Supplemental Digital Content 1, Table. Background variables in the study subjects
Unvaccinated older siblings of FinIP participants enrolled in 2011 study
Control N=518
PHiD-CV10 2+1 N=482
PHiD-CV10 3+1 N=445
Median age, years (range) 4 (3 to 7) 4 (3 to 7) 4 (3 to 7)
Gender, % males 50.4 47.3 51.9
Median number of siblings (range) 2 (1 to 11) 1.5 (1 to 9) 2 (1 to 11)
Parental smoking, % 21.6 21.6 25.6
Day care/school outside home, % 79.5 79.5 73.0
Day care at day care center, % 42.7 40.5 38.7
Antimicrobial exposure within 2 months prior to
enrolmenta, % 13.3 9.8 12.4
Current respiratory infection symptoms, % 28.4 28.7 26.1
Unvaccinated older siblings of FinIP participants enrolled in 2013 study
Control N=539
PHiD-CV10 2+1 N=524
PHiD-CV10 3+1 N=516
Median age, years (range) 6 (5 to 9) 6 (5 to 9) 6 (5 to 9)
Gender, % males 49.9 51.3 55.4
Median number of siblings (range) 2 (1 to 10) 2 (1 to 9) 2 (1 to 11)
Parental smoking, % 18.9 20.4 22.5
Day care/school outside home, % 97.9 99.4 96.9
Day care at day care centre, % 29.6 30.9 29.6
Antimicrobial exposure within 2 months prior to
enrolmenta, % 8.3 9.2 5.4
Current respiratory infection symptoms, % 17.7 15.8 15.9
FinIP participants enrolled in 2013 study Control N=532
PHiD-CV10 2+1 N=517
PHiD-CV10 3+1 N=501
Median age, years (range) 4 (3 to 5) 4 (3 to 5) 4 (3 to 5)
Gender, % males 51.1 51.1 48.9
Median number of siblings (range) 2 (1 to 10) 2 (1 to 9) 2 (1 to 11)
Parental smoking, % 19.0 20.9 22.6
Day care/school outside home, % 82.0 85.7 79.6
Day care at day care centre, % 61.3 65.2 61.1
Antimicrobial exposure within 2 months prior to
enrolmenta, % 7.9 8.5 7.4
Current respiratory infection symptoms, % 22.4 18.6 20.4
a Antimicrobial exposure within the previous 4 weeks was an exclusion criterion
