Supplemental Table 2: Denominator counts (N) and annual prevalence (per 1000 women) of a prescription claim for an oral estrogen, transdermal estrogen patch, vaginal estrogen cream, and vaginal estrogen ring or insert, by age group and calendar year.
Age group 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015
55-54 years
N 396,508 1,115,507 1,280,861 1,376,046 1,386,894 1,418,213 1,348,252 1,362,838 1,203,028 983,453
oral 94.1 94.2 83.5 78.0 72.6 66.2 64.3 61.2 58.4 57.9
patch 23.2 23.7 22.1 23.1 23.3 22.6 23.3 23.8 23.3 22.3
cream 17.7 18.9 18.6 19.6 20.2 20.7 20.7 19.9 19.7 20.6
ring/insert 13.6 13.4 13.8 13.2 12.7 11.5 10.6 10.0 9.5 8.9
55-59 years
N 350,002 976,055 1,138,139 1,243,574 1,264,612 1,314,499 1,275,133 1,313,308 1,175,707 1,224,793
oral 116.7 112.5 99.2 90.9 83.4 75.3 71.4 66.8 63.4 59.5
patch 22.2 22.4 21.6 22.3 22.9 22.5 23.2 23.6 23.8 22.1
cream 28.2 29.7 29.8 32.1 33.5 34.2 34.4 33.4 33.1 31.6
ring/insert 21.3 22.3 23.9 23.6 23.1 21.6 20.3 19.3 18.2 15.7
60-64 years
N 260,622 750,139 903,796 1,015,239 1,045,608 1,091,426 1,046,080 1,085,574 991,745 1,068,739
oral 110.2 106.0 93.8 85.8 78.6 69.2 64.8 59.9 56.3 51.3
patch 17.8 17.8 17.0 17.2 17.2 16.6 16.9 17.0 17.4 16.3
cream 30.4 32.7 33.3 35.2 36.6 37.4 37.8 36.9 37.2 35.2
ring/insert 20.6 21.9 23.6 23.8 24.3 23.2 22.5 22.4 21.4 18.7
65-69 years
N 124,499 281,314 331,565 352,971 310,329 345,754 324,349 331,282 295,629 316,813
oral 75.6 82.0 73.6 67.5 62.5 57.3 53.5 47.5 42.0 36.6
patch 10.6 12.6 12.0 12.2 12.0 11.6 11.5 11.1 10.8 9.9
cream 24.5 29.1 29.4 30.4 32.0 33.9 33.2 31.7 29.8 26.7
ring/insert 12.2 15.2 16.6 17.1 17.8 18.3 17.9 18.0 16.5 14.5
70-74 years
N 90,557 177,768 202,141 206,235 167,098 182,983 155,554 153,650 133,350 144,530
oral 54.0 63.7 57.2 51.5 49.9 45.0 38.9 34.4 29.9 25.4
patch 6.1 8.2 8.0 8.0 8.4 8.4 7.7 7.7 6.9 6.2
cream 18.1 25.8 26.4 26.6 29.1 29.5 27.7 26.6 23.3 20.6
ring/insert 7.0 10.3 11.1 11.1 11.6 11.7 10.6 11.5 11.2 9.7
Age group 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015
≥75 years
N 187,115 349,315 398,481 404,197 322,301 343,998 264,136 228,368 183,482 197,894
oral 29.8 36.0 32.0 28.9 27.4 24.5 19.5 17.9 15.1 13.3
patch 1.7 2.5 2.7 2.6 2.8 2.8 2.4 2.5 2.5 2.3
cream 12.8 19.3 20.3 20.0 21.9 23.1 19.8 19.0 16.5 14.9
ring/insert 3.0 5.0 5.4 5.2 5.6 5.3 4.5 4.9 4.7 4.3
