(1)Supplementary Table 1: Baseline characteristics of the cohorts at time of diagnosis with acute HIV infection Characteristic

Supplementary Table 1: Baseline characteristics of the cohorts at time of diagnosis with acute HIV infection Characteristic. Overall (N=160). Time post seroconversion; days [median (IQR)] Age; years [median (IQR)] Highest level of schooling [% (n)]. Ethnicity [% (n)]. <Grade 8. Site [%, (n)]. CAPRISA 004 cohort (N=98) 42 (25 – 65) 23 (21‐ 26). p‐value. 0.005. 4.4% (7). 8.1% (5). 2.0% (2). Grade 8‐10. 25.0% (40). 35.5% (22). 18.4% (18). Grade 11‐12. 70.6% (113). 56.5% (35). 79.6% (78). Black. 99.4% (159). 100% (62). 99.0% (97). 0.6% (1). 0.0% (0). 1.0% (1). Single. 18.1% (29). 12.9% (8). 21.4% (21). Stable partner. 75.0% (120). 71.0% (44). 77.6% (76). Many partners. 6.9% (11). 16.1% (10). 1.0% (1). Coloured Marital status [% (n)]. 42 (28 – 62) 24 (21‐ 28). Original CAPRISA 002 and sero‐incidence cohorts (N=62) 42 (34 – 59) 25 (21‐ 33). 0.775 0.022. 1.000. <0.001. Rural. 48.8% (78). 25.8% (16). 63.3% (62). Urban. 51.3% (82). 74.2% (46). 36.7% (36). 27 (23‐32). 27 (24‐32). 27 (23‐32). 0.986. BMI; kg/m2 [median (IQR)]. <0.001. Past medical history [% (n)]. DM HTN CAD CVA. 0.6% (1) 1.9% (3) 0.0% (0) 0.6% (1). 1.6% (1) 4.8% (3) 0.0% (0) 1.6% (1). 0.0% (0) 0.0% (0) 0.0% (0) 0.0% (0). 0.387 0.057 N/A 0.389. Family history [% (n)]. DM HTN CAD CVA. 26.3% (42) 29.4% (47) 3.8% (6) 5.0% (8). 27.4% (17) 33.9% (21) 3.2% (2) 6.5% (4). 25.5% (25) 26.5% (26) 4.1% (4) 4.1% (4). 0.854 0.374 1.000 0.712. IQR: interquartile range; BMI: Body mass index; DM: Diabetes Mellitus; HTN: Hypertension; CAD: Coronary artery disease; CVA: Cerebrovascular disease.