Supplementary Table S1. Types of malignancy (n=23) in 128 patients with acute cholecystitis treated with percutaneous cholecystostomy
The data are expressed as number (percent).
Types of malignancy Number (%)
Hepatocellular carcinoma 1 (4.3)
cholangiocarcinoma 1 (4.3)
Prostate cancer 1 (4.3)
Tonsillar cancer 1 (4.3)
Renal cell carcinoma 1 (4.3)
Malignancy of unknown origin, without liver metastasis
2 (8.7) Pancreatic adenocarcinoma 3 (13.0)
Gastric cancer 4 (17.4)
Colon adenocarcinoma 4 (17.4)
Lung cancer 5 (21.7)
Supplementary Table S2. Clinical characteristics in patients who received
cholecystectomy stratified by severity of acute cholecystitis and antibiotic groups (n=70)
The data are expressed as median (interquartile range) or number (percent). p values were determined by the Mann–Whitney U-test, chi-square test or Fisher’s exact test. ASA classification: The American Society of Anesthesiologists (ASA) physical status classification system.
“-” means not applicable
Severity grade by Tokyo guideline Moderate, grade II (n=52) Severe, grade III (n=18) Variables
Group A (n=41)
Group B (n=11)
p Group A (n=14)
Group B (n=4)
p Duration between cholecystostomy
and cholecystectomy (day)
41.0 (22.5- 58.0)
25.0 (15.0- 43.0)
0.097 37.5 (33.3- 123.3)
45.0 (38.5- 120.5)
0.395 ASA classification
II 6 (14.6) 0 (0.0) 0.322 1 (7.1) 0 (0.0) 1.000
III 35 (85.4) 11 (100.0) 0.322 12 (85.7) 2 (50.0) 0.197
IV 0 (0.0) 0 (0.0) - 1 (7.1) 2 (50.0) 0.108
Acalculous cholecystitis (+) 1 (2.4) 0 (0.0) 1.000 0 (0.0) 0 (0.0) -
Supplementary Table S3. Bacterial isolates from blood cultures (n=5) and bile cultures (n=29) with polymicrobial infection
The data are expressed as number.
Microorganism Number of isolates Blood Bile Gram-negative
Escherichia coli 3 14
Klebsiella spp. 4 17
Enterobacter spp. 3 2
Proteus spp. 1 2
Pseudomonas spp. 0 1
Citrobacter spp. 0 5
Aeromonas spp. 0 1
Serratia spp. 0 1
Morganella spp. 0 3
Gram-positive
Enterococcus spp. 0 14
Streptococci spp. 0 1
Staphylococcus spp. 0 1
Anaerobes 0 4
