Table S1. Baseline clinical characteristics
AL = axial length, CCT= central corneal thickness, VA= visual acuity, HFA = Humphrey visual field analyzer, MD = mean deviation, TD = total deviation, IOP= intraocular pressure
Age (years
old) Sex AL
(mm) CCT
(μm)
VA (decimal fraction) HFA 24-2 (pre-op) In-hospital IOP (mmHg)
Post-op complications Pre-op
6M post -op MD (dB) Mean TD in the 4 central points
(dB) Pre-op Maximum Minimum
78 Male 25.3 481 1.2 0.6 -22.2 -18.0 14 25 7 Hyphema
78 Female 22.6 495 1.2 0.7 -30.0 -24.3 20 30 4 Bleb leak
65 Female 25.7 504 0.5 0.2 -21.7 -34.0 16 41 9 Hyphema
29 Male 27.7 510 0.5 0.2 -30.3 -33.1 33 18 6 -
20 Male 27.0 504 1.2 0.8 -33.5 -36.8 28 14 2 Hyphema
67 Female 28.5 532 0.9 0.2 -30.4 -30.5 24 16 3 -
33 Female 26.7 416 0.4 0.05 -25.5 -26.8 18 19 2 Shallow anterior chamber
Table S2. Comparison between patients with and without VA decline VA decline
(n=7)
Stable VA (n=63)
P value
Age (years) * 52.9 ± 22.8 67.0 ± 11.0 0.181
Central corneal thickness (μm) * 491.7 ± 34.1 512.0 ± 33.7 0.205
Axial length (mm) * 26.2 ± 1.8 24.8 ± 1.7 0.113
VA (logMAR) * Pre-op 0.16 ± 0.18 0.11 ± 0.20 0.553
6M post-op 0.59 ± 0.38 0.11 ± 0.22 0.022
IOP (mmHg) ✝ Pre-op 21.9 ± 6.3 19.5 ± 6.3 0.410
6M post-op 10.8 ± 5.8 11.3 ± 4.3 0.869 HFA 24-2
MD (dB) ✝ Pre-op -27.7 ± 4.2 -22.4 ± 5.2 0.021
6M Post-op -25.9 ± 4.1 -20.7 ± 5.7 0.109
FT (dB) ✝ Pre-op 26.0 ± 4.9 29.9 ± 6.2 0.105
6M Post-op 24.5 ± 5.4 30.0 ± 5.8 0.176 Mean TD in the 4 central
points (dB) ✝
Pre-op -29.0 ± 6.0 -19.4 ± 8.6 0.006
6M Post-op -23.5 ± 5.8 17.9 ± 8.1 0.194 OCT (pre-op)
Overall macula (μm)
mRNFLT* 13.3 ± 10.0 15.7 ± 7.4 0.577
GCL/IPLT* 50.9 ± 6.3 54.0 ± 5.7 0.283
GCCT* 64.2 ± 11.1 69.7 ± 11.2 0.276
PMB (μm) mRNFLT* 9.6 ± 4.8 18.5 ± 8.3 0.003
GCL/IPLT* 47.2 ± 10.0 54.4 ± 10.4 0.135
GCCT* 56.8 ± 13.1 72.9 ± 16.3 0.023
cpRNFLT (μm)
Average* 72.3±12.7 69.8±13.1 0.656
Superior* 83.3±16.5 76.2±17.4 0.350
Temporal* 73.7±17.6 63.1±16.7 0.197
Inferior* 61.7±13.9 68.9±14.9 0.263
Nasal* 70.9±12.4 71.0±18.4 0.984
*P values were calculated between pairs of groups with the Welch test.
✝ P values were calculated between pairs of groups with the Mann-Whitney U-test.
VA= visual acuity, IOP= intraocular pressure, HFA = Humphrey visual field analyzer, MD = mean deviation, FT= foveal threshold, TD = total deviation, OCT= optical coherence tomography, mRNFLT=
macular retinal nerve fiber layer thickness, GCL/IPLT= ganglion cell layer/inner plexiform layer thickness, GCCT= ganglion cell complex thickness, PMB= papillomacular bundle
cpRNFLT= circumpapillary
retinal nerve fiber layer thickness,Quadrant temporal RNFLT was further divided into 3 regions(30 degree each), sT, superiotemporal, mT, midtemporal, iT, inferotemporal
mT* 75.6±18.1 62.5±18.7 0.133
iT* 72.6±24.4 62.3±18.1 0.348
Table S3. Comparison of preoperative and postoperative OCT parameters
*P values were calculated between pairs of groups with the Welch test.
VA= visual acuity, OCT= optical coherence tomography, mRNFLT= macular retinal nerve fiber layer thickness, GCL/IPLT= ganglion cell layer/inner plexiform layer thickness, GCCT= ganglion cell complex thickness, PMB= papillomacular bundle
VA decline Stable VA
Pre-op (n=7)
6M post-op (n=5)
P value Pre-op (n=63)
6M post-op (n=30)
P value
Overall macula
mRNFLT (μm) * 13.3 ± 10.0 12.6 ± 4.7 0.892 15.7 ± 7.4 17.0 ± 8.0 0.488 GCL/IPLT (μm) * 50.9 ± 6.3 50.6 ± 6.4 0.444 54.0 ± 5.7 54.9 ± 5.8 0.280 GCCT (μm) * 64.2 ± 11.1 63.2 ± 6.5 0.951 69.7 ± 11.2 71.9 ± 11.7 0.491 PMB mRNFLT (μm) * 9.6 ± 4.8 12.1 ± 4.8 0.907 18.5 ± 8.3 20.4 ± 7.6 0.557 GCL/IPLT (μm) * 47.2 ± 10.0 47.9 ± 7.0 0.872 54.4 ± 10.4 55.8 ± 10.6 0.415 GCCT (μm) * 56.8 ± 13.1 60.0 ± 10.5 0.684 72.9 ± 16.3 76.2 ± 16.5 0.372
Table S4. Preoperative visual field and OCT parameters, with the area under the curve, optimal cut-off values for predicting VA decline, sensitivity and specificity
Preoperative AUC Cut-off Sensitivity Specificity OR OR P-
value
AIC BIC IDI P-value NRI.all P-value NRI.even
t
P-value NRI.non.even t
P-value
HFA 24-2 (n=74)
MD 0.8 -30 dB 57% 97% 0.78
(0.60- 0.94)
0.028 43.17 47.78 reference reference reference reference reference reference reference reference
FT 0.76 26.0 dB 71% 83% 0.93
(0.83- 1.03)
0.138 48.09 52.67 -0.09 (- 0.2-0.03)
0.141 -0.4 (- 1.17- 0.38)
0.314 -0.14 (- 0.88- 0.59)
0.703 -0.25 (-0.5-- 0.01)
0.043
Mean TD in the 4 central points
0.81 -18.0 dB
100% 46% 0.86
(0.73- 0.96)
0.021 42.51 47.12 0 (-0.09- 0.1)
0.923 0.01 (- 0.77- 0.79)
0.980 -0.14 (- 0.88- 0.59)
0.703 0.15 (-0.1-0.4) 0.236
Overall macula (n=70)
mRNFLT 0.67 11.3 μm 71% 68% 0.87
(0.72- 1.00)
0.101 45.21 49.62 -0.06 (- 0.18- 0.06)
0.314 -0.23 (- 1-0.55)
0.565 -0.14 (- 0.88- 0.59)
0.703 -0.08 (-0.34- 0.17)
0.514
GCL/IPLT 0.65 46.5 μm 43% 92% 0.90
(0.76- 1.04)
0.193 46.97 51.37 -0.07 (- 0.19- 0.04)
0.223 -0.65 (- 1.36- 0.07)
0.075 -0.43 (- 1.1-0.24)
0.209 -0.22 (-0.47- 0.03)
0.083
GCCT 0.65 59.7 μm 57% 78% 0.92
(0.82- 1.00)
0.088 45.09 49.50 -0.05 (- 0.17- 0.07)
0.401 -0.19 (- 0.97- 0.58)
0.625 -0.14 (- 0.88- 0.59)
0.703 -0.05 (-0.31- 0.2)
0.696
PMB (n=70) mRNFLT 0.83 9.5 μm 71% 89% 0.76
(0.60- 0.91)
0.009 37.97 42.38 0.11 (- 0.08- 0.31)
0.246 0.78 (0.07- 1.5)
0.030 0.43 (- 0.24-1.1)
0.209 0.36 (0.12- 0.59)
0.003
GCL/IPLT 0.69 45.7 μm 71% 73% 0.92
(0.82- 1.01)
0.109 45.57 49.98 -0.05 (- 0.19- 0.09)
0.493 -0.16 (- 0.94- 0.62)
0.687 -0.14 (- 0.88- 0.59)
0.703 -0.02 (-0.27- 0.24)
0.896
GCCT 0.8 60.5 μm 86% 71% 0.92 (0.83- 0.98)
0.041 42.10 46.51 0.02 (- 0.14- 0.18)
0.785 -0.02 (- 0.8-0.75)
0.951 -0.14 (- 0.88- 0.59)
0.703 0.12 (-0.13- 0.37)
0.359
VA= visual acuity, HFA = Humphrey visual field analyzer, MD = mean deviation, FT= foveal threshold, TD = total deviation, mRNFLT= macular retinal nerve fiber layer thickness, GCL/IPLT= ganglion cell layer/inner plexiform layer thickness, GCCT= ganglion cell complex thickness, PMB= papillomacular bundle, AUC= area under the curve
AIC= The Akaike’s information criterion, BIC= the Bayesian Information Criterion, IDI= Integrated Discrimination Improvement, NRI= Net Reclassification Improvement
