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8.7 Conclusion
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with non- infected wound exudate. Recently, Gilmore and co- workers described the development of hydrogel- based medical device coatings bearing PEGylated peptidyl prodrugs of conventional antibiotics which are substrates for the Staph. aureus V8 serine protease. In the presence of Staph. aureus expressing V8 protease, the protease activated antibiotic- peptide conjugate is cleaved, releasing sufficient concentrations of antibiotic to effectively prevent adhesion and biofilm formation (unpublished data), thus validating this approach to controlling bacterial adhesion to material surfaces (Gilmore, 2012). In a similar approach, Komnatnyy and colleagues exploited the production of lipases by P. aeruginosa to trigger the release of ciprofloxacin from poly(ethylene glycol) materials and control biofilm formation on the polymer surface (Komnatnyy et al. , 2013).
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