(yr. of publication) leukemia yrs. > 14% 14 USA NM yrs

Supplemental Digital Content 3. Summary of evaluable studies regarding neutropenia in immunocompetent children (2005-2016)

* of them 20 (28%) with an infectious etiology

** in the 20 patients with infectious etiology MDS-myelodysplastic syndrome

NM-not mentioned

Malignancy Serious

bacterial infections Neutropenia

<0.5 cells x 10⁹/L Young

patients No.

patients Country

Reference no. (yr. of publication)

leukemia 3 4.51%

41%

3 yrs.

>

14%

14 USA

2005)

14 )

NM 151% 1.7%

2 yrs.

>

1151%

4111

32 USA (2010)

NM No

bacteremias 2 UTI 11%

73%<3 yrs.

..

Kuweit

33 (2012)

2 MDS leukemia 2 4151%

21%

2 yrs.

>

66%

464 Greece

10 (2013)

15.% NM 4151%

14 NM Israel

34 (2015)

none 5.69

events/1000 days at risk**

.5%

Mean age 108 m 14*

Sweden

35(2015)

NM 4651% 2.1%

29.5%<3m 415

Spain

36 (2016)

6 leukemia 4156%

15.%

.256%<3 m 654

Israel Present study

(2017)