Table E1 Definitions of Septic Shock and Shock reversal

Table E1 Definitions of Septic Shock and Shock reversal

Study Definition of Septic Shock Definition of Shock Reversal

Blood pressure Urine output

(ml/kg/hr) Capillary Refill

Time (secs) Other Santhanam

(13) Tachycardia and poor perfusion defined as decreased peripheral pulses compared to central pulses, altered alertness, CRT >2 secs, mottled extremities and decreased urine output (7)

Normal BP for age > 1 < 2 Warm peripheries

Upadhyay (14) Sepsis and hypotension OR Sepsis and 3 out of decreased pulse volume,

CRT ≥ 3secs, tachycardia and urine output < 1ml/k/hr (5) BP > 5th percentile > 1 < 3 CVP > 10cmH2O, normal HR for age de Oliveira

(15) Severe sepsis (evidence of infection and 2 of hypo-/hyperthermia, tachy- /bradycardia, tachypnoea, WBC count >12000cells/ml3 or < 4000cells/ml3 and at least 1 indicator of organ hypoperfusion: altered mental state, hypoxaemia, lactataemia, bounding pulses, oliguria or hypotension OR fluid refractory septic shock (>40ml/Kg of fluid) or Vasoactive agents (4)

Normal BP for age > 1 < 2 Normal pulses