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Supplementary Table 3. Stepwise conditional analysis of association among the signals in the MHC region.

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Academic year: 2023

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Test SNP Conditioning SNP (s) Unconditioned P Conditioned P

rs9271366 rs9271366 2.16E-09 NA

rs6935053 rs9271366 9.05E-07 1.94E-06

rs4713270 rs9271366 9.05E-07 1.94E-06

rs6916422 rs9271366 9.05E-07 1.94E-06

rs2076523 rs9271366, rs6935053 7.80E-05 3.64E-05

rs3093998 rs9271366, rs6935053, rs2076523 8.84E-07 5.26E-04 rs6905353 rs9271366, rs6935053, rs2076523, rs3093998 1.76E-04 1.10E-03

Supplementary Table 3. Stepwise conditional analysis of association among the signals in the MHC region.

Note: rs9271366 has shown the major MHC signal near HLA-DRB4 and HLA-DQA1.

rs9271366, rs6935053, rs2076523, rs3093998, and rs6905353 have shown five independent signals in MHC region. Strong linkage disequilibrium (LD, r2>0.995) was detected

between the three SNPs (rs6935053, rs4713270, and rs6916422). NA, not applicable.

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