Supplementary Digital Content 1
Coun ts
Limonene (ng/µL)
Supplementary Digital Content 2
Li mone ne (ng /L)
Cirrhosis + HCC Control Cirrhosis
P = 0.0001
P = 0.0005
P = 0.37
N = 40 N = 32 N = 12
Median: 6.2 LQ: 2.6 UQ: 9.57
Median: 32.6 LQ: 6.5 UQ: 123.0
Median: 82.1 LQ: 16.3 UQ: 199.3
Cirrhosis + HCC Control Cirrhosis
N = 40 N = 32 N = 12
Log
10(Li mone ne (ng /L))
A
B
Daily Non-Daily
P = 0.0093
Li mone ne (ng /L)
N = 17 N = 23
Median: 131.9 LQ: 10.7 UQ: 367.9
Median: 15.4 LQ: 4.9 UQ: 43.5
Supplementary Digital Content 3
NO YES
N = 21 N = 19
Li mone ne (ng /L)
P = 0.0053 P = 0.25
CYP2C9/19 substrates
CYP2C9/19 Inhibitors
NO YES
N = 21 N = 19
Median: 10.2 LQ: 3.5 UQ: 56.7
Median: 74.0 LQ: 15.7 UQ: 137.2
Median: 11.2 LQ: 4.3 UQ: 163.1
Median: 50.7 LQ: 12.6 UQ: 125.5
Supplementary Digital Content 4
NO YES
N = 29 N = 14
P = 0.41
