325743_77409120 STEAP2_chr7_+_89841000_89866992 CDK14_chr7_+_90338712_90839904 FZD1_chr7_+_90893783_90898132 FAM133B_chr7_‐_92190072_92219706 CDK6_chr7_‐_92234235_92465941 SAMD9_chr7_‐_92728826_92747336 SAMD9L_chr7_‐_92759368_92777680 ZKSCAN5_chr7_+_99102273_99131445 AGFG2_chr7_+_100136834_100165843 CUX1_chr7_+_101459184_101927250 LRWD1_chr7_+_102105390_102113612 NAPEPLD_chr7_‐_102740023_102789569 ORC5_chr7_‐_103766788_103848495

LOC100216545_chr7_‐_104650989_104654588 MLL5_chr7_+_104654637_104754532

ATXN7L1_chr7_‐_105245221_105517031 DOCK4_chr7_‐_111366164_111846462 MDFIC_chr7_+_114562209_114659970 TES_chr7_+_115850547_115898837 CAV2_chr7_+_116139655_116148595 MET_chr7_+_116312459_116438440 ST7‐OT3_chr7_+_116822735_116849991 C7orf58_chr7_+_120628751_120937498 LOC646329_chr7_‐_130565751_130598069 FLJ43663_chr7_‐_130628919_130793562 MKLN1_chr7_+_130794855_131181398 FAM180A_chr7_‐_135414346_135433594 DGKI_chr7_‐_137074385_137531609 CREB3L2_chr7_‐_137559725_137686847 HIPK2_chr7_‐_139246316_139477693 PARP12_chr7_‐_139723549_139763521 JHDM1D_chr7_‐_139784546_139876741 BRAF_chr7_‐_140433813_140624564 LMBR1_chr7_‐_156473570_156685902 UBE3C_chr7_+_156931655_157062066 AGPAT5_chr8_+_6565878_6619021 CNOT7_chr8_‐_17086740_17104387 SLC39A14_chr8_+_22224762_22291640 TNFRSF10A_chr8_‐_23048970_23082680 LOC100507156_chr8_+_23193721_23223638

(10)

DOCK5_chr8_+_25042287_25270619 NRG1_chr8_+_31497268_32622558 PROSC_chr8_+_37620101_37637286 ASH2L_chr8_+_37963011_37997598 BAG4_chr8_+_38034106_38070819 WHSC1L1_chr8_‐_38132561_38239790 PLAT_chr8_‐_42032236_42065194 THAP1_chr8_‐_42691817_42698474 HOOK3_chr8_+_42752033_42885682 SGK196_chr8_+_42948657_42978323 IMPAD1_chr8_‐_57870488_57906430 ARMC1_chr8_‐_66514691_66546452 PDE7A_chr8_‐_66626569_66753969 SULF1_chr8_+_70378859_70573147 ZFHX4_chr8_+_77593515_77779521 PKIA_chr8_+_79428336_79517502 WWP1_chr8_+_87354994_87480178 MMP16_chr8_‐_89049460_89339717 OSGIN2_chr8_+_90914096_90940095 TMEM64_chr8_‐_91634223_91658133 LOC100127983_chr8_‐_91970706_91997485 KCNS2_chr8_+_99439250_99443023

RRM2B_chr8_‐_103216729_103251346 ATP6V1C1_chr8_+_104033248_104085285 FZD6_chr8_+_104310661_104345094 LRP12_chr8_‐_105501459_105601252 RAD21_chr8_‐_117858173_117887105 HAS2_chr8_‐_122625271_122653630 ZHX1_chr8_‐_124260690_124287781 ZNF572_chr8_+_125985539_125991630 MYC_chr8_+_128748315_128753680 FAM49B_chr8_‐_130851839_131028897 PTK2_chr8_‐_141668481_142011412 BREA2_chr8_+_144779285_144780583 ZNF250_chr8_‐_146102336_146126846 CD274_chr9_+_5450503_5470567 PDCD1LG2_chr9_+_5510545_5571282 BNC2_chr9_‐_16409501_16870786 HAUS6_chr9_‐_19053141_19102902 DDX58_chr9_‐_32455300_32526322 B4GALT1_chr9_‐_33110639_33167356 DNAJB5_chr9_+_34989638_34998430 RMRP_chr9_‐_35657748_35658015 CCIN_chr9_+_36169389_36171331 APBA1_chr9_‐_72042449_72287275 TMEM2_chr9_‐_74298282_74383800 TLE4_chr9_+_82186878_82341656

(11)

AGTPBP1_chr9_‐_88161454_88356944 C9orf47_chr9_+_91605778_91611057 S1PR3_chr9_+_91606324_91620069 ZNF484_chr9_‐_95607313_95640320 SUSD3_chr9_+_95820989_95847415 FAM120A_chr9_+_96214173_96328397 GABBR2_chr9_‐_101050364_101471479 MSANTD3_chr9_+_103189495_103214016

MSANTD3‐TMEFF1_chr9_+_103204188_103339918 ZNF189_chr9_+_104161163_104172942

PALM2‐AKAP2_chr9_+_112542577_112934791 AKAP2_chr9_+_112810878_112934791

LPAR1_chr9_‐_113636054_113800365 ZNF883_chr9_‐_115759400_115774472 ZFP37_chr9_‐_115804174_115818996 SLC31A2_chr9_+_115913238_115926422 TRIM32_chr9_+_119449581_119463579 TTLL11_chr9_‐_124584204_124855885 OR1L1_chr9_+_125423995_125424927 DENND1A_chr9_‐_126141933_126692417 PPP6C_chr9_‐_127908852_127952218 STXBP1_chr9_+_130374486_130454995 NCS1_chr9_+_132934857_132999583 ABL1_chr9_+_133589268_133763062 SURF4_chr9_‐_136228340_136242970 LARP4B_chr10_‐_855484_931702 PFKFB3_chr10_+_6186843_6277507 UPF2_chr10_‐_11962021_12085169 MKX_chr10_‐_27961803_28034778 KIAA1462_chr10_‐_30301729_30348488 CCDC7_chr10_+_32735041_32863492 NRP1_chr10_‐_33466419_33623833 FZD8_chr10_‐_35927177_35930362 ZNF37A_chr10_+_38383264_38412278 CSGALNACT2_chr10_+_43633934_43680749 SYT15_chr10_‐_46955444_46970601

MAPK8_chr10_+_49609687_49643183 ARHGAP22_chr10_‐_49654068_49864310 ERCC6_chr10_‐_50664491_50747147 CCDC6_chr10_‐_61548506_61666414 REEP3_chr10_+_65281123_65384883 HERC4_chr10_‐_69681656_69835103 EIF4EBP2_chr10_+_72163861_72188374 KIAA1274_chr10_+_72238564_72328206 DDIT4_chr10_+_74033677_74035797 KCNMA1_chr10_‐_78629359_79397577 POLR3A_chr10_‐_79734907_79789298

(12)

TNKS2_chr10_+_93558151_93625232 ZNF518A_chr10_+_97889472_97923517 LCOR_chr10_+_98592017_98724198 C10orf12_chr10_+_98741041_98745585 ENTPD7_chr10_+_101419263_101471002 CHUK_chr10_‐_101948124_101989344 MXI1_chr10_+_111967363_112047123 GPAM_chr10_‐_113909622_113943537 C10orf118_chr10_‐_115881974_115934364 GFRA1_chr10_‐_117816442_118033126 PDZD8_chr10_‐_119042606_119134937 PPAPDC1A_chr10_+_122216466_122349367 BUB3_chr10_+_124913760_124924886 ADAM12_chr10_‐_127702902_128077127 PAOX_chr10_+_135192741_135205198 LOC619207_chr10_+_135267432_135281953 PHRF1_chr11_+_576483_612222

OR6A2_chr11_‐_6815756_6817139 OR10A6_chr11_‐_7949265_7950209 NLRP10_chr11_‐_7981156_7985059 IPO7_chr11_+_9406169_9469674 EIF4G2_chr11_‐_10818593_10830582 GALNTL4_chr11_‐_11292421_11643561 MICAL2_chr11_+_12132138_12285331 RRAS2_chr11_‐_14299466_14386052 SPTY2D1_chr11_‐_18627948_18656020 NAV2_chr11_+_19372271_20143147 LGR4_chr11_‐_27387508_27494334 LIN7C_chr11_‐_27515965_27528326 BDNF_chr11_‐_27676442_27743605 QSER1_chr11_+_32914792_33001814 HIPK3_chr11_+_33279168_33375939 C11orf41_chr11_+_33563877_33695646 CD44_chr11_+_35160417_35253949 FJX1_chr11_+_35639735_35642421 NUP160_chr11_‐_47799670_47870057 PTPRJ_chr11_+_48002110_48192394 LPXN_chr11_‐_58294344_58345639 CNTF_chr11_+_58390146_58393205 OSBP_chr11_‐_59341871_59383617 SYT7_chr11_‐_61281188_61348344 SNORA57_chr11_+_62432894_62433042 TMEM151A_chr11_+_66059373_66064135 PITPNM1_chr11_‐_67259239_67272843 CDK2AP2_chr11_‐_67273968_67276102 CCND1_chr11_+_69455873_69469242 FADD_chr11_+_70049269_70053508

(13)

P2RY2_chr11_+_72929344_72947395 C2CD3_chr11_‐_73745480_73882064 PGM2L1_chr11_‐_74041361_74109502 ARRB1_chr11_‐_74971166_75062875 C11orf30_chr11_+_76156069_76262589 ACER3_chr11_+_76571917_76734850 RSF1_chr11_‐_77377274_77531880 KCTD21_chr11_‐_77882298_77899664 ODZ4_chr11_‐_78364328_79151695 PCF11_chr11_+_82868137_82896835 PICALM_chr11_‐_85668214_85780923 SLC36A4_chr11_‐_92880850_92931095 MAML2_chr11_‐_95711440_96076344 BIRC2_chr11_+_102217966_102249401 SLC35F2_chr11_‐_107661717_107729914 DLAT_chr11_+_111895538_111935002 DDX6_chr11_‐_118618473_118661972 TBCEL_chr11_+_120894803_120960354 MIR100HG_chr11_‐_121959811_122073770 BLID_chr11_‐_121986062_121986923 UBASH3B_chr11_+_122526398_122685187 CLMP_chr11_‐_122943033_123066007 KIRREL3_chr11_‐_126293396_126870766 NTM_chr11_+_131240371_132206716 NCAPD3_chr11_‐_134022337_134094426 ERC1_chr12_+_1100404_1605099

ADIPOR2_chr12_+_1800247_1897845 FKBP4_chr12_+_2904108_2914587 STYK1_chr12_‐_10771538_10826891 ETV6_chr12_+_11802788_12048325 DUSP16_chr12_‐_12626216_12715448 RECQL_chr12_‐_21621844_21654603 ABCC9_chr12_‐_21950324_22089628 RASSF8_chr12_+_26111964_26232825 ASUN_chr12_‐_27058112_27091254 MED21_chr12_+_27175483_27182682 REP15_chr12_+_27849428_27850566 KLHDC5_chr12_+_27933187_27955973 DNM1L_chr12_+_32832137_32898584 KIF21A_chr12_‐_39687030_39837192 SLC2A13_chr12_‐_40148823_40499661 PUS7L_chr12_‐_44122412_44152596 ARID2_chr12_+_46123620_46301819 RPAP3_chr12_‐_48055715_48099844 FMNL3_chr12_‐_50031724_50101197 BCDIN3D_chr12_‐_50229826_50236912 SRGAP1_chr12_+_64238541_64541613

(14)

IRAK3_chr12_+_66582978_66648394 FRS2_chr12_+_69864129_69973562 GLIPR1L2_chr12_+_75784889_75817820 GLIPR1_chr12_+_75874513_75895716 BBS10_chr12_‐_76738266_76742222 C12orf26_chr12_+_82752276_82873016 LRRIQ1_chr12_+_85430099_85638883 TMTC3_chr12_+_88536073_88593664 KITLG_chr12_‐_88886570_88974250 DUSP6_chr12_‐_89741837_89746296 EEA1_chr12_‐_93166285_93323107 ELK3_chr12_+_96588207_96661606 CDK17_chr12_‐_96672039_96794366

UHRF1BP1L_chr12_‐_100430863_100536642 GNPTAB_chr12_‐_102139275_102224645 HCFC2_chr12_+_104458236_104500304 CHST11_chr12_+_104850692_105155792 APPL2_chr12_‐_105567075_105630008 POLR3B_chr12_+_106751436_106903976 SELPLG_chr12_‐_109015680_109027670 SSH1_chr12_‐_109176466_109251359 FAM216A_chr12_+_110906232_110928192 CCDC63_chr12_+_111284811_111345338 ATXN2_chr12_‐_111890018_112037480 C12orf52_chr12_+_113623555_113630119 WSB2_chr12_‐_118470492_118498951 SRSF9_chr12_‐_120899471_120907558 TMED2_chr12_+_124069076_124082688 DHX37_chr12_‐_125431370_125473667 BRI3BP_chr12_+_125478194_125510349 EP400NL_chr12_+_132568828_132610885 SACS_chr13_‐_23902965_24007841 NUPL1_chr13_+_25875666_25916561 KATNAL1_chr13_‐_30776767_30881624 USPL1_chr13_+_31191830_31233686 HSPH1_chr13_‐_31710763_31736117 STARD13_chr13_‐_33677272_34250932 KBTBD7_chr13_‐_41765711_41768702 OR7E37P_chr13_+_42016700_42017902 EPSTI1_chr13_‐_43460524_43566407 SLC25A30_chr13_‐_45967454_45992516 LRCH1_chr13_+_47127296_47327175 FNDC3A_chr13_+_49550048_49783915 KPNA3_chr13_‐_50273443_50367057 TRIM13_chr13_+_50571143_50592603 INTS6_chr13_‐_51935701_52027275 KLF12_chr13_‐_74260149_74708066

(15)

TBC1D4_chr13_‐_75858809_76056250 GPR180_chr13_+_95254104_95286899 DNAJC3_chr13_+_96329393_96447243 LINC00359_chr13_‐_97593535_97636426 RAP2A_chr13_+_98086475_98120252 IPO5_chr13_+_98605929_98676550

TNFSF13B_chr13_+_108921977_108960832 TUBGCP3_chr13_‐_113139328_113242481 RASA3_chr13_‐_114747194_114898095 RPPH1_chr14_‐_20811230_20811570 SLC7A8_chr14_‐_23594504_23652869 BAZ1A_chr14_‐_35221937_35344853 MIS18BP1_chr14_‐_45672393_45722605 DNAAF2_chr14_‐_50091892_50101948 FRMD6‐AS1_chr14_‐_52116236_52118462 STYX_chr14_+_53196883_53241705 GNPNAT1_chr14_‐_53241911_53258386 FERMT2_chr14_‐_53323989_53417815 CGRRF1_chr14_+_54976587_55005334 MAPK1IP1L_chr14_+_55518362_55536912 NAA30_chr14_+_57857271_57879466 DACT1_chr14_+_59100786_59115038 HIF1A_chr14_+_62162119_62214977 WDR89_chr14_‐_64063757_64108641 ZBTB1_chr14_+_64971292_65000408

LOC100506321_chr14_+_65556636_65561029 MPP5_chr14_+_67708012_67802778

PLEK2_chr14_‐_67853700_67878828 ADAM20_chr14_‐_70989078_71001732 PCNX_chr14_+_71374122_71582099 DPF3_chr14_‐_73136660_73360809 MLH3_chr14_‐_75480467_75518235 GTF2A1_chr14_‐_81641796_81687575 PTPN21_chr14_‐_88932122_89021123 TDP1_chr14_+_90422246_90511108 GPR68_chr14_‐_91698876_91720224 SMEK1_chr14_‐_91923956_91976644 TRIP11_chr14_‐_92434243_92506403 ITPK1_chr14_‐_93403259_93582263 BTBD7_chr14_‐_93703896_93799385 PPP4R4_chr14_+_94640649_94746072 PAPOLA_chr14_+_96968713_97033453 SNORD113‐1_chr14_+_101391158_101391227 DIO3_chr14_+_102027688_102029789

TECPR2_chr14_+_102829300_102968818 TDRD9_chr14_+_104394817_104519004 NIPA1_chr15_‐_23043279_23086843

(16)

FMN1_chr15_‐_33057747_33360085 SLC12A6_chr15_‐_34522197_34630265 ACTC1_chr15_‐_35080297_35087927 FSIP1_chr15_‐_39892232_40075039 C15orf52_chr15_‐_40623653_40633168 SECISBP2L_chr15_‐_49280835_49338760 TNFAIP8L3_chr15_‐_51348799_51397473 ARPP19_chr15_‐_52839432_52861213 NEDD4_chr15_‐_56119122_56285835 RFX7_chr15_‐_56382731_56535483 LOC145783_chr15_‐_57178368_57210697 CGNL1_chr15_+_57668703_57842925 CA12_chr15_‐_63615730_63674075 CSNK1G1_chr15_‐_64457716_64648442 DPP8_chr15_‐_65737998_65810035 PIAS1_chr15_+_68346572_68480404 PAQR5_chr15_+_69591294_69699976 UACA_chr15_‐_70946893_71055850 THAP10_chr15_‐_71173681_71184772 MIR630_chr15_+_72879558_72879654 LOC100287616_chr15_‐_74209809_74220589 PEAK1_chr15_‐_77400498_77712446

KIAA1024_chr15_+_79724858_79764642 KIAA1199_chr15_+_81071712_81243999 BNC1_chr15_‐_83924655_83953468 PDE8A_chr15_+_85523744_85682376 ANPEP_chr15_‐_90328126_90358072 FURIN_chr15_+_91411885_91426687 SOLH_chr16_+_577856_604636 HN1L_chr16_+_1728278_1752073 PDPK1_chr16_+_2587965_2653191 ZNF597_chr16_‐_3486110_3493490 SLX4_chr16_‐_3631184_3661585 GSPT1_chr16_‐_11961985_12010519 CPPED1_chr16_‐_12753656_12897744 XYLT1_chr16_‐_17196181_17564738 ITPRIPL2_chr16_+_19125254_19132952 CCP110_chr16_+_19535179_19564728 C16orf52_chr16_+_22019456_22095972 PALB2_chr16_‐_23614483_23652678 NETO2_chr16_‐_47115431_47177936 HEATR3_chr16_+_50099881_50139375 PAPD5_chr16_+_50186829_50269219 ADCY7_chr16_+_50321823_50352043 CYLD_chr16_+_50775961_50835846 CHD9_chr16_+_53088945_53361414 LPCAT2_chr16_+_55542913_55620582

(17)

MT1E_chr16_+_56659585_56661024 RSPRY1_chr16_+_57220241_57272947 CNOT1_chr16_‐_58553850_58663790 CMTM4_chr16_‐_66648653_66730610 CBFB_chr16_+_67063050_67134958 FHOD1_chr16_‐_67263292_67281425 NFAT5_chr16_+_69599869_69738569 FTSJD1_chr16_‐_71316203_71323509 ZNF19_chr16_‐_71507976_71523254 SNORA70D_chr16_‐_71732470_71732604 ADAT1_chr16_‐_75632247_75657221 CMIP_chr16_+_81478775_81745367 KIAA0182_chr16_+_85645029_85709812 CRK_chr17_‐_1324647_1359561

RAP1GAP2_chr17_+_2699732_2941035 ZZEF1_chr17_‐_3907739_4046253 ANKFY1_chr17_‐_4066665_4167274 ZNF594_chr17_‐_5082831_5095178 DERL2_chr17_‐_5377613_5389494 XAF1_chr17_+_6659156_6678964 DLG4_chr17_‐_7093210_7123369 POLR2A_chr17_+_7387698_7417935 MGC12916_chr17_+_14207057_14209062 TEKT3_chr17_‐_15207129_15244958 FOXO3B_chr17_‐_18569236_18576494 FAM83G_chr17_‐_18874381_18908060 FAM222B_chr17_‐_27082996_27169841 PHF12_chr17_‐_27232271_27278508 TAOK1_chr17_+_27717943_27878921 SSH2_chr17_‐_27952965_28257018 PSMD11_chr17_+_30771502_30808042 CCL2_chr17_+_32582296_32584220 NR1D1_chr17_‐_38249037_38256973 KRT26_chr17_‐_38922490_38928411 KRTAP1‐5_chr17_‐_39182279_39183454 KLHL11_chr17_‐_40009799_40021629 ACLY_chr17_‐_40023179_40075272 PSME3_chr17_+_40985159_40995777 NBR1_chr17_+_41322498_41363707 DUSP3_chr17_‐_41843489_41856368 GJC1_chr17_‐_42875816_42908179 EFTUD2_chr17_‐_42927655_42976993

MIR4315‐1_dup1_chr17_‐_43552729_43552801 MIR4315‐2_dup1_chr17_‐_43552729_43552801 NGFR_chr17_+_47572655_47592382

ITGA3_chr17_+_48133340_48167849 ANKRD40_chr17_‐_48770551_48785270

(18)

CLTC_chr17_+_57697050_57774317 VMP1_chr17_+_57784863_57917952 TANC2_chr17_+_61086898_61505067 ERN1_chr17_‐_62120390_62207502 SMURF2_chr17_‐_62540735_62658386 BPTF_chr17_+_65821780_65980494 SLC9A3R1_chr17_+_72744751_72765499 CDR2L_chr17_+_72983727_73001892 ACOX1_chr17_‐_73937589_73975515 SPHK1_chr17_+_74380690_74383941 UBE2O_chr17_‐_74385613_74449288 FSCN2_chr17_+_79495417_79504156 FOXK2_chr17_+_80477594_80562483 FLJ35776_chr18_+_3594112_3597377 ZFP161_chr18_‐_5289018_5297052 ANKRD12_chr18_+_9136751_9285983 PPP4R1_chr18_‐_9546792_9614600 SEH1L_chr18_+_12947983_12987536 CEP192_chr18_+_12991361_13125051 ANKRD30B_chr18_+_14748239_14852737 TAF4B_chr18_+_23806409_23971650 CDH2_chr18_‐_25530930_25757445 TRAPPC8_chr18_‐_29409136_29523091 ZNF24_chr18_‐_32912178_32924426 RPRD1A_chr18_‐_33569792_33647373 EPG5_chr18_‐_43427574_43547305 HAUS1_chr18_+_43684298_43708299 C18orf25_chr18_+_43753988_43846955 TCF4_chr18_‐_52889562_53303188 MALT1_chr18_+_56338618_56417370 CCBE1_chr18_‐_57098171_57364644 RNF152_chr18_‐_59482304_59560304 ZCCHC2_chr18_+_60190658_60245818 SERPINB8_chr18_+_61637263_61656608 DSEL_chr18_‐_65173819_65183967 RTTN_chr18_‐_67671043_67872962 SOCS6_chr18_+_67956137_67997434 ARID3A_chr19_+_926037_972803 TLE2_chr19_‐_2997636_3047633 SH3GL1_chr19_‐_4360364_4400565 TICAM1_chr19_‐_4815936_4831754 XAB2_chr19_‐_7684411_7694439 RAB11B_chr19_+_8455205_8469317 ZNF561_chr19_‐_9718002_9731916 DOCK6_chr19_‐_11309969_11373168 RAB3D_chr19_‐_11432722_11450344 CNN1_chr19_+_11649579_11661138

(19)

ZNF823_chr19_‐_11832080_11849760 ZNF878_chr19_‐_12154620_12163782 ZNF788_chr19_+_12203078_12225494 CALR_chr19_+_13049414_13055304 ZSWIM4_chr19_+_13906274_13943044 SYDE1_chr19_+_15218214_15225789 RAB8A_chr19_+_16222490_16244445 C19orf44_chr19_+_16607205_16632163 SLC35E1_chr19_‐_16660648_16683193 GATAD2A_chr19_+_19496642_19619741 ZNF208_chr19_‐_22148897_22193745 ZNF91_chr19_‐_23540498_23578269 ZNF681_chr19_‐_23921997_23941693 ZNF507_chr19_+_32836514_32878573 ZNF30_chr19_+_35417807_35436076 ZNF566_chr19_‐_36936021_36980463 LOC728752_chr19_+_36980529_36981942 ZNF260_chr19_‐_37001589_37019248 ZNF567_chr19_+_37180302_37212225 ZNF420_chr19_+_37569382_37620651 ZNF585A_chr19_‐_37641001_37663615 ZNF585B_chr19_‐_37672481_37701451 ZNF569_chr19_‐_37902060_37958339 ZNF570_chr19_+_37959982_37976242 ZNF540_chr19_+_38042273_38105079 ZFP30_chr19_‐_38123389_38146313 LOC644554_chr19_+_38308051_38317278 SIPA1L3_chr19_+_38397868_38699008 CATSPERG_chr19_+_38826443_38861589 MED29_chr19_+_39881963_39891203 AXL_chr19_+_41725108_41767671 ZNF574_chr19_+_42580290_42585720 PSG7_chr19_‐_43428284_43441330 ZNF223_chr19_+_44556164_44572142 LOC100379224_chr19_‐_44609492_44617336 SNAR‐E_chr19_‐_47333842_47333961

SULT2A1_chr19_‐_48373723_48389654 GYS1_chr19_‐_49471382_49496610 SNAR‐G2_chr19_‐_49534926_49535044 ZNF473_chr19_+_50529212_50552031 ZNF175_chr19_+_52074531_52092991 ZNF649_chr19_‐_52392488_52408305 ZNF808_chr19_+_53030909_53059303 DNAAF3_chr19_‐_55670029_55678090 ZNF583_chr19_+_56915383_56936400 ZNF17_chr19_+_57922529_57933307 FKBP1AP1_chr19_‐_58336667_58338830

(20)

ZNF8_chr19_+_58790318_58807254 ZSCAN22_chr19_+_58838385_58853712 ZNF132_chr19_‐_58944181_58951589 LOC100289473_chr20_‐_1754011_1760392 SNORD86_chr20_+_2636743_2636828 SNORD57_chr20_+_2637585_2637656 FERMT1_chr20_‐_6055492_6104191 BMP2_chr20_+_6748745_6760910 PLCB4_chr20_+_9049701_9461462 ANKRD5_chr20_+_10015697_10037407 SEC23B_chr20_+_18488188_18542059 CBFA2T2_chr20_+_32077928_32237837 MMP24_chr20_+_33814539_33864804 UQCC_chr20_‐_33890369_33999945 PHF20_chr20_+_34359923_34538288 SAMHD1_chr20_‐_35520227_35580246 KCNS1_chr20_‐_43720950_43729753 ZMYND8_chr20_‐_45838381_45985474 NCOA3_chr20_+_46130601_46285621 B4GALT5_chr20_‐_48249483_48330421 ADNP_chr20_‐_49506883_49547527 ZNF217_chr20_‐_52183610_52199636 TFAP2C_chr20_+_55204358_55214338 PMEPA1_chr20_‐_56223448_56286592 VAPB_chr20_+_56964175_57026156 SYCP2_chr20_‐_58438618_58507209 C20orf20_chr20_+_61427805_61431945 NRIP1_chr21_‐_16333556_16437126 BACH1_chr21_+_30671220_30734217 SCAF4_chr21_‐_33043313_33104431 SYNJ1_chr21_‐_34001069_34100351 IFNAR1_chr21_+_34697214_34732128 SLC5A3_chr21_+_35445870_35478561 CBR3‐AS1_chr21_‐_37504065_37528606 DOPEY2_chr21_+_37536839_37666572 MORC3_chr21_+_37692487_37748944 KCNJ6_chr21_‐_38996786_39288696 BRWD1_chr21_‐_40557404_40685712 C2CD2_chr21_‐_43305219_43373999 U2AF1_chr21_‐_44513066_44527688 PDXK_chr21_+_45138978_45182188 KRTAP10‐8_chr21_+_46031996_46032871 CCDC117_chr22_+_29168662_29185283 LIMK2_chr22_+_31608250_31676066 TIMP3_chr22_+_33196802_33259028 KDELR3_chr22_+_38864083_38879445 EP300_chr22_+_41488614_41576081

(21)

EFCAB6_chr22_‐_43924624_44208217 MXRA5_chrX_‐_3226609_3264684 STS_chrX_+_7137472_7272682 PIGA_chrX_‐_15337573_15353676 NHS_chrX_+_17393543_17754113 RPS6KA3_chrX_‐_20168029_20284750 KLHL15_chrX_‐_24001833_24045303 ARX_chrX_‐_25021813_25034065 BCOR_chrX_‐_39910499_40036582 KDM6A_chrX_+_44732423_44971845 PHF16_chrX_+_46771736_46920641 ZNF81_chrX_+_47696301_47781655 ZNF630_chrX_‐_47917567_47931025 PHF8_chrX_‐_53963113_54071569 FAM120C_chrX_‐_54094757_54209714 NHSL2_chrX_+_71130938_71363424 MAP2K4P1_chrX_‐_72744111_72782921 SLC16A2_chrX_+_73641328_73753764 RPS6KA6_chrX_‐_83313354_83442943 CHM_chrX_‐_85116185_85302566 PCDH19_chrX_‐_99546642_99665271 TMEM31_chrX_+_102965837_102968960 PRPS1_chrX_+_106871654_106894256 NXT2_chrX_+_108779010_108787927 KCNE1L_chrX_‐_108866929_108868393 ACSL4_chrX_‐_108884564_108976621 AMMECR1_chrX_‐_109437414_109683461 ZBTB33_chrX_+_119384607_119392251 OCRL_chrX_+_128674252_128726530 ENOX2_chrX_‐_129757357_130037208 MOSPD1_chrX_‐_134021662_134049297 IDS_chrX_‐_148560295_148586884 VMA21_chrX_+_150565657_150577836 GAB3_chrX_‐_153903527_153979348 VAMP7_chrX_+_155110943_155173433