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Renz et al (2018) DOI: 10.2106/JBJS.17.01005
Alpha Defensin Lateral Flow Test for Diagnosis of Periprosthetic Joint Infection Not a Screening but a Confirmatory Test
Using Alpha Defensin Lateral Flow Test to confirm diagnosis of Periprosthetic Joint Infection
© 2018 Journal of Bone & Joint Surgery, Inc. (JBJS)
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Three classification systems were used to assess the performance of Alpha Defensin Lateral Flow test
in diagnosing acute and chronic PJI
in aspiration samples collected from the prosthetic hip or knee of 212 patients before revision arthroplasty
0 20 40 60 80 100
Musculoskeletal
Infection Society Infectious Diseases
Society of America European Bone and Joint Infection Society
84 96
67
96
54
99
Applied Definition Criteria
Percent
Sensitivity Specificity
The Alpha Defensin Lateral Flow test is...
Limited Sensitivity Highly Specific
>95%
Quick
Within 10 minutes Misses low-grade
infections
The Alpha Defensin Lateral Flow test can be used as a confirmatory test for PJI as it is quick and highly specific, but not as a screening test due to its limited sensitivity.
Determination of Alpha Defensin in the synovial fluid has been proposed as a new diagnostic test
for Periprosthetic joint infection (PJI)
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