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Supplemental digital content
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Table of contents 3
- Supplemental table 1: Biology results during the first 24 hours.
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- Supplemental table 2: International Classification of Diseases, ninth revision 5
(ICD-9) diagnostic codes most represented in the study population.
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- Supplemental Table 3: Baseline differences amongst patients that survived or 7
died in Intensive Care Unit.
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- Supplemental figure 1: Time-weighted average PaO2 distribution between 9
normoxia and hyperoxia groups.
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- Supplemental figure 2: In-Intensive Care Unit mortality in normoxemia and 11
hyperoxemia groups using a multivariable logistic regression model.
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Supplemental table 1: Biology results during the first 24 hours. PaO2 data were 14
collected during the first 24 hours of ICU stay, the other data represent the worst values 15
during the first 24 hours. Results are presented as medians with [interquartile ranges].
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TWA-PaO2, time-weighted average PaO2 during the first 24 hours 17
All (n = 488)
Normoxia (n = 214)
Hyperoxia (n = 274)
p value Arterial blood gases
TWA-PaO2
(mmHg) 125.9 [101.1–154.0] 99.1 [88.9–107.6] 151.5 [133.6–180.2] <0.001 First PaO2
(mmHg) 114.0 [76.0, 215.3] 94.5 [74.0–165.0] 130.0 [86.3–247.5] <0.001 Average PaO2
(mmHg) 130.3 [105.8–158.0] 104.9 [91.8–120.4] 149.8 [130.3–184.4] <0.001 Lowest PaO2
(mmHg) 71.0 [59.0–88.0] 66.0 [55.0–77.0] 77.5 [62.0–102.0] <0.001 Highest PaO2
(mmHg) 235.5 [170.0–330.3] 170.5 [129.3–257.8] 284.0 [218.5–382.0] <0.001 Serum lactate
(mmol/L) 3.9 [2.7–6.0] 3.8 [2.6–6.1] 3.9 [2.7–5.8] 0.980
PaCO2 (mmHg) 46.0 [39.0–55.0] 47.0 [40.0–55.0] 44.0 [37.0–54.0] 0.069
pH 7.22 [7.15–7.29] 7.21 [7.15–7.30] 7.23 [7.15–7.29] 0.488
Chemistry Bicarbonate
(mmol/L) 17.0 [14.0–20.0] 18.0 [14.0–20.0] 17.0 [13.0–20.0] 0.080 Albumin (g/dL) 2.5 [2.1–3.0] 2.6 [2.2–2.9] 2.5 [2.0–3.0] 0.507 Bilirubin (mg/dL) 1.0 [0.6–3.1] 1.1 [0.6–4.3] 1.0 [0.5–2.7] 0.146 Creatinine
(mg/dL) 1.8 [1.1–2.8] 1.8 [1.1–2.9] 1.7 [1.2–2.8] 0.823
Chloride (mmol/L) 110 [106–115] 109 [105–114] 111 [107–115] 0.006 Sodium (mmol/L) 141 [138–145] 140 [138–144] 142 [139–145] 0.021 Potassium
(mmol/L) 4.8 [4.3–5.5] 4.7 [4.2–5.5] 4.8 [4.3–5.4] 0.255
Blood count and hemostasis
Hematocrit (%) 28.1 [24.5–31.9] 29.0 [25.0–33.8] 27.6 [24.0–30.8] 0.001 Hemoglobin
(g/dL) 9.4 [8.1–10.8] 9.6 [8.4–11.2] 9.2 [7.9–10.4] 0.006
Platelets (G/L) 155 [86–238] 152 [89–233] 157 [85–244] 0.811
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Supplemental table 2: International Classification of Diseases, ninth revision 19
(ICD-9) diagnostic codes most represented in the study population (n = 488).
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ICD9 code Code description n (%)
518.81 Acute respiratory failure 382 (78.3)
995.92 Severe sepsis 353 (72.3)
584.9 Acute kidney failure 316 (64.8)
428.0 Congestive heart failure 277 (56.8)
401.9 Hypertension 276 (56.6)
785.52 Septic shock 275 (56.4)
038.9 Septicemia 262 (53.7)
427.31 Atrial fibrillation 229 (46.9)
599.0 Urinary tract infection 165 (33.8)
276.2 Acidosis 158 (32.4)
507.0 Pneumonitis due to inhalation of food or vomitus 157 (32.2) 250.00 Diabetes mellitus without mention of complication 154 (31.6)
285.9 Anemia 128 (26.2)
414.01 Coronary atherosclerosis of native coronary artery 119 (24.4)
244.9 Hypothyroidism 118 (24.2)
486.0 Pneumonia, organism unspecified 114 (23.4)
584.5 Acute kidney failure with lesion of tubular necrosis 108 (22.1)
403.91 Hypertensive chronic kidney disease, unspecified, with chronic
kidney disease stage V or end stage renal disease 94 (19.3)
272.4 Other and unspecified hyperlipidemia 93 (19.1)
287.5 Thrombocytopenia 89 (18.2)
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Supplemental Table 3: Baseline differences amongst patients that survived or 23
died in Intensive Care Unit. Results are presented as medians with [interquartile 24
ranges] or numbers with (percentages). BMI, body mass index; ENT, ear nose and 25
throat; ICU, intensive care unit; IQR, interquartile range; SAPS II, simplified acute 26
physiology score II; SD, standard deviation; SOFA, sequential organ failure 27
assessment; TWA-PaO2, time-weighted average PaO2 during the first 24 hours.
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*PaO2 data were collected during the first 24 hours of ICU stay, the other data 29
represent the worst values during the first 24 hours.
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Survived (n = 322) Deceased (n = 166) p value
Age (years) 65 [53–77] 65 [53–76] 0.860
Male 173 (54) 98 (59) 0.307
BMI (kg/m2) 28.0 [23.7–33.0] 27.1 [22.7–30.6] 0.265
SAPS II 50 [43–60] 62 [52–71] <0.001
SOFA score 9 [7–11] 11 [9–14] <0.001
First ICU 0.004
Surgical ICU 97 (30.1) 29 (17.5)
Medical ICU 225 (69.9) 137 (82.5)
Admission type 0.213
Emergency/Urgent 305 (94.7) 162 (97.6)
Elective 17 (5.3) 4 (2.4)
Biology results*
TWA-PaO2 (mmHg) 128.8 [103.1–162.6] 117.8 [97.4–143.7] 0.007
TWA-PaO2 > 120 mmHg 193 (59.9) 81 (48.8) 0.024
PaCO2 (mmHg) 46.0 [39.0–54.0] 46.0 [38.3–57.8] 0.679
pH 7.24 [7.16–7.30] 7.19 [7.12–7.28] 0.001
Serum lactate (mmol/L) 3.6 [2.6–5.5] 4.4 [3.0–7.7] <0.001
Bicarbonate (mmol/L) 18.0 [14.0–20.0] 16.0 [12.0–19.0] 0.002
Albumin (g/dL) 2.6 [2.1–3.0] 2.4 [2.1–2.9] 0.058
Bilirubin (mg/dL) 0.8 [0.5–2.3] 1.5 [0.8–5.6] <0.001
Creatinine (mg/dL) 1.6 [1.1–2.6] 2.1 [1.3–3.4] 0.001
Hemoglobin (g/dL) 9.4 [8.2–10.9] 9.3 [8.1–10.6] 0.273
Comorbidities
Cardiac 155 (48.1) 79 (47.6) 0.985
Vascular 66 (20.5) 35 (21.1) 0.973
Neurologic 52 (16.1) 16 (9.6) 0.067
Pulmonary 57 (17.7) 29 (17.5) 1
Metabolic 112 (34.8) 62 (37.3) 0.645
Renal 44 (13.7) 34 (20.5) 0.069
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Hepatic 39 (12.1) 33 (19.9) 0.031
Cancer 30 (9.3) 41 (24.7) <0.001
Infection sources
Pulmonary 128 (39.8) 64 (38.6) 0.874
Genito-urinary 24 (7.5) 8 (4.8) 0.357
Neurologic 8 (2.5) 2 (1.2) 0.543
Digestive 93 (28.9) 37 (22.3) 0.146
Osteo-articular 3 (0.9) 1 (0.6) 1
ENT 1 (0.3) 1 (0.6) 1
Cardiologic 2 (0.6) 1 (0.6) 1
Cutaneous 14 (4.3) 5 (3.0) 0.634
Other/Unknown 56 (17.4) 53 (31.9) <0.001
