Table S1: Comparison between included (N=166) and not included patients (N=101) prior to start of RRT.
Variable Included Not
included P
Age at start of RRT (years) 13.8 ± 3 14.9 ± 3 0.002
Male, n, proportion (%) 62.3% 63.4% 0.907
Underlying disease, n, proportion
(%)
CAKUT 62.1% 61.4%
0.573
Glomerulopathies 9% 12.9%
Other 28.9 25.7%
Time from CKD II to RRT (years),
median, IQR 5.5, 2.8-10.6 7, 4.2-12 0.178
Time from CKD II to assessment prior to RRT (months), median, IQR
5.3, 2-10 6.8, 3.9-11.6 0.087
Height (cm) 146 ± 18 149.6 ± 17.7 0.113
Height SDS -1.4 ± 1.4 -1.7 ± 1.7 0.155
BMI (kg/m2) 19.2 ± 3.9 18.9 ± 3.9 0.543
BMI SDS 0.2 ± 1.2 0.03 ± 1.3 0.165
Waist-hip ratio 0.9 ± 0.1 0.9 ± 0.1 0.675
Systolic BP (mmHg) 119.4 ± 17.3 118.2 ± 14.8 0.582
Systolic BP SDS 1.3 ± 1.7 0.9 ± 1.3 0.062
Diastolic BP (mmHg) 73.3 ± 13.3 72.5 ± 12.1 0.581
Diastolic BP SDS 0.95 ± 1.2 0.7 ± 1.1 0.068
eGFR (ml/min/1.73m2) 17.7 ± 8.3 15.1 ± 4.5 0.002
Total cholesterol (mg/dl) 190.5 ± 64.5 179.7 ± 53.1 0.158
HDL (mg/dl) 47.7 ± 18.4 49.2 ± 17.6 0.548
LDL (mg/dl) 106.2 ± 52.5 100.2 ± 44.9 0.370
Triglyceride (mg/dl) 168.6 ± 104.4 161.5 ± 82.1 0.558 Bicarbonate (mmol/l) 20.4 ± 3.9 20.7 ± 3.8 0.621
Calcium (mmol/l) 2.3 ± 0.3 2.3 ± 0.3 0.891
Potassium (mmol/l) 4.5 ± 0.7 4.5 ± 0.7 0.987
Phosphorus (mmol/l) 1.8 ± 0.4 1.8 ± 0.4 0.621
PTH (pmol/l) 34.6 ± 36.1 40.3 ± 40.4 0.249
Serum albumin (g/l) 37.6 ± 8.5 38.5 ± 6.2 0.339
Ferritin (µg/l) 153.9 ± 150.5 166.2 ±
265.8 0.696
Hemoglobin (g/dl) 11 ± 1.4 10.6 ± 1.9 0.065
Hematocrit (l/l) 0.3 ± 0.1 0.3 ± 0.1 0.091
Uric acid (mg/dl) 6.7 ± 1.9 6.8 ± 1.7 0.477
PWV 5.1 ± 0.8 5.2 ± 1.04 0.465
PWV SDS 0.47 ± 1.6 0.41 ± 1.8 0.779
IMT 0.46 ± 0.05 0.48 ± 0.05 0.061
IMT SDS 1.77 ± 1.11 2.04 ± 1.32 0.095
LVMI 46.5 ± 14.4 48.5 ± 15.9 0.326
All values are mean ± SD unless stated otherwise.
Table S2: Immunosuppressive therapy received by transplanted patients after RRT
start (N=76).
N %
Calcineurin inhibitor, CNI 74 97
Mycophenolate mofetil, MMF 61 80
mTOR inhibitor 10 13
Steroid 60 79
Number of
immunosuppressive drugs used in combination
0 0 0
1 2 3
2 23 30
3 43 57
4 8 10
Table S3A: Antihypertensive drugs received prior to and after RRT start per group (N=166).
Antihypertensive Drugs
Prior to RRT
p
After RRT
p Dialysis
(N=90)
Trans- plantation
(N=76)
Dialysis (N=90)
Trans- plantation
(N=76)
N % N % N % N %
ACE inhibitor 32 36 19 25 0.14 28 31 16 21 0.14
Angiotensin receptor
blocker, ARB 6 7 7 9 0.54 6 7 1 1 0.13
Calcium channel
blocker, CCB 41 46 29 38 0.34 41 46 35 46 0.95
Beta blocker 12 13 9 12 0.77 15 17 15 20 0.61
Peripheral alpha
blocker 11 12 6 8 0.45 13 14 1 1 0.004
Central acting agent 1 1 0 0 - 1 1 0 0 -
Loop diuretics 8 9 5 7 0.58 12 13 4 5 0.11
Thiazide diuretics 0 0 3 4 0.094 0 0 3 4 0.094
Vasodilators 1 1 0 0 - 1 1 1 1 -
Table S3B: Number of antihypertensive drugs received prior to and after RRT start per group (N=166).
Number of antihypertensive
drugs
Prior to RRT After RRT
Dialysis (N=90)
Transplantation (N=76)
Dialysis (N=90)
Transplantation (N=76)
N % N % N % N %
0 24 27 27 36 29 32 28 37
1 34 38 29 38 28 31 26 34
2 23 26 10 13 20 22 17 22
3 4 4 9 12 7 8 4 5
4 5 5 1 1 3 3 1 1
5 0 0 0 0 2 2 0 0
6 0 0 0 0 1 1 0 0
