Table S1: Characteristics of Resorbable Plating Systems
System Composition Reabsorption Time
Biomet LactoSorb 82% Poly-L-Lactic Acid and 18% Poly-Glycolic
Acid 12 months
Inion CPS Baby System L-Lactide, D,L-Lactide, Polyglycolide and
Trimethylene Carbonate (TMC) 24-36 months
Stryker Delta 85% Poly L-Lactide, 10% Poly-Glycolide, and 5%
Poly D-Lactide 8-13 months
KLS Martin SonicWeld Rx Amorphous poly-(50%D, 50%L)-lactide 12-30 months PDS suture Polydioxanone suture/poly(p-diaxanone) <2 months
Table S2: Patient and surgical characteristics, stratified by plating system.
Overall
202 (100%) Biomet Lactosorb
120 (59%) Other systems 82 (41%) Patient characteristics
Male, n (%) 123 (61) 70 (58) 53 (65)
Age, in days, median (IQR) 383 (227–802) 434 (230–967) 325 (214–595)
White, n (%) 119 (59) 71 (59) 48 (59)
Synostosis diagnosis, n (%)
Metopic 75 (37) 44 (37) 31 (38)
Coronal 42 (21) 26 (22) 16 (20)
Sagittal 71 (35) 45 (38) 26 (32)
Lambdoid 5 (2) 2 (2) 3 (4)
Multiple 23 (11) 14 (12) 9 (11)
Syndrome, n (%)
Apert 3 (1) 1 (1) 2 (2)
Beare-Stevenson 1 (1) 0 (0) 1 (1)
Catel Manzke 1 (1) 0 (0) 1 (1)
Cerebral palsy 4 (2) 3 (3) 1 (1)
Chromosomal abnormality 3 (1) 3 (3) 0 (0)
Cornelia de Lange 1 (1) 1 (1) 0 (0)
Crouzon 2 (1) 2 (0) 0 (0)
Muenke 3 (1) 1 (1) 2 (2)
Opitz G/BBB 1 (1) 0 (0) 1 (1)
Pfeiffer 2 (1) 1 (1) 1 (1)
Saethre-Chotzen 2 (1) 2 (2) 0 (0)
Turner 1 (1) 0 (0) 1 (1)
Other 15 (7) 9 (8) 6 (7)
Nonsyndromic, n (%) 163 (81) 97 (81) 66 (80)
Surgical characteristics Surgery type, n (%)
Cranial vault reconstruction 89 (44) 46 (38) 43 (53) Frontal orbital advancement 112 (56) 74 (62) 38 (47) Plating system, n (%)
Biomet 120 (59) 120 (100) --
Delta 26 (13) -- 26 (32)
PDS 33 (16) -- 33 (40)
Inion 12 (6) -- 12 (15)
KLS Martin 11 (5) -- 11 (13)
Abbreviations: IQR, interquartile range
Table S3: Crude and adjusted association between Biomet Lactosorb, compared to other plating systems, on 1-year incidence of wound complications.
Rate, per
10,000 days Crude Adjusteda
HR (95% CI) p-value HR (95% CI) p-value Biomet Lactosorb 8.5 2.27 (1.03, 5.00) 0.04 2.86 (1.15, 7.11) 0.02
Other systems 3.7 ref -- ref --
Abbreviations: HR, hazard ratio; CI, confidence interval
a Adjusted for year of surgery, patient age, in days, and surgery type; age was modeled as a restricted cubic spline
