Table S1. Univariate logistic regression analysis of clinical risk factors for severe PGD
Univariate variables OR (95% CI) p-value
Age (per 1 year) 1.00 (0.97-1.03) 0.95
Female sex 0.53 (0.17-1.64) 0.27
Nonischemic cardiomyopathy 0.72 (0.29-1.77) 0.48
Diabetes Mellitus 2.47 (0.99-6.21) 0.05
Hypertension 0.32 (0.13-0.81) 0.02
Chronic Kidney Disease 1.03 (0.38-2.78) 0.95
UNOS status 1A at heart
transplant 0.48 (0.18-1.33) 0.16
BMI (per 1 kg/m2) 1.05 (0.96-1.15) 0.25
CF-LVAD 6.24 (1.42-27.45) 0.02
Duration of CF-LVAD support
(per 1 year) 1.45 (1.01-2.09) <0.05
Aspirin 1.04 (0.40-2.69) 0.93
ACE-I/ARB 0.65 (0.26-1.60) 0.35
Beta-blockers 3.87 (0.50-29.77) 0.19
Aldosterone antagonist 1.39 (0.57-3.41) 0.47
Hydralazine 1.38 (0.53-3.59) 0.51
Nitrate 1.38 (0.48-3.98) 0.55
Sildenafil 2.89 (1.03-8.08) 0.04
Amiodarone use 4.01 (1.59-10.14) <0.01
Amiodarone dosage (per
100mg) 1.24 (1.02-1.53) 0.04
Pre-surgery IABP 0.88 (0.11-7.08) 0.90
Donor age (per 1 year) 0.98 (0.94-1.03) 0.43
Donor anoxia as cause of death 2.85 (1.07-7.63) 0.04
Donor CPR time (per 1 min) 1.02 (1.00-1.03) 0.10
Donor-recipient size mismatch (donor to recipient PHM ratio <
0.86) 2.12 (0.77-5.85) 0.15
Improved donor left ventricular
systolic dysfunction 1.33 (0.36-4.85) 0.67
Dual organ transplant 1.69 (0.36-8.06) 0.51
Total Ischemic time (per 1 min) 1.01 (1.00-1.02) 0.23
Intraoperative RBC transfusion
(per 100ml) 1.05 (1.01-1.10) 0.02
Intraoperative FFP transfusion
(per 100 ml) 1.01 (0.95-1.09) 0.71
Intraoperative Platelet
transfusion (per 100 ml) 1.06 (0.96-1.17) 0.22
Table S2a. Multivariate logistic regression model of clinical risk factors for severe PGD with adjustment for era and urgency status for heart transplantation*
Risk factors OR (95% CI) p-value
Duration of CF-LVAD support
(per 1 year) 1.81 (1.16-2.81) 0.01
Amiodarone (per 100mg) 1.35 (1.06-1.71) 0.02
Recipient Diabetes 4.90 (1.60-15.00) 0.01
Recipient Hypertension 0.16 (0.05-0.49) <0.01
Intraoperative RBC transfusion
(per 100ml) 1.08 (1.03-1.14) <0.01
* adjusted for recipient diabetes, recipient hypertension, era, urgency status for heart transplantation (ill patients compared to stable patients), duration of CF-LVAD support (per 1 year), beta-blocker, sildenafil, amiodarone dose (per 100mg), donor CPR time (per 1 minute), anoxia as donor cause of death, donor- recipient size mismatch, intraoperative RBC transfusion (per 100ml)
Table S2b. Multivariate logistic regression model of multiplicative interaction between duration of CF- LVAD support and amiodarone dose with adjustment for era and urgency status for heart transplantation*
Risk factors OR (95% CI) p-value
Duration of CF-LVAD support (per 1 year) x Amiodarone (per
100mg) 1.43 (1.15-1.78) <0.01
Recipient Diabetes 4.45 (1.48-13.38) 0.01
Recipient Hypertension 0.19 (0.06-0.55) <0.01
Intraoperative RBC transfusion
(per 100ml) 1.07 (1.01-1.13) 0.01
* adjusted for recipient diabetes, recipient hypertension, era, urgency status for heart transplantation (ill patients compared to stable patients), duration of CF-LVAD support (per 1 year), beta-blocker, sildenafil, amiodarone dose (per 100mg), donor CPR time (per 1 minute), anoxia as donor cause of death, donor- recipient size mismatch, intraoperative RBC transfusion (per 100ml), duration of CF-LVAD support (per 1 year) x amiodarone dose (per 100mg)
Figure S1
0 3 6 9 12
2006-2009 2010-2013 2014-2017
Se ve re P rim ar y G ra ft D ysf unc tion (% )
Era of Heart Transplantation (years)
p=0.19
Figure S2
0 20 40 60 80 100
2006-2009 2010-2013 2014-2017
Ur ge nc y f or H ea rt T ra ns pl an ta tio n ba se d on U NO S St atus (% )
Era of Heart Transplantation (years)
Status 1A Hospitalized on inotropes Status 1A Non-dischargeable VAD/ECMO/IABP Status 1A LVAD related complications Status 1A LVAD elective 30-day time
Status 1A exception Status 1B
Status 2
p= 0.09
0 2 4 6 8 10 12 14 16 18
