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Table S1

S = Surgical/Anatomical (S) Describes the surgical/anatomical. Here the physical features of the AVM and the

involvement of different anatomical structures are described.

S1 One single anatomical site, such as the

subcutaneous tissue, a muscle, or a bony segment.

The AVM does not involve adjacent sites. (Fig.

1). No vital structures are involved.

S2 Two adjacent anatomical sites are involved. One

example may be a pre-auricular AVM that also involves the underlying parotid gland. (Fig. 2). No vital structures are involved.

S3 The AVM infiltrates important structures such as

the cheek, tongue, larynx, orbit, but not vital ones.

For example, a cheek AVM that deepens into the plane of the facial nerve would be considered S3.

AVMs infiltrating the orbital cone, the tongue, or the larynx are other examples. (Fig. 3).

S4 AVMs may involve vital structures such as the

carotid artery, internal jugular vein and/or base of skull. (Fig. 4).

E = Endovascular (E) Describes the endovascular characteristics of the AVM.

E1 Arterio-Venous (Fig. 5)

E2 Arteriolo-Venous (Fig. 6)

E3 Arteriolo-Venular (Fig. 7)

C = Clinical (C) Describes clinical features and/or complications.

C0 No Symptoms nor complications are present

C1 The lesion is symptomatic but without

complications. Pulsations (or thrills and bruits), paresthesia and visible swelling.

C2 There are local complications: ulceration,

infection and/or hemorrhage.

C3 There are general complications such as

congestive cardiac failure, fatigue, and/or anemia.

G = Growth/progression of the AVM (G) Describes the growth/progression of the AVM

(G-) AVM(s) have remained stable during the past 6

months.

(G+) AVMs have been progressive during the past 6

months.

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Table S2

Anticipated Result of Treatment Stage

Curable S1-S2

Curable with Severe Functional or Cosmetic

Disturbances S3

Not Curable S4

Indications to Treat

Relative Indications (Or No Indications) C0-C1, G-

Absolute Indications C2-C3, G+

Notes: Outcomes analysis is critical and without a comprehensive system we are not able to evaluate any treatment outcomes

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