ﻪﻠﺠﻣ مﻮﻠﻋ يزار ﻲﻜﺷﺰﭘ هرود
19
، هرﺎﻤﺷ 100
، ﺮﻬﻣ ﻲﺸﻫوﮋﭘ ﻪﻟﺎﻘﻣ 1391
ﻪﻣﺪﻘﻣ ﺎﻳﻮﻟﺎﺳ هﺎﻴﮔ Salvia )
(
،
،ﻲـﻔﻠﻋ ﺖﺳا ﻲﻫﺎﻴﮔ ﺪـﻨﭼ
ﻲﻠﮔ ﻢﻳﺮﻣ مﺎﻧ ﻪﺑ و هدﻮﺑ نﺎﻴﺋﺎﻨﻌﻧ هداﻮﻧﺎﺧ زا ﻪﻛ ﻪﻟﺎﺳ ﺖﺳا مﻮﺳﺮﻣ .
دوﺪـﺣ ﻲـﻠﮔ ﻢﻳﺮﻣ ﺲﻨﺟ 900
ﻪـﻧﻮﮔ
هداﻮﻧﺎـﺧ زا ﺲﻨـﺟ ﻦﻳﺮـﺘﮔرﺰﺑ ،ﺚﻴﺣ ﻦﻳا زا و ﺖﺳا ﺖﺳا نﺎﻴﺋﺎﻨﻌﻧ .
،ﻲـﻌﻴﺒﻃ يﺎﻫ ﻪﺻﺮﻋ رد هﺎﻴﮔ ﻦﻳا رد
ﻪـﻧاﺮﺘﻳﺪﻣ ﻲﺣاﻮﻧ ناﺮـﻳا و ﺎـﭘورا زا ﻲﻳﺎـﻫ ﺶـﺨﺑ ،يا
دﻮﺷ ﻲﻣ ﺖﻓﺎﻳ )
1 و 2 .(
ﻋ ﻪﺑ ﻲﻠﮔ ﻢﻳﺮﻣ تﺎﺒﻴﻛﺮﺗ ناﻮﻨ
اﺬﻏ رد ﻲﻨﺷﺎﭼ ترﻮﺻ ﻪﺑ ﻲﻳاﺬﻏ ﺎـﻫ ﻲﻧﺪﻴـﺷﻮﻧ و ﺎﻫ
ﻲـﻣ رﺎـﻛ ﻪﺑ
ﺪـﻴﻟﻮﺗ رد ﻦﻴـﻨﭽﻤﻫ و دور يﺎـﻫوراد تا
ﻲﻧﺎﻣرد فرﺎﺼﻣ و ﻲﻫﺎﻴﮔ دراد دﺮﺑرﺎﻛ
. هدﺎﻔﺘـﺳا ﻚﻳ
ﺖـﺳا ﻲﻠﮔ ﻢﻳﺮﻣ يﺎﭼ ناﻮﻨﻋ ﻪﺑ نآ هﺪﻤﻋ .
هدﺎـﻣ ود ﺎـﻔﻟآ ﺲﻧﺎـﺳا و رﻮﻓﺎـﻛ ﻞﻣﺎـﺷ نآ هرﺎﺼﻋ رد دﻮﺟﻮﻣ
نوژﻮﺗ Alpha ) Thujene
( ياﺮـﺑ ﻲﺘـﺷاﺪﻬﺑ دراﻮـﻣ
ﻲﻣ رﺎﻛ ﻪﺑ ﺪـﻧور
) - 1 6 .(
ﺪـﺿ ﺖـﻴﻟﺎﻌﻓ ياراد ﺎﻳﻮﻟﺎـﺳ
ﺑ ﻲﻣ ﺰﻴﻧ ﻲﺑوﺮﻜﻴﻣ ﺪـﺷﺎ
) 7 و 8 .(
ﻪـﻴﻠﻋ ﺮـﺑ ﺎﻳﻮﻟﺎـﺳ زا
رد ﻲﺘـﺳﻮﭘ يﺎـﻫ ﻢـﺧز مﺎـﻴﺘﻟا و ﻲﺑﺎﻬﺘﻟا تﻻﻼﺘﺧا
دﻮـﺷ ﻲـﻣ هدﺎﻔﺘﺳا ﻲﺘﻨﺳ ﻲﻜﺷﺰﭘ )
9 و 10 .(
هزوﺮـﻣا
ﻪﻛ ﺖﺳا هﺪﺷ ﻪﺘﺧﺎﺳ ﺎﻳﻮﻟﺎﺳ هرﺎﺼﻋ زا يﺪﻳﺪﺟ دﺎﻤﭘ ﺮﺛﺆﻣ ﺎﻫ ﻢﺧز مﺎﻴﺘﻟا رد ﺖﺳا
) 9 .(
ﺰﻳﻮـﺠﺗ ،ﻲﻳﻮـﺳ زا
تﺎﻴــﺻﻮﺼﺧ ندﺮــﻛ راﺮــﻗﺮﺑ ﺎــﺑ ﺎﻳﻮﻟﺎــﺳ هرﺎــﺼﻋ ﻲﻜﻳژﺮﻨﻴﻟﻮﻛ Cholinergic )
( دﺮـﻜﻠﻤﻋ دﻮـﺒﻬﺑ ﺐﺒﺳ
دﻮﺷ ﻲﻣ ناﻮﺟ ﻎﻟﺎﺑ داﺮﻓا رد ﻲﻛاردا )
11 .(
يﺎﻫ ﻪﺼﺨﺸﻣ زا ﻲﻜﻳ ،از نﺎﻃﺮﺳ ﻲﻧﺎﻳور نژ ﻲﺘﻧآ
يﺪﻤﺣا ﻢﻴﺣر ﺮﺘﻛد :
ناﺮﻳا ،ناﺪﻤﻫ ،ناﺪﻤﻫ ﺪﺣاو ،ﻲﻣﻼﺳا دازآ هﺎﮕﺸﻧاد ،ﻪﻳﺎﭘ مﻮﻠﻋ هﺪﻜﺸﻧاد ،يژﻮﻟﻮﻳﺰﻴﻓ هوﺮﮔ ،يژﻮﻟﻮﻳﺰﻴﻓ ﺺﺼﺨﺘﻣ و رﺎﻳدﺎﺘﺳا [email protected] .
* ﻲﻳازﺮﻴﻣ ﺪﻧواﺪﻫ اﺮﻫز :
ﻚﻴﺘﻧژ ﺪﺷرا ﻲﺳﺎﻨﺷرﺎﻛ يﻮﺠﺸﻧاد ﺎﻘﻴﻘﺤﺗ و مﻮﻠﻋ ﺪﺣاو ،ﻲﻣﻼﺳا دازآ هﺎﮕﺸﻧاد ،ﻪﻳﺎﭘ مﻮﻠﻋ هﺪﻜﺸﻧاد ،ﻚﻴﺘﻧژ هوﺮﮔ ،
ناﺮﻳا ،ناﺮﻬﺗ ،ت
*) . هﺪﻨﺴﻳﻮﻧ لﻮﺌﺴﻣ .(
ﻲﻓﺎﻣ رﺎﻴﻬﻣ ناﺮﻳا ،ناﺮﻬﺗ ،ناﺮﻬﺗ ﻲﻜﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد ،مﺮﻛا لﻮﺳر نﺎﺘﺳرﺎﻤﻴﺑ ،ﺮﻛرﺎﻣ رﻮﻣﻮﺗ و ﻲﻧﻮﻣرﻮﻫ ﺶﺠﻨﺳ ﺶﺨﺑ ،ﺪﺷرا ﻲﺳﺎﻨﺷرﺎﻛ يﻮﺠﺸﻧاد:
.
رد از نﺎﻃﺮﺳ ﻲﻧﺎﻳور نژ ﻲﺘﻧآ ﻲﻣﺮﺳ ﺢﻄﺳ ﺮﺑ ﻲﻠﮔ ﻢﻳﺮﻣ هﺎﻴﮔ هرﺎﺼﻋ ﺮﺛا ﻲﺳرﺮﺑ ﺮﻧ ﻲﻳاﺮﺤﺻ يﺎﻫ شﻮﻣ
هﺪﻴﻜﭼ
ﻪﻨﻴﻣز و فﺪﻫ : ﺖﺳا كﺪﻧا رﺎﻴﺴﺑ رﻮﻣﻮﺗ يﺎﻫ ﻪﺼﺨﺸﻣ و ﻲﻠﮔ ﻢﻳﺮﻣ هﺎﻴﮔ هرﺎﺼﻋ ﻦﻴﺑ طﺎﺒﺗرا هرﺎﺑرد تﺎﻌﻟﺎﻄﻣ .
هﺎﻴﮔ هرﺎﺼﻋ ﺮﺛا ﻲﺳرﺮﺑ ،ﻪﻌﻟﺎﻄﻣ ﻦﻳا زا فﺪﻫ
يﺎﻫ شﻮﻣ رد از نﺎﻃﺮﺳ ﻲﻧﺎﻳور نژ ﻲﺘﻧآ ﺮﻛرﺎﻣ رﻮﻣﻮﺗ ﻲﻣﺮﺳ ﺢﻄﺳ ﺮﺑ ﻲﻠﮔ ﻢﻳﺮﻣ ﺪﺷﺎﺑ ﻲﻣ ﺮﻧ ﻲﻳاﺮﺤﺻ
.
شور رﺎﻛ :
،ﻲﺑﺮﺠﺗ ﻲﻫﺎﮕﺸﻳﺎﻣزآ ﻪﻌﻟﺎﻄﻣ ﻦﻳا رد 20
،ﻦﻴﻟﺎﺳ لﺎﻣﺮﻧ هﺪﻨﻨﻛ ﺖﻓﺎﻳرد ،ﺪﻫﺎﺷ هوﺮﮔ ﻪﺑ ﻲﻓدﺎﺼﺗ رﻮﻃ ﻪﺑ رﺎﺘﺴﻳو داﮋﻧ ﺮﻧ ﻲﻳاﺮﺤﺻ شﻮﻣ سأر
زود ﺎﺑ ﻲﻠﮔ ﻢﻳﺮﻣ هﺎﻴﮔ هرﺎﺼﻋ هﺪﻨﻨﻛ ﺖﻓﺎﻳرد Dose)
( 100 و 200 هوﺮﮔ ﺮﻫ رد ﻪﻛ ﺪﻧﺪﻳدﺮﮔ يﺪﻨﺑ ﻢﻴﺴﻘﺗ ،نﺪﺑ نزو مﺮﮔﻮﻠﻴﻛ ﺮﻫ يازا ﻪﺑ مﺮﮔ ﻲﻠﻴﻣ 5
شﻮﻣ
ﺖﺷاد دﻮﺟو . ﻪﻧﻮﻤﻧ تﺪﻣ ﻦﻳا زا ﺲﭘ و ﺪﻨﺘﻓﺮﮔ راﺮﻗ ﻲﻫﺎﮕﺸﻳﺎﻣزآ تﺎﻴﺑﺮﺠﺗ ﺖﺤﺗ ﻪﺘﻔﻫ ﺖﻔﻫ تﺪﻣ ﻪﺑ ﺎﻫ ﻪﻧﻮﻤﻧ زا ﻲﻧﻮﺧ يﺎﻫ
ﺐﻠﻗ زا يﺮﻴﮕﻧﻮﺧ ﻚﻴﻨﻜﺗ ﻖﻳﺮﻃ
ﻳور نژ ﻲﺘﻧآ ﻲﻣﺮﺳ ﺢﻄﺳ ،مﺮﺳ ﻪﻴﻬﺗ زا ﺲﭘ و هﺪﺷ ﻪﻴﻬﺗ ﻲﺳاﻮﻧﻮﻴﻤﻳا ﻮﻳدار شور زا هدﺎﻔﺘﺳا ﺎﺑ از نﺎﻃﺮﺳ ﻲﻧﺎ
(Radioimmunoassay) يﺮﻴﮔ هزاﺪﻧا
ﺪﻳدﺮﮔ . ﺖﻓﺮﮔ راﺮﻗ ﻪﺴﻳﺎﻘﻣ درﻮﻣ ﺎﻫ هوﺮﮔ ﻦﻴﺑ ﻪﻓﺮﻄﻜﻳ ﺲﻧﺎﻳراو يرﺎﻣآ نﻮﻣزآ زا هدﺎﻔﺘﺳا ﺎﺑ ﺎﻫ هداد ﺖﻳﺎﻬﻧ رد .
ﺎﻫ ﻪﺘﻓﺎﻳ : هوﺮﮔ رد از نﺎﻃﺮﺳ ﻲﻧﺎﻳور نژ ﻲﺘﻧآ ﻲﻣﺮﺳ ﺢﻄﺳ ﻪﻛ ﺪﻧداد نﺎﺸﻧ ﺞﻳﺎﺘﻧ زود ﺎﺑ ﻲﻠﮔ ﻢﻳﺮﻣ هﺎﻴﮔ هرﺎﺼﻋ هﺪﻨﻨﻛ ﺖﻓﺎﻳرد
200 ،ﺪﻫﺎﺷ هوﺮﮔ ﻪﺑ ﺖﺒﺴﻧ
ﺪﻳدﺮﮔ رادﺎﻨﻌﻣ ﺶﻫﺎﻛ ياراد )
007 / 0 p= (
، ﻲﻣﺮﺳ ﺢﻄﺳ ﻪﭼﺮﮔ زود ﺎﺑ هرﺎﺼﻋ هﺪﻨﻨﻛ ﺖﻓﺎﻳرد هوﺮﮔ رد نژ ﻲﺘﻧآ ﻦﻳا
100 يرادﺎﻨﻌﻣ توﺎﻔﺗ ﺪﻫﺎﺷ هوﺮﮔ ﻪﺑ ﺖﺒﺴﻧ
داﺪﻧ نﺎﺸﻧ دﻮﺧ زا ار .
ﻪﺠﻴﺘﻧ يﺮﻴﮔ : ﻦﻳا زا ﻞﺻﺎﺣ ﺞﻳﺎﺘﻧ عﻮﻤﺠﻣ رد ﺶﻫﺎﻛ ﺐﺒﺳ ﺪﻧاﻮﺗ ﻲﻣ ،ﺐﺳﺎﻨﻣ زود ﺎﺑ ﻲﻠﮔ ﻢﻳﺮﻣ هﺎﻴﮔ هرﺎﺼﻋ ﻪﻛ ﺪﻧداد نﺎﺸﻧ ﻖﻴﻘﺤﺗ
نژ ﻲـﺘﻧآ ﻲﻣﺮﺳ ﺢﻄﺳ
ددﺮﮔ از نﺎﻃﺮﺳ ﻲﻧﺎﻳور .
رد ﻲﻠﮔ ﻢﻳﺮﻣ هﺎﻴﮔ هرﺎﺼﻋ ﻲﻳوراد دﺮﺑرﺎﻛ ،سﺎﺳا ﻦﻳا ﺮﺑ ﺮﻛرﺎـﻣ رﻮﻣﻮﺗ ﻦﻳا ﺢﻄﺳ ﻪﻛ ﻲﻳﺎﻫ نﺎﻃﺮﺳ نﺎﻣرد
Tumor markers) (
رد
ﺮﺛﺆﻣ ﺪﻧاﻮﺗ ﻲﻣ ،ﺪﺑﺎﻳ ﻲﻣ ﺶﻳاﺰﻓا ﺎﻬﻧآ ﺪﺷﺎﺑ
.
هژاوﺪﻴﻠﻛ ﺎﻫ :
، از نﺎﻃﺮﺳ ﻲﻧﺎﻳور نژ ﻲﺘﻧآ ،ﻲﻠﮔ ﻢﻳﺮﻣ ﻲﻳاﺮﺤﺻ شﻮﻣ
.
ﺖﻓﺎﻳرد ﺦﻳرﺎﺗ :
17 / 12 / 90 شﺮﻳﺬﭘ ﺦﻳرﺎﺗ :
20 / 3 / 91
ﺮﺘﻛد يﺪﻤﺣا ﻢﻴﺣر و
نارﺎﻜﻤﻫ 38
هﺪـﺷ نﺎـﻴﺑ نﺎﻃﺮـﺳ يﺎـﻫ ﺖﻓﺎﺑ رد ﻪﻛ ﺖﺳا رﻮﻣﻮﺗ ﺮﺳ رد ﺢﺷﺮﺗ ترﻮﺻ ﻪﺑ ار دﻮﺧ ﺐﻠﻏاو ﻲـﻣ نﺎﺸﻧ م
ﺪﻫد ) 12 .(
رد اﺪـﺘﺑا رد از نﺎﻃﺮـﺳ ﻲﻧﺎﻳور نژ ﻲﺘﻧآ
مﻮﻨﻴــــﺳرﺎﻛﻮﻧدآ Adenocarcinoma )
( ﻢﺘــــﺴﻴﺳ
ـﺷ ﻒﺸﻛ نﺎﺴﻧا شراﻮﮔ ﺪ
) - 13 15 .(
نژ ﻲـﺘﻧآ ﻦـﻳا
ﺖـﺳا لﻮﻠـﺳ يﺎـﺸﻏ ﻲﺤﻄـﺳ ﻦﻴﺌﺗوﺮﭘﻮـﻜﻴﻠﮔ ﻚﻳ ) 16 و 17 .(
زا از نﺎﻃﺮـﺳ ﻲﻧﺎـﻳور نژ ﻲـﺘﻧآ لﻮﻜﻟﻮﻣ
ـﺷﺮﺗ ﻲﺘﻓﺎﺑ نﺎﻴﻣ يﺎﻀﻓ ﻪﺑ لﻮﻠﺳ ﺢﻄﺳ زا و هﺪـﺷ ﺢ
دﻮــﺷ ﻲــﻣ نﻮــﺧ شدﺮــﮔ ﻢﺘــﺴﻴﺳ دراو ﺎــﺟ نآ ) 18 و 19 .(
ﻲــﺘﻧآ نژ ﻦﻴــﻨﭽﻤﻫ از نﺎﻃﺮــﺳ ﻲﻧﺎــﻳور
ﻲﻣ ﺖﻇﺎﻔﺣرد ﺪﻧاﻮﺗ يﺎـﻘﺑ و رﻮـﻣﻮﺗ يﺎـﻫ لﻮﻠﺳ زا
لﻮﻠﺳ ﻦﻳا ﻪﺘـﺷاد ﺶـﻘﻧ نﻮﺧ شدﺮﮔ ﻢﺘﺴﻴﺳ رد ﺎﻫ
ﺪﺷﺎﺑ ) 20 .(
هرﺎـﺼﻋ ﻪـﻛ ﺪـﻧا هداد نﺎـﺸﻧ تﺎـﻌﻟﺎﻄﻣ
ﺮﺑ لﻮﻠﺳ ﺪﺷر ﺪﺿ ﺖﻴﻟﺎﻌﻓ ياﺮﺑ ﺎﻳﻮﻟﺎﺳ هﺎﻴﮔ ﻲﻟﻮﻧﺎﺘﻣ نﺎﻃﺮﺳ و ﺖﺳﻮﭘ نﺎﻃﺮﺳ ،ﻢﺣر ندﺮﮔ نﺎﻃﺮﺳ ﻪﻴﻠﻋ ﺖــﺳا ﺮﺛﺆــﻣ نﺎﺘــﺴﭘ )
21 .(
زا يرﺎﻴــﺴﺑ ﻦﻴــﻨﭽﻤﻫ
زا ﺮـﻄﻌﻣ نﺎـﻫﺎﻴﮔ ﻪـﺑ ﺮـﮕﻳد ﻲﻧﺎﻃﺮـﺳ ﺪـﺿ صاﻮﺧ ﻲﻣ هداد ﺖﺒﺴﻧ ﻲﻠﮔ ﻢﻳﺮﻣ ﺲﻨﺟ دﻮﺷ
) 22 .(
هرﺎـﺼﻋ
يﺎـﻫ لﻮﻠـﺳ رﺎـﻬﻣ رد ﺪـﻧاﻮﺗ ﻲـﻣ ﻲـﻠﮔ ﻢﻳﺮﻣ هﺎﻴﮔ ﺪــﻳﺎﻤﻧ ﺎــﻔﻳا ﺶــﻘﻧ گرﺰــﺑ هدور ﻲﻧﺎﻃﺮــﺳ )
23 .(
رد
ﻪﭼ ﺮﮔا ،عﻮﻤﺠﻣ هرﺎﺼﻋ ﺎﺑ ﻪﻄﺑار رد يدﺎﻳز تﺎﻌﻟﺎﻄﻣ
ﺎـﻣا ،هﺪـﺷ مﺎـﺠﻧا ﺎﻫﺮﻛرﺎﻣ رﻮﻣﻮﺗ ﺮﺑ ﻒﻠﺘﺨﻣ نﺎﻫﺎﻴﮔ ﺮـﺑ ﻲـﻠﮔ ﻢﻳﺮـﻣ هرﺎـﺼﻋ تاﺮﺛا صﻮﺼﺧ رد تﺎﻌﻟﺎﻄﻣ ﺖﺳا كﺪﻧا رﺎﻴﺴﺑ ﺎﻬﻧآ .
،ﺮـﺿﺎﺣ ﻖﻴﻘﺤﺗ ،ﺎﻨﺒﻣ ﻦﻳا ﺮﺑ
ﺮـﺑ ﻲـﻠﮔ ﻢﻳﺮـﻣ هﺎـﻴﮔ ي هرﺎـﺼﻋ ﺮﺛا ﻲﺳرﺮﺑ ﻲﭘ رد نﺎﻃﺮﺳ ﻲﻧﺎﻳور نژ ﻲﺘﻧآ ﺮﻛرﺎﻣ رﻮﻣﻮﺗ ﻲﻣﺮﺳ ﺢﻄﺳ از
شﻮﻣ رد ﺪﺷﺎﺑ ﻲﻣ ﺮﻧ ﻲﻳاﺮﺤﺻ يﺎﻫ
.
شور ﻲﺳرﺮﺑ
و هدﻮـﺑ ﻲﻫﺎﮕﺸﻳﺎﻣزآ ﻲﺑﺮﺠﺗ عﻮﻧ زا ﺮﺿﺎﺣ ﻪﻌﻟﺎﻄﻣ نآ ﻲﻃ ﻲﻫﺎﮕـﺸﻳﺎﻣزآ تﺎﻴﺑﺮﺠﺗ زا ﻞﺻﺎﺣ يﺎﻫ هداد
هوﺮﮔ ﻦﻴﺑ
ﺪـﻨﺘﻓﺮﮔ راﺮـﻗ يرﺎـﻣآ ﻪﺴﻳﺎﻘﻣ درﻮﻣ ﺎﻫ .
رد
ﺶﻫوﮋـﭘ ﻦﻳا
ﺤـﺻ يﺎـﻫ شﻮـﻣ داﮋـﻧ ﻎﻟﺎـﺑ ﺮـﻧ ﻲﻳاﺮ
نزو ﺎﺑ رﺎﺘﺴﻳو
± 200 180 رﻮﺘﺳﺎﭘ ﻮﺘﻴﺘﺴﻧا زا و مﺮﮔ
ﺪﻧﺪﻳدﺮﮔ ﻪﻴﻬﺗ ناﺮﻳا .
شﻮﻣ ﻦﻳا صﻮﺼﺨﻣ قﺎﺗا رد ﺎﻫ
يﺎﻣد رد تﺎﻧاﻮﻴﺣ
± 20 24 هرود و داﺮﮕﻴﺘﻧﺎﺳ ﻪﺟرد
يرﻮﻧ - ﻲﻜﻳرﺎﺗ 12
و ﻲﻳﺎﻨـﺷور ﺖﻋﺎـﺳ 12
ﺖﻋﺎـﺳ
ﺖﻋﺎﺳ زا يرﻮﻧ هرود عوﺮﺷ ﻦﺘﻓﺮﮔ ﺮﻈﻧ رد ﺎﺑ ﻲﻜﻳرﺎﺗ 8 ﺢﺒــﺻ ترﻮــﺻ ﻪــﺑ اﺬــﻏ و بآ ،ﺪﻧﺪــﺷ يراﺪــﻬﮕﻧ
ﻴﺣ سﺮﺘﺳد رد دوﺪﺤﻣﺎﻧ ﻲـﻣ راﺮﻗ تﺎﻧاﻮ
ﺖـﻓﺮﮔ ) بآ ماد ﺖﻛﺮـﺷ زا ﻪـﻛ شﻮـﻣ هدﺎـﻣآ كارﻮـﺧو يﺮﻬﺷ
دﻮــﺑ هﺪــﺷ ﻪــﻴﻬﺗ سرﺎــﭘ .(
هوﺮــﮔ ﺮــﻫ رد تﺎــﻧاﻮﻴﺣ
هرﺎﻤﺷ ﻪـﺑ ﺖﺒﺴﻧ ﺰﻴﻧ و هﺪﺷ يراﺬﮔ يﺮـﺠﻣ رﻮـﻀﺣ
ﻲﻣ رﺎﮔزﺎﺳ ،حﺮﻃ ﺪﻧﺪﻳدﺮﮔ
. تﺎـﻧاﻮﻴﺣ زا ماﺪـﻛ ﭻﻴـﻫ
ﻲـﻨﺒﻣ ﺪﻫاﻮـﺷ ﺎﻳ يرﺎﻤﻴﺑ ﺪﺟاو ،ﺶﻳﺎﻣزآ مﺎﮕﻨﻫ ﺮـﺑ
ﺪﻧدﻮﺒﻧ يرﺎﻤﻴﺑ .
ﻳرﺰﺗ و ﻪﻴﻬﺗ شور ﮔ هرﺎﺼﻋ ﻖ
ﺮـﺑ ،ﻲـﻠﮔ ﻢﻳﺮـﻣ هﺎـﻴ
دﻮـﺑ راﻮﺘﺳا ﻲﻠﺒﻗ تﺎﻌﻟﺎﻄﻣ يﺎﻨﺒﻣ )
, 14 25 و 27 .(
رد
،ﺪـﺷ هداد ﻮـﺸﺘﺴﺷ هﺎﻴﮔ يﺎﻫ گﺮﺑ اﺪﺘﺑا ،ﺎﺘﺳار ﻦﻳا ــﺳ رد ﻪــﺘﻔﻫ ﻚــﻳ تﺪــﻣ ﻪــﺑ هﺎــﮔ نآ ﻚــﺸﺧ ﻪﻳﺎ
ﺪﻧﺪﻳدﺮﮔ .
ًﺎﺒﻗﺎﻌﺘﻣ ﻂـﺳﻮﺗ هﺪـﺷ ﻚـﺸﺧ يﺎـﻫ گﺮﺑ
رد ﻞـﺻﺎﺣ ردﻮﭘ و هﺪﺷ ﻞﻳﺪﺒﺗ ردﻮﭘ ﻪﺑ ﻲﻗﺮﺑ بﺎﻴﺳآ لﻮﻧﺎﺗا 80 ﺪﻳدﺮﮔ ﻞﺣ ﺪﺻرد .
ندﺮـﻛ فﺎـﺻ زا ﺲـﭘ
يرﺎـﺗور هﺎﮕﺘـﺳد زا هدﺎﻔﺘـﺳا ﺎـﺑ ،لﻮﻠﺤﻣ Rotary )
(
ًﺎـﺘﻳﺎﻬﻧ ،هﺪـﺷ اﺪـﺟ هرﺎﺼﻋ زا لﻼﺣ ﻚـﺸﺧ زا ﺲـﭘ
لﻮﻠﺤﻣ،ﻦﻴﻟﺎـﺳ لﺎﻣﺮﻧ ندﻮﻤﻧ ﻪﻓﺎﺿا ﺎﺑ ،هرﺎﺼﻋ ندﺮﻛ ﺪﻳدﺮﮔ ﻞﺻﺎﺣ هرﺎﺼﻋ ﻲﺑآ .
ﻪﺑ ﻲﻳاﺮﺤﺻ يﺎﻫ شﻮﻣ 4
هوﺮـﮔ 5 ،لﺮـﺘﻨﻛ ﻲﻳﺎـﺗ
هﺪــﻨﻨﻛ ﺖــﻓﺎﻳرد و ﻦﻴﻟﺎــﺳ لﺎــﻣﺮﻧ هﺪــﻨﻨﻛ ﺖــﻓﺎﻳرد زود ﺎﺑ هرﺎﺼﻋ 100
و 200 مﺮﮔ ﻲﻠﻴﻣ /
ﻪـﺑ مﺮﮔﻮـﻠﻴﻛ
ﺪﻧﺪــﺷ يﺪــﻨﺑ ﻢﻴــﺴﻘﺗ نﺪــﺑ نزو يازا .
ﻪــﺑ هرﺎــﺼﻋ
ﺖﻓﺮﮔ راﺮﻗ ﻖﻳرﺰﺗ درﻮﻣ ﻲﻗﺎﻔﺻ نورد ترﻮﺻ .
مﺎـﻤﺗ
راﺮـﻗ يﺮﻴﮕﻧﻮـﺧ درﻮـﻣ ﻪﺘﻔﻫ ﺖﻔﻫ زا ﺲﭘ تﺎﻧاﻮﻴﺣ ﺪــﻨﺘﻓﺮﮔ .
ﻚــﻴﻨﻜﺗ ﻖــﻳﺮﻃ زا نﻮــﺧ يﺎــﻫ ﻪــﻧﻮﻤﻧ
ﺐﻠﻗ زا يﺮﻴﮕﻧﻮﺧ (Cardiac Puncture)
ﺪـﺷ ﻪﻴﻬﺗ .
ﻲﺷﻮﻬﻴﺑ درﻮﻣ ﺮﺗا ﻂﺳﻮﺗ ﺎﻫ ﻪﻧﻮﻤﻧ اﺪﺘﺑا شور ﻦﻳا رد
ًﺎـﺒﻗﺎﻌﺘﻣ ،ﻪﺘﻓﺮﮔ راﺮﻗ ﻲﺒﺴﻧ نزﻮـﺳ ﻦﺘﺧﺎـﺳ دراو ﺎـﺑ
ﻦﻴﺑ ،ﭗﭼ ﻦﻄﺑ ﻪﺑ ﮓﻧﺮﺳ 3
ﺎـﺗ 5 نﻮـﺧ ﻲـﺳ ﻲـﺳ
ﺪﻳدﺮﮔ ﻪﻴﻬﺗ .
ﻲﻧﻮﺧ يﺎﻫ ﻪﻧﻮﻤﻧ ﺲﭙﺳ 15
رد ﻪﻘﻴﻗد
ﺪﻧﺪﺷ يراﺪﻬﮕﻧ هﺎﮕﺸﻳﺎﻣزآ يﺎﻣد .
ـﻴﻬﺗ رﻮـﻈﻨﻣ ﻪـﺑ ﻪ
رود رد ﻲﻧﻮـﺧ يﺎـﻫ ﻪﻧﻮﻤﻧ ،مﺮﺳ 3000
ﻪـﻘﻴﻗد رد
يﺎـﻫ ﻪﻧﻮﻤﻧ ،مﺮﺳ ﻚﻴﻜﻔﺗ زا ﺲﭘ و هﺪﺷ ژﻮﻴﻔﻳﺮﺘﻧﺎﺳ ﻲﻣﺮـﺳ ﺢﻄـﺳ يﺮـﻴﮔ هزاﺪـﻧا ﺖﻬﺟ زﺎﻴﻧ درﻮﻣ مﺮﺳ يﺎﻣد رد ، از نﺎﻃﺮﺳ ﻲﻧﺎﻳور نژ ﻲﺘﻧآ – 20
ﻪـﺟرد
ﺪﻧﺪﺷ يراﺪﻬﮕﻧ داﺮﮕﻴﺘﻧﺎﺳ .
از نﺎﻃﺮـﺳ ﻲﻧﺎـﻳور نژ ﻲﺘﻧآ ﻲﻣﺮﺳ ﺢﻄﺳ ﺖﻈﻠﻏ ﻮﻳدار شور زا هدﺎﻔﺘﺳا ﺎﺑ ﺖـﻴﻛ ﻂـﺳﻮﺗ ﻲـﺳاﻮﻧﻮﻴﻤﻳا
ﻲــــﺼﻴﺨﺸﺗ (Immunotech A Beckman
Coulter/ref) هزاﺪـﻧا درﻮﻣ
ﺖـﻓﺮﮔ راﺮـﻗ يﺮـﻴﮔ .
رد
قﻮـﻘﺣ ﻲـﻠﻠﻤﻟا ﻦﻴـﺑ ﻦﻴﻧاﻮـﻗ ﻪﻴﻠﻛ،ﺶﻫوﮋﭘ ﺮﺳﺎﺗﺮﺳ
ﻲﻠﮔ ﻢﻳﺮﻣ هﺎﻴﮔ هرﺎﺼﻋ ﺮﺛا ﻲﺳرﺮﺑ ﻲﻣﺮﺳ ﺢﻄﺳ ﺮﺑ
39
...لوﺪﺟ - CEAﺖﻈﻠﻏ ﻲﻠﮔ ﻢﻳﺮﻣ هرﺎﺼﻋ هﺪﻨﻨﻛ ﺖﻓﺎﻳرد و لﺮﺘﻨﻛ ﺮﻧ ﻲﻳاﺮﺤﺻ يﺎﻫ شﻮﻣ رد
p* p CEA ﺺﺧﺎﺷ هوﺮﮔ
- - 0/620± 0/021 لﺮﺘﻨﻛ
- NS 0/609 ± 0/062 ﻦﻴﻟﺎﺳ لﺎﻣﺮﻧ هﺪﻨﻨﻛ ﺖﻓﺎﻳرد
- NS 0/586 ± 0/039 (100mg/kg ) هرﺎﺼﻋهﺪﻨﻨﻛﺖﻓﺎﻳرد
000 /
0 0/007 0/071 ± 0/055 (200mg/kg) هرﺎﺼﻋ هﺪﻨﻨﻛ ﺖﻓﺎﻳرد
ﻦﻴﮕﻧﺎﻴﻣ سﺎﺳا ﺮﺑ ﺎﻫ هداد ﺪﻧا هﺪﺷ نﺎﻴﺑ رﺎﻴﻌﻣ فاﺮﺤﻧا±
. ﺮﻳدﺎﻘﻣ )P ﻪﻓﺮﻃ ﻚﻳ ﺲﻧﺎﻳراو ﺰﻴﻟﺎﻧآ زا ﻞﺻﺎﺣ (
هﺪﺷ ﻪﺴﻳﺎﻘﻣ لﺮﺘﻨﻛ هوﺮﮔ ﻪﺑ ﺖﺒﺴﻧ ﺪﻧا
. ﺮﻳدﺎﻘﻣ p*
زود ﺎﺑ هرﺎﺼﻋ هﺪﻨﻨﻛ ﺖﻓﺎﻳرد هوﺮﮔ ﻪﺑ ﺖﺒﺴﻧ ﻪﺴﻳﺎﻘﻣ هﺪﻨﻫد نﺎﺸﻧ 100
ﺪﺷﺎﺑ ﻲﻣ NS . ﺖﺳا لﺮﺘﻨﻛ هوﺮﮔ ﺎﺑ ﻪﺴﻳﺎﻘﻣ رد فﻼﺘﺧا ندﻮﺑ راد ﻲﻨﻌﻣ مﺪﻋ ﺮﮕﻧﺎﻴﺑ .
ﺖﻳﺎﻋر ﻲﻠﻠﻤﻟا ﻦﻴﺑ يﺎﻫدراﺪﻧﺎﺘﺳا سﺎﺳا ﺮﺑ ﺎﻫ ﻪﻧﻮﻤﻧ ﺪﺷ ) 28 .(
يراﺰـﻓا مﺮﻧ ﻪﻣﺎﻧﺮﺑ زا هدﺎﻔﺘﺳا ﺎﺑ ﺎﻫ هداد ﺖﻳﺎﻬﻧ رد
SPSS19 ﺎﻣآ شور و
ﻪـﻓﺮﻃ ﻚﻳ ﺲﻧﺎﻳراو ﺰﻴﻟﺎﻧآ ير
ﻞــﻴﻠﺤﺗ و ﻪــﻳﺰﺠﺗ درﻮــﻣ ﺪﻧﺪــﺷ ﻊــﻗاو
. ﺰﻴﻟﺎــﻧآ رد
ﺎـﺑ ﺎـﻫ هوﺮـﮔ نﺎـﻴﻣ فﻼﺘـﺧا يراد ﻲﻨﻌﻣ ،ﺲﻧﺎﻳراو ﺪـﻳدﺮﮔ ﻦﻴﻴﻌﺗ ﻲﻛﻮﺗ نﻮﻣزآ زا هدﺎﻔﺘﺳا .
رد فﻼﺘـﺧا
زا ﺮــﺘﻤﻛ لﺎــﻤﺘﺣا ﺢﻄــﺳ 05
/ 0 ﺮــﻈﻧ رد راد ﻲــﻨﻌﻣ
ﺪﺷ ﻪﺘﻓﺮﮔ .
ﻳ ﻪﺘﻓﺎ ﺎﻫ هرﺎﻤـــــﺷ لوﺪـــــﺟ 1
ﺖـــــﻈﻠﻏ ﺮﮕﻧﺎـــــﺸﻧ
(Carcinogenic Embryonic Antigen) رد CEA
ﺎﻫ شﻮﻣ مﺮﺳ ﺪﺷﺎﺑ ﻲﻣ ﺮﻧ ﻲﻳاﺮﺤﺻ ي
.
هوﺮـﮔ و لﺮﺘﻨﻛ هوﺮﮔ نﺎﻴﻣ ﺎﻫ هداد يرﺎﻣآ ﻪﺴﻳﺎﻘﻣ دﻮـﺟو مﺪـﻋ ﺮﮕﻧﺎـﻴﺑ ،ﻦﻴﻟﺎـﺳ لﺎـﻣﺮﻧ هﺪﻨﻨﻛ ﺖﻓﺎﻳرد
هوﺮﮔ ﻦﻳا ﻦﻴﺑ راد ﻲﻨﻌﻣ فﻼﺘﺧا ﺪﺷﺎﺑ ﻲﻣ ﺎﻫ
. ﻦﻳا ﺮﺑ
تﺎــﻴﺑﺮﺠﺗ ﺞﻳﺎــﺘﻧﺮﺑ ،هرﺎــﺼﻋ نﺪــﻧارﻮﺧ شور ،ﺎــﻨﺒﻣ ﺷاﺪﻧ يﺮﻴﺛﺎﺗ ،ﺮﺿﺎﺣ ﺶﻫوﮋﭘ ﺖﺳا ﻪﺘ
. ﺞﻳﺎﺘﻧ ،ﻲﻳﻮﺳزا
ﺖــﻈﻠﻏ ﻪــﻛ ﺪــﻨﻧآ ﺮﮕﻧﺎــﻴﺑ يﺎــﻫ شﻮــﻣ رد CEA
زود ﺎـﺑ ﻲﻠﮔ ﻢﻳﺮﻣ هرﺎﺼﻋ هﺪﻨﻨﻛ ﺖﻓﺎﻳرد ﺮﻧ ﻲﻳاﺮﺤﺻ 200 مﺮﮔ ﻲﻠﻴﻣ /
،ﺪﻫﺎـﺷ هوﺮـﮔ ﻪـﺑ ﺖﺒﺴﻧ مﺮﮔﻮﻠﻴﻛ
ﺖـــﺳا ﻪـــﺘﻓﺎﻳ يراد ﻲـــﻨﻌﻣ ﺶﻫﺎـــﻛ )
05 /
< 0 .( p
ﻲﻧﺎـﻳور نژ ﻲـﺘﻧآ ﻲﻣﺮـﺳ ﺢﻄـﺳ راﺪـﻘﻣ ،ﻦﻴﻨﭽﻤﻫ هﺪﻨﻨﻛ ﺖﻓﺎﻳرد ﺮﻧ ﻲﻳاﺮﺤﺻ يﺎﻫ شﻮﻣ رد از نﺎﻃﺮﺳ زود ﺎﺑ هرﺎﺼﻋ 100
مﺮﮔ ﻲﻠﻴﻣ /
ﻪـﺑ ﺖﺒـﺴﻧ مﺮﮔﻮﻠﻴﻛ
داﺪﻧ نﺎﺸﻧ دﻮﺧ زا يراد ﻲﻨﻌﻣ توﺎﻔﺗ ،ﺪﻫﺎﺷ هوﺮﮔ .
ﺚﺤﺑ ﺘﻧو ﻴ ﻪﺠ ﮔ ﻴ ﺮ ي
ﺐﺒﺳ ﻲﻠﮔ ﻢﻳﺮﻣ ﻲﺑآ هرﺎﺼﻋ ﺮﺿﺎﺣ ﻪﻌﻟﺎﻄﻣ ﻖﺑﺎﻄﻣ ﻫﺎﻛ ﺶ از نﺎﻃﺮـﺳ ﻲﻧﺎـﻳور نژ ﻲـﺘﻧآ ﻲﻣﺮـﺳ ﺢﻄﺳ ﻲﻣ ﺮﻈﻧ ﻦﻳا زا و ﺖﺳا هﺪﺷ
ردﺎﻗ ﻪﻛ ﺖﻔﮔ ناﻮﺗ ﺖﺳا
ﺪﺷﺎﺑ ﻪﺘﺷاد ﻲﻧﺎﻃﺮﺳ ﺪﺿ ﺖﻴﻟﺎﻌﻓ .
يﺮﮕﻳد تﺎﻘﻴﻘﺤﺗ
ﺖـﺳا ردﺎـﻗ ﻲﻠﮔ ﻢﻳﺮﻣ هرﺎﺼﻋ ﻪﻛ ﺪﻧا هداد نﺎﺸﻧ ﺰﻴﻧ ﺮـﻴﺜﻜﺗ و ﺪـﺷر رﺎـﻬﻣ ﺚﻋﺎﺑ ﻲﻟﻮﻠﺳ ﺖﺸﻛ ﻂﻴﺤﻣ رد لﺎــﺘﻛرﻮﻟﻮﻛ ﻲﻧﺎﻃﺮــﺳ يﺎــﻫ لﻮﻠــﺳ Colorectal )
(
ددﺮﮔ ) 22 .(
نﺎـﺸﻧ يﺮـﮕﻳد ﻪـﻌﻟﺎﻄﻣ رد ،ﻦﻴـﻨﭽﻤﻫ
ﺖــﺳا هﺪــﺷ هداد ﻦﻴــﻨﻴﻛ ﻪــﻛ
ﺪــﻴﻳﻮﻨﭘﺮﺘﻳد يﺎــﻫ
(Diterpenoid Quinines) هﺎـﻴﮔ زا هﺪـﺷ جاﺮﺨﺘﺳا
ﺐﻴـﺳآ و ﻚﻴـﺴﻛﻮﺗﻮﺘﻴﺳ تاﺮـﺛا ياراد ﻲـﻠﮔ ﻢﻳﺮـﻣ ﺪﻨﻧﺎﺳر ﺮﺑ ه و نﻮـﻟﻮﻛ ﻲﻧﺎﻃﺮـﺳ يﺎـﻫ لﻮﻠـﺳ DNA
ﻦـﻳا ﻪﺑ ﻪﻛ ﺪﻨﺷﺎﺑ ﻲﻣ ﻲﻟﻮﻠﺳ ﺖﺸﻛ ﻂﻴﺤﻣ رد ﺪﺒﻛ ﻲـﻣ يﺮﻴﮔﻮـﻠﺟ يرﻮﻣﻮﺗ يﺎﻫ لﻮﻠﺳ ﺪﺷر زا ﻪﻄﺳاو ﺪﻨﻳﺎﻤﻧ 23 )
. ( ﺮﺛا ﻲﺳرﺮﺑ ﻦﻴﻨﭽﻤﻫ ﺮـﺑ ﻲﻠﮔ ﻢﻳﺮﻣ تا
ﺰﻴﺋﻮﺘﻧﻻآﻮﻳرﻮﻛ يﺎﺸﻏ Corio-Allantoises )
( ﻪﺟﻮﺟ
گرﺪﺿ ﺖﻴﻟﺎﻌﻓ ﺮﮕﻧﺎﺸﻧ هرﺎـﺼﻋ يﺮﻴﺜﻜﺗ ﺪﺿ و ﻲﻳاز
ﺪﺷﺎﺑ ﻲﻣ هﺎﻴﮔ ﻦﻳا ﺮﻛرﺎـﻣ رﻮﻣﻮﺗ ﻪﻛ ﺎﺠﻧآ زا و
CEA
رد ﻟﺎﻌﻓ ــﻴ ﺖ ﺎــﻫ ي رﺎــﭼد ﻲﻟﻮﻠــﺳ ﺐــﻳﺮﺨﺗ و ﺮــﻴﺜﻜﺗ
ناﺰـﻴﻣ ﺶﻫﺎـﻛ ،ﻦﻳاﺮﺑﺎـﻨﺑ ؛ددﺮﮔ ﻲﻣ ﺶﻳاﺰﻓا CEA
،دراﻮﻣ ﻦﻳا رد ﻲﻣﺮﺳ دﻮـﺑ ﺪﻫاﻮﺧ رﺎﻈﺘﻧا درﻮﻣ
) 28 .(
ﻲـﻣ نﺎـﺸﻧ تﺎـﻘﻴﻘﺤﺗ ،ﺮـﺿﺎﺣ ﺶﻫوﮋـﭘ يﺎﺘﺳار رد لﻮــﺌﻨﻴﭘﺮﺗ ﺎــﻔﻟآ ﺐــﻴﻛﺮﺗ ﻪــﻛ ﺪــﻨﻫد Alpha )
Terpineol (
رد دﻮــﺟﻮﻣ ﻲﻠــﺻا تﺎــﺒﻴﻛﺮﺗ زا ﻪــﻛ
ﺪـﺷر رﺎـﻬﻣ ﺚﻋﺎﺑ ﺪﻧاﻮﺗ ﻲﻣ ،ﺖﺳا ﻲﻠﮔ ﻢﻳﺮﻣ هرﺎﺼﻋ دﻮﺷ يرﻮﻣﻮﺗ يﺎﻬﻟﻮﻠﺳ ﺪـﻧاﻮﺗ ﻲـﻣ ﺐﻴﺗﺮﺗ ﻦﻳا ﻪﺑ و
ﺎـﺳدازآ و ﺢـﺷﺮﺗ ﺮﺑ يرﺎﻬﻣ تاﺮﺛا ﺮﻛرﺎـﻣ رﻮـﻣﻮﺗ يز
ﺪـﺷﺎﺑ ﻪﺘﺷاد ، CEA )
29 .(
ﺶﻫوﮋـﭘ ،ﻦﻴـﻨﭽﻤﻫ ﺎـﻫ
ﻢﻳﺮـﻣ هرﺎـﺼﻋ ياﺰـﺟا زا ﻲﺧﺮﺑ ﻪﻛ ﺪﻨﻫد ﻲﻣ نﺎﺸﻧ ﻦﭘﺮﺗﻮــﻧﻮﻣ ﻞــﻴﺒﻗ زا ﻲــﻠﮔ نژﻮــﺗ يﺎــﻫ
Thujene )
Monoterpenes (
ﻦﻨـــﻴﭘ ﺎـــﺘﺑ ، Beta-Pinene )
( و
ﻞﺋﻮﻨﻴﺳ Cineol )
( لﻮﻠﺳ ﺪﺷر رﺎﻬﻣ ﺎﺑ ﺪﻨﻧاﻮﺗ ﻲﻣ ﺎـﻫ
ﺪﻨــﺷﺎﺑ ﻪﺘــﺷاد ﺶــﻘﻧ نﺎﻃﺮــﺳ نﺎــﻣرد رد )
30 .(
زا
ﺮﺘﻛد يﺪﻤﺣا ﻢﻴﺣر و
نارﺎﻜﻤﻫ 40
ﻲﺳرﺮﺑ ،ﻲﻳﻮﺳ ﻲﻣ نﺎﺸﻧ ﺎﻫ
يﺎـﻫ ﻲـﺑﺮﭼ ﻪـﻛ ﺪـﻨﻫد
ﺖـﻴﻟﺎﻌﻓ ياراد ﻲﻠﮔ ﻢﻳﺮﻣ هرﺎﺼﻋ رد دﻮﺟﻮﻣ يروﺮﺿ ﻲﻣ يرﻮﻣﻮﺗ ﺪﺿ ﺪﻨـﺷﺎﺑ
) 21 و 31 .(
ﻲـﻣ عﻮـﻤﺠﻣ رد
ﻢﻳﺮـﻣ هﺎـﻴﮔ هرﺎﺼﻋ رد دﻮﺟﻮﻣ ياﺰﺟا ﻪﻛ ﺖﻔﮔ ناﻮﺗ ﻦﭘﺮﺗﻮﻧﻮﻣ ،لﻮﺌﻨﻴﭘﺮﺗ ﺎﻔﻟآ هﮋﻳو ﻪﺑ ،ﻲﻠﮔ ﺎﺘﺑ ،نژﻮﺗ يﺎﻫ
ﻲــﺑﺮﭼ و ﻞﺋﻮﻨﻴــﺳ ،ﻦﻨــﻴﭘ ﺒــﺳ ،يروﺮــﺿ يﺎــﻫ
ﺐ
يﺮﻴﮕﺸﻴﭘ ﺰﻴﻧ و ﻢﻟﺎﺳ يﺎﻬﻟﻮﻠﺳ ﺐﻳﺮﺨﺗ زا يﺮﻴﮔﻮﻠﺟ لﻮﻠﺳ رد ﻲﻳازرﻮﻣﻮﺗ ﺖﻴﻟﺎﻌﻓ زا ﻲﻣ ﺎﻫ
ﺮﻣا ﻦﻳا و ﺪﻧﻮﺷ
ﺮﻛرﺎـﻣ رﻮﻣﻮﺗ ﻲﻣﺮﺳ ﺢﻄﺳ ﺶﻫﺎﻛ رد ﻢﻬﻣ ﻞﻣاﻮﻋ زا ﺖﺳا نﻮﺧ مﺮﺳ رد CEA .
طﺎـﺒﺗرا رد ﻲﻟﻮـﻜﻟﻮﻣ ﻢﺴﻴﻧﺎﻜﻣ ﺪﻨﭼ ﺮﻫ ،ﻲﻓﺮﻃ زا ﻦـﻳا ﺎﺑ ،ﺖﺳا فﻮﺸﻜﻣﺎﻧ ﺎﻫ نﺎﻃﺮﺳ ﻲﺧﺮﺑ زﺎﺘﺳﺎﺘﻣ ﺎﺑ
ﺪﻴﻟﻮﺗ ،لﺎﺣ ﻲﺑﺮﺠﺗ و ﻲﻨﻴﻟﺎﺑ ترﻮﺻ ود ﺮﻫ ﻪﺑ CEA
ﺖـﺳا حﺮـﻄﻣ زﺎﺘـﺳﺎﺘﻣ رد يﺮﺛﻮـﻣ رﻮﺘﻛﺎﻓ ناﻮﻨﻋ ﻪﺑ ) 20 .(
ﺢﻄـﺳ ﻦﻴـﺑ ﻪـﻛ ﺪـﻧا هداد نﺎـﺸﻧ تﺎﻌﻟﺎﻄﻣ ﻲﻣﺮﺳ ﺪﺒﻛ ﻪﺑ لﺎﺘﻛرﻮﻟﻮﻛ نﺎﻃ ﺮﺳ زﺎﺘﺳﺎﺘﻣ و CEA
دراد دﻮﺟو ﻲﻜﻳدﺰﻧ ﻪﻄﺑار )
32 .(
ﺎﺠﻧآ زا ،ﺎﻨﺒﻣ ﻦﻳا ﺮﺑ
ﺪــﺿ تاﺮــﺛا ياراد ﻲــﻠﮔ ﻢﻳﺮــﻣ هﺎــﻴﮔ هرﺎــﺼﻋ ﻪــﻛ ﺢﻄـﺳ ﺮﺑ هرﺎﺼﻋ ﻦﻳا ﻲﮔﺪﻨﻫﺎﻛ ﺮﺛا ،ﺖﺳا يزﺎﺘﺳﺎﺘﻣ ﻲﻣﺮــﺳ ﺪــﻴﻳﺎﺗ ﻞــﺑﺎﻗ ﺰــﻴﻧ ﺮــﻈﻨﻣ ﻦــﻳا زا CEA
ﻲﻣ ﺪﺷﺎﺑ ) 28 .(
رد تﺎـﻌﻟﺎﻄﻣ ﻲﺧﺮﺑ ،ﻞﺑﺎﻘﻣ رد و ﻪﺘﺒﻟا
نﺎﻃﺮﺳ ﻲﻧﺎﻳور نژ ﻲﺘﻧآ ﻲﻣﺮﺳ ﺢﻄﺳ طﺎﺒﺗرا درﻮﻣ ﺮﺗ و ﻚﺷ ﺎﺑ زﺎﺘﺳﺎﺘﻣ ﺎﺑ از ﺪـﻨﻳﺎﻤﻧ ﻲـﻣ درﻮـﺧﺮﺑ ﺪﻳد
) 33 .(
ﻳﺎﻫ ﻪﺘﻓﺎﻳ ،ﻲﻠﻛ يﺪﻨﺑ ﻊﻤﺟ رد ﻖﻴﻘﺤﺘ
نﺎﺸﻧ ﺮﺿﺎﺣ
ﺮـﺛا ياراد ﻲـﻠﮔ ﻢﻳﺮـﻣ هﺎـﻴﮔ هرﺎـﺼﻋ ﻪـﻛ ﺪﻨﻫد ﻲﻣ ﻲﻧﺎـﻳور نژ ﻲـﺘﻧآ ﻲﻣﺮـﺳ ﺢﻄـﺳ ناﺰﻴﻣ ﺮﺑ ﻲﺸﻫﺎﻛ ﻲــﻣ از نﺎﻃﺮــﺳ ﺪــﺷﺎﺑ
. ﺪــﺿ تاﺮــﺛا ،ﺎــﻨﺒﻣ ﻦــﻳا ﺮــﺑ
ﻪـﻈﺣﻼﻣ ﻞـﺑﺎﻗ هﺎـﻴﮔ ﻦﻳا ﻲﻧﺎﻃﺮﺳ ﺪﺿ و يزﺎﺘﺳﺎﺘﻣ ﻲﻣ و هدﻮﺑ هزﻮﺣ رد ﺪﻧاﻮﺗ
درﻮـﻣ ،ﻲﻨﻴﻟﺎـﺑ يﺎﻫدﺮﺑرﺎﻛ
دﺮﻴﮔ راﺮﻗ ﻪﺟﻮﺗ .
تاﺮـﻴﻴﻐﺗ ﻲـﺳرﺮﺑ هزﻮـﺣ رد ﺎـﻬﻨﺗ ﺮـﺿﺎﺣ ﻖﻴﻘﺤﺗ ﻲﻣﺮﺳ ﺢﻄﺳ ﻲﻗﺎﻔـﺻ نورد ﻖـﻳرﺰﺗ ﺐـﻗﺎﻌﺘﻣ CEA
و هﺪــﻳدﺮﮔ ﻲــﺣاﺮﻃ ﻲــﻠﮔ ﻢﻳﺮــﻣ هﺎــﻴﮔ هرﺎــﺼﻋ ﻲﺳرﺮﺑ ﺮـﻈﻧ درﻮـﻣ ﻲﻟﻮـﻜﻟﻮﻣ و ﻲﻟﻮﻠـﺳ ﺢﻄـﺳ يﺎﻫ رد ﻂـﻘﻓ ،ﻞﺻﺎﺣ ﺞﻳﺎﺘﻧ ﺮﻴﺴﻔﺗ ،ﻦﻳاﺮﺑﺎﻨﺑ ؛ﺖﺳا هدﻮﺒﻧ
رﻮﻣﻮﺗ ﻲﻣﺮﺳ تاﺮﻴﻴﻐﺗ ﺢﻄﺳ نﺎـﻜﻣا ﺮﻈﻧ درﻮﻣ ﺮﻛرﺎﻣ
ﻲﻟﻮـﻜﻟﻮﻣ ﺎـﻳ ﻲﻟﻮﻠـﺳ ﺢﻄـﺳ رد ﺮﻴﺳﺎﻔﺗ و هدﻮﺑ ﺮﻳﺬﭘ ﺖﺳا ﺶﻫوﮋﭘ ﻦﻳا يﺎﻫ ﻪﺘﻓﺎﻳ هدوﺪﺤﻣ زا جرﺎﺧ .
ﺮﻜﺸﺗو ﺮﻳﺪﻘﺗ
ﺶﻫوﮋﭘ ﻦﻳا ﺎﺑ
ﺎﻤﺣ ﻳ ﺖ ﺎﻫ ي ﻌﻣ هزﻮـﺣ ﻲﻟﺎﻣ و يﻮﻨ
ﺪﺣاو ﻲﻣﻼﺳا دازآ هﺎﮕﺸﻧاد ﻲﺸﻫوﮋﭘ مﺮﺘﺤﻣ ﺖﻧوﺎﻌﻣ
ﺖـﺳا هﺪﻴـﺳر مﺎـﺠﻧا ﻪﺑ ناﺪﻤﻫ .
زا ﻪﻠﻴـﺳو ﻦـﻳا ﻪـﺑ
و ﻚﻤﻛ ﻪـﺑ ﺮﻜـﺸﺗ و ﺮﻳﺪـﻘﺗ ناﺰـﻳﺰﻋ ﻦﻳا تﺪﻋﺎﺴﻣ
ﺪﻳآ ﻲﻣ ﻞﻤﻋ .
ﻊﺑﺎﻨﻣ
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Original Article
The effects of Salvia officinalis extract on serum level of CEA in male rats
Rahim Ahmadi, PhD. Assistant Professor of Physiology, Department of Physiology, Faculty of Basic Sciences, Islamic Azad University, Hamedan Branch, Hamedan, Iran. [email protected]
*Zahra Hodavand Mirzaee, BS, MSc candidate. Faculty of Basic Sciences, Islamic Azad University, Science and Research Branch, Tehran, Iran. (*Corresponding author). [email protected]
Mahyar Mafi, BS, MSc candidate. Department of Hormone and Tumor Marker Assay, Rasool-e Akram Hospital, Tehran University of Medical Sciences, Tehran, Iran. [email protected]
Abstract
Background: There are few studies indicating the association of Salvia officinalis extract with tumor markers. The main aim of this study was to determine the effects of Salvia officinalis extract on serum level of CEA (Carcinogenic embryonic antigen) in male rats.
Methods: In this laboratory experimental study, male Wistar rats were randomly divided into control, normal saline or Salvia officinalis extract (100 or 200 mg/kg/body weight) receiving animals of 5 in each group. After 7 weeks blood samples were collected using cardiac puncture method. Following serum collection, CEA level was measured by radioimmunoassay method. Data were statistically analyzed and compared between groups using ANOVA.
Results: The results indicated that serum CEA level was significantly decreased in rats receiving Salvia officinalis extract (200mg/kg/body weight) compared with control animals (P<0.05), however, CEA serum level was not significantly changed in rats receiving 100mg/kg/body weight of extract compared to control animals
Conclusion: Our findings show that appropriate dose of Salvia officinalis extract can decrease serum level of CEA, on which medicinal application of this extract particularly in cancers accompanied by CEA increased serum level is conceivable.
Keywords: Salvia officinalis, CEA, Rat.
