٧١٨
ﺘﺳﺍ ﺮﺛﺍ ﻴ ﻞ ﻝﺁ ﻧ ﺭﺎﮐ ﻴ ﺘ ﻴ ﻦ ﮔﻮﻠ ﺟ ﺭﺩ ﻴ ﺮ ﻱ ﻠ ﺤﺗ ﺯﺍ ﻴ ﻞ ﻥﻭﺭﻮﻧ ﺎﻫ ﻱ ﻫ ﻴ ﭗ ﻤﮐﻮﭙ ﻓ ﻥﺩﺯ ﻪﻧ ﺍﻮﺟ ﻭ
ﻴ ﺮﺒ ﺎﻫ ﻱ ﻩﺰﺧ ﺍ ﻱ ﻝﺪﻣ ﺭﺩ
ﮔ ﻉﺮﺻ ﻲ ﺑﺮﺠﺗ ﻴ
ﻫﺎﮕﺠ ﻲ ﻲ ﻳ ﺍﺮﺤﺻ ﺵﻮﻣ ﺭﺩ
ﻨﻏﻭﺭ ﺩﺍﺩﺮﻬﻣ ﻲ
١٭ ﺩﺍﮋﻧ ﭺﻮﻠﺑ ﺖﺧﺪﻧﺍﺭﻮﺗ ،
٢ﺩﺮﺠﻣ ﻤﺳ ، ﻴ ﻪ ﺪﻧﻭﺩﻻﻮﭘ ٣
ﺖﻓﺎﯾرد ﺦﯾرﺎﺗ
18 / 04 /
شﺮﯾﺬﭘ ﺦﯾرﺎﺗ1393 30
/ 06 / 1393
ﮑﭼ ﻩﺪﻴ
ﭘ ﻴ ﺶ ﻣﺯ ﻴ ﻪﻨ ﻭ ﻑﺪﻫ ﮔ ﻉﺮﺻ: ﻴ ﻫﺎﮕﺠ ﻲ ﺖﻠﻋ ﻪﺑ ﺣﺎﻧ ﺭﺩ ﻚﻴﻟﻮﺑﺎﺘﻣ ﻭ ﻲﻧﺎﻤﺘﺧﺎﺳ ﺕﺍﺮﻴﻴﻐﺗ ﻴ
ﻪ ﻫ ﻴ ﭗ ﻤﮐﻮﭙ ﻞﻣﺎﺷ ﻠﺤﺗ ﻴ ﻦﺘﻓﺭ ﻞ ﻥﻭﺭﻮﻧ ﺎﻫ ﻣ ﻲ ﺪﺷﺎﺑ ﻪﺑ ﻪﺟﻮﺗ ﺎﺑ . ﺮﺛﺍ ﺪﺿ ﺠﻨﺸﺗ ﻲ
ﻭ ﺒﺼﻋ ﺖﻇﺎﻔﺣ ﻲ
ﺘﺳﺍ ﻴ ﻞ ﻝﺁ ﻧﺭﺎﮐ ﻴ ﺘ ﻴ ﻦ ﺍ ﺪﻨﻣﺩﻮﺳ ﺮﺛﺍ ﻦﻴﻴﻌﺗ ﺮﺿﺎﺣ ﻲﺳﺭﺮﺑ ﻑﺪﻫ ، ﻳ
ﻦ ﺎﻣ ﻩﺩ ﻛﻮﭙﻴﻫ ﻪﻴﺣﺎﻧ ﺭﺩ ﻲﺘﻓﺎﺑ ﺕﺍﺮﻴﻴﻐﺗ ﺯﺍ ﻱ ﺮﻴﮔﻮﻠﺟ ﺭﺩ ﺎ
ﻉﺮﺻ ﻲﺑﺮﺠﺗ ﻝﺪﻣ ﺭﺩ ﭗ ﻣ
ﮔ ﻴ ﻫﺎﮕﺠ ﻲ .ﺩﻮﺑ
ﺩﺍﻮﻣ ﺵﻭﺭ ﻭ ﺭﺎﮐ ﺍ ﺭﺩ : ﻳ ﻦ ﺳﺭﺮﺑ ﻲ
، ۳۲ ﺵﻮﻣ ﻲﻳﺍﺮﺤﺻ ﻪﺑ ﺭﺎﻬﭼ ﻩﻭﺮﮔ ﻳ
،ﻢﺷ ﻥﺎﺴﮑ ﻢﺷ ﭘ ﻴ ﺗ ﺶ ﻴ ﺎﺑ ﻩﺪﺷ ﺭﺎﻤ ﺘﺳﺍ
ﻴ ﻞ ﻝﺁ ﻧﺭﺎﮐ ﻴ ﺘ ﻴ
،ﻦ ﻲﻋﺮﺻ ﭘ ﻲﻋﺮﺻ ﻭ ﻴ ﺶ ﺗ ﻴ ﺭﺎﻤ ﺎﺑ ﻩﺪﺷ
ﺘﺳﺍ ﻴ ﻞ ﻝﺁ ﻧﺭﺎﮐ ﻴ ﺘ ﻴ ﻦ ﺍﺮﺑ .ﺪﻧﺪﺷ ﻢﻴﺴﻘﺗ ﻱ
ﻋﺮﺻ ﻲ ﺣ ﻥﺩﻮﻤﻧ ﻴ ﺕﺎﻧﺍﻮ ﺭﺰﺗ ﺯﺍ ﻳ ﻖ ﻫ ﻞﺧﺍﺩ ﻴ ﭙﻤﮐﻮﭙ ﻲ ﻭ ﻳ ﮏ ﻪﻓﺮﻃ ﻱ ﺳﺍ ﻴ ﺪ ﺎﮐ ﻳ ﻨ ﻴ ﮏ ﻣ ﻪﺑ ﻴ ﻥﺍﺰ ۴ ﻣ ﻴ ﻡﺮـﮔﻭﺮﮑ ﺍﺮـﺑ ﻱ ﺮـﻫ ﺵﻮـﻣ
ﺘﺳﺍ .ﺪﺷ ﻩﺩﺎﻔﺘﺳﺍ ﻴ
ﻞ ﻝﺁ ﻧﺭﺎﮐ ﻴ ﺘ ﻴ ﻦ ﻣ ﻪﺑ ﻴ ﻥﺍﺰ ۱۰۰ ﻣ ﻴ ﻠ ﻲ ﻡﺮﮔ ﺮﺑ ﮐ ﻴ ﻡﺮﮔﻮﻠ ﻪﺑ ﺕﺭﻮﺻ ﮐﺍﺭﻮﺧ ﻲ ﻭ ﻪﻧﺍﺯﻭﺭ ﻭ ﺕﺪﻣ ﻪﺑ ۳ ﺣﺍﺮﺟ ﻥﺎﻣﺯ ﺎﺗ ﺯﻭﺭ ﻲ
ﻮﺠﺗ ﻳ ﺪﺷ ﺰ ﺎﭘ ﺭﺩ . ـﻳ ﻥﺎ ﺭﺎـﮐ ﻭﺩ ،
ﺵﻭﺭ ﮓ ﻧﺭ ﻣﺁ ﻴ ﺰ ﻱ ﻧ ﻴ ﻞﺴ ﺗ ﻭ ﻴ ﻢ ﺩﺭﻮﻣ ﺭﺩ ﺵﺮﺑ ﺎﻫ ﻱ ﺘﻓﺎﺑ ﻲ ﺍﺮﺟﺍ .ﺪﺷ
ﻪﺘﻓﺎﻳ ﺎﻫ ﺳﺍ ﺎﺑ ﻉﺮﺻ ﺎﻘﻟﺍ : ﻴ
ﺪ ﺎﮐ ﻳ ﻨ ﻴ ﮏ ﺎﺑ ﻳ ﮏ ﺠﻨﺸﺗ ﺭﺎﺘﻓﺭ ﻲ
ﻭ ﺩﻮﺑ ﻩﺍﺮﻤﻫ ﺯﺭﺎﺑ ﭘ
ﻴ ﺗ ﺶ ﻴ ﺎﺑ ﺭﺎﻤ ﺘﺳﺍ ﻴ ﻞ ﻝﺁ ﻧﺭﺎﮐ ﻴ ﺘ ﻴ ﻦ ﺶﻫﺎﮐ ﺐ ﺟﻮﻣ ﻨﻌﻣ
ﻲ ﺭﺍﺩ ﺠﻨـﺸﺗ ﺕﻼﻤﺣ ﺕﺪﺷ ﻲ
ﺪـﺷ
۰۱) ۰/ p<
ﻢﮐﺍﺮﺗ ،(
ﻥﻭﺭﻮﻧ ﺎﻫ ﻱ ﻧ ﻴ ﻞﺴ ﺣﺎﻧ ﻪﺳ ﺭﺩ ﻴ ﻪ ،CA1 ﻭCA3 ﻓﺎﻧ ﻲ ﻫ ﻴ ﻋﺮﺻ ﻩﻭﺮﮔ ﺭﺩ ﭗ ﻤﮐﻮﭙ ﻲ
ﻩﺪﺷ ﻳ ﮏ ﺶﻫﺎﮐ ﻨﻌﻣ ﻲ ﺭﺍﺩ ﺎﻘﻣ ﺭﺩ ﻳ ﻪﺴ ﻢـﺷ ﻩﻭﺮـﮔ ﺎـﺑ ﻥﺎـﺸﻧ
ﺩﺍﺩ
۰۰۱) ۰/ ۰۰۵- ۰/ p<
ﻭ ( ﭘ ﻴ ﺶ ﻥﺎﻣﺭﺩ ﺘﺳﺍ ﺎﺑ ﻴ ﻞ ﻝﺁ ﻧﺭﺎﮐ ﻴ ﺘ ﻴ ﻦ ﺐ ﺟﻮﻣ ﺍﺰﻓﺍ ﻳ ﺶ ﻨﻌﻣ ﻲ ﺭﺍﺩ ﺣﺎﻧ ﻭﺩ ﺭﺩ ﻥﺁ ﻴ ﻪ ﻭCA1 ﺩﺮﮔCA3 ﻳ ﺪ ۰۱) ۰/ ۰۵- ۰/ p<
،(
ﺮﻈﻧﺯﺍ ﺕﺪـﺷ ﻪـﻧﺍﻮﺟ
ﻥﺩﺯ ﻓ ﻴ ﺎﻫﺮﺒ ﻱ ﻩﺰﺧ ﺍ ﻱ ﻧ ﻴ ﺰ ﻋﺮﺻ ﻩﻭﺮﮔ ﺭﺩ ﻲ
ﻩﺪﺷ
، ﻳ ﮏ ﺍﺰﻓﺍ ﻳ ﺶ ﻨﻌﻣ ﻲ ﺭﺍﺩ ) ﺪﺷ ﻩﺪﻫﺎﺸﻣ ﻢﺷ ﻩﻭﺮﮔ ﻪﺑ ﺖﺒﺴﻧ ۰۰۵
۰/ p<
ﭘ ﻭ ( ﻴ ﺶ ﺗ ﻴ ﺭﺎﻤ ﺘﺳﺍ ﺎﺑ ﻴ ﻞ ﻝﺁ ﻧﺭﺎـﮐ ﻴ ﺘ ﻴ ﻦ ﺐ ـﺟﻮﻣ
ﺶﻫﺎﮐ ﻨﻌﻣ ﻲ ﺭﺍﺩ ﺩﺮﮔ ﻥﺁ ﻳ ﺪ ۰۵) ۰/ p<
.(
ﺘﻧ ﻴ ﻪﺠ ﻱ ﺮﻴﮔ ﺘﺳﺍ ﺰﻳﻮﺠﺗ: ﻴ ﻞ ﻝﺁ ﻧﺭﺎﮐ ﻴ ﺘ ﻴ ﻦ ﺍﺭﺍﺩ ﻱ ﻋﺮﺻ ﺪﺿ ﺮﺛﺍ ﻲ
ﻣ ﻲ ﺪﺷﺎﺑ ﻧﻭﺭﻮﻧ ﻢﮐﺍﺮﺗ ﻆﻔﺣ ﺐ ﺟﻮﻣ ، ﻲ
ﺣﺍﻮﻧ ﺭﺩ ﻲ ﻭCA1 ﻫCA3 ﻴ ﭗ ﻤﮐﻮﭙ ﻣ ﻲ ﺩﺩﺮﮔ ﺶﻫﺎـﮐ ﺚﻋﺎﺑ ﻭ
ﺕﺪﺷ ﻥﺩﺯ ﻪﻧﺍﻮﺟ ﺣﺎﻧ ﺭﺩ ﻴ ﻪ ﻪﻧﺍﺪﻧﺩ ﺭﺍﺩ ﻫ ﻴ ﺑﺮﺠﺗ ﻝﺪﻣ ﺭﺩ ﭗ ﻤﮐﻮﭙ ﻲ
ﻉﺮﺻ ﮔ ﻴ ﻫﺎﮕﺠ ﻲ ﻣ ﻲ ﺩﺩﺮﮔ .
ﻠﮐ ﻴ ﻩﮊﺍﻭﺪ ﺎﻫ ﺘﺳﺍ : ﻴ ﻞ ﻝﺁ ﻧﺭﺎﮐ ﻴ ﺘ ﻴ
،ﻦ ﻫ ،ﺞﻨﺸﺗ ،ﻉﺮﺻ ﻴ
ﭗ ﻤﮐﻮﭙ ﻠﺤﺗ ، ﻴ ﻧﻭﺭﻮﻧ ﻦﺘﻓﺭ ﻞ ﻲ
ﻥﺩﺯ ﻪﻧﺍﻮﺟ ، ﻓ ﻴ ﺎﻫﺮﺒ ﻱ ﻩﺰﺧ ﺍ ﻱ
ﻪﻠﺠﻣ
ﮑﺷﺰﭘ ﻲ ﻣﻭﺭﺍ ﻩﺭﻭﺩ ،ﻪﻴ ﺑ ﻭ ﺖﺴﻴ ﻢﺠﻨﭘ ، ﻩﺭﺎﻤﺷ ﻢﺘﺸﻫ ﺹ ، ۷۲۶ ۷۱۸- ، ﻥﺎﺑﺁ ١٣٩٣
ﻪﺒﺗﺎﮑﻣ ﺱﺭﺩﺁ ﻪﺒﺗﺎﻜﻣ ﺱﺭﺩﺁ :
ﻥﺍﺮﻬﺗ :ﻝﻮﺌﺴﻣ ﻩﺪﻨﺴﻳﻮﻧ ﺎﺑ ﻩﺪﻜﻫﺩ) ﻩﺩﺍﺯ ﷲ ﺍﺪﺒﻋ ﺪﻴﻬﺷ ﻥﺎﺑﺎﻴﺧ ،ﺯﺭﻭﺎﺸﻛ ﺭﺍﻮﻠﺑ-
ﮎﻼﭘ ،( ٣١ ﻓ ﻩﻭﺮﮔ ،ﺪﻫﺎﺷ ﻲﻜﺷﺰﭘ ﻩﺪﻜﺸﻧﺍﺩ- ﻴ
ﺰ ﻳ ﮊﻮﻟﻮ ﻱ ،
:ﻦﻔﻠﺗ ۰۹۱۲۱۷۹۴۹۵۰
Email: [email protected]
ﻘﺤﺗ ﺰﮐﺮﻣ ﺩﺎﺘﺳﺍ١
ﻴ ﺕﺎﻘ ﻓﻭﺭﻮﻧ ﻴ ﺰ ﻳ ﮊﻮﻟﻮ ﻱ
، ﻥﺍﺮﻬﺗ ،ﺪﻫﺎﺷ ﻩﺎﮕﺸﻧﺍﺩ (ﻝﻮﺌﺴﻣ ﻩﺪﻨﺴﻳﻮﻧ)
ﻓ ﻩﻭﺮﮔ ﺩﺎﺘﺳﺍ٢
ﻴ ﺰ ﻳ ﮊﻮﻟﻮ ﻱ
، ﮑﺷﺰﭘ ﻩﺪﮑﺸﻧﺍﺩ ﻲ
، ﮑﺷﺰﭘ ﻡﻮﻠﻋ ﻩﺎﮕﺸﻧﺍﺩ ﻲ
ﺍ ﻳ ﻥﺍﺮ
ﺶﻧﺍﺩ٣
ﮑﺷﺰﭘ ﻩﺪﮑﺸﻧﺍﺩ ﻪﺘﺧﻮﻣﺁ ﻲ
ﻥﺍﺮﻬﺗ ﺪﻫﺎﺷ ﻩﺎﮕﺸﻧﺍﺩ
ﻪﻣﺪﻘﻣ
ﻲﻫﺎﮕﺠﻴﮔ ﻉﺮﺻ ﺎـﺷ
ﻊﻳ ﻦﻳﺮـﺗ ﻌـﺿﻮﻣ ﻉﺮـﺻ ﻲ
ﺭﺩ ﮒ ﺭﺰـﺑ ﻥﻻﺎـﺳ
ﺏﻮﺴﺤﻣ ﻣ ﻲ ﺩﻮﺷ ﻪﺑ ﻪﻛ ﻥﺎﻣﺭﺩ ﺎﻫ ﻱ ﺞﻳﺍﺭ ﻲﺋﻭﺭﺍﺩ ﻭ ﺖـﺳﺍ ﻡﻭﺎـﻘﻣ
ﻪـﺑ
ﺖﻠﻋ ﺩﻮﺟﻭ ﻥﻮﻧﺎﮐ ﺎﻫ ﻱ ﺥﺭ ﻝﺍﺪـﮕ ﻴﻣﺁ ﺎﻳ ﻭ ﭗ ﻤﻛﻮﭙﻴﻫ ﺭﺩ ﺭﺮﻜﻣ ﻪﻴﻠﺨﺗ
ﻣ ﻲ ﺪﻫﺩ ﻢـﺋﻼﻋ ﻭ ﻩﺩﻮﺑ ﻩﺍﺮﻤﻫ ﻱ ﺭﺎﻴﺷﻮﻫ ﻦﺘﻓﺭ ﺖﺳﺩ ﺯﺍ ﺎﺑ ﺕﺎﺠﻨﺸﺗ ﻭ ﺕﺎﮐﺮﺣ ﻭ ﻥﺪﺷ ﻩﺮﻴﺧ ﻥﺁ
ﻱ ﺩﺍﺭﺍﺮﻴﻏ ﻧﺎﻫﺩ ﻲ ﺷﺭﺍﻮﮔ ﻭ ﻲ ﻣ ﻲ ﺪﺷﺎﺑ ۳) ۱- .(
ﺮــﻈﻧﺯﺍ ﺖــﻠﻋ ﻩﺪــﻨﻨﮐﺩﺎﺠﻳﺍ ﺑ ﻦــﻳﺍ ،
ﻴ ﺭﺎــﻤ ﻱ ﻭ ﻲﻧﺎﻤﺘﺧﺎــﺳ ﺕﺍﺮــﻴﻴﻐﺗ ﻪــﺑ
ﮔ ﻱ ﺎﻫﺭﺎﺘﺧﺎﺳ ﺭﺩ ﻚﻴﻟﻮﺑﺎﺘﻣ ﻴ
ﻫﺎﮕﺠ ﻲ ﻩﺩﺍﺩ ﺖﺒـﺴﻧ ﺰﻐﻣ ـﻣ
ﻲ ﺩﻮـﺷ ﺎـﺑ ﻭ
ﻠﺤﺗ ﻴ ﻥﺎـﻳﺮﺟ ﺶﻫﺎـﻛ ﻞﻣﺎـﺷ ﻱ ﺩﺮﻜﻠﻤﻋ ﺕﺍﺮﻴﻴﻐﺗ ﻭ ﭗ ﻤﻛﻮﭙﻴﻫ ﻦﺘﻓﺭ ﻞ
ﺶﻳﺍﺰﻓﺍ ﻭ ﺕﻼﻤﺣ ﻦﻴﺑ ﻞﺻﺍﻮﻓ ﺭﺩ ﺰﻛﻮﻠﮔ ﻢﺴﻴﻟﻮﺑﺎﺘﻣ ﻭ ﺰﻐﻣ ﻥﻮﺧ ﻦﻳﺍ
٧١٩
ﺺﺨﺸﻣ ﺕﻼﻤﺣ ﻥﺎﻣﺯ ﺭﺩ ﺎﻫﺮﺘﻣﺍﺭﺎﭘ ﻣ
ﻲ ﺩﻮـﺷ ۵،۴) ﻪـﮑﻧﺁﺎﺑ.(
ﺭﺩ
ﻃ ﻲ ﻟﺎﺳ ﻴ ﺧﺍ ﻥﺎ ﻴ ﺎﻫﻭﺭﺍﺩ ﺮ ﻱ ﺪﺟ ـﻳ ﺍﺮـﺑ ﺪ ﻱ ﻭ ﻉﺮـﺻ ﻝﺮـﺘﻨﮐ ﻭ ﻥﺎـﻣﺭﺩ
ﺷﺎﻧ ﺽﺭﺍﻮﻋ ﻲ
ﻥﺁ ﺯﺍ ﻪﺋﺍﺭﺍ ﻩﺪﺷ ﺧﺮﺑ ﻥﺎﻛﺎﻤﻛ ﻲﻟﻭ ﺖﺳﺍ ﻲ
ﺦﺳﺎﭘ ﻥﺍﺭﺎﻤﻴﺑ
ﻦﻣﺰـﻣ ﻑﺮـﺼﻣ ﻭ ﻩﺩﺍﺪـﻧ ﻥﺎـﺸﻧ ﺎـﻫﻭﺭﺍﺩ ﻪـﺑ ﺐ ﺳﺎﻨﻣ ﻥﺁ
ﺎـﻫ ﺭﺩ ﹰﻼـﻤﻋ
) ﺩﺭﺍﺪـﻧ ﺏﻮـﻠﻄﻣ ﺮـﺛﺍ ﻱ ﺭﺎـﻤﻴﺑ ﺖﻓﺮﺸﻴﭘ ﺯﺍ ﻱ ﺮﻴﮔﻮﻠﺟ ۶
ـﻤﻫ ﺭﺩ .(
ﻴ ﻦ
ﺯﺍ ﻩﺩﺎﻔﺘﺳﺍ ﻪﺑ ﻥﺎﻘﻘﺤﻣ ﻪﺟﻮﺗ ،ﻁﺎﺒﺗﺭﺍ ﺎﺑ ﺩﺍﻮﻣ
ﺄﺸﻨﻣ ﻥﺎﻣﺭﺩ ﺭﺩ ﻲﻌﻴﺒﻃ
ﻲﺘﻇﺎﻔﺣ ﺑ ﻴ ﺭﺎﻤ ﻱ ﺎﻫ ﻱ ) ﺖـﺳﺍ ﻩﺪـﺷ ﻑﻮـﻄﻌﻣ ﻲﺒﺼﻋ ٧
ﺘـﺳﺍ .(
ﻴ ﻞ ﻝﺁ
ﻧﺭﺎﮐ ﻴ ﺘ ﻴ ﻦ ﻳ ﮐﺮﺗ ﮏ ـﻴ ﺐ ﻣﺁ ﻴ ـﺳﺍﻮﻨ ﻴ ﺪ ﻱ ﻟ ﺯﺍ ﻖﺘـﺸﻣ ـﻴ
ﺰ ﻳ ﺘﻣ ﻭ ﻦ ـﻴ ﻧﻮ ﻴ ﻦ
ﻣ ﻲ ﺪﺷﺎﺑ ﻤﻫﺍ ﺰﺋﺎﺣ ﺶﻘﻧ ﻪﮐ ﻴ
ﺘ ﻲ ﻟﻮﺑﺎﺘﻣ ﺭﺩ ﻴ ﺋﺍﺬـﻏ ﺩﺍﻮﻣ ﻢﺴ ﻲ
ﻪـﺑ ﻭ ـﻳ ﻩﮋ
ﺑﺮﭼ ﻲ ﺎﻫ ﻭ ﺩﺭﺍﺩ ﻪﺑ ﻥﺍﻮﻨﻋ ﻳ ﺋﺍﺬﻏ ﻞﻤﮑﻣ ﮏ ﻲ
ﻪـﺟﻮﺗﺩﺭﻮﻣ ﻪـﺘﻓﺮﮔ ﺭﺍﺮـﻗ
ﺍ ﺩﺭﻮﻣ ﺭﺩ .ﺖﺳﺍ ﻳ
ـﺴﮐﺍ ﺱﺮﺘـﺳﺍ ﺪـﺿ ﺕﺍﺮـﺛﺍ ﻩﺩﺎـﻣ ﻦ ﻴ
ﺗﺍﺪ ﻴ ﺶﻫﺎـﮐ ،ﻮ
ﮔﺪﻨﻫﺩ ﻲ ﻣ ﻴ ﺳﺁ ﻥﺍﺰ ﻴ ﺰﻐﻣ ﺐ ﻱ ﻝﺎﺒﻧﺩ ﻪﺑ ﺍ ﺎﻘﻟﺍ ﻳ ﻤﮑﺴ ﻲ ﺠﻨـﺸﺗ ﺪـﺿ ، ﻲ
ﺑﺮﺠﺗ ﻝﺪﻣ ﺭﺩ ﻲ
ﻉﺮﺻ ﻩﺪﺷﺎﻘﻟﺍ ﺘﻨﭘ ﺎﺑ ﻴ ﺍﺰﻟﺁ ﺪﺿ ،ﻝﻭﺯﺍﺮﺘﺗ ﻦﻠ ﻳ
ﻭ ﺮﻤ ﺪﺿ
ﮐﺭﺎﭘ ﻴ ) ﺖـﺳﺍ ﻪـﺘﻓﺮﮔ ﺭﺍﺮـﻗ ﺕﺎـﺒﺛﺍ ﺩﺭﻮﻣ ﻥﻮﺴﻨ ١٣
٨- ﻪـﺑ ﻪـﺟﻮﺗ ﺎـﺑ.(
ﻉﺮﺻ ﻝﺪﻣ ﻱ ﻻﺎﺑ ﺖﻫﺎﺒﺷ ﻩﺪﺷﺎﻘﻟﺍ
ﻞـﺧﺍﺩ ﻖـﻳﺭﺰﺗ ﻂ ﺳﻮﺗ ﻫ
ﻴ ﭙﻤﮐﻮـﭙ ﻲ
ﻉﺮﺻ ﺪﻧﻭﺭ ﺎﺑ ﻚﻴﻨﻳﺎﻛ ﺪﻴﺳﺍ ﺐ ﻟ
ﻴﮔ ﺠ ﻉﻮـﻧ ﻦﻳﺍ ﻲﻨﻴﻟﺎﺑ ﺖﻴﻤﻫﺍ ﻭ ﻲﻫﺎﮕ
) ﻉﺮﺻ ١٤ ﺘـﺳﺍ ﺪﻨﻣﺩﻮـﺳ ﺮـﺛﺍ ﻦﻴـﻴﻌﺗ ﺮـﺿﺎﺣ ﻲﺳﺭﺮﺑ ﻑﺪﻫ ،(
ﻴ ﻞ ﻝﺁ
ﻧﺭﺎﮐ ﻴ ﺘ ﻴ ﻦ ﻲﺘﻓﺎﺑ ﺕﺍﺮﻴﻴﻐﺗ ﺯﺍ ﻱ ﺮﻴﮔﻮﻠﺟ ﺭﺩ ـﻣ ﺭﺩ ﭗ ﻤﻛﻮﭙﻴﻫ ﻪﻴﺣﺎﻧ
ﻝﺪ
ﻉﺮﺻ ﻲﺑﺮﺠﺗ ﮔ
ﻴ ﻫﺎﮕﺠ ﻲ ﻩﺪﺷﺎﻘﻟﺍ ﺎﺑ ﻲﻳﺍﺮﺤﺻ ﺵﻮﻣ ﺭﺩ ﻚﻴﻨﻳﺎﻛ ﺪﻴﺳﺍ
ﺩﻮﺑ .
ﻭ ﺩﺍﻮﻣ ﺵﻭﺭ ﺎﻫ
ﺯﺍ ﻪﻌﻟﺎﻄﻣ ﻦﻳﺍ ﺭﺩ ٣٢
ﺮﻧ ﻲﻳﺍﺮﺤﺻ ﺵﻮﻣ ﺮﺳ ﻔﺳ
ﻴ ﺪ ﺭﺎﺘـﺴﻳﻭ ﺩﺍﮋﻧ
ﻲﻧﺯﻭ ﻩﺩﻭﺪﺤﻣ ﺭﺩ (ﻥﺍﺮﻬﺗ ،ﺭﻮﺘﺳﺎﭘ ﻮﺘﻴﺘﺴﻧﺍ) ٢٦٠
٢١٠- ﻩﺩﺎﻔﺘﺳﺍ ﻡﺮﮔ
ﻧﺍﻮﻴﺣ ﻡﺎﻤﺗ .ﺪﺷ ﺕﺎ
ﻱ ﺎﻣﺩ ﺭﺩ ٢٣
٢١- ﻲﺘﻧﺎﺳ ﻪﺟﺭﺩ ﺭﺩ ﺩﺍﺮﮔ
ﻩﻭﺮﮔ ﺎﻫ ﻱ
٣ ﺎﺗ ٤ ـﻧﺍﻮﻴﺣ .ﺪﻧﺪـﺷ ﻩﺩﺍﺩ ﺭﺍﺮـﻗ ﺲـﻔﻗ ﺮـﻫ ﺭﺩ ﻲﻳﺎﺗ ﺕﺎ
ﻪـﺑ ﻪـﻧﺍﺩﺍﺯﺁ
ﺏﺁ ﻪﻟﻮﻟ ﺸﮐ ﻲ ﺵﻮﻣ ﺹﻮﺼﺨﻣ ﻱ ﺍﺬﻏ ﻭ ﺕﺪـﻣ ﻪﺑ
٦ ﻲـﺳﺮﺘﺳﺩ ﻪـﺘﻔﻫ
ﺱﺎﺳﺍ ﺮﺑ ﻲﺳﺭﺮﺑ ،ﻦﻤﺿ ﺭﺩ .ﺪﻨﺘﺷﺍﺩ ﻞﮑﺗﻭﺮﭘ
ﺎﻫ ﻭ ﻞﻤﻌﻟﺍﺭﻮﺘـﺳﺩ ﺎـﻫ
ﻱ
ﺻﻮﺗ ﻴ ﻪ ﻩﺪﺷ ﻭ ﻱ ﺭﺍﺪـﻬﮕﻧ ﻱ ﺍﺮـﺑ ﺎـﻜﻳﺮﻣﺁ ﺖﺷﺍﺪﻬﺑ ﻲﻠﻣ ﻮﺘﻴﺘﺴﻧﺍ ﻂ ﺳﻮﺗ
ﺕﺎﻧﺍﻮﻴﺣ ﺯﺍ ﻩﺩﺎﻔﺘﺳﺍ .ﺪﻴﺳﺭ ﻡﺎﺠﻧﺍ ﻪﺑ ﻲﻫﺎﮕﺸﻳﺎﻣﺯﺁ
ﺵﻮﻣ ﺎﻫ ﻱ ﻲﻳﺍﺮﺤﺻ ﺩﺍﺪﻌﺗ ﻪﺑ ٣٢ ﺮﺳ ﻪﺑ ﺭﻮﻃ ﻪﺑ ﻲﻓﺩﺎﺼﺗ ٤
ﻩﻭﺮﮔ
ﻳ = ﻩﻭﺮﮔ ﺮﻫ ﺭﺩ ﺵﻮﻣ ﺩﺍﺪﻌﺗ) ﻥﺎﺴﮑ ٨
( ﺣﺍﺮﺟ)Sham ﻲ
،(ﺏﺫﺎﮐ ﻢﺷ
ﺭﺩ ﻳ ﺖﻓﺎ ﻩﺪﻨﻨﮐ ﺘﺳﺍ ﻴ ﻞ ﻝﺁ ﻧﺭﺎﮐ ﻴ ﺘ ﻴ ﻦ ﻲﻋﺮﺻ ، ﻲﻋﺮﺻ ﻭ ﺭﺩ ﻳ ﺖﻓﺎ ﻩﺪـﻨﻨﮐ
ﺘﺳﺍ ﻴ ﻞ ﻝﺁ ﻧﺭﺎﮐ ﻴ ﺘ ﻴ ﺯﺍ ﺕﺎـﻧﺍﻮﻴﺣ ﻥﺩﻮﻤﻧ ﻲﻋﺮﺻ ﻱ ﺍﺮﺑ .ﺪﻧﺪﺷ ﻢﻴﺴﻘﺗ ﻦ
ﺪﻴﺳﺍ ﺳ) ﻚﻴﻨﻳﺎﻛ ﻴ
ﺮﻣﺁ ،ﺎﻤﮕ ﻳ ﻥﺍﺰـﻴﻣ ﻪـﺑ (ﺎﮑ ٤
ﺍﺮـﺑ ﻡﺮـﮔﻭﺮﻜﻴﻣ ﻱ
ﺮـﻫ
ﺵﻮﻣ ﻞﺣ ﻩﺪﺷ ﻦﻴﻟﺎﺳ ﻝﺎﻣﺮﻧ ﻝﻮﻠﺤﻣ ﺭﺩ ﺭﺰﺗ
ﻳ ﻖ ﻩﺪﺷ ﺣﺎﻧ ﻞﺧﺍﺩ ﻪﺑ ـﻴ
ﻪ
:ﻲـﻔﻠﺧ ﻲﻣﺍﺪـﻗ ﺕﺎـﺼﺘﺨﻣ ﺎـﺑ ﺖـﺳﺍﺭ ﺖﻤﺳ ﭗ ﻣﺎﻛﻮﭙﻴﻫCA3 ٣
٤/
ﻣ ﻴ ﻠ ﻲ ﺮﺘﻣ :ﻲﺒﻧﺎﺟ ، ٢ ٤/ ﻣ ﻴ ﻠ ﻲ ﺮﺘﻣ ﻝﺍﺮﺘﻧﻭ ﻭ ٢ ٤/ ﺎﺗ ٤ ٤/ ﻣ ﻴ ﻠ ﻲ ﺮﺘﻣ ﺮـﻳﺯ
) ﻪﻤﺠﻤﺟ ﺢﻄﺳ ١٥
ﻣﺎﻫ ﮓ ﻧﺮﺳ ﺯﺍ ﻩﺩﺎﻔﺘﺳﺍ ﺎﺑ ( ﻴ
ﺭﺰﺗ ﻢﺠﺣ ﺎﺑ) ﻥﻮﺘﻠ ﻳ
ﻖ
٥ ﻣ ﻴ ﻟﻭﺮﮑ ﻴ ﻣﺎﺘﮐ ﻁﻮﻠﺨﻣ ﺎﺑ ﻲﺷﻮﻬﻴﺑ ﻭ ﻲﺴﻛﺎﺗﻮﻳﺮﺘﺳﺍ ﺵﻭﺭ ﻪﺑ ﻭ (ﺮﺘ ﻴ
ﻦ ١٠٠)
ﻣ ﻴ ــﻠ ﻲ ﻡﺮــﮔ ﮐ ﺮــﺑ ﻴ ﺰــﮔ ﻭ (ﻡﺮﮔﻮــﻠ ﻳ
ﺯﻼ ﻳ ) ﻦ ٢٠ ﻣ ﻴ ــﻠ ﻲ ﻡﺮــﮔ ﺮــﺑ
ﮐ ﻴ ﻥﺎﻤﻫ ﺎﺑ ﺍﺭ ﻦﻴﻟﺎﺳ ﻝﻮﻠﺤﻣ ﻂ ﻘﻓ ﺰﻴﻧ ﻢﺷ ﻩﻭﺮﮔ .ﺪﺷ ﻩﺩﺎﻔﺘﺳﺍ (ﻡﺮﮔﻮﻠ
ﺘﺳﺍ .ﺩﻮﻤﻧ ﺖﻓﺎﻳﺭﺩ ﻢﺠﺣ ﻴ
ﻞ ﻝﺁ ﻧﺭﺎﮐ ﻴ ﺘ ﻴ ﻦ ﺳ) ﻴ
،ﺎﻤﮕ ﺮﻣﺁ ﻳ ﺎﮑ ﻥﺍﺰﻴﻣ ﻪﺑ (
١٠٠ ﻣ ﻴ ﻠ ﻲ ﻡﺮﮔ ﻡﺮﮔﻮﻠﻴﻛ ﺮﺑ ﻪﺑ
ﺭﻮﻃ ﻪﻧﺍﺯﻭﺭ ﻭ ﮊﺍﻭﺎﮔ ﻥﺯﻮﺳ ﺯﺍ ﻩﺩﺎﻔﺘﺳﺍ ﺎﺑ
ـﺣﺍﺮﺟ ﻥﺎـﻣﺯ ﺎـﺗ ﻲـﺣﺍﺮﺟ ﺯﺍ ﻞﺒﻗ ﺯﻭﺭ ﻪﺳ ﺯﺍ ﻲ
ﺯﺍ ﺲـﭘ .ﺪـﺷ ﺰﻳﻮـﺠﺗ
ﺖﺷﺬﮔ ٤ ،ﻪﺘﻔﻫ ﺵﻮﻣ ﺎﻫ ﺮﻈﻧﺯﺍ ﺠﻨﺸﺗ ﺭﺎﺘﻓﺭ ﻲ
ﺱﺎﺳﺍ ﺮﺑ ﺴﻘﺗ ﻴ ﻢ ﺪﻨﺑ ﻱ
ﺳﺍﺭ ﻴ ) ﻦ ﻪﺒﺗﺭ ﺪﻨﺑ ﻱ ﺭﺩ (ﺞﻨﭘ ﺎﺗ ﺮﻔﺻ ﺯﺍ ﻳ
ﻧﺎﻣﺯ ﻪﻠﺻﺎﻓ ﮏ ﻲ
ﻪﺘﻋﺎـﺳﺭﺎﻬﭼ
ﺑﺭﻭﺩ ﺯﺍ ﻩﺩﺎﻔﺘﺳﺍ ﺎﺑ ﻴ
ﻝﺎﻘﺘﻧﺍ ﻭ ﺭﺎﺘﻓﺭ ﺖﺒﺛ ﻦ ﻩﺩﺍﺩ
ﺎﻫ ﭙﻣﺎـﮐ ﻪﺑ ﻴ ﺩﺭﻮـﻣ ﺮﺗﻮ
ﺍ ﺭﺩ .ﺪﻨﺘﻓﺮﮔ ﺭﺍﺮﻗ ﻖﻴﻗﺩ ﻲﺑﺎﻳﺯﺭﺍ ﻳ
ﺍﺮـﺑ ﺮﻔـﺻ ﻩﺮﻤﻧ ،ﺹﻮﺼﺧ ﻦ ﻱ
ﻡﺪـﻋ
ﻩﺮﻤﻧ ،ﺦﺳﺎﭘ ﻩﺪﻫﺎﺸﻣ ﻳ
ﺍﺮﺑ ﮏ ﻱ ﺘﻧﺎﻣ ﻴ ﻥﺩﺯ ﮏ ﻤﺸﭼ ،ﮓ ﻨ ﻭ
ﻳ ﺱﻮﻧﻮﻠﮐ ﺎ
ﻔﺧ ﺪــﺣ ﺭﺩ ﺕﺭﻮــﺻ ــﻴ
ﺍﺮــﺑ ﻭﺩ ﻩﺮــﻤﻧ ،ﻒ ﻱ
ﻭ ﺮــﺳ ﻥﺩﺍﺩ ﻥﺎــﮑﺗ ــﻳ
ﺎ
ﺱﻮﻧﻮﻠﮐ ﺎﻫ ﻱ ﺣﺎﻧ ﺭﺩ ﺩﺪـﻌﺘﻣ ـﻴ
ﺍﺮـﺑ ﻪـﺳ ﻩﺮـﻤﻧ ،ﺮـﺳ ﻪ ﻱ
ﺵﺮـﭘ ﺎـﻫ ﻱ
ﻣ ﻴ ﻧﻮﻠﮐﻮ ﻴ ﺭﺩ ﮏ ﻡﺍﺪﻧﺍ ﺎﻫ ﻱ ﺘﮐﺮﺣ ﻲ ﺍﺮـﺑ ﺭﺎـﻬﭼ ﻩﺮﻤﻧ ،ﻮﻠﺟ ﻱ
ﺕﺎﺠﻨـﺸﺗ
ﻧﻮﻠﮐ ﻴ ﺘﮐﺮﺣ ﻡﺍﺪﻧﺍ ﺭﺩ ﮏ ﻲ
ﺋﻮﻠﺟ ﻲ ﻭﺭ ﺮﺑ ﻥﺪﺷ ﺪﻨﻠﺑ ﻭ ﻱ
ﺎﭘ ﻭﺩ ﻩﺮـﻤﻧ ﻭ
ﺍﺮﺑ ﺞﻨﭘ ﻱ ﻧﻮﻠﮐ ﺕﺎﺠﻨﺸﺗ ﻴ
ﺮﺳﺎﺗﺮﺳ ﻭ ﮏ ﻱ
ﻦﺘـﻓﺭ ﺖـﺳﺩ ﺯﺍ ﻭ ﻥﺪﺑ ﺭﺩ
) ﺪﺷ ﻪﺘﻓﺮﮔ ﺮﻈﻧ ﺭﺩ ﻅﺎﺤﻟ ﻝﺩﺎﻌﺗ ١٥
ﺎﻣﺯﺁ ،ﻪﻣﺍﺩﺍ ﺭﺩ .(
ﻳ ﺪﻌﺑ ﺕﺎﺸ ﻱ
ﺭﺩ
ﺩﺭﻮﻣ ﻥﺁ ﺎﻫ .ﺪﺷ ﻡﺎﺠﻧﺍ
ﻓﺮﭘ ﻴ ﺮﻃ ﺯﺍ ﻥﮊﻮ ﻳ ﺐ ﻠﻗ ﻖ :
ﺵﻮﻣ ﺎﻫ ﻣﺎﺘﮐ ﻂ ﺳﻮﺗ ﻴ
ﻤﻋ ﺭﻮﻃ ﻪﺑ ﻦ ـﻴ
ﺑ ﻖ ﻴ ﺮـﺷ ،ﻩﺪـﺷ ﺵﻮـﻬ ﻳ
ﻥﺎ
ــﻟﻭﺰﻧ ﺕﺭﻮــﺋﺁ ﻲ
) ﺪــﺷ ﻪﺘــﺴﺑ ١٥
ﻓ ﻝﻮــﻠﺤﻣ ﺎــﺗ ( ﻴ
ﺗﺎــﺴﮑ ﻴ ﺭﺩ ﻂ ــﻘﻓ ﻮ
ﺖﻤﺴﻗ ﺎﻫ ﻱ ﻻﺎﺑ ﻲﻳ ﺮﺟ ﺵﻮﻣ ﻥﺪﺑ ﻳ
ﻥﺎ ﻳ ﺭﺎﭙﻫ ﺪﺣﺍﻭ ﻭﺩ .ﺪﺑﺎ ﻳ
ﻦ ١ ﺪﺻﺭﺩ
ﭗ ﭼ ﻦﻄﺑ ﻪﺑ ﺵﻮﻣ
ﺎﻫ ﻧ ﻴ ﺭﺰﺗ ﺰ ﻳ ﺩﺮﮔ ﻖ ﻳ ﻝﻮﻧﺎﮐ .ﺪ ﻓﺮﭘ ﺖـﺳ ـﻴ ﺩﺭﺍﻭ ﻥﮊﻮ
ﻭ ﺪﺷ ﭗ ﭼ ﻦﻄﺑ ١٠٠
ﻣ ﻴ ﻠ ﻲ ﻟ ﻴ ﺮﺘ ﻟﺎﺳ ﻝﺎﻣﺮﻧ ﻴ ﺪﻌﺑ ﻭ ﻦ ﻥﺁ ﺯﺍ ٥٠ ﻣ ﻴ ﻠ ﻲ
ﻟ ﻴ ﻔﻟﻮﺳ ﻝﻮﻠﺤﻣ ﺮﺘ ﻴ
ﺪﺳ ﺪ ﻳ ﻢ ٢ ١/ ﺪـﺻﺭﺩ ﺕﺎﻔـﺴﻓ ﻭ (ﻥﺎـﻤﻟﺁ ،ﮎﺮـﻣ)
ﺪﺳ ﻳ ﺩ ﻢ ﻱ ﺯﺎﺑ ﻳ ﮏ ١ ﺪﺻﺭﺩ (ﻥﺎـﻤﻟﺁ ،ﮎﺮـﻣ) ﻪـﻣﺍﺩﺍ ﺭﺩ ﻭ
١٠٠ ٢٠٠-
ﻣ ﻴ ﻠ ﻲ ﻟ ﻴ ﺋﺪﻟﺎﻣﺮﻓﺍﺭﺎﭘ ﻝﻮﻠﺤﻣ ﺮﺘ ﻴ
ﺪ ٤ ﺪـﺻﺭﺩ (ﻥﺎـﻤﻟﺁ ،ﮎﺮـﻣ) ﺮﻓﺎـﺑ ﺭﺩ
ﺕﺎﻔﺴﻓ ١ ٠/ ) ﺪـﺷ ﻩﺩﺍﺩ ﺭﻮﺒﻋ ﺭﻻﻮﻣ ١٥
ﺯﺍ ﺰـﻐﻣ ﻥﺩﻮـﻤﻧ ﺝﺭﺎـﺧ ﺎـﺑ .(
ﺠﻤﺟ ﺕﺪﻣ ﻪﺑ ،ﻪﻤ ٢
٣- ﻓ ﻝﻮﻠﺤﻣ ﺭﺩ ﺯﻭﺭ ﻴ
ﺗﺎﺴﮑ ﻴ .ﺪﺷ ﻩﺩﺍﺩ ﺭﺍﺮﻗ ﻻﺎﺑ ﻮ
ﮕ ﺷﺮﺑ ﻴ ﺮ ﻱ :
ﮕ ﺷﺮﺑ ﻴ ﺮ ﻱ ﺳﻭ ﻪﺑ ﻴ ﻣ ﻩﺎﮕﺘﺳﺩ ﻪﻠ ﻴ
ﺮﻓ ﻡﻮﺗﻭﺮﮑ ﻳ ﺰ ﻳ ﻻ) ﮓ ﻨ ﻳ
،ﺎﮑ (ﻥﺎﻤﻟﺁ
ﻪﻧﻮﻤﻧ .ﺪﺷ ﻡﺎﺠﻧﺍ ﺕﺪﻣ ﻪﺑ ﺎﻫ
٢ ﺯﻭﺮﮐﻮـﺳ ﻝﻮـﻠﺤﻣ ﺭﺩ ﺯﻭﺭ ٣٠
ﺪـﺻﺭﺩ
(ﻥﺎـﻤﻟﺁ ،ﮎﺮﻣ) ـﺳﺁ ﺯﺍ ﺎـﺗ ﺪـﻨﺘﻓﺮﮔ ﺭﺍﺮـﻗ
ﻴ ﺘﻓﺎـﺑ ﺐ ﻲ ـﺷﺎﻧ ﻲ ﺎﻣﺮـﺳ ﺯﺍ
ﮔﻮﻠﺟ ﻴ ﺮ ﻱ ﺁ ﻞﻤﻋ ﻪﺑ ﻳ ﺎﺑ .ﺪ ﻭﺎﺣ ﺰﻐﻣ ﮎﻮﻠﺑ ﻥﺩﻮﻤﻧ ﺍﺪﺟ ﻱ
ﻫ ﻴ ﺯﺍ ﭗ ﻤﮐﻮﭙ
ﺎﺳ ﻳ ﺮ ﺖﻤﺴﻗ ﺎﻫ ﻱ ﺵﺮﺑ ،ﺰﻐﻣ ﺖﻣﺎﺨﺿ ﺎﺑ ﺎﻫ ٢٠
ﻣ ﻴ ﻬﺗ ﻥﻭﺮﮑ ﻴ ﻪ ﺩﺮﮔ ـﻳ ﺪ
ﻭﺭ ﻪﺑ ﻪﮐ ﻱ ﺎﻫ ﻡﻻ ﻱ ﺗﻻﮊ ﻴ .ﺪﻧﺪﺷ ﻞﻘﺘﻨﻣ ﻪﻨ
ﮓ ﻧﺭ ﻣﺁ ﻴ ﺰ ﻱ ﻧ ﻴ ﻞﺴ :
ﻞﺣﺍﺮﻣ ﮓ ﻧﺭ ﻣﺁ ﻴ ﺰ ﻱ ﻫﺪﺑﺁ ﻞﻣﺎﺷ ﻲ
ﻥﺩﺍﺩ ﺭﺍﺮﻗ ، ﻪﻧﻮﻤﻧ ﺎـﻫ ﮓ ـﻧﺭ ﺭﺩ
ﺯﺮﮐ ﻳ ﻭ ﻞ ﻳ ﺳ) ﻪﻟﻮ ﻴ (ﺎﻤﮕ ١ ٠/ ﺪﺻﺭﺩ ﺕﺪﻣ ﻪﺑ ٥ ٣- ﻗﺩ ﻴ ﮕ ﺑﺁ ،ﻪـﻘ ـﻴ ﺮ ﻱ ﻭ
ﺯﺎﺳ ﻑﺎﻔﺷ ﻱ
ﻃ ﺯﺍ ﺲﭘ .ﺩﻮﺑ ﻲ
ﺍ ﻳ ﺭﺍﺬﮔ ﻞﻣﻻ ،ﻞﺣﺍﺮﻣ ﻦ ﻱ
ﺯﺍ ﻩﺩﺎﻔﺘﺳﺍ ﺎﺑ
.ﺪﺷ ﻡﺎﺠﻧﺍ (ﻥﺎﻤﻟﺁ ،ﮎﺮﻣ) ﻥﻼﺘﻧﺍ ﺐ ﺴﭼ
٧٢٠
ﮓ ﻧﺭ ﻣﺁ ﻴ ﺰ ﻱ ﺗ ﻴ ﻢ :
ﻞﺣﺍﺮﻣ ﮓ ﻧﺭ ﻣﺁ ﻴ ﺰ ﻱ ﻫﺪﺑﺁ ﻞﻣﺎﺷ ﻲ
ﻥﺩﺍﺩ ﺭﺍﺮﻗ ، ﻪﻧﻮﻤﻧ ﺎﻫ ﺭﺎﮐ ﻝﻮﻠﺤﻣ ﺭﺩ ﻱ
ﺗ ﻴ ﻭﺎﺣ ﻢ ﻱ ﺑﺮﻋ ﻎﻤﺻ ﻲ
٥٠ ﺪﺻﺭﺩ ١٨٠) ﻣ ﻴ ﻠ ﻲ ﻟ ﻴ ،(ﺮﺘ ٣٠ ﻣ ﻴ ﻠ ﻲ ﻟ ﻴ ﺮﻓﺎـﺑ ﺮـﺘ
ﺪﺳ ﻳ ﺳ ﻢ ﻴ ﺕﺍﺮﺘ ٢ ،ﺭﻻﻮﻣ ٩٠ ﻣ ﻴ ﻠ ﻲ ﻟ ﻴ ﻫ ﻝﻮﻠﺤﻣ ﺮﺘ ﻴ
ﮐﻭﺭﺪ ﻴ ﻥﻮﻨ ٦ ٥/ ﺪﺻﺭﺩ ﻭ ﻧ ﻝﻮﻠﺤﻣ ﻴ ﻩﺮﻘﻧ ﺕﺍﺮﺘ ١٧
٠/ ﺪﺻﺭﺩ ﮕ ﺑﺁ ﻭ ﻮﺸﺘﺴﺷ ، ﻴ
ﺮ ﻱ ﺯﺎﺳ ﻑﺎﻔﺷ ، ﻱ
ﻞﻣﻻ ﻭ
ﺭﺍﺬﮔ ﻱ ) ﺩﻮﺑ ١٥ .(
ﻧﻭﺭﻮﻧ ﺵﺭﺎﻤﺷ ﻲ
:
ﺍﺮﺑ ﻱ ﻧﻭﺭﻮﻧ ﺵﺭﺎﻤﺷ ﻲ
، ﺵﺮﺑ ﺎﻫ ﻱ ﺣﺎﻧ ﻴ ﻫ ﻪ ﻴ ﻩﺩﻭﺪـﺤﻣ ﺭﺩ ﭗ ﻤﮐﻮﭙ
٤mm ٤/ ﻟﺍ ﻲ ٢mm ٦/ ﺍ ﻳ ﺴﮐﺎﭘ ﺲﻠﻃﺍ ﻝﺍﺭﻭﺍﺮﺘﻨ ﻴ
ﺩﺭﻮﻣ ﻥﻮﺴﺗﺍﻭ ﻭ ﺯﻮﻨ
ﺳﺭﺮﺑ ﻲ ﺩﺍﺪﻌﺗ .ﺪﻨﺘﻓﺮﮔ ﺭﺍﺮﻗ ﻥﻭﺭﻮﻧ
ﺎﻫ ﻱ ﺭﺩ ﻊـﻗﺍﻭ ﺶـﺨﺑ ﺎـﻫ ﻱ ،CA1
ﻓﺎــﻧ ﻭCA3 ﻲ ﻫ ﻴ ﺎــﻤﻨﮔﺭﺰﺑ ﺭﺩ ﺢﻄــﺳ ﺪــﺣﺍﻭ ﺭﺩ ﭗ ــﻤﮐﻮﭙ ﻲﻳ
٤٠٠X
ﺣ ﺮﻫ ﺩﺭﻮﻣ ﺭﺩ .ﺪﻧﺪﺷ ﺵﺭﺎﻤﺷ ﻴ
ﺍﺮـﺑ ﺵﺭﺎﻤـﺷ ،ﻥﺍﻮ ﻱ
ﺭﺎـﻬﭼ ﻞﻗﺍﺪـﺣ
ﻞﻗﺍﺪﺣ ﻢﻫ ﺯﺍ ﻪﮐ) ﺵﺮﺑ ٨٠
ﻣ ﻴ ﻭ ﺪـﺷ ﻡﺎـﺠﻧﺍ (ﺪﻨﺘﺷﺍﺩ ﻪﻠﺻﺎﻓ ﺮﺘﻣﻭﺮﮑ
ﻥﻭﺭﻮﻧ ﺎﻫ ﻱ ﻧ ﻴ ﺳ ﻩﺩﻭﺪﺤﻣ ﺎﺑ ﻞﺴ ﻴ
ﻤﺳﻼﭘﻮﺘ ﻲ ﺵﺭﺎﻤﺷ ﺢﺿﺍﻭ ﺩﺮﮔ
ﻳ ﺪـﻧﺪ
١٥) .(
ﺪﻧﺍ ﻳ ﺗ ﺲ ﻴ ﻢ :
ﺍﺮﺑ ﻱ ﺍ ﻪﺒﺳﺎﺤﻣ ﻳ ﺪـﻧﺍ ﻦ ﻳ ﺣﺎﻧ ﺖﺣﺎـﺴﻣ ،ﺲ ـﻴ
ﻪ ﻪـﻧﺍﺪﻧﺩ ﺭﺍﺩ ﻭﺎـﺣ ﻱ
ﻝﻮﻧﺍﺮﮔ ﺎﻫ ﻱ ﺗ ﻴ ﮔ ﻩﺯﺍﺪﻧﺍ ﻢ ﻴ ﺮ ﻱ ﺍ ﻝﻮﻃ ﺮﺑ ﻭ ﺪﺷ ﻳ
ﺣﺎﻧ ﻦ ﻴ ﺴﻘﺗ ﻪ ﻴ ﺩﺮﮔ ﻢ ﻳ ﺪ
ﺪﺣﺍﻭ ﺮﮐﺫ ﻥﻭﺪﺑ ﻪﻠﺻﺎﺣ ﺏﺍﻮﺟ ﻭ ﻪﺑ
ﺕﺭﻮﺻ ﺭﺩ .ﺪـﺷ ﺵﺭﺍﺰـﮔ ﻖـﻠﻄﻣ ﺣ ﺮﻫ ﺩﺭﻮﻣ
ﻴ ﻧ ﻥﺍﻮ ﻴ ﺍﺮﺑ ﺵﺭﺎﻤﺷ ﺰ ﻱ
) ﺪﺷ ﻡﺎﺠﻧﺍ ﺵﺮﺑ ﻭﺩ ﻞﻗﺍﺪﺣ ١٥
.(
ﻟﺎﻧﺁ ﻴ ﺰ ﺭﺎﻣﺁ ﻱ :
ﺮﻈﻧﺯﺍ ﺕﺭﻮﺼﺑ ﺞﻳﺎﺘﻧ ﻲﻣﺎﻤﺗ ،ﻱ ﺭﺎﻣﺁ ﻦﻴﮕ ﻧﺎﻴﻣ
ﺩﺭﺍﺪﻧﺎﺘﺳﺍ ﻱ ﺎﻄﺧ±
) ﺯﺍ ﺲﭘ .ﺪﻳﺩﺮﮔ ﻥﺎﻴﺑ (SEM ﺋﺎﺗ
ﻴ ﺪ ﻊﻳﺯﻮﺗ ﻝﺎـﻣﺮﻧ ﻩﺩﺍﺩ ﺎـﻫ ﻥﻮـﻣﺯﺁ ﺯﺍ ،
ﺍﻭﻮــﻧﺁ ﻱ ﻳ ﻪــﻓﺮﻄﮑ ﻘﻌﺗ ﺖــﺴﺗ ﻭ ﻴ ــﺒ ﻲ ﮐﻮــﺗ ﻲ ﺰﻴﻟﺎــﻧﺁ ﻱ ﺍﺮــﺑ ﻩﺩﺍﺩ
ﺎــﻫ ﻱ
ﺖﺴﺗ ﺎﻫ ﻱ ﺭﺎـﺘﻓﺭ ﻱ ﺘﻓﺎـﺑ ﻭ ﻲ .ﺪـﻳﺩﺮﮔ ﻩﺩﺎﻔﺘـﺳﺍ ﻡﺎـﻤﺗ ﺭﺩ
ـﺳﺭﺮﺑ ﻲ ﺎـﻫ
p<0/05 ﻪﺑ ﻥﺍﻮﻨﻋ ﺢﻄﺳ ﻲﻨﻌﻣ ﺭﺍﺩ .ﺪﺷ ﻪﺘﻓﺮﮔ ﺮﻈﻧ ﺭﺩ
ﻪﺘﻓﺎﻳ ﺎﻫ
ﺭﺍﺩﻮﻤﻧ ١ ﺎﺘﻧ ﻳ ﻤﮐ ﻪﺑ ﻁﻮﺑﺮﻣ ﺞ ﻴ
ﺠﻨـﺸﺗ ﺭﺎـﺘﻓﺭ ﺖ ﻲ
ﺣ ـﻴ ﺮـﺑ ﺍﺭ ﻥﺍﻮ
ﺱﺎﺳﺍ ﻢﻴﺴﻘﺗ ﻱ ﺪﻨﺑ ـﺳﺍﺭ ﻴ ) ﻦ ﻪـﺒﺗﺭ ﻱ ﺪـﻨﺑ ﺯﺍ ٠ ﺎـﺗ ٥ ﺭﺩ ( ﻩﻭﺮـﮔ ﺎـﻫ ﻱ
ﻥﺎﺸﻧ ﻒﻠﺘﺨﻣ ﻣ
ﻲ ﺪﻫﺩ ﺍ ﺭﺩ . ﻳ ﭘ ﻭ ﻢﺷ ﻩﻭﺮﮔ ﺭﺩ ﺹﻮﺼﺧ ﻦ ﻴ
ﺗ ﺶ ﻴ ﺭﺎـﻤ
ﺘﺳﺍ ﺎﺑ ﻩﺪﺷ ﻴ ﻞ ﻝﺁ ﻧﺭﺎـﮐ ﻴ ﺘ ﻴ ـﻫ ﹰﻼـﻤﻋ ﻦ ﻴ ﺠﻨـﺸﺗ ﺭﺎـﺘﻓﺭ ﻪـﻧﻮﮔ ﭻ ﻲ
ﺭﺩ
ﺣ ﻴ ﻋﺮﺻ ﻩﻭﺮﮔ ﺭﺩ .ﺪﺸﻧ ﻩﺪﻫﺎﺸﻣ ﺕﺎﻧﺍﻮ ﻲ
ﺳﺍ ﺎﺑ ﻩﺪﺷ ﻴ ﺎﮐ ﺪ ﻳ ﻨ ـﻴ ﮏ ـﻳ ﮏ
ﺠﻨﺸﺗ ﺭﺎﺘﻓﺭ ﻲ
ﭘ ﻭ ﺪﺷ ﻩﺪﻫﺎﺸﻣ ﺯﺭﺎﺑ ﻴ
ﺗ ﺶ ﻴ ﺘﺳﺍ ﺎﺑ ﺭﺎﻤ ﻴ ﻞ ﻝﺁ ﻧﺭﺎﮐ ﻴ ﺘ ﻴ ﻦ
ﺯﻭﺩ ﺭﺩ ١٠٠ ﻲﻠﻴﻣ ﻡﺮﮔ ﮐ ﺮﺑ ﻴ ﺶﻫﺎـﮐ ﺚـﻋﺎﺑ ﻡﺮﮔﻮـﻠ ﻲـﻨﻌﻣ
ﺭﺍﺩ ﺭﺎـﺘﻓﺭ
ﺠﻨﺸﺗ ﻲ ﺣ ﻴ ) ﺪﺷ ﺕﺎﻧﺍﻮ ٠١
٠/ p<
.(
ﺭﺍﺩﻮﻤﻧ ١)
ﺠﻨﺸﺗ ﺭﺎﺘﻓﺭ:(
ﻲ ﺭﺩ ﻩﻭﺮﮔ ﺎﻫ ﻱ ﻒﻠﺘﺨﻣ ﺖﺷﺬﮔ ﺯﺍ ﺲﭘ ٤
ﻪﺘﻔﻫ ﭘ ﻢﺷ ﻭ ﻢﺷ ﻩﻭﺮﮔ ﻭﺩ ﺭﺩ . ﻴ
ﺗ ﺶ ﻴ ﺘﺳﺍ ﺎﺑ ﻩﺪﺷ ﺭﺎﻤ ﻴ
ﻞ ﻝﺁ ﻧﺭﺎﮐ ﻴ ﺘ ﻴ ﺭﺎﺘﻓﺭ ﻦ
ﺠﻨﺸﺗ ﻲ ﻩﻭﺮﮔ ﺭﺩ ﻭ ﺪﺸﻧ ﻩﺪﻫﺎﺸﻣ ﺕﺎﻨﺋﺎﮐ
ﭘ ﻴ ﺗ ﺶ ﻴ ﺘﺳﺍ ﺎﺑ ﻩﺪﺷ ﺭﺎﻤ ﻴ
ﻞ ﻝﺁ ﻧﺭﺎﮐ ﻴ ﺘ ﻴ ﺠﻨﺸﺗ ﺭﺎﺘﻓﺭ ﻦ ﻲ
ﻩﻭﺮﮔ ﺯﺍ ﺕﺎﻨﺋﺎﮐ ﻪﺑ ﺭﻮﻃ ﻨﻌﻣ ﻲ ﺭﺍﺩ .ﺩﻮﺑ ﺮﺘﻤﮐ
٠١# ٠/ P<
ﻩﻭﺮﮔ ﺎﺑ ﻪﺴﻳﺎﻘﻣ ﺭﺩ) ﺕﺎﻨﺋﺎﮐ
(
ﺩ ﻲﺳﺭﺮﺑ ﺭ ﺳﺎﻨﺷ ﺖﻓﺎﺑ ﻲ
ﺵﻭﺭ ﺎﺑ ﮓ ﻧﺭ ﻣﺁ ﻴ ﺰ ﻱ ﻧ ﻴ ﺯﺍ ﻩﺩﺎﻔﺘﺳﺍ ﻭ ﻞﺴ
ﺯﺮﮐ ﮓ ﻧﺭ ﻳ ﻭ ﻞ ﻳ ،ﻪﻟﻮ ﻩﻭﺮﮔ ﺭﺩ ،ﻢﺷ ﺮﻫ ﺭﺩ ﻪﺳ ﻪﻴﺣﺎﻧ ﻭCA1
ﻭCA3
ﻓﺎﻧ ﻲ ﻫ ﻴ ،ﭗ ﻤﮐﻮﭙ ﻥﻭﺭﻮﻧ ﺎﻫ ﻱ ﺎﺑ ﻲﻣﺮﻫ ﻪﺘﺴﻫ ﺎﻫ ﻱ ﻱ ﺎـﻫ ﻚﺘـﺴﻫ ،ﺩﺮﮔ
ﻢﺳﻼﭘﻮﺘﻴﺳ ﻭ ﻪﺘﺴﺟﺮﺑ ﺢﺿﺍﻭ
ﻩﺪﻫﺎـﺸﻣ ﻞـﺑﺎﻗ ﻢـﺷ ﻩﻭﺮـﮔ ﺭﺩ ،ﺪـﻧﺩﻮﺑ
ﺗ ﻴ ﺘﺳﺍ ﺎﺑ ﻩﺪﺷ ﺭﺎﻤ ﻴ
ﻞ ﻝﺁ ﻧﺭﺎﮐ ﻴ ﺘ ﻴ ﻐﺗ ﻦ ﻴﻴ ﺻﺎﺧ ﺮ ﻲ ﺍ ﺯﺍ ﻳ ﻩﺪﻫﺎﺸﻣ ﺮﻈﻧ ﻦ
ﻋﺮـﺻ ﻩﻭﺮـﮔ ﺭﺩ ،ﺪﺸﻧ ﻲ
ـﺳﺍ ﺎـﺑ ﻩﺪـﺷ ﻴ
ﺎﮐ ﺪ ﻳ ﻨ ـﻴ ﻩﺯﺍﺪـﻧﺍ ﮏ ﻥﻭﺭﻮـﻧ ﺎـﻫ
ﮏ ﭼﻮﮐ ﺮﺗ ، ﻪﺘﺴﻫ ﺎـﻫ ﺢـﺿﺍﻭﺮﻴﻏ ﺎـﻫ ﻚﺘـﺴﻫ ،ﻩﺪـﻴﻛﻭﺮﭼ ﻩﺩﻭﺪـﺤﻣ ﻭ
ﺳ ﻴ ﻤﺳﻼﭘﻮﺘ ﻲ ﻧ ﻝﻮﻠﺳ ﻴ ﺭﺩ ﺰ ﺑ ﻴ ﺩﻮـﺒﻧ ﺺﺨـﺸﻣ ﺏﻮﺧ ﺩﺭﺍﻮﻣ ﺮﺘﺸ ﺭﺩ ﻭ
ﻋﺮﺻ ﻩﻭﺮﮔ ﻲ
ﺗ ﻭ ﻴ ﺘـﺳﺍ ﺎﺑ ﻩﺪﺷ ﺭﺎﻤ ﻴ
ﻞ ﻝﺁ ﻧﺭﺎـﮐ ﻴ ﺘ ﻴ ﻣ ﻪـﺑ ﻦ ـﻴ ﻥﺍﺰ ١٠٠
ﻣ ﻴ ﻠ ﻲ ﻡﺮﮔ ﮐ ﺮﺑ ﻴ ﻌـﺿﻭ ﻡﺮﮔﻮﻠ ﻴ
ﺮـﺘﻬﺑ ﺖ ﻱ ﺍ ﺯﺍ ـﻳ ﺖـﺷﺍﺩ ﺩﻮـﺟﻭ ﺮـﻈﻧ ﻦ
ﻞﮑﺷ) ﺎﻫ ﻱ ١ ﻭ ٢ ﺮﻈﻧﺯﺍ .(
ﻟﻮﻠـﺳ ﻢﮐﺍﺮﺗ ﻲ
ﻧ ـﻴ ﺗ ،ﺰ ﻴ ﺎـﺑ ﻢـﺷ ﻩﻭﺮـﮔ ﺭﺎـﻤ
ﺘﺳﺍ ﻴ ﻞ ﻝﺁ ﻧﺭﺎـﮐ ﻴ ﺘ ﻴ ﻐﺗ ﻦ ـﻴﻴ ﻭ ﺱﻮـﺴﺤﻣ ﺮ ـﻨﻌﻣ
ﻲ ﺭﺍﺩ ﻫ ﺭﺩ ﻴ ﭽ ـﻴ ﺯﺍ ﮏ
ﺣﺍﻮﻧ ﻲ ﻧ ﺩﻮﺟﻮﺑ ﻴ ﻋﺮﺻ ﻩﻭﺮﮔ ﺭﺩ ،ﺩﺭﻭﺎ ﻲ
ـﺳﺍ ﺎـﺑ ﻩﺪﺷ ﻴ ﺎﮐ ﺪ ﻳ ﻨ ـﻴ ﮏ ـﻳ ﮏ
ﻭ ﺯﺭﺎﺑ ﺶﻫﺎﮐ ﻨﻌﻣ
ﻲ ﺭﺍﺩ ﻧﻭﺭﻮـﻧ ﻢﮐﺍﺮﺗ ﻲ
ﺣﺎﻧ ﻪـﺳ ﺮـﻫ ﺭﺩ ـﻴ
ﻩﺪﻫﺎـﺸﻣ ﻪ
ﺩﺮﮔ ﻳ ) ﺪ ٠٠١ ٠/ ٠٠٥- ٠/ p<
ﻭ ( ﭘ ﻴ ﺶ ﻥﺎﻣﺭﺩ ﺘﺳﺍ ﺎﺑ ﻴ ﻞ ﻝﺁ ﻧﺭﺎﮐ ﻴ ﺘ ﻴ ﻧ ﻦ ﻴ ﺰ
ﺍﺰــﻓﺍ ﺐ ــﺟﻮﻣ ﻳ
ﺶ ــﻨﻌﻣ ﻲ ﺭﺍﺩ ﻧﻭﺭﻮــﻧ ﻢﮐﺍﺮــﺗ ﻲ
ﻭﺩ ﺭﺩ ﺣﺎﻧ ــﻴ ﻪ ﻭCA1
٧٢١
ﺎﻘﻣ ﺭﺩCA3 ﻳ ﻋﺮﺻ ﻩﻭﺮﮔ ﺎﺑ ﻪﺴ ﻲ
ﺩﺮﮔ ﻩﺪـﺷ ـﻳ ﺪ ٠١) ٠/ ٠٥- ٠/ p<
ﻭ ( ﺣﺎﻧ ﺩﺭﻮﻣ ﺭﺩ
ﻴ ﻓﺎﻧ ﻪ ﻲ ﻧ ﻴ ﻨﭼ ﺰ ﻴ ﺍﺰﻓﺍ ﻦ ﻳ ﺸ ﻲ ﺍﺭ ﻝﺎﺒﻧﺩ ﻪﺑ ﺭﺍﺩﻮـﻤﻧ) ﺖﺷﺍﺪﻧ
٢ .(
ﺭﺍﺩﻮﻤﻧ ٢) ﻢﮐﺍﺮﺗ:(
ﻥﻭﺭﻮﻧ ﺎﻫ ﻱ ﻧ ﻴ ﺣﺍﻮﻧ ﺭﺩ ﻞﺴ ﻲ
ﻫ ﻒﻠﺘﺨﻣ ﻴ ﭗ ﻤﮐﻮﭙ ﺭﺩ ﻩﻭﺮﮔ ﺎﻫ ﻱ ﺖﺷﺬﮔ ﺯﺍ ﺲﭘ ﻒﻠﺘﺨﻣ ٤
.ﻪﺘﻔﻫ
٠١* ٠/ p<
، ٠٠٥**
٠/ p<
، ٠٠١***
٠/ p<
ﻩﻭﺮﮔ ﺎﺑ ﻪﺴﻳﺎﻘﻣ ﺭﺩ) ﻢﺷ
(
٠٥# ٠/ p<
، ٠١##
٠/ p<
ﻩﻭﺮﮔ ﺎﺑ ﻪﺴﻳﺎﻘﻣ ﺭﺩ) ﺕﺎﻨﺋﺎﮐ
(
ﺍ ﺭﺩ ﻳ ﺳﺭﺮﺑ ﻦ ﻲ ﺍﺮﺑ ﻱ ﺳﺭﺮﺑ ﻲ ﻥﺩﺯ ﻪﻧﺍﻮﺟ ﺕﺪﺷ ﻓ
ﻴ ﺎﻫﺮﺒ ﻱ ﻩﺰﺧ ﺍ ﻱ
ﺣﺎﻧ ﺭﺩ ﻴ ﻓﺎﻧ ﻪ ﻲ ﻫ ﻴ ﺵﻭﺭ ﺯﺍ ﭗﻤﮐﻮﭙ ﮓ ﻧﺭ
ﻣﺁ ﻴ ﺰ ﻱ ﺗ ﻴ ﻧ ﺎﺑ ﻢ ﻴ ﻩﺮﻘﻧ ﺕﺍﺮﺘ
ﺍ ﺭﺩ ﻭ ﺪﺷ ﻩﺩﺎﻔﺘﺳﺍ ﻳ
ﺪﻧﺍ ﻪﻄﺑﺍﺭ ﻦ ﻳ
ﺗ ﺲ ﻴ ﻢ ﺭﺍﺩﻮﻤﻧ) ﺪﺷ ﻪﺒﺳﺎﺤﻣ ٣
ﻭ
ﻞﮑﺷ ٣ ﺗ ﻢﺷ ﻩﻭﺮﮔ ﺭﺩ .(
ﻴ ﺘﺳﺍ ﺎﺑ ﻩﺪﺷ ﺭﺎﻤ ﻴ
ﻞ ﻝﺁ ﻧﺭﺎﮐ ﻴ ﺘ ﻴ ﻦ ﺮﻈﻧﺯﺍ ﺍ ﻳ ﻦ
ﺪﻧﺍ ﻳ ﻐﺗ ﺲ ﻴﻴ ﺮ ﻨﻌﻣ ﻲ ﺭﺍﺩ ﺎﻘﻣ ﺭﺩ ﻳ ﺩﺮﮕﻧ ﻩﺪﻫﺎﺸﻣ ﻢﺷ ﻩﻭﺮﮔ ﺎﺑ ﻪﺴ ﻳ
ﺭﺩ ،ﺪ ﻋﺮﺻ ﻩﻭﺮﮔ
ﻲ ﺳﺍ ﺎﺑ ﻩﺪﺷ ﻴ ﺎﮐ ﺪ ﻳ ﻨ ﻴ ) ﮏ ﺕﺎﻨﺋﺎﮐ ﺍﺰﻓﺍ ( ﻳ ﻭ ﺯﺭﺎﺑ ﺶ ﻨﻌﻣ ﻲ ﺭﺍﺩ
ﺍ ﻳ ﺪﻧﺍ ﻦ ﻳ ﺎﻘﻣ ﺭﺩ ﺲ ﻳ ﺩﺮﮔ ﻩﺪﻫﺎﺸﻣ ﻢﺷ ﻩﻭﺮﮔ ﺎﺑ ﻪﺴ ﻳ
) ﺪ ٠٠٥ ٠/ p<
ﻭ(
ﭘ ﻴ ﺗ ﺶ ﻴ ﺭﺎﻤ ﺵﻮﻣ ﺎﻫ ﻱ ﻋﺮﺻ ﻲ ﺘﺳﺍ ﺎﺑ ﻩﺪﺷ ﻴ ﻞ ﻝﺁ ﻧﺭﺎﮐ ﻴ ﺘ ﻴ ﺐ ﺟﻮﻣ ﻦ
ﺶﻫﺎﮐ ﻨﻌﻣ ﻲ ﺭﺍﺩ ﺍ ﻳ ﺩﺮﮔ ﺮﺘﻣﺍﺭﺎﭘ ﻦ ﻳ
) ﺪ ٠٥ ٠/ p<
ﻩﺪﻨﻫﺩ ﻥﺎﺸﻧ ﻪﮐ (
ﺍ ﺭﺩ ﺮﺘﻤﮐ ﻥﺩﺯ ﻪﻧﺍﻮﺟ ﻳ
ﻩﻭﺮﮔ ﻦ ﻣ ﻲ ﺪﺷﺎﺑ .
ﺭﺍﺩﻮﻤﻧ ٣)
ﺪﻧﺍ:(
ﻳ ﺗ ﺲ ﻴ ﺣﺎﻧ ﺭﺩ ﻢ ﻴ ﻪ ﻪﻧﺍﺪﻧﺩ ﺭﺍﺩ ﻫ ﻴ ﺭﺩ ﭗ ﻤﮐﻮﭙ ﺭﺩ ﻩﻭﺮﮔ ﺎﻫ ﻱ ﺖﺷﺬﮔ ﺯﺍ ﺲﭘ ﻒﻠﺘﺨﻣ ٤
.ﻪﺘﻔﻫ ﺪﻧﺍ ﻳ ﺗ ﺲ ﻴ ﻩﻭﺮﮔ ﺭﺩ ﻢ ﺕﺎﻨﺋﺎﮐ
ﻳ ﮏ
ﺍﺰﻓﺍ ﻳ ﻭ ﺯﺭﺎﺑ ﺶ ﻨﻌﻣ ﻲ ﺭﺍﺩ ﺍ ﻭ ﺩﺍﺩ ﻥﺎﺸﻧ ﻳ
ﺪﻧﺍ ﻦ ﻳ ﻩﻭﺮﮔ ﺭﺩ ﺲ ﺕﺎﻨﺋﺎﮐ
ﭘ ﻴ ﺗ ﺶ ﻴ ﺘﺳﺍ ﺎﺑ ﻩﺪﺷ ﺭﺎﻤ ﻴ
ﻞ ﻝﺁ ﻧﺭﺎﮐ ﻴ ﺘ ﻴ .ﺩﻮﺑ ﺮﺘﻤﮐ ﻦ
٠٥* ٠/ p<
، ٠٠٥**
٠/ p<
ﻩﻭﺮﮔ ﺎﺑ ﻪﺴﻳﺎﻘﻣ ﺭﺩ) ﺕﺎﻨﺋﺎﮐ
(
٠٥# ٠/ p<
ﻩﻭﺮﮔ ﺎﺑ ﻪﺴﻳﺎﻘﻣ ﺭﺩ) ﺕﺎﻨﺋﺎﮐ
ﭘ ﻴ ﺗ ﺶ ﻴ ﺎﺑ ﻩﺪﺷ ﺭﺎﻤ ﺘﺳﺍ
ﻴ ﻞ ﻝﺁ ﻧﺭﺎﮐ ﻴ ﺘ ﻴ ﻦ (
٧٢٢
ﻞ ﮑﺷ ١) ﻣ ﺲﮑﻋ:(
ﻴ ﭖﻮﮑﺳﻭﺮﮑ ﺭﻮﻧ ﻱ ﺯﺍ ﺣﺍﻮﻧ ﻲ ﻒﻠﺘﺨﻣ ﻫ ﻴ ﭗ ﻤﮐﻮﭙ ﻩﻭﺮﮔ ﺎﻫ ﻱ ﻒﻠﺘﺨﻣ ﮓ ﻧﺭ ﻣﺁ ﻴ ﺰ ﻱ ﺯﺮﮐ ﺎﺑ ﻩﺪﺷ ﻳ ﻭ ﻞ ﻳ ﭘ ﻢﺷ ﻩﻭﺮﮔ ﺭﺩ .ﻪﻟﻮ ﻴ
ﺗ ﺶ ﻴ ﺭﺎﻤ
ﺘﺳﺍ ﺎﺑ ﻩﺪﺷ ﻴ ﻞ ﻝﺁ ﻧﺭﺎﮐ ﻴ ﺘ ﻴ ﻐﺗ ﻦ ﻴﻴ ﻩﻭﺮﮔ ﺭﺩ ،ﺪﺸﻧ ﻩﺪﻫﺎﺸﻣ ﺱﻮﺴﺤﻣ ﺮ ﺕﺎﻨﺋﺎﮐ
ﻳ ﻧﻭﺭﻮﻧ ﺶﻫﺎﮐ ﮏ ﻲ
ﺣﺎﻧ ﻪﺳ ﺮﻫ ﺭﺩ ﻴ
ﻪ ﻭCA1 ﻭCA3 ﻓﺎﻧ ﻲ ﻫ ﻴ ﭗ ﻤﮐﻮﭙ
ﺍ ﻭ ﺪﺷ ﻩﺪﻫﺎﺸﻣ ﻳ
ﻩﻭﺮﮔ ﺭﺩ ﺶﻫﺎﮐ ﻦ ﺕﺎﻨﺋﺎﮐ
ﭘ ﻴ ﺗ ﺶ ﻴ ﺘﺳﺍ ﺎﺑ ﻩﺪﺷ ﺭﺎﻤ ﻴ
ﻞ ﻝﺁ ﻧﺭﺎﮐ ﻴ ﺘ ﻴ .ﺩﻮﺑ ﺮﺘﻤﮐ ﻦ = ﺭﺎﺑ
٥٠٠ ﻣ ﻴ ﺮﺘﻣﻭﺮﮑ
ﻞ ﮑﺷ ٢) ﻣ ﺲﮑﻋ:(
ﻴ ﭖﻮﮑﺳﻭﺮﮑ ﺭﻮﻧ ﻱ ﺣﺎﻧ ﺯﺍ ﻴ ﻪ ﻫCA3 ﻴ ﭗ ﻤﮐﻮﭙ ﻩﻭﺮﮔ ﺎﻫ ﻱ ﻒﻠﺘﺨﻣ ﮓ ﻧﺭ ﻣﺁ ﻴ ﺰ ﻱ ﺯﺮﮐ ﺎﺑ ﻩﺪﺷ ﻳ ﻞ ﻭ ﻳ ﻪﻟﻮ ﺋﺎﻤﻧ ﺖﺷﺭﺩ ﺭﺩ ﻲ
ﺭﺩ .ﻻﺎﺑ
ﻩﻭﺮﮔ ﺕﺎﻨﺋﺎﮐ ﻳ ﮏ ﻧﻭﺭﻮﻧ ﺶﻫﺎﮐ ﻲ
ﺍ ﻭ ﺪﺷ ﻩﺪﻫﺎﺸﻣ ﻳ
ﻦ ﻩﻭﺮﮔ ﺭﺩ ﺶﻫﺎﮐ ﺕﺎﻨﺋﺎﮐ
ﭘ ﻴ ﺶ ﺗ ﻴ ﺭﺎﻤ ﺘﺳﺍ ﺎﺑ ﻩﺪﺷ ﻴ ﻞ ﻝﺁ ﻧﺭﺎﮐ ﻴ ﺘ ﻴ ﻦ ﮐ ﺮﺘﻤ ﺩﻮﺑ = ﺭﺎﺑ . ٥٠ ﻣ ﻴ ﺮﺘﻣﻭﺮﮑ
٧٢٣
ﻞ ﮑﺷ ٣) ﻣ ﺲﮑﻋ:(
ﻴ ﭖﻮﮑﺳﻭﺮﮑ ﺭﻮﻧ ﻱ ﺣﺎﻧ ﺯﺍ ﻴ ﻪ ﻪﻧﺍﺪﻧﺩ ﺭﺍﺩ ﻫ ﻴ ﭗ ﻤﮐﻮﭙ ﻩﻭﺮﮔ ﺎﻫ ﻱ ﻒﻠﺘﺨﻣ ﮓ ﻧﺭ ﻣﺁ ﻴ ﺰ ﻱ ﺗ ﺵﻭﺭ ﺎﺑ ﻩﺪﺷ ﻴ
ﻩﻭﺮﮔ ﺭﺩ .ﻢ ﺕﺎﻨﺋﺎﮐ
ﻑﺍﺮﻃﺍ ﺭﺩ
ﺣﺎﻧ ﻴ ﻪ ﻪﻧﺍﺪﻧﺩ ﺭﺍﺩ ﻳ ﻻ ﮏ ﻳ ﺗ ﻪ ﻴ ﻩﺪﻫﺎﺸﻣ ﺢﺿﺍﻭ ﺭﻮﻃ ﻪﺑ ﮓ ﻧﺭ ﻩﺮ ﻣ
ﻲ ﺩﻮﺷ ﻩﻭﺮﮔ ﺭﺩ ﻭ ﺕﺎﻨﺋﺎﮐ ﭘ ﻴ ﺗ ﺶ ﻴ ﺘﺳﺍ ﺎﺑ ﻩﺪﺷ ﺭﺎﻤ ﻴ
ﻞ ﻝﺁ ﻧﺭﺎﮐ ﻴ ﺘ ﻴ ﺍ ﺖﺣﺎﺴﻣ ﻦ ﻳ
ﺣﺎﻧ ﻦ ﻴ ﻪ
ﺮﺘﻤﮐ ﻣ ﻲ ﺪﺷﺎﺑ = ﺭﺎﺑ . ١٠٠ ﻣ ﻴ ﺮﺘﻣﻭﺮﮑ
ﺚﺤﺑ
ﺎﺘﻧ ﻳ ﺞ ﺍ ﻳ ﻦ ﻘﺤﺗ ﻴ ﻖ ﻪﮐ ﺩﺍﺩ ﻥﺎﺸﻧ ﺭﺰﺗ ﺎﺑ ﻉﺮﺻ ﺎﻘﻟﺍ
ﻳ ﻞﺧﺍﺩ ﻖ
ﻫ ﻴ ﭙﻤﮐﻮﭙ ﻲ ﺳﺍ ﻴ ﺎﮐ ﺪ ﻳ ﻨ ﻴ ﺎﺑ ﮏ ﻳ ﮏ ﺠﻨﺸﺗ ﺭﺎﺘﻓﺭ ﻲ
،ﻩﺩﻮﺑ ﻩﺍﺮﻤﻫ ﺯﺭﺎﺑ
ﻮﺠﺗ ﻳ ﺰ ﺘﺳﺍ ﻴ ﻞ ﻝﺁ ﻧﺭﺎﮐ ﻴ ﺘ ﻴ ﻦ ﺶﻫﺎﮐ ﺐ ﺟﻮﻣ ﻨﻌﻣ
ﻲ ﺭﺍﺩ ﺕﻼﻤﺣ ﺕﺪﺷ
ﺠﻨﺸﺗ ﻲ ،ﺪﺷ ﻢﮐﺍﺮﺗ ﻥﻭﺭﻮﻧ ﺎﻫ ﻱ ﻧ ﻴ ﺣﺎﻧ ﻪﺳ ﺭﺩ ﻞﺴ ﻴ
ﻪ ،CA1 ﻭCA3
ﻓﺎﻧ ﻲ ﻫ ﻴ ﻋﺮﺻ ﻩﻭﺮﮔ ﺭﺩ ﭗ ﻤﮐﻮﭙ ﻲ
ﻩﺪﺷ ﻳ ﺶﻫﺎﮐ ﮏ ﻨﻌﻣ ﻲ ﺭﺍﺩ ﺭﺩ
ﺎﻘﻣ ﻳ ﻭ ﺩﺍﺩ ﻥﺎﺸﻧ ﻢﺷ ﻩﻭﺮﮔ ﺎﺑ ﻪﺴ ﭘ
ﻴ ﺶ ﻥﺎﻣﺭﺩ ﺘﺳﺍ ﺎﺑ ﻴ ﻞ ﻝﺁ ﻧﺭﺎﮐ ﻴ ﺘ ﻴ ﻦ
ﺍﺰﻓﺍ ﺐ ﺟﻮﻣ ﻳ ﺶ ﻨﻌﻣ ﻲ ﺭﺍﺩ ﺣﺎﻧ ﻭﺩ ﺭﺩ ﻥﺁ ﻴ
ﻪ ﻭCA1 ﺩﺮﮔCA3
ﻳ ،ﺪ
ﺮﻈﻧﺯﺍ ﺗﻭﺮﭙﺳﺍ ﺕﺪﺷ ﻴ
ﮓ ﻨ ﻓ ﻴ ﺎﻫﺮﺒ ﻱ ﻩﺰﺧ ﺍ ﻱ ﻧ ﻴ ﻋﺮﺻ ﻩﻭﺮﮔ ﺭﺩ ﺰ ﻲ
ﻩﺪﺷ
ﻳ ﺍﺰﻓﺍ ﮏ ﻳ ﺶ ﻨﻌﻣ ﻲ ﺭﺍﺩ ﻭ ﺪﺷ ﻩﺪﻫﺎﺸﻣ ﻢﺷ ﻩﻭﺮﮔ ﻪﺑ ﺖﺒﺴﻧ ﭘ
ﻴ ﺶ ﻥﺎﻣﺭﺩ
ﺘﺳﺍ ﺎﺑ ﻴ ﻞ ﻝﺁ ﻧﺭﺎﮐ ﻴ ﺘ ﻴ ﺶﻫﺎﮐ ﺐ ﺟﻮﻣ ﻦ ﻨﻌﻣ
ﻲ ﺭﺍﺩ ﺩﺮﮔ ﻥﺁ ﻳ ،ﻩﻭﻼﻌﺑ .ﺪ
ﭘ ﻴ ﺶ ﻥﺎﻣﺭﺩ ﺘﺳﺍ ﺎﺑ ﻢﺷ ﻩﻭﺮﮔ ﻴ
ﻞ ﻝﺁ ﻧﺭﺎﮐ ﻴ ﺘ ﻴ ﻐﺗ ﻦ ﻴﻴ ﺮ ﻨﻌﻣ ﻲ ﺭﺍﺩ ﺮﻈﻧﺯﺍ
ﻧﻭﺭﻮﻧ ﻢﮐﺍﺮﺗ ﻲ
ﺗﻭﺮﭙﺳﺍ ﺕﺪﺷ ﻭ ﻴ
ﻓ ﮓ ﻨ ﻴ ﺎﻫ ﺮ ﻱ ﻩﺰﺧ ﺍ ﻱ ﺣﺎﻧ ﺭﺩ ﻴ ﻪ
ﻫ ﻴ ﻧ ﺩﻮﺟﻮﺑ ﭗ ﻤﮐﻮﭙ ﻴ
.ﺩﺭﻭﺎ
ﺎﺘﻧ ﻳ ﻘﺤﺗ ﺞ ﻴ ﻠﺒﻗ ﺕﺎﻘ ﻲ ﻥﺎﺸﻧ ﻣ ﻲ ﺪﻫﺩ ﻪﮐ ﺑ ﺭﺩ ﻴ ﻥﺍﺭﺎﻤ ﻼﺘﺒﻣ ﻪﺑ
ﮔ ﺐ ﻟ ﻉﺮﺻ ﻴ ﻫﺎﮕﺠ ﻲ ﺣ ﻝﺪﻣ ﺭﺩ ﻭ ﻴ
ﻧﺍﻮ ﻲ ﻥﺁ ﻩﺪﺷﺎﻘﻟﺍ ﺭﺰﺗ ﻂ ﺳﻮﺗ ﻳ ﻖ
ﻫ ﻞﺧﺍﺩ ﻴ ﭙﻤﮐﻮﭙ ﻲ ﺳﺍ ﻴ ﺪ ﺎﮐ ﻳ ﻨ ﻴ ﮏ ﻭ ﻳ ﺎ ﺻﺎﺧ ﺎﺑ ﺩﺍﻮﻣ ﻴ
ﺖ ﻤﺳ ﻴ ﺖ
ﺮﺤﺗ ﻳ ﮑ ﻲ ، ﺖﻠﻋ ﻪﺑ ﺳﺁ ﻴ ﺐ ﻥﻭﺭﻮﻧ ﺎﻫ ﻱ ) ﻑﺪﻫ ﻠﺤﺗ ﻴ ﻦﺘﻓﺭ ﻞ ﻥﻭﺭﻮﻧ ﺎﻫ ﻱ
ﭘ ﻴ ﻣﺍﺮ ﻴ ﻝﺍﺪ ﻭCA3 ﻝﻮﻠﺳ ﺎﻫ ﻱ ﻓﺎﻧ ﻲ ﺍ ﻪﻧﺍﺪﻧﺩ ﺞﻨﮑﺷ ﻱ
ﻥﺩﺯ ﻪﻧﺍﻮﺟ (
ﻓ ﻴ ﺎﻫﺮﺒ ﻱ ﮊﺮﺗﺎﻣﺎﺗﻮﻠﮔ ﻥﺍﺭﻭﺁ ﻳ
ﮏ ﺣﺎﻧ ﺯﺍ ﻴ ﻪ ﺍ ﻪﻧﺍﺪﻧﺩ ﺞﻨﮑﺷ ﻱ
ﻪﺑ ﻡﻮﺳﻮﻣ ﻓ
ﻴ ﺎﻫﺮﺒ ﻱ ﻩﺰﺧ ﺍ ﻱ ﺥﺭ ﻣ ﻲ ﺪﻫﺩ ﻪﮐ ﺮﻈﻧﺯﺍ ﻫ ﻴ ﮊﻮﻟﻮﺗﺎﭘﻮﺘﺴ ﻱ
ﺀﺰﺟ
ﺕﺎﺼﺨﺸﻣ ﻝﺪﻣ
ﺎﻫ ﻱ ﺣ ﻴ ﻧﺍﻮ ﻲ ﮔ ﺐ ﻟ ﻉﺮﺻ ﻴ ﻫﺎﮕﺠ ﻲ ﻣ ﻲ ﺪﺷﺎﺑ ﺍ ﻪﮐ ﻳ ﻦ
ﻣ ﻲ ﺪﻧﺍﻮﺗ ﺪﺸﺗ ﺐ ﺟﻮﻣ ﻳ
ﺪ ﻟﺎﻌﻓ ﻴ ﺖ ﺴﻣ ﻴ ﺎﻫﺮ ﻱ ﮊﺮﺗﺎﻣﺎﺗﻮﻠﮔ ﻳ ﮏ ﻥﺁ ﺭﺩ
ﺣﺎﻧ ﻴ ﻪ ﻫ ﻴ ﺍﺭ ﺩﻮﺧ ﻪﮐ ﺩﺩﺮﮔ ﭗ ﻤﮐﻮﭙ ﻪﺑ
ﺕﺭﻮﺻ ﺯﺍ ﻒﻠﺘﺨﻣ ﺕﺎﺟﺭﺩ
ﺳﺁ ﺕﺪﺷ ﻪﺑ ﻪﺟﻮﺗ ﺎﺑ ﻉﺮﺻ ﺕﻼﻤﺣ ﻴ
ﺐ ﺪﻫﺩ ﻥﺎﺸﻧ ﻘﺤﺗ ﺭﺩ ﻪﮐ
ﻴ ﻖ
ﺎﺘﻧ ﺎﺑ ﻭ ﺪﻣﺁ ﺖﺳﺪﺑ ﺮﺿﺎﺣ ﻳ
ﻠﺒﻗ ﺕﺎﻌﻟﺎﻄﻣ ﺞ ﻲ
ﺍ ﺭﺩ ﻳ ﺖﻘﺑﺎﻄﻣ ﻩﺯﻮﺣ ﻦ
ﺖﺷﺍﺩ ۱۵،۱۶) .(
ﺕﺍﺮﺛﺍ ﺹﻮﺼﺧ ﺭﺩ ﺘﺳﺍ ﺪﻨﻣﺩﻮﺳ
ﻴ ﻞ ﻝﺁ ﻧﺭﺎﮐ ﻴ ﺘ ﻴ ﻦ ﺍ ﺭﺩ ﻳ ﻦ ﺳﺭﺮﺑ ﻲ
،
ﺩﺍﻮﻣ ﻪﮐ ﺖﺳﺍ ﻩﺪﺷ ﺺﺨﺸﻣ ﺻﺎﺧ ﺎﺑ
ﻴ ﮔﺪﻨﻨﮐ ﻑﺬﺣ ﺖ ﻲ
ﺩﺍﺭ ﻳ ﻝﺎﮑ ﺎﻫ ﻱ
) ﺩﺍﺯﺁ ﺘﻧﺁ ﻲ ﺴﮐﺍ ﻴ ﺖﻧﺍﺪ (ﺎﻫ ﻋﺮﺻ ﺪﺿ ﺕﺍﺮﺛﺍ ﻝﺎﻤﻋﺍ ﻪﺑ ﺭﺩﺎﻗ ﻲ
ﻥﺪﺑ ﺭﺩ
ﻣ ﻲ ﺪﻨﺷﺎﺑ ۱۸) ۱۶- ﺎﺘﻧ .(
ﻳ ﺞ ﺳﺭﺮﺑ ﻲ ﺎﻫ ﻱ ﻠﺒﻗ ﻲ ﻥﺎﺸﻧ ﻣ ﻲ ﺪﻫﺩ ﺘﻧﺁ ﻪﮐ ﻲ
ﺴﮐﺍ ﻴ ﺖﻧﺍﺪ ﺮﻃ ﺯﺍ ﺎﻫ ﻳ ﻖ ﺴﮐﺍ ﺱﺮﺘﺳﺍ ﻥﺩﺍﺩ ﺶﻫﺎﮐ ﻴ
ﺗﺍﺪ ﻴ ﻮ ﻭ
ﺴﮐﺍﺮﭘ ﻴ ﺳﺍﺪ ﻴ ﻥﻮ ﻟ ﻴ ﭙ ﻴ ﺪ ﻱ ﺷﺎﻧ ﻲ ﺪﺸﺗ ﺯﺍ ﻳ ﺪ ﮑﺸﺗ ﻴ ﻞ ﺩﺍﺭ ﻳ ﻝﺎﮑ ﺎﻫ ﻱ ﺩﺍﺯﺁ
ﺴﮐﺍ ﻴ ﻥﮋ ﺣﺍﻮﻧ ﺭﺩ ﻲ ﺧﺩ ﻴ ﻞ ﻫ ﻞﻣﺎﺷ ﻉﺮﺻ ﺰﻧﮊﻮﺗﺎﭘ ﺭﺩ ﻴ
ﺐ ﺟﻮﻣ ﭗ ﻤﮐﻮﭙ
ﻝﺎﻤﺘﺣﺍ ﻭ ﺕﺪﺷ ﺶﻫﺎﮐ ﺩﺍﺪﺧﺭ
ﺕﻼﻤﺣ ﺣ ﺭﺩ ﻉﺮﺻ ﻴ
ﺕﺎﻧﺍﻮ
ﺎﻣﺯﺁ ﻳ ﻫﺎﮕﺸ ﻲ ﻣ ﻲ ﺪﻧﺩﺮﮔ ۱۹) ﻤﻫ ﺭﺩ .(
ﻴ ﻦ ﻠﺒﻗ ﺕﺎﻌﻟﺎﻄﻣ ﻁﺎﺒﺗﺭﺍ ﻲ
ﻥﺎﺸﻧ
ﺖﺳﺍ ﻩﺩﺍﺩ ﻪﮐ
ﮐﺮﺗ ﻴ ﺕﺎﺒ ﺘﻧﺁ ﻲ ﺴﮐﺍ ﻴ ﺘﻧﺍﺪ ﻲ ﻣ ﻲ ﺪﻨﻧﺍﻮﺗ ﺮﻃ ﺯﺍ ﻳ ﻖ ﺍﺰﻓﺍ ﻳ ﺶ
ﻥﺩﺍﺩ ﺎﭘ ﻳ ﺭﺍﺪ ﻱ ﺎﻫﺎﺸﻏ ﻱ ﻟﻮﻠﺳ ﻲ ﺍﺰﻓﺍ ﺐ ﺟﻮﻣ ﻳ ﺶ ﺖﻣﻭﺎﻘﻣ ﻥﻭﺭﻮﻧ ﺎﻫ ﺭﺩ
ﺳﺁ ﺮﺑﺍﺮﺑ ﻴ ﺐ ﺴﮐﺍ ﻴ ﺗﺍﺪ ﻴ ﻮ ﻓﺮﻃ ﺯﺍ ﻭ ﺪﻧﺩﺮﮔ ﻲ
ﻓﺮﻇ ﻴ ﺖ ﺘﻧﺁ ﻲ ﺴﮐﺍ ﻴ ﺘﻧﺍﺪ ﻲ
٧٢٤
ﺳﺁ ﺮﺑﺍﺮﺑ ﺭﺩ ﺍﺭ ﺰﻐﻣ ﻴ
ﺐ ﺴﮐﺍ ﻴ ﺗﺍﺪ ﻴ ﻮ ﺍﺰﻓﺍ ﻳ ﺶ ) ﺪﻨﻫﺩ ۱۹ ﻤﻫ .(
ﻴ ﻦ
ﻧﺎﮑﻣ ﻴ ﻢﺴ ﹰ
ﻻﺎﻤﺘﺣﺍ ﻣ ﻲ ﺪﻧﺍﻮﺗ ﺘﻇﺎﻔﺣ ﺕﺍﺮﺛﺍ ﺩﺭﻮﻣ ﺭﺩ ﻲ
ﺘﺳﺍ ﻴ ﻞ ﻝﺁ
ﻧﺭﺎﮐ ﻴ ﺘ ﻴ ﻦ ﻉﺮﺻ ﻝﺪﻣ ﺭﺩ ﻩﺪﺷﺎﻘﻟﺍ
ﺳﺍ ﻂ ﺳﻮﺗ ﻴ ﺪ ﺎﮐ ﻳ ﻨ ﻴ ﮏ ﺍ ﺭﺩ ﻳ ﻦ ﻘﺤﺗ ﻴ ﻖ
.ﺪﺷﺎﺑ ﺡﺮﻄﻣ ﻘﺤﺗ ﺭﺩ
ﻴ ﻘ ﻲ ﺭﺩ ﻥﺍﺭﺎﮑﻤﻫ ﻭ ﺩﺍﮋﻧ ﭺﻮﻠﺑ ﻂ ﺳﻮﺗ ﻪﮐ ﻂ ﺒﺗﺮﻣ
ﺸﺨﺑ ﺮﺛﺍ ﺩﺭﻮﻣ ﻲ
ﺰﻧﺁﻮﮐ ﻳ ﻢ ﻤﻫ ﺭﺩQ10 ﻴ ﺪﺷ ﻩﺩﺎﻔﺘﺳﺍ ﻉﺮﺻ ﻝﺪﻣ ﻦ
ﺩﺮﮔ ﺺﺨﺸﻣ ﻳ
ﺸﺨﺑ ﺪ ﻲ ﻥﺁ ﺪﻨﻣﺩﻮﺳ ﺕﺍﺮﺛﺍ ﺯﺍ ﺖﻠﻋ ﻪﺑ
ﺻﺎﺧ ﻴ ﺘﻧﺁ ﺖ ﻲ
ﺴﮐﺍ ﻴ ﻧﺍﺪ ﻲ ﻥﺁ ﻣ ﻲ ﺪﺷﺎﺑ ۱۵) ﻤﻫ ﻪﮐ ( ﻴ ﺭﺩ ﺩﺭﻮﻣ ﻦ ﺘﺳﺍ ﺎﺑ ﻪﻄﺑﺍﺭ
ﻴ ﻞ ﻝﺁ
ﻧﺭﺎﮐ ﻴ ﺘ ﻴ ﻧ ﻦ ﻴ ﺡﺮﻄﻣ ﺰ ﻣ ﻲ ﺪﺷﺎﺑ ﻘﺤﺗ ﻪﺑ ﺩﻮﺧ ﺪﻨﭼ ﺮﻫ ﻴ
ﺑ ﺕﺎﻘ ﻴ ﻧ ﺮﺘﺸ ﻴ ﺯﺎ
ﻨﭽﻤﻫ .ﺩﺭﺍﺩ ﻴ
ﻦ ﮊﺎﻓﻮﺗﻭﺍ ﻉﺮﺻ ﺖﻟﺎﺣ ﺭﺩ ﻪﮐ ﺖﺳﺍ ﻩﺪﺷ ﻡﻮﻠﻌﻣ ﻱ
ﺭﺩ
ﺧﺮﺑ ﻲ ﺣﺍﻮﻧ ﻲ ﺍﺰﻓﺍ ﺰﻐﻣ ﻳ ﺶ ﻣ ﻲ ﻳ ﺪﺑﺎ ﮐﺮﺗ ﻭ ﻴ ﺕﺎﺒ ﺻﺎﺧ ﺎﺑ ﻴ ﺖ ﺘﻧﺁ ﻲ
ﺴﮐﺍ ﻴ ﻧﺍﺪ ﻲ ﻣ ﻲ ﺪﻨﻧﺍﻮﺗ ﮊﺎﻓﻮﺗﻭﺍ ﺶﻫﺎﮐ ﺖﻬﺟ ﺭﺩ ﻱ
ﻧﻭﺭﻮﻧ ﮒ ﺮﻣ ﻭ ﻲ
ﻞﻤﻋ
ﺎﻤﻧ ﻳ ﺪﻨ ۲۰) ﺋﺎﺗ ﺭﺩ .(
ﻴ ﺪ ﺍ ﻳ ﻦ ﺭﺩ ﻥﺍﺭﺎﻜﻤﻫ ﻭ ﻱ ﺍﺭﻭﺩﺎﻧﺁ ﻱ ﺍ ﻪﻌﻟﺎﻄﻣ ﻪﺘﻔﮔ
ﻝﺎﺳ ۲۰۱۱ ۲۱) ﺘﺳﺍ ﻪﮐ ﺩﺍﺩ ﻥﺎﺸﻧ ( ﻴ
ﻞ ﻝﺁ ﻧﺭﺎﮐ ﻴ ﺘ ﻴ ﻦ ﻪﺑ ﺭﺩﺎﻗ
ﺭﺩ ﻦﺑﺮﻛﺪﻳﺮﻠﻛﺍﺮﺘﺗ ﺯﺍ ﻲﺷﺎﻧ ﻮﻴﺗﺍﺪﻴﺴﻛﺍ ﺱﺮﺘﺳﺍ ﺯﺍ ﻱ ﺮﻴﮕ ﺸﻴﭘ ﺵﻮﻣ ﺎﻫ ﻱ ﺋﺍﺮﺤﺻ ﻲ ﻣ ﻲ ﺪﺷﺎﺑ ﺍ ﺯﺍ ﻪﮐ ﻳ ﻦ ﺘﻧﺁ ﻪﺑﺎﺸﻣ ﺮﻈﻧ ﻲ
ﺴﮐﺍ ﻴ ﺖﻧﺍﺪ
ﺎﻫ ﻱ ﺒﻃ ﻴ ﻌ ﻲ ﻈﻧ ﻴ ﺮ ﻭ ﻳ ﻣﺎﺘ ﻴ ﻦ ﻞﻤﻋE ﻣ ﻲ ﺎﻤﻧ ﻳ ﺪ ﺸﺨﺑ ،ﻩﻭﻼﻌﺑ . ﻲ
ﺮﺛﺍ ﺯﺍ
ﺘﺳﺍ ﺪﻨﻣﺩﻮﺳ ﻴ
ﻞ ﻝﺁ ﻧﺭﺎﮐ ﻴ ﺘ ﻴ ﻦ ﺍﺭ ﹰﻻﺎﻤﺘﺣﺍ ﻣ ﻲ ﻥﺍﻮﺗ ﺕﺍﺮﺛﺍ ﻪﺑ ﺘﻇﺎﻔﺣ ﻲ
ﮔﻮﻠﺟ ﺭﺩ ﻥﺁ ﻴ
ﺮ ﻱ ﺳﺁ ﺯﺍ ﻴ ﺐ ﻥﻭﺭﻮﻧ ﺎﻫ ﻱ ﻫ ﻴ ﭗ ﻤﮐﻮﭙ ﻝﺎﺒﻧﺩ ﻪﺑ ﺭﺰﺗ ﻳ ﻖ
ﺳﺍ ﻴ ﺪ ﺎﮐ ﻳ ﻨ ﻴ ﮏ ﺍ ﻪﮐ ﺩﺍﺩ ﺖﺒﺴﻧ ﻳ
ﻦ ﺕﺪﺷ ﻥﺩﺍﺩ ﺶﻫﺎﮐ ﺎﺑ ﻥﺩﺯ ﻪﻧﺍﻮﺟ
ﻓ ﻴ ﺎﻫﺮﺒ ﻱ ﻩﺰﺧ ﺍ ﻱ ﺭﺩ ﺎﻫﺯﻭﺭ ﻱ ﺪﻌﺑ
، ﺠﻨﺸﺗ ﺭﺎﺘﻓﺭ ﻲ
ﺮﺘﻤﮐ ﻱ ﺍﺭ ﻝﺎﺒﻧﺩ ﻪﺑ
ﺍ ﺭﺩ .ﺩﺭﺍﺩ ﻳ ﻦ ﺘﮑﺗﻭﺭﮊﻭﺭﻮﻧ ﺕﺍﺮﺛﺍ ﻪﻄﺑﺍﺭ ﻴ
ﻮ ﺍ ﻳ ﻦ ﻩﺩﺎﻣ ﹰ ﻼﺒﻗ ﻭ ﺎﺘﻫ ﻂ ﺳﻮﺗ
ﻫ ﻥﺍﺭﺎﻜﻤ ﻝﺎﺳ ﺭﺩ ۲۰۱۱
ﺑﺮﺠﺗ ﻝﺪﻣ ﺭﺩ ﻲﺒﺼﻋ ﺖﻈﻓﺎﺤﻣ ﺭﺩ ﻲ
ﻲﺴﻛﻮﭙﻴﻫ ﻩﺪﺷﺎﻘﻟﺍ
ﺋﺎﺗ ﺩﺭﻮﻣ ﻴ ﺪ ) ﺖﺳﺍ ﻪﺘﻓﺮﮔ ﺭﺍﺮﻗ ۲۲
،ﻩﻭﻼﻌﺑ .(
ﺘﻧﺁ ﻪﮐ ﺖﺳﺍ ﻩﺪﺷ ﺺﺨﺸﻣ ﻲ
ﺴﮐﺍ ﻴ ﺖﻧﺍﺪ ﺎﻫ ﻣ ﻲ ﺪﻨﻧﺍﻮﺗ ﻝﻼﺘﺧﺍ ﺯﻭﺮﺑ ﺯﺍ ﺩﺮﮑﻠﻤﻋ
ﻱ ﺳ ﻴ ﻡﻭﺮﮐﻮﺘ ﺴﮐﺍ ﻴ ﺯﺍﺪ ﮔﻮﻠﺟ ﻴ ﺮ ﻱ ﮐﺮﺗ ﺢﻄﺳ ﻭ ﻩﺩﻮﻤﻧ ﻴ
ﺕﺎﺒ
ﮊﺮﻧﺍ ﺮﭘ ﺭﺍﺩ ﺕﺎﻔﺴﻓ ﻱ
ﻧ ﻭ ﻴ ﺮﺘ ﻳ ﮏ ﺴﮐﺍ ﻴ ﺪ ﺍﺭ ﺭﺩ ﺣﺍﻮﻧ ﻲ ﺰﻐﻣ ﻒﻠﺘﺨﻣ
ﻪﺑ ﻭ ﻳ ﻩﮋ ﺣﺎﻧ ﻴ ﻪ ﻫ ﻴ ) ﺪﻨﻫﺩ ﺶﻫﺎﮐ ﭗ ﻤﮐﻮﭙ ۲۳
ﺍ ﻪﮐ ( ﻳ ﻦ ﺶﻫﺎﮐ ﺐ ﺟﻮﻣ
ﺳﺁ ﺕﺪﺷ ﻴ ﺐ ﻧﻭﺭﻮﻧ ﻲ ﻝﺎﺒﻧﺩ ﻪﺑ ﺭﺰﺗ ﻳ ﻖ ﻩﺩﺎﻣ ﻤﺳ ﻲ ﺳﺍ ﻴ ﺪ ﺎﮐ ﻳ ﻨ ﻴ ﮏ
ﺰﻐﻣ ﻞﺧﺍﺪﺑ ﻣ ﻲ ﺩﺩﺮﮔ ﺘﻧ ﺭﺩ ﻪﮐ ﻴ ﻪﺠ ﻐﺗ ﻴﻴ ﺕﺍﺮ ﺘﺳﻼﭘ ﻴ ﺴ ﻴ ﻪﺘ ﺮﺘﻤﮐ ﻱ ﺭﺩ
ﺣﺎﻧ ﻴ ﻪ ﻫ ﻴ ﺥﺭ ﭗ ﻤﮐﻮﭙ ﻣ
ﻲ ﺪﻫﺩ ﺍ ﻭ ﻳ ﻦ ﺕﻼﻤﺣ ﺮﺘﻤﮐ ﺕﺎﻌﻓﺩ ﻭ ﺕﺪﺷ ﺎﺑ
ﺠﻨﺸﺗ ﻲ ﻥﺎﺸﻧ ﺍﺭ ﺩﻮﺧ ﻣ
ﻲ ﺪﻫﺩ .
ﺯﺍ ﺩﻭﺪﺤﻣ ﻳ ﺖ ﺎﻫ ﻱ ﺳﺭﺮﺑ ﻲ ﺮﺿﺎﺣ ﻣ ﻲ ﻥﺍﻮﺗ ﻥﺩﻮـﺑ ﺕﺪـﻣ ﻩﺎﺗﻮﮐ ﻪﺑ
ﺳﺭﺮﺑ ﻲ ﺠﻨﺸﺗ ﺭﺎﺘﻓﺭ ﻲ
ﺣ ﺭﺩ ﻴ ﻡﺎﺠﻧﺍ ﻡﺪﻋ ،ﺕﺎﻧﺍﻮ ﺳﺭﺮﺑ
ﻲ ﺎـﻫ ﻱ ﻟﻮـﮑﻠﻣ ﻲ
ﺎﻗﻭ ﺹﻮﺼﺧ ﺭﺩ ﻳ
ﻠﮔﻭﺮﺘـﺳﺁ ﻭ ﺯﻮﺘﭘﻮﭘﺁ ﻊ ﻴ
ﺯﻮ ﻝﺎـﺒﻧﺩ ﻪـﺑ ﺭﺰﺗ ـﻳ ﻞـﺧﺍﺩ ﻖ
ﻫ ﻴ ﭙﻤﮐﻮﭙ ﻲ ﺳﺍ ﻴ ﺎﮐ ﺪ ﻳ ﻨ ﻴ ﺸﺨﺑ ﺮﺛﺍ ﻭ ﮏ ﻲ
ﺘﺳﺍ ﻴ ﻞ ﻝﺁ ﻧﺭﺎﮐ ﻴ ﺘ ﻴ ﺍ ﺭﺩ ﻦ ـﻳ ﻦ
ﻪﻄﺑﺍﺭ ﺳﺭﺮﺑ ﻭ ﻲ ﺸﺨﺑ ﺮﺛﺍ ﻲ ﻮﺠﺗ ﻳ ﺍ ﺰ ﻳ ﻩﺩﺎﻣ ﻦ ﻝﺎﺒﻧﺩ ﻪﺑ ﺑﺮﺠﺗ ﻝﺪﻣ ﺎﻘﻟﺍ ﻲ
.ﺩﻮﻤﻧ ﻩﺭﺎﺷﺍ ﻉﺮﺻ ﻪﺑ ﺭﻮﻃ ﭘ ،ﻪﺻﻼﺧ ﻴ ﺗ ﺶ ﻴ ﺎﺑ ﺭﺎﻤ ﺘﺳﺍ ﻴ ﻞ ﻝﺁ ﻧﺭﺎﮐ ﻴ ﺘ ﻴ ﻦ ﺍﺭﺍﺩ ﻱ ﺪﺿ ﺮﺛﺍ
ﺠﻨﺸﺗ ﻲ ﻣ ﻲ ﺪﺷﺎﺑ ﻧﻭﺭﻮـﻧ ﻢﮐﺍﺮـﺗ ﻆـﻔﺣ ﺐ ﺟﻮﻣ ، ﻲ
ﺣﺍﻮـﻧ ﺭﺩ ﻲ ﻭCA1
ﻫCA3 ﻴ ﭗ ﻤﮐﻮﭙ ﻣ ﻲ ﺩﺩﺮـﮔ ﺕﺪـﺷ ﺶﻫﺎـﮐ ﺚـﻋﺎﺑ ﻭ ﻥﺩﺯ ﻪـﻧﺍﻮﺟ
ﺭﺩ
ﺣﺎﻧ ﻴ ﻪ ﻪﻧﺍﺪﻧﺩ ﺭﺍﺩ ﻫ ﻴ ﭗ ﻤﮐﻮﭙ ـﺑﺮﺠﺗ ﻝﺪـﻣ ﺭﺩ ﻲ
ﻉﺮـﺻ ﮔ ﺐ ـﻟ ﻴ ﻫﺎـﮕ ﺠ ﻲ
ﻩﺪﺷﺎﻘﻟﺍ ﺳﺍ ﺎﺑ ﻴ ﺪ ﺎﮐ ﻳ ﻨ ﻴ ﮏ ﻣ ﻲ ﺩﺩﺮﮔ .
ﺮﻜﺸﺗ ﻭ ﺮﻳﺪﻘﺗ
ﺶﻫﻭﮋﭘ ﺮﺿﺎﺣ ﻞﺻﺎﺣ ﻥﺎﻳﺎﭘ ﻪﻣﺎﻧ ﻮﺠﺸﻧﺍﺩ ﻱ ﮑﺷﺰﭘ ﻲ ﺏﻮﺼﻣ
ﺖﻧﻭﺎﻌﻣ ﺸﻫﻭﮋﭘ ﻲ ﮑﺷﺰﭘ ﻩﺪﮑﺸﻧﺍﺩ ﻲ
ﻩﺎﮕﺸﻧﺍﺩ ﺪﻫﺎﺷ ﺭﺩ ﻝﺎﺳ ۱۳۹۰
ﻣ ﻲ ﺪﺷﺎﺑ ﻭ ﺎﺑ ﺖﻳﺎﻤﺣ ﻲﻟﺎﻣ ﻦﻳﺍ ﻩﺎﮕﺸﻧﺍﺩ ﻪﺑ ﻡﺎﺠﻧﺍ ﻩﺪﻴﺳﺭ ﺖﺳﺍ ﻪﮐ
ﺪﺑ ﻳ ﺳﻮﻨ ﻴ ﻪﻠ ﺮﮑﺸﺗ ﻣ ﻲ ﺩﺩﺮﮔ .
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THE EFFECT OF ACETYL L CARNITINE ON PREVENTION OF HIPPOCAMPAL NEURODEGENERATION AND MOSSY FIBER SPROUTING IN AN EXPERIMENTAL MODEL OF TEMPORAL LOBE
EPILEPSY IN RAT
Mehrdad Roghani٭1, Tourandokht Baluchnejadmojarad2, Somaye Pooladvand3
Received: 9 Jul , 2014; Accepted: 21 Sep , 2014
Abstract
Background & Aims: Temporal lobe epilepsy is due to structural and metabolic changes in hippocampus including marked degeneration of neurons. Considering some evidences on antiepileptic and neuroprotective activity of acetyl L carnitine (ALC), this study was undertaken to evaluate the preventive effect of ALC on structural changes in hippocampus in an experimental model of temporal lobe epilepsy.
Materials & Methods: In this study, 32 rats were divided into sham, ALC-pretreated sham, epileptic, and ALC-pretreated epileptic group. Rat model of epilepsy was induced by unilateral intrahippocampal administration of 4 μg of kainic acid per rat. Rats received ALC (100 mg/kg, p.o) daily for 3 days before surgery. Finally, brain sections were stained with Nissl and Timm methods.
Results: The induction of epilepsy was followed by a prominent seizure and ALC pretreatment attenuated seizure intensity (p<0.01). In addition, density of Nissl-stained neurons in CA1, CA3, and dentate regions of hippocampus was significantly lower in epileptic rats versus sham group (P<0.005- 0.001) and ALC pretreatment significantly increased it in CA1 and CA3 regions (p<0.05-0.01).
Regarding mossy fiber sprouting, epileptic rats showed a higher degree of sprouting as compared to sham group (p<0.005) and ALC treatment significantly lowered it (p<0.05).
Conclusion: ALC administration has an antiepileptic activity; it preserves neurons in CA1 and CA3 regions, and lowers mossy fiber sprouting in dentate gyrus of hippocampus in kainate-induced epileptic animals.
Keywords: Acetyl L carnitine, Epilepsy, Seizure, Hippocampus, Neurodegeneration, Mossy fiber sprouting
Address: Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran, Tel: +98 9121794950
Email: [email protected]
SOURCE: URMIA MED J 2014: 25(8): 726 ISSN: 1027-3727
1 Professor, Neurophysiology Research Center, Shahed University, Tehran, Iran (Corresponding Author)
2 Professor, Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
3 Medical Graduate, School of Medicine, Shahed University, Tehran, Iran
