ﻪﻠﺠﻣ مﻮﻠﻋ يزار ﻲﻜﺷﺰﭘ هرود
19
، هرﺎﻤﺷ 99
، رﻮﻳﺮﻬﺷ ﻲﺸﻫوﮋﭘ ﻪﻟﺎﻘﻣ 1391
ﻪﻣﺪﻘﻣ مرﺪﻨــﺳ ناﺪــﻤﺨﺗ
ﻲــﻠﭘ ﻚﻴﺘــﺴﻴﻛ -PCOS))
(
ﻲﻣﻮﻤﻋ ﻦﻳﺮﺗ يرﺎﻤﻴﺑ ﻲﻨﻳﺮﻛوﺪﻧآ رد
نﺎﻧز ﺖﺳا ) 1 .(
ﻲﻣﺮﻓPCOS زا دﺮﻜﻠﻤﻋ ﻢﺴﻴﻧژورﺪﻧآﺮﭙﻴﻫ
ناﺪـﻤﺨﺗ
ﻲﻣ ﺪﺷﺎﺑ . لﻼﺘﺧا رد ﺪﻴﻟﻮﺗ نژورﺪﻧآ ﻂﺳﻮﺗ
ناﺪﻤﺨﺗ
رد ﻦــﺳ غﻮــﻠﺑ رﺎﻜــﺷآ ﺖــﺳا ﻲــﻟو ﻪــﺸﻳر رد نارود
ﻲﻛدﻮــﻛ و
ﺎــﻳ ﻲــﺘﺣ رد نارود ﻲــﻨﻴﻨﺟ دراد
) 2 ( .
%PCOS 8 - 6 نﺎﻧز ار رد ﻦﻴﻨﺳ يرورﺎﺑ ﺖﺤﺗ ﺮﻴﺛﺎـﺗ
راﺮﻗ هداد و ﻞﻣﺎﻋ ﻊﻳﺎﺷ
ًﺎﺒﻳﺮﻘﺗ
% 75 يرورﺎﺑﺎﻧ ﻲـﺷﺎﻧ
زا مﺪﻋ ﻚﻤﺨﺗ يراﺬﮔ ﻲﻣ ﺪﺷﺎﺑ . هوﻼﻋ ﺮﺑ
،يرورﺎـﺑﺎﻧ ﺎــﺑPCOS
ﺖــﻣﺎﻘﻣ ﻪــﺑ
،ﻦﻴﻟﻮــﺴﻧا
،ﺎﻤﻨﻴﻟﻮــﺴﻧاﺮﭙﻳﺎﻫ
،ﻢﺴﻴﻧژورﺪﻧآﺮﭙﻳﺎﻫ ﻲﮔﮋﻳو
يﺎﻫ مرﺪﻨـﺳ ﻚـﻴﻟﻮﺑﺎﺘﻣ
و
ﻚــﻳ ﺶﻳاﺰــﻓا ﻚــﺴﻳر
ﺮــﻄﺧ ياﺮــﺑ ﺖــﺑﺎﻳد هاﺮــﻤﻫ
ﻲﻣ ﺪﺷﺎﺑ ) 1 (.
داﺮﻓا ﻼﺘﺒﻣ PCOSﻪﺑ
حﻮﻄﺳ يﺮﺗﻻﺎﺑ زا نﻮـﻣرﻮﻫ
Luteinizing
،
،نوﺮﺘﺳﻮﺘﺴﺗ
،ﻦﻴﻟﻮـﺴﻧا لوﺮﺘـﺴﻠﻛ
و
يﺮﺗ ﺪﻳﺮﺴﻴﻠﮔ ﺖﺒﺴﻧ
ﻪﺑ داﺮﻓا ﻢﻟﺎﺳ ﺪﻧراد . ﻦﻴﻨﭽﻤﻫ
نﺎﻧز ﻼﺘﺒﻣ PCOSﻪﺑ
حﻮﻄﺳ ﻦﻴﻳﺎﭘ يﺮﺗ زا نﻮﻣرﻮﻫ
) FSH نﻮﻣرﻮﻫ كﺮﺤﻣ
ﺪـﺷر ﻲﻟﻮـﻜﻴﻟﻮﻓ (
SHBG ،
) ﻦﻴﻟﻮﺑﻮﻠﮔ ﻞـﺼﺘﻣ
هﺪﻧﻮـﺷ ﻪـﺑ نﻮـﻣرﻮﻫ ﻲـﺴﻨﺟ
( و
ﻪﻤﻃﺎﻓ ﻲﻤﺷﺎﻫ : ﺪﺷرا سﺎﻨﺷرﺎﻛ هوﺮﮔ ،ﻲﻤﻴﺷﻮﻴﺑ
ﺖﺴﻳز
،ﻲﺳﺎﻨﺷ ﺪﺣاو مﻮﻠﻋ تﺎﻘﻴﻘﺤﺗ
،ناﺮﻬﺗ هﺎﮕﺸﻧاد دازآ
،ﻲﻣﻼﺳا
،ناﺮﻬﺗ ناﺮﻳا [email protected].
ﺮﺘﻛد ﺮﻬﭽﻳﺮﭘ ﻲﺋﺎﻤﻐﻳ : هوﺮﮔ ،ﻲﻤﻴﺷﻮﻴﺑ ﺺﺼﺨﺘﻣ و دﺎﺘﺳا ﺖﺴﻳز
،ﻲﺳﺎﻨﺷ ﺪﺣاو مﻮﻠﻋ تﺎﻘﻴﻘﺤﺗ
،ناﺮﻬﺗ هﺎﮕﺸﻧاد دازآ
،ﻲﻣﻼﺳا
،ناﺮﻬﺗ ناﺮﻳا [email protected].
ﻪﻤﻐﻧ ﻲﺗدﺎﻌﺳ : هوﺮﮔ ،ﻲﻤﻴﺷﻮﻴﺑ ﺪﺷرا سﺎﻨﺷرﺎﻛ ﺖﺴﻳز
،ﻲﺳﺎﻨﺷ ﺪﺣاو مﻮﻠﻋ تﺎﻘﻴﻘﺤﺗ
،ناﺮﻬﺗ هﺎﮕﺸﻧاد دازآ
،ﻲﻣﻼﺳا
،ناﺮﻬﺗ ناﺮﻳا [email protected] .
هﺪﻴﭙﺳ ﻲﻘﻴﻘﺣ هدﻮﭘ : هوﺮﮔ ،ﻲﻤﻴﺷﻮﻴﺑ ﺪﺷرا سﺎﻨﺷرﺎﻛ ﺖﺴﻳز
،ﻲﺳﺎﻨﺷ ﺪﺣاو مﻮﻠﻋ تﺎﻘﻴﻘﺤﺗ
،ناﺮﻬﺗ هﺎﮕﺸﻧاد دازآ
،ﻲﻣﻼﺳا
،ناﺮﻬﺗ ناﺮﻳا [email protected].
ﺮﺘﻛد ﻪﻤﻴﻬﻓ ﻲﻧﺎﻀﻣر ﻲﻧاﺮﻬﺗ :
،نﺎﻤﻳاز و نﺎﻧز يﺎﻫ يرﺎﻤﻴﺑ ﺺﺼﺨﺘﻣ و رﺎﻳدﺎﺘﺳا ﺰﻛﺮﻣ
تﺎﻘﻴﻘﺤﺗ يژﻮﻟﻮﻨﻳﺮﻛوﺪﻧآ ﺪﻴﻟﻮﺗ
،ﻞﺜﻣ هﺪﻜﺸﻫوﮋﭘ مﻮﻠﻋ دﺪﻏ نورد ﺰﻳر و
،ﻢﺴﻴﻟﻮﺑﺎﺘﻣ هﺎﮕﺸﻧاد
مﻮﻠﻋ ﻲﻜﺷﺰﭘ ﺪﻴﻬﺷ
،ﻲﺘﺸﻬﺑ
،ناﺮﻬﺗ ناﺮﻳا [email protected].
* ﺮﺘﻛد يﺪﻬﻣ ﻲﺘﻳاﺪﻫ : نورد دﺪﻏ ﻲﻟﻮﻜﻠﻣ و ﻲﻟﻮﻠﺳ تﺎﻘﻴﻘﺤﺗ ﺰﻛﺮﻣ ،ﻲﻨﻴﻟﺎﺑ ﻲﻤﻴﺷﻮﻴﺑ ﺺﺼﺨﺘﻣ و رﺎﻴﺸﻧاد ﺰﻛﺮﻣ ،ﺰﻳر
تﺎﻘﻴﻘﺤﺗ يﺮﻴﮕﺸﻴﭘ و نﺎﻣرد
،ﻲﻗﺎﭼ هﺪﻜﺸﻫوﮋﭘ مﻮﻠﻋ دﺪﻏ
نورد ﺰﻳر و
،ﻢﺴﻴﻟﻮﺑﺎﺘﻣ هﺎﮕﺸﻧاد مﻮﻠﻋ ﻲﻜﺷﺰﭘ ﺪﻴﻬﺷ
،ﻲﺘﺸﻬﺑ
،ناﺮﻬﺗ ناﺮﻳا
*) لﻮﺌﺴﻣ ﻒﻟﻮﻣ [email protected].(
طﺎﺒﺗرا ﺢﻄﺳ
ﻲﻣﺮﺳ ﻦﻴﺴﭙﻳدآ
ﺎﺑ مرﺪﻨﺳ ناﺪﻤﺨﺗ
ﻲﻠﭘ ﻚﻴﺘﺴﻴﻛ )
PCOS (
هﺪﻴﻜﭼ
ﻪﻨﻴﻣز و فﺪﻫ : ﻦﻴﻛﻮﭙﻳدآ
،ﺎﻫ ﻦﻴﺌﺗوﺮﭘ يﺎﻫ ﻪﺤﺷﺮﺘﻣ زا ﺖﻓﺎﺑ ﻲﺑﺮﭼ ﻪﻛ ﺪﻨﺘﺴﻫ رد لﺮﺘﻨﻛ ﻢﺴﻴﻟﻮﺑﺎﺘﻣ نﺪﺑ ﺖﻛﺮﺷ ﺪﻧراد . ﻦﻴﺴﭙﻳدآ زا ﻪﻠﻤﺟ ﻦﻴﻛﻮﭙﻳدآ ﺎﻫ هدﻮﺑ ﻪﻛ
ﺶﻘﻧ ﻚﻴﻤﺘﺴﻴﺳ رد ﻢﺴﻴﻟﻮﺑﺎﺘﻣ ﻲﺑﺮﭼ ﺎﻳ ﺮﻳﺎﺳ ﻢﺘﺴﻴﺳ يﺎﻫ ﻚﻳژﻮﻟﻮﻳﺰﻴﻓ ﻂﺒﺗﺮﻣ
ﺎﺑ ﺲﻧﻻﺎﺑ يژﺮﻧا نﺪﺑ دراد . رد تﺎﻌﻟﺎﻄﻣ نﻮﮔﺎﻧﻮﮔ ﺢﻄﺳ ﻲﻣﺮﺳ ﻦﻴﺴﭙﻳدآ ﺎﺑ ﺮـﻴﻴﻐﺗ
رد ﺺﺧﺎﺷ هدﻮﺗ ﻲﻧﺪﺑ Body Mass Index-BMI) (
، و ﺖﻣوﺎﻘﻣ ﻪﺑ ﻦﻴﻟﻮﺴﻧا هاﺮﻤﻫ هدﻮﺑ ﺖﺳا . ﻦﻳا ﻪﻌﻟﺎﻄﻣ ﺎﺑ فﺪﻫ ﻲﺳرﺮﺑ طﺎﺒﺗرا ﻦﻴﺴﭙﻳدآ ﺎﺑ مرﺪﻨﺳ ناﺪﻤﺨﺗ
ﻲﻠﭘ ﻚﻴﺘﺴﻴﻛ Poly Cystic Ovary Syndrome -PCOS ) (
مﺎﺠﻧا ﺪﺷ .
شور رﺎﻛ : ﻦﻳا ﻪﻌﻟﺎﻄﻣ درﻮﻣ - يﺪﻫﺎﺷ رد لﺎﺳ 1390 يور نارﺎﻤﻴﺑ ﻼﺘﺒﻣ ﻪﺑ مرﺪﻨﺳ ناﺪـﻤﺨﺗ ﻲـﻠﭘ ﻚﻴﺘـﺴﻴﻛ PCOS) ( ﻪـﻌﺟاﺮﻣ هﺪـﻨﻨﻛ ﻪـﺑ هﺎـﮕﻧﺎﻣرد ﺰـﻛﺮﻣ
تﺎﻘﻴﻘﺤﺗ دﺪﻏ نورد ﺰﻳر هﺎﮕﺸﻧاد مﻮﻠﻋ ﻲﻜﺷﺰﭘ ﺪﻴﻬﺷ ﻲﺘﺸﻬﺑ مﺎﺠﻧا ﺪﺷ . 45 رﺎﻤﻴﺑ ﻼﺘﺒﻣ ﻪﺑ مرﺪﻨﺳ ناﺪﻤﺨﺗ ﻲﻠﭘ ﻚﻴﺘﺴﻴﻛ و 45 ﺮﻔﻧ ﻪﺑ ناﻮﻨﻋ هوﺮـﮔ ﺪﻫﺎـﺷ ﻪـﺑ
شور ﻪﻧﻮﻤﻧ يﺮﻴﮔ نﺎﺳآ بﺎﺨﺘﻧا و ﻲﺳرﺮﺑ ﺪﻧﺪﺷ . ﺢﻄﺳ ﻲﻣﺮﺳ نﻮﻣرﻮﻫ ﻦﻴﺴﭙﻳدآ و ﻦﻴﻟﻮﺴﻧا ﻪﺑ شور اﺰﻳﻻا و ﺢﻄﺳ ﻲﻣﺮﺳ ﺰﻛﻮﻠﮔ ﻪﺑ شور ﮓﻧر ﻲﺠﻨﺳ ﻲﻤﻳﺰﻧآ
رد ﺖﻟﺎﺣ ﺎﺘﺷﺎﻧ هﺪﻴﺠﻨﺳ ﺪﺷ . هداد ﺎﻫ ﺎﺑ هدﺎﻔﺘﺳا زا نﻮﻣزآ
،ﻞﻘﺘﺴﻣT ﺐﻳﺮﺿ ﻲﮕﺘﺴﺒﻤﻫ و ﺰﻴﻟﺎﻧآ ﺲﻧﺎﻳراو ﻚﻳ ﻪﻓﺮﻃ ﻪﺑ ﻚﻤﻛ مﺮﻧ راﺰﻓا SPSS16 ﻞﻴﻠﺤﺗ ﺪﺷ .
ﺎﻫ ﻪﺘﻓﺎﻳ : طﺎﺒﺗرا ﻲﻨﻌﻣ يراد ﻦﻴﺑ ناﺰﻴﻣ ﻦﻴﺴﭙﻳدآ مﺮﺳ و يرﺎﻤﻴﺑ مرﺪﻨﺳ ناﺪﻤﺨﺗ ﻲﻠﭘ ﻚﻴﺘﺴﻴﻛ دﻮﺟو ﺖﺷاﺪﻧ ) 24 /
±7 93 / 15 مﺮﮔﻮﻧﺎﻧ ﺮﺑ ﻲﺳد ﺮﺘﻴﻟ رد نارﺎـﻤﻴﺑ
ﻼﺘﺒﻣ PCOSﻪﺑ و
±7,53 14,24 مﺮﮔﻮﻧﺎﻧ ﺮﺑ ﻲﺳد ﺮﺘﻴﻟ رد هوﺮـﮔ ﺪﻫﺎـﺷ 272 / p=0 ( . ناﺰـﻴﻣ ﺰﻛﻮـﻠﮔ و ﻦﻴﻟﻮـﺴﻧا رد داﺮـﻓا رﺎـﻤﻴﺑ ) ﻪـﺑ ﺐـﻴﺗﺮﺗ 4 /
±13 1 / 104
) 047 / (p= 0 ﻲﻠﻴﻣ مﺮﮔ ﺮﺑ ﻲﺳد ﺮﺘﻴﻟ و 2 /
±5 8 / 10 ) ، 000 / (p<0 ﻲﻠﻴﻣ ﺖﻴﻧﻮﻳ ﺮﺘﻴﻟ ﺮﺑ ( ﺮﺗﻻﺎﺑ زا داﺮﻓا هوﺮﮔ ﺪﻫﺎﺷ ﻮﻫدﻮﺑ ﻦﻳا داﺮﻓا ﻼﺘﺒﻣ ﻪﺑ ﺖﻣوﺎﻘﻣ ﻪﺑ ﻦﻴﻟﻮﺴﻧا
ﺪﻧدﻮﺑ .
ﻪﺠﻴﺘﻧ يﺮﻴﮔ : ﻦﻳا ﻪﻌﻟﺎﻄﻣ طﺎﺒﺗرا ﻲﻨﻌﻣ يراد ﻦﻴﺑ ناﺰﻴﻣ ﻦﻴﺴﭙﻳدآ و مرﺪﻨﺳ ناﺪﻤﺨﺗ ﻲﻠﭘ ﻚﺘﺴﻴﻛ نﺎﺸﻧ ﻲﻤﻧ ﺪﻫد . ﻦﻜﻤﻣ ﺖﺳا ﺎﺑ گرﺰﺑ ﺮﺗ ندﺮـﻛ ﻪـﻌﻣﺎﺟ ﺎـﻳ
دوﺪﺤﻣ ندﺮﻛ هدر ﻲﻨﺳ طﺎﺒﺗرا ﻲﻨﻌﻣ يراد ﻦﻴﺑ نﻮﻣرﻮﻫ ﻦﻴﺴﭙﻳدآ و مرﺪﻨﺳ ناﺪﻤﺨﺗ ﻲﻠﭘ ﻚﻴﺘﺴﻴﻛ دﻮﺟو ﻪﺘﺷاد ﺪﺷﺎﺑ .
هژاوﺪﻴﻠﻛ ﺎﻫ :
،ﻦﻴﺴﭙﻳدآ
،ﻲﻗﺎﭼ ﺖﻣوﺎﻘﻣ ﻪﺑ
،ﻦﻴﻟﻮﺴﻧا مرﺪﻨﺳ ناﺪﻤﺨﺗ ﻲﻠﭘ ﻚﻴﺘﺴﻴﻛ PCOS ) (.
ﺖﻓﺎﻳرد ﺦﻳرﺎﺗ :
26 / 9 / 90 شﺮﻳﺬﭘ ﺦﻳرﺎﺗ :
17 / 2 / 91
و ﻲﻤﺷﺎﻫ ﻪﻤﻃﺎﻓ
نارﺎﻜﻤﻫ 2
ﻦﻴﺌﺗوﺮﭘﻮﭙﻴﻟ يﺎﻫ
ﺎﺑ ﻪﺘﻴـﺴﻧاد ﻻﺎـﺑ
ﺖﺒـﺴﻧ ﻪـﺑ داﺮـﻓا
ﻢﻟﺎﺳ ﺪﻧراد ) 5 - 2 (.
ًاﺮﻴﺧا ﺖﻓﺎﺑ ﻲﺑﺮﭼ ﻪﻧ ﺎـﻬﻨﺗ ﻪـﺑ ناﻮـﻨﻋ ﻚـﻳ ماﺪـﻧا
هﺮﻴﺧذ يا يژﺮﻧا دازﺎﻣ ﻪﻜﻠﺑ ﻪﺑ ناﻮﻨﻋ ﻢﺘﺴﻴﺳ لﺎـﻌﻓ
ﻲﻧﻮﻣرﻮﻫ رد
لﺮﺘﻨﻛ ﻢﺴﻴﻟﻮﺑﺎﺘﻣ حﺮـﻄﻣ
هﺪـﺷ ﺖـﺳا .
ﻦﻳا ﺖﻓﺎﺑ ﻦﻳﺎﻛﻮﺘﻴﺳﻮﭙﻳدآ ﺎﻫ
ﻪﻛ يداﺪﻌﺗ ﻦﻴﺌﺗوﺮﭘ
ﺎـﺑ
ﺖﻴﻟﺎﻌﻓ ﻲﺘﺴﻳز ﻲﻣ ﺪﻨﺷﺎﺑ ار ﺢﺷﺮﺗ ﻲﻣ ﺪﻨﻛ ) 6 (.
زا نﺎﻴﻣ ﻦﻴﺌﺗوﺮﭘ يﺎـﻫ
ﻲﺤـﺷﺮﺗ زا
ﺖـﻓﺎﺑ ﻲـﺑﺮﭼ
ﻦﻴــﺴﭙﻳدآ ﻲﻟدﺎــﻌﻣ
ياﺮــﺑ رﻮﺘﻛﺎــﻓ ﻞــﻤﻜﻣ
ﺖــﺳاD
) 7 و 8 ( . ﻦﻴﺴﭙﻳدآ ﻂﺳﻮﺗ
CFDنژ Complement )
Factor D (
ﺮﺑ يور موزﻮﻣوﺮﻛ 10
نﺎﻴﺑ هﺪﺷ ﺖـﺳا .
نژ ﻦﻴﺴﭙﻳدآ ﺖﺒﺴﻧ
ﻪﺑ ﻞﺤﻣ يﺮـﻴﮔراﺮﻗ نژ
ﺖـﺑﺎﻳد
) موزﻮﻣوﺮﻛ 4
( ﺎﻳ ﻲﻗﺎﭼ ) موزﻮﻣوﺮﻛ 6
( نرﺎﻘﺘﻣﺎﻧ ﺖﺳا
.
ﻦﻳاﺮﺑﺎﻨﺑ تاﺮﻴﻐﺗ
ﺖﻈﻠﻏ ﻦﻴﺴﭙﻳدآ رد
ﻦﻳا يرﺎﻤﻴﺑ ﺎﻫ
ﻪﺑ ﻞﻴﻟد ﺺﻘﻧ ﻲـﻤﻴﻈﻨﺗ ﻲـﻣ
ﺪـﺷﺎﺑ ) 9 ( . ﻦﻴـﺴﭙﻳدآ
ًﻼﺒﻗ ﻪﺑ ترﻮﺻ رﻮﺘﻛﺎـﻓ ﻞـﻤﻜﻣ ﻲﻧﺎـﺴﻧا D
ﻪﺘﺧﺎﻨـﺷ
ﻲﻣ
،ﺪﺷ ﻲﻟو هزوﺮـﻣا ﻪـﺑ ناﻮـﻨﻋ ﻦﻴـﺴﭙﻳدآ ﻲﻧﺎـﺴﻧا
ﻪﺘﺧﺎﻨــﺷ ﻲــﻣ
دﻮــﺷ ) 10 ( . رﻮﺘﻛﺎــﻓ ﻞــﻤﻜﻣ
ﺎــﻳD
ﻦﻴــﺴﭙﻳدآ يﻮــﻀﻋ
زا هداﻮﻧﺎــﺧ ﻦﻴــﺴﭙﻳﺮﺗﻮﻤﻴﻛ
يﺎــﻫ
ﻦﻳﺮﺳ زﺎﺌﺗوﺮﭘ ﺖﺳا ﻪﻛ زا ﺖﻴﺳﻮﭙﻳدآ ﺎﻫ
ﻪـﺑ نﺎـﻳﺮﺟ
نﻮــﺧ ﺢــﺷﺮﺗ ﻲــﻣ ﺪﻧﻮــﺷ ) 11 و 12 .(
رد يﺎﻫﺪــﻨﻳآﺮﻓ
ﻚﻳژﻮﻟﻮﻴﺑ ﻲﻋﻮﻨﺘﻣ
زا ﻪﻠﻤﺟ ﻪﺘﺨﻟ نﺪﺷ
،نﻮﺧ لﺎﻌﻓ
نﺪﺷ ﻞﻤﻜﻣ
،ﺎﻫ
،يرورﺎﺑ ﻢﺘـﺴﻴﺳ
،ﻲـﻨﻤﻳا ﻪﻌـﺳﻮﺗ
و
ﻢﻴﻣﺮﺗ
،ﺎﻫ ﺖﻓﺎﺑ
،نﻮﺧرﺎﺸﻓ ﺮﻴﺛﺎﺗ
يورﺮـﺑ نزو
،نﺪـﺑ
بﺬﺟ
،ﻲﻳاﺬﻏداﻮﻣ ﻪـﻳﺰﺠﺗ
،ﻦﻳﺮـﺒﻴﻓ ﺮـﻴﺜﻜﺗ
،ﻲﻟﻮﻠـﺳ
مﺮـﻓ ﻲـﻫد ناﻮﺨﺘـﺳا و
ﺰﻳزﻮـﺘﭘﻮﭘآ ﻞـﻴﺧد
ﺪﻨﺘـﺴﻫ
) 11 و 13 .(
ﻦﻴﺴﭙﻳدآ ﺶﻘﻧ
ﻲﻤﻬﻣ رد ﻢﺘﺴﻴﺳ ﻲﻋﺎـﻓد
نﺎـﺑﺰﻴﻣ
ﻪﺑ ناﻮﻨﻋ ﻢﻳﺰﻧآ هﺪﻨﻨﻛدوﺪﺤﻣ ﺖﻋﺮﺳ
ﺶﻨـﻛاو ﺎـﻫ رد
ﺮﻴﺴﻣ نﺎﻤﻠﭙﻤﻛﻮﻴﺗﺎﻧﺮﺘﻟآ ﺖﻟﺎﺧد
دراد ) 11 و 14 .(
ﻦـﻳا
ﺮﻴــﺴﻣ ﻚــﻳژﻮﻟﻮﻴﺑ رد
عﺎــﻓد ﻲــﻌﻴﺒﻃ نﺪــﺑ
رد ﺮــﺑاﺮﺑ
ﻞــﻣاﻮﻋ ﻲﻧﻮــﻔﻋ
ﺶــﻘﻧ ﻲــﻤﻬﻣ دراد
. ﻦﻴــﺴﭙﻳدآ /
ﻞﻤﻜﻣرﻮﺘﻛﺎﻓ ردD
ﺖﻓﺎﺑ ﻲـﺑﺮﭼ ﺎـﺑ ﺖـﻈﻠﻏ ﻲﻳﻻﺎـﺑ
دﻮﺟو دراد ﻪﻛ نﺎﺸﻧ ﻲﻣ ﺪﻫد لﺎﻌﻓ يزﺎـﺳ ﻲـﻠﻤﻜﻣ
رد ﺖﻓﺎﺑ ﻲﺑﺮﭼ خر ﻲﻣ ﺪﻫد ) 7 و 14 .(
ﻲﻳﺎﺳﺎﻨﺷ ﻦﻴﺴﭙﻳدآ
ﻪﺑ ناﻮـﻨﻋ يرﻮﺘﻛﺎـﻓ ﻢـﻬﻣ
رد
يرﺎﻤﻴﺑ ﻲﻳﺎﻫ نﻮﭼ ﻲﻗﺎـﭼ و ﺖـﺑﺎﻳد ﺖﻣﺪـﻗ يدﺎـﻳز
دراﺪﻧ و زﻮﻨﻫ ﻪﺑ رﻮﻃ ﻞﻣﺎﻛ دﺮـﻜﻠﻤﻋ ﻦـﻳا
ﻦﻴﺌﺗوﺮـﭘ
ﻪﺘﺧﺎﻨﺷ هﺪﺸﻧ
ﺖﺳا ) 15 ( . ﻦﻴﺌﺗوﺮﭘ ﻦﻴﺴﭙﻳدآ
ياﺮـﺑ
ﻦﻴﻟوا رﺎﺑ رد لﺎـﺳ 1986 زا ﺖﻴـﺳﻮﭙﻳدآ ﺎـﻫ
ﻪـﻟوﺰﻳا هﺪــﺷ
ﺖــﺳا ) 16 ( ﻪــﻛ ﻪــﺑ رﻮــﻃ هﺪــﻤﻋ ﻂــﺳﻮﺗ
ﺖﻴﺳﻮﭙﻳدآ يﺎﻫ
L1 3T3- ﺢﺷﺮﺗ ﻲﻣ دﻮﺷ ) 13 (.
نﻮﻨﻛﺎﺗ ﻪﻌﻟﺎﻄﻣ يا ﺮﺑ يور طﺎﺒﺗرا ﻦﻴﺑ ﻦﻴﺴﭙﻳدآ و
مرﺪﻨﺳ ناﺪﻤﺨﺗ ﻲﻠﭘ
ﻚﻴﺘﺴﻴﻛ ترﻮﺻ
ﻪﺘﻓﺮﮕﻧ ﺖﺳا .
ﻲﻟو ﺎﺑ ﻪﺟﻮﺗ ﻪﺑ ﻪﻜﻧآ ﺖـﻈﻠﻏ ﻦﻴـﺴﭙﻳدآ رد
ﻲﻗﺎـﭼ و
ﺖﻣوﺎﻘﻣ ﻪـﺑ
ﻦﻴﻟﻮـﺴﻧا ﺮـﻴﻴﻐﺗ
ﻲـﻣ
،ﺪـﻨﻛ ﺮـﻈﻧ رد ﺎـﺑ
طﺎــﺒﺗرا لﺎــﻤﺘﺣا ﻦﺘﻓﺮــﮔ ﻢﻴﻘﺘــﺴﻣ
ﻦﻴــﺑ ﻲﻗﺎــﭼ و
ﺖـــﻣوﺎﻘﻣ ﻪـــﺑ
مرﺪﻨـــﺳ و ﻦﻴﻟﻮـــﺴﻧا ناﺪـــﻤﺨﺗ
ﻲﻠﭘ ﻚﻴﺘﺴﻴﻛ
،ﺖﺳا ﻪﻌﻟﺎﻄﻣ ﺮﺿﺎﺣ ﺎﺑ فﺪـﻫ ﻲـﺳرﺮﺑ
طﺎﺒﺗرا ﻦﻴﺴﭙﻳدآ مرﺪﻨﺳو
ناﺪﻤﺨﺗ ﻲـﻠﭘ
ﻚﻴﺘـﺴﻴﻛ
مﺎﺠﻧا ﺖﻓﺮﮔ .
شور رﺎﻛ
ﻪﻌﻟﺎﻄﻣ ﺮﺿﺎﺣ ﻚﻳ ﻪﻌﻟﺎﻄﻣ درﻮﻣ - يﺪﻫﺎـﺷ ﺖـﺳا
ﻪــﻛ يور نارﺎــﻤﻴﺑ ﻼﺘــﺒﻣ
ﻪــﺑ مرﺪﻨــﺳ ناﺪــﻤﺨﺗ
ﻲﻠﭘ ﻚﻴﺘـﺴﻴﻛ ﻪـﻌﺟاﺮﻣ
هﺪـﻨﻨﻛ ﻪـﺑ هﺎـﮕﻧﺎﻣرد نﺎـﻧز
نﺎﺘﺳرﺎﻤﻴﺑ ﺖﻳآ
ﷲا ﻲﻧﺎﻘﻟﺎﻃ رد
لﺎـﺳ 1390 مﺎـﺠﻧا
ﺖﻓﺮﮔ .
45 ﺮﻔﻧ رد هوﺮﮔ نارﺎﻤﻴﺑ ﻼﺘﺒﻣ PCOSﻪـﺑ
و 45
ﺮﻔﻧ رد هوﺮﮔ ﺪﻫﺎﺷ درﻮﻣ ﻲﺑﺎﻳزرا راﺮﻗ ﺪﻨﺘﻓﺮﮔ . هوﺮـﮔ
ﺪﻫﺎــﺷ زا نﺎــﻧز ﺐــﻠﻃواد ﺪــﻗﺎﻓ
يرﺎــﻤﻴﺑ رﻮﻛﺬــﻣ
ﺎــﺑ
نﺎﺴﻤﻫ يزﺎﺳ
ﻲﻨﺳ و ﺺﺧﺎﺷ هدﻮﺗ
ﻲﻧﺪـﺑ بﺎـﺨﺘﻧا
ﺪﻧﺪــﺷ . يداﺮــﻓا ﻪــﻛ
ﻲﻳﺎــﻫوراد ﺮــﻴﻈﻧ
ﻦﻴﻣرﻮــﻔﺘﻣ و
ﻲﻳﺎﻫوراد ﻪﻛ
ﺮﺑ نﻮﻣرﻮﻫ ﺎﻫ و ﻢﺴﻴﻟﻮﺑﺎﺘﻣ نﺪـﺑ
ﺮﺛﻮـﻣ
ﺪﺷﺎﺑ فﺮﺼﻣ هدﺮﻛ ﺪﻧا
، زا ﻪـﻌﻟﺎﻄﻣ فﺬـﺣ
ﺪﻧﺪـﺷ . زا
ﻦﻴﻌﺟاﺮﻣ ﻪﺑ
هﺎﮕﻧﺎﻣرد ﺰﻛﺮﻣ
تﺎﻘﻴﻘﺤﺗ دﺪﻏ
نورد ﺰﻳر
هﺎﮕـﺸﻧاد مﻮــﻠﻋ
ﻲﻜـﺷﺰﭘ ﺪﻴﻬــﺷ
ﻲﺘـﺸﻬﺑ )
ﻪــﺑ شور
ﻪﻧﻮﻤﻧ يﺮﻴﮔ نﺎﺳآ ( و ﻦﺘـﺷاد ﺖﻳﺎـﺿر
ﻪـﻣﺎﻧ ﻲـﺒﺘﻛ
ﺖــﻬﺟ هدﺎﻔﺘــﺳا زا
ﻪــﻧﻮﻤﻧ نﻮــﺧ ﺎﺘــﺷﺎﻧ
، رد حﺮــﻃ
ﻲﺗﺎﻘﻴﻘﺤﺗ هدﺎﻔﺘﺳا
ﺪﺷ .
تﺎــﺼﺨﺸﻣ ﻲﻓاﺮﮔﻮــﻣد
ﻞﻣﺎــﺷ
،ﻦــﺳ ﺲﻨــﺟ و
هداد يﺎــﻫ ﻲــﭘوﺮﺘﻧآ ﻞﻣﺎــﺷ
ﺪــﻗ ﺎــﺑ ﺖﻴــﺳﺎﺴﺣ 5
/ 0
ﻲﺘﻧﺎﺳ ﺮﺘﻣ
، نزو ﺎﺑ ﺖﻴﺳﺎﺴﺣ
100 مﺮﮔ و ﻪﭽﺨﻳرﺎﺗ
يرﺎﻤﻴﺑ ﺬﺧا ﺪﺷ و ﺺﺧﺎـﺷ هدﻮـﺗ
ﻲﻧﺪـﺑ زا ﻢﻴـﺴﻘﺗ
نزو ) مﺮﮔﻮﻠﻴﻛ (
ﺮﺑ روﺬﺠﻣ ﺪـﻗ ) ﻊـﺑﺮﻣﺮﺘﻣ (
ﻪﺒـﺳﺎﺤﻣ
ﺪﺷ . زا داﺮﻓا ﺐﻠﻃواد 3
ﻲﻠﻴﻣ ﺮﺘﻴﻟ نﻮﺧ يﺪﻳرو ﺎﺘـﺷﺎﻧ
رد ﺖﻟﺎﺣ ﻪﺘﺴﺸﻧ ﻪﺘﻓﺮﮔ ﺪﺷ . ﺲﭘ زا 5 ﻪﻘﻴﻗد نﺎـﻣز
،دﺎــﻘﻌﻧا مﺮــﺳ يﺎــﻫ رﻮﻛﺬــﻣ رد
يﺎــﻣد 80 - ﻪــﺟرد
ﻲﺘﻧﺎﺳ داﺮﮔ ﺎﺗ نﺎﻣز مﺎﺠﻧا ﺶﻳﺎﻣزآ يراﺪﻬﮕﻧ
ﺪﻧﺪـﺷ .
ناﺪﻤﺨﺗ مرﺪﻨﺳ ﺎﺑ ﻦﻴﺴﭙﻳدآ ﻲﻣﺮﺳ ﺢﻄﺳ طﺎﺒﺗرا
3 ...
لوﺪﺟ -1 تﺎﺼﺨﺸﻣ ﻲﻳﺎﻴﻤﻴﺷﻮﻴﺑ ﻚﻳﺮﺘﻣﻮﭘوﺮﺘﻧآو هوﺮﮔ
نارﺎﻤﻴﺑ ﻼﺘﺒﻣ ﻪﺑ مرﺪﻨﺳ ناﺪﻤﺨﺗ ﻲﻠﭘ ﻚﻴﺘﺴﻴﻛ PCOS ) ( و هوﺮﮔ ﺪﻫﺎﺷ
هوﺮﮔ ﺺﺧﺎﺷ نارﺎﻤﻴﺑ
ﻼﺘﺒﻣ PCOSﻪﺑ
n=45) ( ﺪﻫﺎﺷ
n=45) ( راﺪﻘﻣ p
هدوﺪﺤﻣ ﻲﻨﺳ 40
- 18 لﺎﺳ ﺎﺑ ﻦﻴﮕﻧﺎﻴﻣ 1 / 34
ﺪﻗ 162
±163 4 / 0 122 / 0
نزو
±71 4 / 0 9
/
±72 792 / 0
)BMI kg/m2 ( 3
/
±4 8 / 26 1
/
±4 7 / 25 98
/ 0
ﻦﻴﺴﭙﻳدآ ng/dl) ( 24
/
±7 93 / 15 53
/
±7 21 / 14 272 / 0
ﻦﻴﻟﻮﺴﻧا mu/l) ( 2
/
±5 8 / 10 4
/
±4 6 / 7 000 / 0
ﺰﻛﻮﻠﮔ mg/dl) ( 4
/
±3 1 / 104 3
/
±9 3 / 100 047
/ 0
ﺺﺧﺎﺷ ﺖﻣوﺎﻘﻣ ﻪﺑ ﻦﻴﻟﻮﺴﻧا HOMA-IR ) (
3
/
±1 8 / 2 1
/
±1 9 / 1 001 / 0
لوﺪﺟ
2 - راﺪﻘﻣ ﻲﮕﺘﺴﺒﻤﻫ نﻮﺳﺮﻴﭘ ﻦﻴﺑ يﺎﻫﺮﻴﻐﺘﻣ ﻲﻤﻛ ﻦﻴﺴﭙﻳدآ و ﺺﺧﺎﺷ ﺖﻣوﺎﻘﻣ ﻪﺑ ﻦﻴﻟﻮﺴﻧا HOMA-IR ) (
رد نارﺎﻤﻴﺑ ﻼﺘﺒﻣ PCOSﻪﺑ
p r لﺮﺘﻨﻛهوﺮﮔتاﺮﻔﻧداﺪﻌﺗ PCOSهوﺮﮔتاﺮﻔﻧداﺪﻌﺗ ﻲﺳرﺮﺑدرﻮﻣيﺎﻫﺮﻴﻐﺘﻣ 553
/
0 0/091 45 45 ﻪﺑﺖﻣوﺎﻘﻣﺺﺧﺎﺷوﻦﻴﺴﭙﻳدآﻲﻣﺮﺳﺢﻄﺳ
ﻦﻴﻟﻮﺴﻧا HOMA-IR) (
ﻪﻧﻮﻤﻧ يﺎﻫ مﺮـﺳ ياﺮـﺑ هزاﺪـﻧا يﺮـﻴﮔ ﺖـﻈﻠﻏ يﺎـﻫ
،ﺰﻛﻮﻠﮔ ﻦﻴﻟﻮﺴﻧا و
ﻦﻴﺴﭙﻳدآ مﺮﺳ
درﻮﻣ ﺶﻳﺎﻣزآ راﺮﻗ
ﺪــﻨﺘﻓﺮﮔ .
ﺢﻄــﺳ ﻦﻴــﺴﭙﻳدآ مﺮــﺳ
ﺎــﺑ شور ياﺰــﻳﻻا
ﻲﭽﻳوﺪﻧﺎﺳ ﺎﺑ
هدﺎﻔﺘـﺳا زا
ﺖـﻴﻛ ياﺰـﻳﻻا ﻦﻴـﺴﭙﻳدآ
ﻲﻧﺎﺴﻧا )
؛پﻮﺗوﺰﻳا ﻦﭘاژ
( ﺎﺑ ﺖﻴﺳﺎﺴﺣ 39
/ 0 مﺮﮔﻮﻜﻴﭘ
ﺮﺑ ﻲﻠﻴﻣ ﺮﺘﻴﻟ ﻦﻴـﻴﻌﺗ ﺪـﺷ . هزاﺪـﻧا يﺮـﻴﮔ نﻮـﻣرﻮﻫ
ﻦﻴﻟﻮﺴﻧا ﺰﻴﻧ
ﻪﺑ شور ياﺰﻳﻻا ﻲﭽﻳوﺪﻧﺎﺳ ﺎﺑ
هدﺎﻔﺘـﺳا
زا ﺖــﻴﻛ )
؛پﻮــﺗوﺰﻳا ﺪﺋﻮــﺳ
( مﺎــﺠﻧا ﺖــﻓﺮﮔ . ناﺰــﻴﻣ
ﺖﻣوﺎﻘﻣ ﻪﺑ
ﻦﻴﻟﻮﺴﻧا ﻪﺑ
شور ﺮﻳز ﻪﺒﺳﺎﺤﻣ ﺪﻳدﺮﮔ
:
HOMA:Fasting Serum Insulin (μu⁄ml) × Insulin Fasting Plasma Glucose (mmol) /22.5
ﺰﻛﻮﻠﮔ ﺎﺑ شور ﮓﻧر ﻲﺠﻨﺳ ﻲﻤﻳﺰﻧآ ﺎﺑ هدﺎﻔﺘـﺳا زا
ﺖﻴﻛ ) ناﺮﻳا ( هزاﺪﻧا يﺮـﻴﮔ ﺪـﺷ . رد ﺖـﻳﺎﻬﻧ بﺬـﺟ
يرﻮﻧ و ﻪﺒﺳﺎﺤﻣ ﺞﻳﺎـﺘﻧ
ﻂـﺳﻮﺗ هﺎﮕﺘـﺳد ﺮﮕـﺸﻧاﻮﺧ
اﺰﻳﻻا هﺪﻧاﻮﺧ ﺪﺷ .
ﻪﻳﺰﺠﺗ و ﻞﻴﻠﺤﺗ هداد ﺎﻫ ﻂﺳﻮﺗ مﺮـﻧ راﺰـﻓا يرﺎـﻣآ
SPSS16 مﺎﺠﻧا ﺖﻓﺮﮔ . مﺎﻤﺗ ﺞﻳﺎﺘﻧ ﻪﺑ ﺖـﺳد هﺪـﻣآ
ﻪﺑ ترﻮﺻ ﻦﻴﮕﻧﺎﻴﻣ فاﺮﺤﻧا±
رﺎـﻴﻌﻣ نﺎـﻴﺑ ﺪـﺷ . ﺎـﺑ
هدﺎﻔﺘﺳا زا
نﻮﻣزآ فوﺮﮔﻮﻤﻟﻮﻛ -
،فﻮﻧﺮﻴﻤـﺳا ﻊـﻳزﻮﺗ
ﺎــﻫﺮﻴﻴﻐﺘﻣ درﻮــﻣ
ﻲــﺳرﺮﺑ راﺮــﻗ
ﺖــﻓﺮﮔ ﻪــﻛ ﻪــﻴﻠﻛ
ﺮﻴﻐﺘﻣ يﺎﻫ ﻲﻤﻛ ﻪﺑ يﺎﻨﺜﺘﺳا
ﺮﻴﻐﺘﻣ ﻦﻴﻟﻮـﺴﻧا ياراد
ﻊﻳزﻮﺗ لﺎـﻣﺮﻧ ﺪـﻧدﻮﺑ ) لﺎـﻣﺮﻧ ندﻮـﺑ ﻊـﻳزﻮﺗ هداد ﺎـﻫ
ﻲﺳرﺮﺑ ﺪـﺷ . ﺲـﭘ زا نﺎـﻨﻴﻤﻃا زا
لﺎـﻣﺮﻧ ندﻮـﺑ رد
ﻒﻴﺻﻮﺗ هداد
ﺎﻫ زا ﻦﻴﮕﻧﺎﻴﻣ هدﺎﻔﺘﺳا
ﺪﺷ .(
ﺎﺑ ﻪـﺟﻮﺗ ﻪـﺑ لﺎـﻣﺮﻧ ندﻮـﺒﻧ ﺮـﻴﻴﻐﺘﻣ ﻦﻴﻟﻮـﺴﻧا
زا
ﻞﻳﺪﺒﺗ ﻲﻤﺘﻳرﺎﮕﻟ ﻪﺑ
رﻮﻈﻨﻣ لﺎﻣﺮﻧ ندﺮﻛ نآ هدﺎﻔﺘﺳا
ﺪﺷ . ﻪﺑ رﻮﻈﻨﻣ ﻪـﺴﻳﺎﻘﻣ ﻦﻴﮕﻧﺎـﻴﻣ
ﻦﻴـﺑ هوﺮـﮔ ﺎـﻫ زا
نﻮــﻣزآ ﻞﻘﺘــﺴﻣT
و ياﺮــﺑ ﻲــﺳرﺮﺑ ﻪــﻄﺑار
ﻦﻴــﺑ
يﺎﻫﺮﻴﻐﺘﻣ ﻲﻤﻛ
رد هوﺮﮔ ﺎﻫ زا ﺐﻳﺮـﺿ ﻲﮕﺘـﺴﺒﻤﻫ
نﻮﺳﺮﻴﭘ هدﺎﻔﺘﺳا
ﺪﺷ . فﻼﺘﺧا ﻲـﻨﻌﻣ
راد ندﻮـﺑ رد
ﺢﻄﺳ 05 / 0 α= ﻲﺳرﺮﺑ ﺪﺷ .
ﻳ ﻪﺘﻓﺎ ﺎﻫ
هدﺪﺤﻣ ﻲﻨﺳ رد ﺮﻫ ود هوﺮﮔ 18 ﺎـﺗ 40 لﺎـﺳ ﺎـﺑ
ﻦﻴﮕﻧﺎﻴﻣ 1
/ 34 لﺎﺳ دﻮﺑ ) لوﺪﺟ 1 .(
ﻦﻴﮕﻧﺎﻴﻣ ﺢﻄﺳ
ﻲﻣﺮﺳ
نﻮﻣرﻮﻫ يﺎﻫ
،ﻦﻴﺴﭙﻳدآ ﻦﻴﻟﻮﺴﻧا
و ﺰﻛﻮـﻠﮔ رد هوﺮـﮔ
ﺪﻫﺎﺷ و هوﺮﮔ رﺎﻤﻴﺑ ﻼﺘﺒﻣ ﻪـﺑ ردPCOS لوﺪـﺟ 1
نﺎــﺸﻧ هداد هﺪــﺷ ﺖــﺳا . ﻦﻴﮕﻧﺎــﻴﻣ ﺢﻄــﺳ
ﻲﻣﺮــﺳ
ﻦﻴﻟﻮـﺴﻧا ﻪــﺑ
رﻮـﻃ ﻲــﻨﻌﻣ يراد رد داﺮـﻓا ﻼﺘــﺒﻣ ﻪــﺑ
ﺮﺘﺸﻴﺑPCOS زا هوﺮﮔ ﺪﻫﺎﺷ دﻮﺑ ) 000 / (p<0 . ﻦﻴﺑ
ﺢﻄﺳ ﻲﻣﺮﺳ ﻦﻴـﺴﭙﻳدآ و
يرﺎـﻤﻴﺑ طﺎـﺒﺗراPCOS
ﻲــﻨﻌﻣ يراد
دﻮــﺟو ﺖــﺷاﺪﻧ
) 272 / (p=0 . ﻲــﻟو
و ﻲﻤﺷﺎﻫ ﻪﻤﻃﺎﻓ
نارﺎﻜﻤﻫ 4
ﻦﻴﮕﻧﺎﻴﻣ ﺢﻄﺳ
ﻲﻣﺮﺳ ﺰﻛﻮﻠﮔ ﻪـﺑ رﻮـﻃ ﻲـﻨﻌﻣ يراد
ﺮﺘﺸﻴﺑ زا هوﺮﮔ ﺪﻫﺎﺷ دﻮﺑ ) 05 / (p<0 ) لوﺪﺟ 1 .(
ﻦﻴﺑ ﺢﻄﺳ ﻲﻣﺮﺳ ﻦﻴﺴﭙﻳدآ ﺖﻣوﺎﻘﻣو
ﻪﺑ ﻦﻴﻟﻮﺴﻧا
رد نارﺎــﻤﻴﺑ ﻼﺘــﺒﻣ
PCOSﻪــﺑ طﺎــﺒﺗرا ﻲــﻨﻌﻣ
يراد
دﻮﺟو ﺖﺷاﺪﻧ 553)
/ (p= 0 ) لوﺪﺟ 2 .(
ﺚﺤﺑ ﺘﻧو ﻴ ﻪﺠ ﮔ ﻴ ﺮ ي
ﺞﻳﺎــﺘﻧ ﻪــﻌﻟﺎﻄﻣ ﺮــﺿﺎﺣ
نﺎــﺸﻧ داد ﻪــﻛ طﺎــﺒﺗرا
ﻲﻨﻌﻣ يراد ﻦﻴﺑ ﺢﻄﺳ ﻲﻣﺮـﺳ ﻦﻴـﺴﭙﻳدآ و
يرﺎـﻤﻴﺑ
مرﺪﻨﺳ ناﺪـﻤﺨﺗ ﻲـﻠﭘ
ﻚﻴﺘـﺴﻴﻛ PCOS)
( دﻮـﺟو
اﺪﻧ در . ﻦﻴﻨﭽﻤﻫ طﺎـﺒﺗرا
ﻲـﻨﻌﻣ يراد ﻦﻴـﺑ ﺢﻄـﺳ
ﻲﻣﺮﺳ ﻦﻴﺴﭙﻳدآ و
ﺖﻣوﺎﻘﻣ ﻪـﺑ
ﻦﻴﻟﻮـﺴﻧا )
ﺺﺧﺎـﺷ
ﺖﻣوﺎﻘﻣ ﻪـﺑ
ﻦﻴﻟﻮـﺴﻧا HOMA-IR
( ﺰـﻴﻧ هﺪﻫﺎـﺸﻣ
ﺪــﺸﻧ . رد ﻦــﻳا ﻪــﻌﻟﺎﻄﻣ طﺎــﺒﺗرا
ﻲــﻨﻌﻣ يراد ﻦﻴــﺑ
ﺖﻣوﺎﻘﻣ ﻪﺑ
ﻦﻴﻟﻮﺴﻧا و
يرﺎﻤﻴﺑ مرﺪﻨﺳ ناﺪﻤﺨﺗ ﻲـﻠﭘ
ﻚﻴﺘﺴﻴﻛ PCOS)
( دﻮﺟو ﺖﺷاد و ناﺰﻴﻣ ﻦﻴﻟﻮـﺴﻧا
و ﺰﻛﻮﻠﮔ رد ﻦﻳا يرﺎﻤﻴﺑ ﺶﻳاﺰﻓا ﺖﻓﺎﻳ . ﻪﺑ رﻮﻃ ﻲـﻠﻛ
نﻮﻨﻛﺎــﺗ ﻪــﻌﻟﺎﻄﻣ
يا ﻪــﺑ رﻮــﻈﻨﻣ ﻲــﺳرﺮﺑ
طﺎــﺒﺗرا
ﻦﻴﺴﭙﻳدآ و
نﻮﻣرﻮﻫ ﺖﻓﺎﺑ
ﻲﺑﺮﭼ ﺎﺑ مرﺪﻨﺳ ناﺪﻤﺨﺗ
ﻲﻠﭘ ﻚﻴﺘﺴﻴﻛ PCOS)
( ترﻮﺻ ﻪﺘﻓﺮﮕﻧ ﺖﺳا .
Traub رد لﺎﺳ 2011 ﻖﺒﻃ ﻪﻌﻟﺎﻄﻣ يا ﻪﻛ مﺎﺠﻧا
داد ﺖﻓﺎﻳرد ناﺰﻴﻣ ﻦﻴﻟﻮﺴﻧا رد
مرﺪﻨﺳ ناﺪﻤﺨﺗ ﻲﻠﭘ
ﻚﻴﺘﺴﻴﻛ PCOS)
( ﺶﻳاﺰﻓا ﻲـﻣ ﺪـﺑﺎﻳ ) 17 ( . ﻪـﺠﻴﺘﻧ
شراﺰﮔ هﺪﺷ ﻮﺴﻤﻫ ﺎـﺑ ﻪـﺘﻓﺎﻳ يﺎـﻫ ﻪـﻌﻟﺎﻄﻣ ﺮـﺿﺎﺣ
ﺖﺳا .
ﻮــﭼ و نارﺎــﻜﻤﻫ رد
لﺎــﺳ 1992 ﺎــﺑ ندﺮﻛرﺎــﻤﻴﺗ
ﺖﻴﺳﻮﭙﻳدآ يﺎﻫ
ﺖﺸﻛ هﺪﺷ ﺎﺑ ﻦﻴﻟﻮﺴﻧا ﻪﺟﻮﺘﻣ
ﺪﻧﺪﺷ
m RNAنﺎﻴﺑ ﻦﻴﺴﭙﻳدآ
% 75 و ﺎﺑ ﻖـﻳرﺰﺗ ﺪـﻨﻗ ﻪـﺑ
شﻮﻣ ﺎﻫ ﺰﻴﻧ m RNAنﺎﻴﺑ
ﻦﻴـﺴﭙﻳدآ
% 68 ﺶﻫﺎـﻛ
ﻲﻣ ﺪﺑﺎﻳ ) 18 ( . رد ﻪﻛ ﻲﻟﺎﺣ رﺎﻨﻴﻠﻣا
ﺮـﺑ ﺶﻧارﺎـﻜﻤﻫ و
سﺎﺳا تﺎﻘﻴﻘﺤﺗ مﺎﺠﻧا
هداد رد لﺎـﺳ 2007 رﺎـﻬﻇا
ﺪﻨﺘﺷاد ناﺰﻴﻣ ﻦﻴﺴﭙﻳدآ رد
ﺖﻣوﺎﻘﻣ ﻪﺑ
ﻦﻴﻟﻮﺴﻧا ﻪﻛ
ناﺰﻴﻣ ﻦﻴﻟﻮﺴﻧا ﺶﻴﺑ
زا ﺪﺣ لﺎـﻣﺮﻧ
،ﺖـﺳا ﺶﻳاﺰـﻓا
ﻲﻣ ﺪﺑﺎﻳ ) 19 ( ﻪﻛ ﻦﻳا ﺞﻳﺎﺘﻧ شراﺰﮔ هﺪـﺷ فﻼﺧﺮـﺑ
ﻪﺠﻴﺘﻧ ﻲﻣ ﺮﺿﺎﺣ ﻪﻌﻟﺎﻄﻣ ﺪﺷﺎﺑ
.
ﻖــﺒﻃ تﺎــﻌﻟﺎﻄﻣ مﺎــﺠﻧا
ﻪــﺘﻓﺮﮔ ﻂــﺳﻮﺗ
نزور و
نارﺎــﻜﻤﻫ رد
لﺎــﺳ 1989 ناﺰــﻴﻣ ﻦﻴــﺴﭙﻳدآ
رد
نﺎﮔﺪﻧﻮﺟ )
ﻞـﺜﻣ شﻮـﻣ ( ﻼﺘـﺒﻣ ﻪـﺑ ﻲﻗﺎـﭼ ﺶﻫﺎـﻛ
ﻲﻣ ﺪﺑﺎﻳ ) 10
، 16 و 20 ( ﻪـﻛ ﻪـﺑ ناﻮـﻨﻋ ﻚـﻳ ﻪﻧﺎـﺸﻧ
ﻪﻳﻮﻧﺎﺛ ﻲﻗﺎﭼ ﻪﺑ رﺎﻤﺷ ﻲﻣ دور ) 23 - 21 (.
رد ﻞﺑﺎﻘﻣ ﺮﺑ سﺎــﺳا
تﺎــﻌﻟﺎﻄﻣ ﻮﻧﺎــﺘﻴﻟﻮﭘﺎﻧ
و نارﺎــﻜﻤﻫ رد
لﺎــﺳ
1994 رد نﺎﺴﻧا
،ﺎﻫ ناﺰـﻴﻣ ﻦﻴـﺴﭙﻳدآ رد
ﻲﻗﺎـﭼ ـﺑ ﺎ
ﺶﻳاﺰﻓا ﺖﻓﺎﺑ ﻲﺑﺮﭼ ﺶﻳاﺰﻓا ﻲﻣ ﺪﺑﺎﻳ ) 16 ( . تﺎﻴﺑﺮﺠﺗ
ﻮﻧﺎﺘﻴﻟﺮﭘﺎﻧ نارﺎﻜﻤﻫو
ﺪﻳﻮﻣ تﺎـﻴﺑﺮﺠﺗ ﺎـﻣ
رد ﻖـﻴﻘﺤﺗ
ﺮﺿﺎﺣ ﺖﺳا .
ﺎﻴــﺴﻜﻳا و
نارﺎــﻜﻤﻫ ﻖــﺒﻃ
ﻲﺗﺎــﻘﻴﻘﺤﺗ رد
لﺎــﺳ
2003 ﻪﺑ ﻦﻳا ﻪﺠﻴﺘﻧ ﺪﻧﺪﻴﺳر ﻪﻛ
رد نادﺮـﻣ ناﺰـﻴﻣ
ﻦﻴﺴﭙﻳدآ رد
ﺖﻓﺎﺑ ﻲﺑﺮﭼ يﺰﻛﺮﻣ ﺶﻳاﺰﻓا رد و ﺖﻓﺎﺑ
ﻲــﺑﺮﭼ ﻲﺘــﺳﻮﭘﺮﻳز ﺶﻫﺎــﻛ
ﻲــﻣ ﺪــﺑﺎﻳ . ﻦﻳاﺮﺑﺎــﻨﺑ ﺎــﺑ
ﺶﻳاﺰﻓا ﺺﺧﺎﺷ هدﻮﺗ
ﻲﻧﺪﺑ ﺖﺒﺴﻧ ﻲﺑﺮﭼ يﺰﻛﺮﻣ ﻪﺑ
ﻲﺑﺮﭼ ﻲﺘﺳﻮﭘﺮﻳز ﻦﻴﺴﭙﻳدآ
ﺶﻳاﺰﻓا ﻲـﻣ
،ﺪـﺑﺎﻳ ﻲـﻟو
رد نﺎــﻧز ﺎــﺑ ﺶﻳاﺰــﻓا ﺺﺧﺎــﺷ
هدﻮــﺗ ﻲﻧﺪــﺑ ناﺰــﻴﻣ
ﻦﻴﺴﭙﻳدآ ﺶﻫﺎﻛ
ﻲﻣ ﺪﺑﺎﻳ ﻪﻛ
ًﻻﺎﻤﺘﺣا ﺶﻫﺎـﻛ نﺎـﻴﺑ
ﻦﻴﺴﭙﻳدآ رد
ﺖﻓﺎﺑ ﻲﺑﺮﭼ نﺎﻧز ﻪـﺑ ﻪﻄـﺳاو دوﺪـﺤﻣ
ندﺮﻛ ﺮﺘﺸﻴﺑ ﻪﻌﺳﻮﺗ ﺖـﻓﺎﺑ ﻲـﺑﺮﭼ رد ﻲﻗﺎـﭼ ﺖـﺳا
) 24 (.
ﻼﻳو و نارﺎـﻜﻤﻫ رد
لﺎـﺳ 2011 رد ﻚـﻳ ﻪـﻌﻟﺎﻄﻣ
لﺮﺘﻨﻛ هﺪﺷ ﻖﻴﻗد ﺮﻴﺧا نﺎﺸﻧ ﺪﻧداد ﻪﻛ نﺎﻧز ﻼﺘـﺒﻣ
PCOSﻪﺑ ﺶﻳاﺰﻓا رد ﻢﺠﺣ ﺖـﻓﺎﺑ ﻲـﺑﺮﭼ ﻲﻳﺎـﺸﺣا
ﺪــﻧراﺪﻧ . ﻦﻳاﺮﺑﺎــﻨﺑ ﻊــﻳزﻮﺗ
ﻲــﺑﺮﭼ رد طﺎــﻘﻧ ﻲﻤﻜــﺷ
ﻒــﻳﺮﻌﺗ و
ﺢﻴــﺿﻮﺗ ﻲﻠﻣﺎــﻛ
ياﺮــﺑ يرﺎــﺠﻨﻫﺎﻧ يﺎــﻫ
ﻲﻜﻴﻟﻮﺑﺎﺘﻣ هﺪﻫﺎﺸﻣ
هﺪـﺷ PCOSرد
ﺖـﺴﻴﻧ )
25 ( .
ﻪﻌﻟﺎﻄﻣ قﻮﻓ ﺎﺑ ﺞﻳﺎﺘﻧ ﻣ ﻄ ﺎ ﻪـﻌﻟ ﺮـﺿﺎﺣ ﻲـﻨﻌﻳ طﺎـﺒﺗرا
ﻢﻴﻘﺘﺴﻣ ﻲﻗﺎﭼ
PCOSﺎﺑ تﺮﻳﺎﻐﻣ دراد
.
طﺎﺒﺗرا ﻲﻨﻌﻣ يراد ﻦﻴﺑ ﺢﻄﺳ ﻲﻣﺮﺳ ﻦﻴـﺴﭙﻳدآ و
يرﺎﻤﻴﺑ مرﺪﻨﺳ ناﺪـﻤﺨﺗ ﻲـﻠﭘ
ﻚﻴﺘـﺴﻴﻛ PCOS)
(
دﻮﺟو ﺖﺷاﺪﻧ . ﻦﻴـﻨﭽﻤﻫ طﺎـﺒﺗرا
ﻲـﻨﻌﻣ يراد ﻦﻴـﺑ
ﻦﻴﺴﭙﻳدآ و
ﺖﻣوﺎﻘﻣ ﻪﺑ
ﻦﻴﻟﻮﺴﻧا ﺰﻴﻧ
ﺖﻓﺎﻳ ﺪﺸﻧ . ﻲﻟو
ناﺰﻴﻣ ﻦﻴﻟﻮﺴﻧا و
ﺰﻛﻮﻠﮔ رد يرﺎﻤﻴﺑ مرﺪﻨﺳ ناﺪﻤﺨﺗ
ﻲﻠﭘ ﻚﻴﺘﺴﻴﻛ ﺶﻳاﺰﻓا
ﻲﻣ ﺪﺑﺎﻳ و طﺎﺒﺗرا ﻲﻨﻌﻣ يراد
ﻦﻴــﺑ ﺖــﻣوﺎﻘﻣ ﻪــﺑ
ﻦﻴﻟﻮــﺴﻧا و
مرﺪﻨــﺳ ناﺪــﻤﺨﺗ
ﻲﻠﭘ ﻚﻴﺘﺴﻴﻛ هﺪﻫﺎﺸﻣ
ﺪﺷ .
زا ﻲﻳﺎﺠﻧآ ﻪـﻛ رد نﺎـﻧز ﺎـﺑ ﺶﻳاﺰـﻓا هدﻮـﺗ
ﻲﻧﺪـﺑ
ناﺰﻴﻣ ﻦﻴﺴﭙﻳدآ مﺮﺳ
ﺶﻫﺎـﻛ و
زا يﻮـﺳ ﺮـﮕﻳد ﺎـﺑ
ﺶﻳاﺰﻓا ﺖﻣوﺎﻘﻣ ﻪﺑ
ﻦﻴﻟﻮﺴﻧا ناﺰﻴﻣ
ﺶﻳاﺰﻓا ﻲﻣ ﺪﺑﺎﻳ
،اﺬﻟ مﺪﻋ هﺪﻫﺎﺸﻣ توﺎﻔﺗ
رد ﻦﻳا هوﺮﮔ ﻲـﻣ ﺪـﻧاﻮﺗ ﻪـﺑ
ﻪﻄﺳاو ﺮﺛا شوﺪﺨﻣ ﻲﮔﺪﻨﻨﻛ
ﻦﻳا ود ﻞﻣﺎﻋ ﺪﺷﺎﺑ . ﻪﺑ
هوﻼﻋ ﺶﻳاﺰﻓا ﻢﺠﺣ ﻪﻧﻮﻤﻧ و ﻦﺘﺷاد ﻪـﻧﻮﻤﻧ ﻲﻓﺎـﻛ زا
هوﺮﮔ يﺎﻫ ﻒﻠﺘﺨﻣ هدﻮﺗ ﻲﻧﺪﺑ ﻲـﻣ ﺪـﻧاﻮﺗ ﻪـﺑ ﻲـﺳرﺮﺑ
تاﺮﻴﻴﻐﺗ ﻦﻴـﺴﭙﻳدآ
رد ﻦﻴـﺑ نﺎـﻳﻼﺘﺒﻣ ﻪـﺑ
مرﺪﻨـﺳ
ناﺪﻤﺨﺗ مرﺪﻨﺳ ﺎﺑ ﻦﻴﺴﭙﻳدآ ﻲﻣﺮﺳ ﺢﻄﺳ طﺎﺒﺗرا
5 ...
ناﺪﻤﺨﺗ ﻲﻠﭘ
ﻚﻴﺘﺴﻴﻛ ﻚﻤﻛ
ﺪﻳﺎﻤﻧ .
ﻊﺑﺎﻨﻣ
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Original Article
Association of serum adipsin levels with polycystic ovarian syndrome
Fatemeh Hashemi, MSc. Department of Biology, Faculty of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran. [email protected]
Parichehre Yaghmaei, PhD. Professor of Biochemistry, Department of Biology, Faculty of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran. [email protected]
Naghmeh Saadati, MSc. Department of Biology, Faculty of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran. [email protected]
Sepideh Haghighi Poodeh, MSc. Department of Biology, Faculty of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran. [email protected]
Fahimeh Ramezani Tehrani, MD. Assistant Professor of Obstetrics and Gynecology, Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
*Mehdi Hedayati, PhD. Associate Professor of Clinical Biochemistry, Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran (*Corresponding author). [email protected]
Abstract
Background: Adipokines are proteins secreted from adipose tissue that are involved in metabolism control. Adipsin is one of the adipokines that has a systemic role in lipid metabolism or physiological systems relating to energy balance. Serum levels are found to be associated with BMI, and insulin resistance in several studies. The aim of this study was to assess adipsins association with Poly Cystic Ovary Syndrome (PCOS).
Methods: This case-control study was performed on patients who referred to the clinic of the Research Institute for Endocrine Sciences of Shahid-Beheshti University in 2011. Forty five patients with PCOS and 45 normal individuals as control group were selected by easy given sampling method and studied. Fasting adipsin and insulin serum levels were measured by Elisa method and fasting glucose serum level was measured by enzyme-calorimetric method. Data were analyzed using independent t-test, Pearson correlation coefficient and one-way ANOVA by SPSS 16 software.
Results: Adipsin serum levels did not correlate with insulin resistance in PCOS (15.93±7.24 ng/dl in PCOS patients and 14.21±7.53 ng/dl in control group). Glucose and insulin serum levels increased in PCOS (104.1±13.4 mg/dl and 10.8±5.2 mU/L respectively) in comparison with controls and these PCOS patients had insulin resistance.
Conclusion: This study does not show the correlation between adipsin level and PCOS. It is possible to find a relationship between PCOS and adipsin through expanding the population or limiting the age levels.
Keywords: Adipsin, Obesity, Insulin resistance, Poly Cystic Ovarian Syndrome (PCOS).
