Supplementary Table 3: Multivariable Cox proportional hazards model for OS
Parameter Level OS 95%CI g
HR a Lower Upper p
Sex Male 1.0 (Ref)
Female 0.8 0.7 0.8 0.000
Surgery Elective 1.0 (Ref)
Emergency 1.4 1.3 1.5 0.000
Health care region b
Region 1 1.0 (Ref)
Region 2 1.0 0.9 1.1 0.391
Region 3 1.1 1.0 1.2 0.211
Region 4 1.2 1.1 1.3 0.002
Region 5 1.2 1.1 1.4 0.000
Region 6 1.1 1.0 1.3 0.054
Age group 0-40 years 1.0 (Ref)
40-50 years 1.0 0.6 1.6 0.981
50-60 years 1.2 0.8 1.8 0.512
60-70 years 1.5 1.0 2.3 0.044
70-80 years 2.7 1.8 4.1 0.000
80-90 years 4.2 2.7 6.4 0.000
90+ years 5.9 3.8 9.3 0.000
BMI c Normal weight 1.0 (Ref)
Underweight BMI 1.6 1.4 1.8 0.000
Overweight 0.9 0.8 1.0 0.001
Obese 0.9 0.8 1.0 0.014
Morbid obesity 0.9 0.8 1.1 0.498
Missing BMI 1.1 1.0 1.1 0.175
ASA d ASA I 1.0 (Ref)
ASA II 1.3 1.2 1.5 0.000
ASA III 2.3 2.0 2.6 0.000
ASA IV and V 3.6 3.1 4.3 0.000
Missing ASA 1.8 1.5 2.2 0.000
Side Right 1.0 (Ref)
Left 1.0 0.9 1.0 0.110
Pretherapeutic
staging No pretherapeutic staging 1.0 (Ref)
Tumor staged 0.9 0.9 1.0 0.047
Lung staged 1.0 0.9 1.1 0.756
Liver staged 1.0 0.9 1.1 0.907
CRM e <3mm 1.0 (Ref)
3-10 mm 1.0 0.9 1.1 0.498
>10 mm 0.9 0.9 1.0 0.162
Missing 1.1 1.0 1.2 0.300
LRM f <50 mm 1.0 (Ref)
50-90 mm 0.9 0.9 1.0 0.047
>90 mm 1.0 0.9 1.1 0.715
Missing 1.0 0.9 1.1 0.628
pT p T1 1.0 (Ref)
pT2 1.2 1.0 1.4 0.035
pT3ab 1.2 1.0 1.4 0.018
pT3cd 1.4 1.2 1.6 0.000
pT3 unknown 1.3 1.1 1.5 0.002
pT4a 2.1 1.7 2.5 0.000
pT4b 2.4 1.9 3.0 0.000
pT4 unknown 2.0 1.7 2.3 0.000
Missing 2.3 1.4 3.7 0.001
pN pN0 1.0 (Ref)
pN1 1.4 1.3 1.5 0.000
pN2a 1.8 1.6 2.1 0.000
pN2b 2.4 2.1 2.9 0.000
Missing 0.9 0.7 1.3 0.610
Malignancy Low-grade 1.0 (Ref)
High-grade 1.1 1.0 1.1 0.094
Missing 1.2 1.0 1.3 0.016
Vascular
invasion No 1.0 (Ref)
Yes 1.3 1.2 1.4 0.000
Missing 1.1 1.0 1.2 0.153
Perineural invasion
No 1.0 (Ref)
Yes 1.3 1.2 1.4 0.000
Missing 1.0 0.9 1.1 0.612
Mucinous No 1.0 (Ref)
Yes 1.0 1.0 1.1 0.276
Missing 1.0 0.9 1.1 0.884
Nodes Each investigated node 1.0 1.0 1.0 0.000
Each positive node 1.0 1.0 1.0 0.000
Postoperative complications
No 1.0 (Ref)
Yes 1.3 1.2 1.4 0.000
Adjuvant treatment
No 1.0 (Ref)
Yes 0.7 0.6 0.7 0.000
a Adjusted hazard ratio (HR)
b Region: Location of patient surgery.
c Body mass index (BMI) calculated before surgery.
d American Society of Anesthesiologists’ classification (ASA) rated by an anesthesiologist before surgery.
e CRM: Circumferential resection margin,
f LRM: Longitudinal resection margin.
g 95% confidence interval (CI).
