Supplemental Table S1. Odds ratio for hypertension incidence according to the quartiles of baseline ankle-brachial index.
Model 1 was adjusted for age, sex, and follow-up periods. Model 2 was adjusted for model 1 and baseline BMI, SBP, DBP, heart rate, non-HDL-cholesterol, HDL-cholesterol, triglyceride, fasting plasma glucose, current smoking, medication for dyslipidemia and diabetes mellitus. Model 3 was adjusted for model 2 along with eGFR.
ABI, ankle-brachial index; CI, confidence interval; OR, odds ratio.
ABI category Q1
(0.91–1.04) n=329
Q2 (1.05–1.09)
n=325
Q3 (1.10–1.13)
n=350
Q4 (1.14–1.39)
n=340
OR OR 95% CI P OR 95% CI P OR 95% CI P
Crude Reference 2.24 1.38–3.63 0.001 2.69 1.68–4.29 <0.001 2.79 1.75–4.45 <0.001 Model 1 2.05 1.26–3.33 0.004 2.34 1.46–3.76 <0.001 2.19 1.35–3.57 0.002 Model 2 1.92 1.12–3.29 0.017 2.26 1.33–3.84 0.003 2.18 1.25–3.79 0.006 Model 3 1.94 1.13–3.32 0.016 2.27 1.34–3.86 0.002 2.20 1.26–3.83 0.005
Supplemental Table S2. Yearly change in hemodynamic parameters according to the quartiles of baseline ankle-brachial index.
Variables Q1
(n=323)
Q2 (n=313)
Q3 (n=335)
Q4
(n=324) P
brachial SBP (mmHg)
Baseline 118 (10) 119 (10) 120 (10) 120 (10) 0.108
Change -0.8 (10.1) 3.1 (10.6)** 3.1 (11.2)** 4.6 (10.4)** <0.001 Change per year -0.21 (2.65) 0.81 (2.80)** 0.75 (2.99)** 1.18 (2.72)** <0.001 ankle SBP
(mmHg)
Baseline 119 (11) 128 (11)** 134 (12)** 140 (13)** <0.001 Change 5.7 (11.3) 4.8 (12.6) 3.4 (12.8)* 2.3 (11.8)** 0.002 Change per year 1.43 (2.96) 1.26 (3.33) 0.81 (3.39)* 0.52 (3.05)** 0.001
ABI
Baseline 1.01 (0.03) 1.07 (0.01)** 1.11 (0.01)** 1.17 (0.03)** <0.001 Change 0.06 (0.06) 0.01 (0.06)** -0.001 (0.02)** -0.03 (0.04)** <0.001 Change per year 0.014 (0.016) 0.003 (0.015)** -0.0002 (0.014)** -0.007 (0.015)** <0.001 baPWV
(cm/s)
Baseline 1298 (184) 1330 (175) 1340 (174)** 1352 (185)** 0.001
Change 23 (126) 44 (131) 43 (130) 62 (131)** 0.002
Change per year 5.9 (32.5) 11.4 (34.2) 10.4 (32.8) 15.5 (33.6)** 0.001 Data are mean (SD) or number (%). ABI, ankle-brachial index; baPWV, brachial-ankle pulse wave velocity; BMI, body mass index; CKD, chronic kidney disease; DBP, diastolic blood pressure; MAP, mean arterial pressure; PP, pulse pressure; SBP, systolic blood pressure. Dunnett’s test, *P<0.05, **P<0.01, vs. Q1.
