HJH/A539

(1)

Association of alerting reaction with LVM index and UACR in the untreated population (1,171 females, 1,030 males), when diastolic BP was used to calculate Alerting ∆BP and Alerting ratio.

Untreated Participants *

LVM/BSA UACR

Variable Standardize d Estimate

P Value Standardize d Estimate

P Value

†∆Alerting BP

(10mmHg increase)

0.08 <0.01 0.07 <0.01

†Alerting Ratio

0.07 <0.01 0.07 <0.01

* Adjusted for age, sex, race, and BMI, (avg3-5) DBP, fasting plasma glucose, total cholesterol level, triglyceride level, waist circumference, heart rate, smoking, and alcohol.

† Alerting ∆BP = 1^st DBP- (avg3-5) DBP, Alerting Ratio = 1^st DBP - (avg3-5) DBP)/ (avg3-5) DBP

(2)

Supplemental Table S2: 10-Year Adjusted Hazard Ratio for Composite CV Events of Alerting Ratio and ∆ Alerting BP in all untreated participants when diastolic BP was used to calculate Alerting ∆BP and Alerting ratio *

Model 1 Hazard Ratio CI P value

*∆ Alerting BP

(5 mmHg increase) 1.21 1.03-1.42 <0.05

*Alerting Ratio 1.18 1.001-1.39 0.048

Model 2

*∆ Alerting BP

(5 mmHg increase) 1.18 1.01-1.39 0.04

*Alerting Ratio 1.16 0.98-1.37 0.08

Model 3

*∆ Alerting BP

(5 mmHg increase) 1.24 1.06-1.44 <0.01

*Alerting Ratio 1.27 1.07-1.50 <0.01

* Alerting ∆BP = 1

^st

DBP- (avg3-5) DBP, Alerting Ratio = 1

^st

DBP - (avg3-5) DBP)/

(avg3-5) DBP

Model 1: age, sex, race, heart rate, and BMI

Model 2: Model 1+, fasting plasma glucose, serum triglyceride, and waist circumference, total cholesterol level, smoking and alcohol

Model 3: Model 2+ avg3-5 DBP

2

(3)

Association of ∆ Alerting BP and Alerting Ratio based on the first 2 BP measurements with LVM index and UACR among untreated population.

Untreated Participants *

Untreated Females (n = 1,171) Untreated Males (n = 1,030)

LVM/BSA UACR LVM/BSA UACR

Variable Standar dized Estimat

e

P Value

Standard ized Estimate

P Value

P Valu e

†∆Alertin g BP (10mmH g

increase)

0.07 <0.01 0.04 0.16 0.12 <0.01 0.09 <0.0 1

†Alerting Ratio

0.06 0.01 0.05 0.06 0.12 <0.01 0.09 <0.0

1

*Adjusted for age, race, and BMI, (avg3-5) SBP, fasting plasma glucose, total cholesterol level, triglyceride level, waist circumference, heart rate, smoking, and alcohol.

†Alerting ∆BP = (avg 1-2) SBP- (avg3-5) SBP,

†Alerting Ratio = ((avg 1-2) - (avg3-5) SBP)/ (avg3-5) SBP

3

(4)

Supplemental Table S4: 10-Year Adjusted Hazard Ratio for Composite CV Events of Alerting Ratio and ∆ Alerting BP based on the first 2 BP measurements in all untreated participants *

Model 1 Hazard Ratio CI P value

*∆ Alerting BP

(10 mmHg increase) 1.19 1.04-1.37 0.01

*Alerting Ratio 1.19 1.03-1.39 0.02

Model 2

*∆ Alerting BP

(10 mmHg increase) 1.19 1.03-1.37 0.02

*Alerting Ratio 1.19 1.02-1.38 0.03

Model 3

*∆ Alerting BP

(10 mmHg increase) 1.22 1.06-1.40 <0.01

*Alerting Ratio 1.24 1.07-1.45 <0.01

*

Alerting ∆BP = (avg 1-2) SBP- (avg3-5) SBP, Alerting Ratio = ((avg 1-2) - (avg3-5) SBP)/

(avg3-5) SBP

Model 1: age, sex, race, heart rate, and BMI

Model 2: Model 1+, fasting plasma glucose, serum triglyceride, and waist circumference, total cholesterol level, smoking and alcohol

Model 3: Model 2+ avg3-5 DBP

4

(5)

(LVM/BSA) and UACR of the treated participants after adjustment for relevant variables (age, BMI, ethnicity, sex, fasting plasma glucose, total cholesterol level, triglyceride level, waist circumference, heart rate, smoking, and alcohol use) plus avg 3-5 SBP (A and C) and after adjustment for relevant variables plus avg 3-5 DBP (B and D) among the 4 different BP groups. * p<0.01 vs. NN Group, †p<0.01 vs. HN group.