Table S1: Comparison of clinical characteristics of normal tension glaucoma patients with baseline central and peripheral visual field defects
Central Defect (n=25)
Peripheral Defect (n=40)
P value
Age, years 69.44 ± 10.03 67.35 ± 9.77 0.409a
Race 0.922b
Malay 7 (28%) 11(27.5%)
Chinese 11(44%) 16(40%)
Indian 7(28%) 13(32.5%)
Gender 0.239b
Male 10(40%) 22(55.5%)
Female 15(60%) 18(45.5%)
Hypertension 18(72%) 25(62.5%) 0.431b
B- blockers 3(12%) 2(5%) 0.365c
Diabetes mellitus (DM) 10(40%) 16(40%) 1.000b Duration of DM, years 5.7 ± 8.2 4.3 ± 7.3 0.493a Ischemic heart disease 6(24%) 8(20%) 0.703b
Asthma 2(8%) 4(10%) 1.000c
a Independent t-test.
b χ2-test.
c Fisher exact test.
Table S2: Comparison of systemic blood pressure measurements of normal tension glaucoma patients with baseline central and peripheral visual field defects
Central Defect (n=25)
Peripheral Defect (n=40)
P value
Mean SBP Day 134.62 ± 15.18 134.12 ± 17.07 0.904 Mean SBP Evening 138.24 ± 23.13 131.39 ± 14.93 0.151 Mean SBP Night 126.36 ± 20.77 120.93 ± 16.52 0.247 Mean DBP Day 77.47 ± 8.42 79.58 ± 10.22 0.390 Mean DBP Evening 77.63 ± 8.57 78.73 ± 8.64 0.618 Mean DBP Night 74.60 ± 8.25 73.41 ± 8.36 0.578
MAP Day 97.34 ± 8.75 98.38 ± 12.66 0.712
MAP Evening 97.84 ± 11.46 95.54 ± 10.66 0.412 MAP Night 91.46 ± 10.84 89.25 ± 9.72 0.398 Nocturnal Dip 4.85 ± 8.68 7.38 ± 8.11 0.239 Nocturnal Dip (%) 6.67 ± 12.48 9.65 ± 10.02 0.294
SBP: Systolic Blood Pressure, DBP: Diastolic Blood Pressure, MAP: Mean Arterial Pressure
Continuous variables are expressed as mean ± standard deviation.
Independent t-test or Mann-Whitney test used to detect differences between groups
Table S3: Comparison of ocular perfusion pressure of NTG patients with baseline central and peripheral visual field defects
Central Defect (n=25)
Peripheral Defect (n=40)
P value
SOPP Day 79.75 ± 11.09 78.08 ± 11.90 0.732 SOPP Evening 81.00 ± 14.68 74.36 ± 11.79 0.337 SOPP Night 73.93 ± 16.24 69.28 ± 13.91 0.477 SOPP Fluctuation 12.55 ± 5.97 9.93 ± 5.26 0.285
DOPP Day 40.49 ± 5.34 40.70 ± 8.37 0.943
DOPP Evening 41.43 ± 3.96 38.44 ± 4.57 0.108 DOPP Night 38.91 ± 6.60 33.37 ± 6.70 0.060 DOPP Fluctuation 6.68 ± 4.02 9.15 ± 3.38 0.133
MOPP Day 53.58 ± 4.44 53.16 ± 8.05 0.873
MOPP Evening 54.61 ± 5.37 50.75 ± 5.59 0.108 MOPP Night 50.59 ± 8.72 43.99 ± 9.30 0.095 MOPP Fluctuation 7.85 ± 4.83 10.64 ± 4.92 0.187
SOPP: Systolic Ocular Perfusion Pressure, DOPP: Diastolic Ocular Perfusion Pressure, MOPP: Mean Ocular Perfusion Pressure
Continuous variables are expressed as mean ± standard deviation.
Independent t-test or Mann-Whitney test used to detect differences between groups
Table S4: Comparison of ocular parameters and visual field indices of NTG patients with baseline central and peripheral visual field defects
Central Defect (n=25)
Peripheral Defect (n=40)
P Value
Initial BCVA 0.27 ± 0.23 0.21 ± 0.19 0.237
CCT (μm) 0.50 ± 0.04 0.51 ± 0.03 0.522 OCT RNFL
Mean 71.64 ± 10.01 74.26 ± 10.64 0.328
Superior 84.36 ± 19.22 86.54 ± 17.18 0.637
Inferior 83.08 ± 14.92 89.07 ± 20.31 0.227
Nasal 60.58 ± 6.47 60.67 ± 7.50 0.926
Temporal 61.14 ± 14.24 60.10 ± 11.62 0.749
IOP Parameters
Mean IOP Day 14.71 ± 2.12 15.05 ± 2.18 0.536
Mean IOP Evening 13.69 ± 2.45 14.64 ± 2.27 0.118 Mean IOP Night 14.82 ± 2.01 15.41 ± 1.95 0.245 IOP Fluctuation 6.88 ± 1.61 6.82 ± 1.52 0.877 Post Therapeutic Mean
IOP 13.68 ± 1.82 14.15 ± 2.00 0.347
Visual Field Indices
Baseline MD -6.03 ± 5.62 -6.12 ± 4.86 0.943
Baseline PSD 5.03 ± 3.23 4.51 ± 3.10 0.517
Follow up MD -9.97 ± 7.93 -7.31 ± 4.79 0.095
Follow up PSD 5.36 ± 3.37 5.35 ± 3.04 0.991
MD Slope -1.21 ± 1.36 -0.43 ± 0.88 0.007*
Progression 13(52%) 10(25%) 0.027*
BCVA: Best Corrected Visual Acuity, CCT: Central corneal thickness, OCT; Optical Coherence Tomography, RNFL: Retinal Nerve Fibre Layer, IOP: Intraocular
Pressure, MD: Mean Deviation, PSD: Pattern Standard Deviation Continuous variables are expressed as mean ± standard deviation.
Independent t-test or Mann-Whitney test used to detect differences between groups
Table S5: Univariable and Multivariable Cox Proportional Hazards Model with Backward Elimination for Prediction of Visual Field Progression in NTG Patients
Age and CCT Controlled
Univariable Regression Analysis
Multivariable Regression Analysis
HR (95% CI) p value
HR (95% CI) p value
Baseline IOP 1.13 (0.96 - 1.98) 0.114 Post therapeutic IOP 0.85 (0.76 - 1.03) 0.015 Inferior RNFL 0.96 (0.92 - 0.98) 0.060 0.86 (0.83 - 0.92) 0.013*
Mean RNFL 1.05 (0.96 - 1.14) 0.184 Baseline MD 0.95 (0.89 - 1.02) 0.153 Baseline PSD 1.10 (0.98 - 1.23) 0.120 1.14 (1.00 - 1.29) 0.050*
Central VF Defect 2.53 (1.12 - 5.80) 0.028* 3.56 (1.17-10.82) 0.025*
CCT: Central corneal thickness, IOP: Intraocular Pressure, RNFL: Retinal Nerve Fibre Layer, MD: Mean Deviation, PSD: Pattern Standard Deviation, VF: Visual Field.
Only variables with <0.20 significance shown in the table
