. / ) 01 &
23
4 5 6 & 7 8 !
I W7c_ =C8
I \ C,
I% < T
* * *<
9 CO *
* # o +- $
E* >* f Y
% L S< #
p
. 7 -. ! G /! 5YG' = >5>?' 791 ` T /! $ !(
- 6 !
! 8
] 6 ! . 7 -. ! . 7 $V 0
) -
>?' 791 ` T /! 5 ! . 7 -. ! G /! 5YG' = >5
- 6 !
5YG' = >5>?' 791 V! / $ !C
- 6 ! . 7 -. ! G /!
6 ! . 7 -. ! ` T /! $ !P
# I:O! . 7
= >5>?' 791 16 S
- 6 ! G /! { 5YG'
-. g
#! . 7 -GI
[
F
6B -G%/
H
% &'
% (
k0 = D * ;- K - ; L @7A BC8
I
+A 1 C CWTC q*C= *
<
I
I
%* ] W1
? )* 4 CO < 5 ' * I ! .0&
D ] >*
] I
> <%,
*
4 5 & 4 T j = 1T < 7 * I
% =
?
> CT 17*
Z 17* C ! I%*%A Cc-
> CT [
% =
> C1* `* D C7- = D . T U r s O
< = 1T
= 1T %# > C1* D C7- = . T U ! = 9
% =
? P%
(
= AC = 4
IL-19
>* C1* j* &* D C7- = C ! I
IL-10
>* D : 5*% DM =
C >* C
5 * = * D + A 9 I
?
S< < C (
I< = T U
$$
%*% IC* t C- = D <%, >* W fp
W! IC* t C- I W u C1 < E
<
ff
_ W
%* ] 9 \ B 17 < ] D C7- = *
?
* vU
4 W1 = 9 >* C1
I
R&D
% :*/ w*<% S< =
%* ] I ]
<
1*
>* C1* vU
%7 C! j1 =
% :*/
I ]
%* ]
? 1 * (
> CT 17* vU > = Z
<
FEV1/FVC
7 + 1 * A C < ] CA< I
d [e[
x
p-
value
g
?
> CT 17* vU < > j Z
A C < ] / = % < ]
< 1 * A C < ]
1 *
E W!
y A C / = u C1
%*% 1 *
% = 7 I M 6 .< W >* T<
C+
? 1 * A C < ]
> CT 17* vU < > j Z
s* : =
FVC
s* : = < s* : FEV1 FEV1/FVC
s
%= *
6 M 7 I C+
?
\ 1 < hL=
I ] ( 9%- 7 .< W
> CT 17*
Z A C < ] > =
A C < 1 *
>* 5_ ;- 1
17* vU
> CT Z C7- =
% * 1 C CWTC = A C C = `* D
%7
>* s* : T<
> C1*
`* D C7 =
% 4 J -
5 & \* < 1T )#C
= 1T I
%7
?
i < % ; ( 17*
> CT Z IC* .0&
1 C CWTC
?
4 * l*
( m f m Z[
S *nO l*
( [ m Y m Z[
Q59 T1$G/! y_ 1&
(*
/ =J. & / 5 5 #! 1 g
%
&
$ :T -/-
"
1V 2
, E/ #! G &
6G ^J 1 ' & 1 G $ p2
79
- f Q/! Q5<<B$ &
4 !
"
( [,
! Q5&
2
mG $ :T / 5 5
1$ 5&
:$ ! - 4 !
o0 16/ & 4 %
$V G - ! 1'
"
8 [,
„ 7& 1V 2 '
Q/1
&1Z & ! I mG 1V! ! 152 4 !
"
) [,
(*R) (*RR
/` l ' / 5 5 Q/!
:$ ! !1/! # 2-G 5 N!1
!1Z 4\12
"
C ,[
5.T0 f E/ $ :T
& Z -GG9
2 / E5%9 ' $/
E5 ` ' E5 ` G5 9
' Q/! $5%5%9 ' 9 4 ! ]5 #1Z E/ ! !
- AB
4 !
"
S P [,
$ :T … !
&
3 … ! = O
"
M , 3 1/
"
15V ' ,
# 2 !
$%5 4 L / f z $B
<
@ ! 2 $%5
G /! $%5 #! B$ ! 7
1&
-/
"
R g ,[
V ' =J.
L / 15
K/ 9 4
'
# 2 ! Q/1 152
Q5 -<
4 ! / 5 5
"
(+
* ,
%5 . 4T V G /!
^1_ ! ; I$T!
-/
"
(8 ((
,[
= !72
# $ :T & 3 ' 9 -
† & - ! '
$%5 1 1. J$V!
! G /!
T
"
() [,
# = dT _
K/ 9 -
Q/1'
$\12 c Q5 -<
/ =- ! / 5 5
4 !
"
(C ,[
4Y b & $%&! / 1V 2 … !
/ … ! 4 ! #0 & 3 ' =-
& #0 !
4\1 5 # 4 p2
-G9
"
(P [, 5&
!-% !
! %:G' 45 1&
w ! . 1& Q 7
/ W ƒ9!1' 45T 5 1& 0
4/ \ G
1 5\ $ . 1& G 4/ W 45 1& ƒ9!1' / 5 5 Q5 -< / 15V ' =!1o! ! /
4 !
"
(S
* [, K/
$ :T 3 1/ … ! Q/1'
Q 7 45 1& / 5 5 Q5 -<
0
- t !72 $. 1&
4 !
"
(R (g ,[
-G/01\
M & I$T!
/! Q 7 l ' -
Q59 $/ $ :T
- ]> & I$T!
!
1&
- ! -I
"
(*
[, Q/ 9 $/
Q5ƒ' 1
-G$% /
! 9 y 1' & %$9! '!~ G /!
-
-/- ! 5%&
- ! ]> & I$T! G /!
[ Q59 T1$G/! 5 \ 1
(+
f
! !
Q/ 9 $/
! 4
IL10/19/20/22/26/28/29
f 9-GL = O & ! V Q/! c ! Q/! -GG9
Q/ 9 $/
4 IG'
# $V .5$ `
. & - ! V # 72! # 1$G/!
! x1$ $w
5 &0 75 I& T fV!
- ! V1&
"
8+
88 ,[
' Q/ 9 $/ Q/! ]> # G9
& I$T!-i f ! f. &
5&
! 2 2
5&
$
"
8)
8(
, 5&
- 9
"
88 8+
, 5&
%:G'
"
8P 8C , 5&
'!
# 5 /!
"
8g 8S ,
$M
5&
1.5
&
"
)+
8R , _ 1&
dT
$\12 !1Z Q59 T1$G/! 4 !
(*
4 ! Z
TH2
-G9 d\ ! [
1Y &
]> Q$\12
IL-19
y_ 0
IL-19
1&!1& 0 #! 5&
-5 G T !1\! #0 y_
- 1'W & 1/ > & 9 4 !
IL-4 IL-13
# 0 1
4 ! a ' !
"
8+
,[
5 ?' mG ' V ! -d& # G9!
& /1Z (++
!7
d / 5 5 -<
2 ! =- ! … ! =J. ! 9 !
-G$% U $
"
)(
,[
= >5>?' = dT _
! Q5 -< - 9 & #0 16 5& / 5 5
45T d\
; B$ ! 4I -/ &
t
>' !1& G
N G /! $%5 # 4/
!
"
)8 ,[
dT _ # G9 ' 5>$%
]5 Q/ 9 $/ -5T ' #!75
& I$T!
IL-19
1
I ! #! 5&
Q 7 … ! ! 9 $ 2 & $\ /
$ / /
[[[
U - 1&
$\16 !
4 ! [
&
45 ! & '
IL-19
! 16/ ./ #! G &
$/
Q/ 9 ! V
IL-10
#!75 9 /- #01&
! Q/ 9 5' Q/!
/ 5 5 #! 1
5/ 1&
[
S< < C
dT _ Q/! 0 d
! ! / 5 5 #!
/ =J.
# $ ! ! z $B
9 1 !1
!-d' 9 - &
)++
! 1:
A5B ' & 9 # 0
# 5%5 9
- =J. ! ! $ ! . 7
- & / 1I
()Rg 4 J ]/ ]/ &
- -/ 12 = # I:O! #!
[ 4/ i pV! ! •
#! . 1:Gcb &
R
- ; B$ ! !1\! ! 20 $9
4%5T
49
# 2-GG9 / I
-/ 12 [ 12 1& !1\!
I !
$\ / I !
$\ 5 9 ! E5\!12 G 1
-& ' AV Q f
f ' 45di
65 - f5 .' & #-5 9 f 9 = G/ d •w
$ L
L A<B$ l ' 5'1' & /
N \ / A<B$
< = O & / A<B' M
G/ d
! f 9 D5Z -
[
f L G/ d
!- !
%. ! ; 5 Q55d' E/ 7 -/ 152 E ! #!75 1& ‡ T 45 ! & !-Z # 6 1&
1 15 # 0 ! :$ ! &
( 8
!- !
L \ 152
5>$% ˆ . T $\! ! :$ ! & : V # 6 1&
) G5/0
& ! [ d
^1 G/ d f $ G/
M 4 %Z 5>$% -/
! :$ ! & #-& z $B
d & 1$ 15w ! 6$
M < f / G/
M ^1
/ \!12 / ! 1& / K
1$ 15w !
HRCT
&
[
1& 1$ 15w ! /1$/!19 3 !
"
(**P ,
American
Thorasic Society
1$ 15w ! 6$ ! :$ ! &
Chest 801
4?'
#! $ 1 ! 12 D5Z = Y
! 0 9 -/ 12
[
!1& dT _ & 5d
12 H
1 45%G Q
8+
' S+
>&
= o!
#! & $ 2 & I ! -
G / 5 5 9 z $B D
- 1 D . 7
#! 5G&
1$ 15w ! U/ $ D
! 12 ! ./ 5& -
= d/ i ! !
z5:V
$\12 !1Z -/- / l $ - &
[
1$G9 12 !1& dT _ & 5d H
45%G
1 Q 8+
' S+
- k V 5& & J$&!
1&
1& 3 !
- !
[
f 12 Q/!
PP
! 1:
# $ ! ! T !1\!
5& # !1 ‰7 / 9 z $B
cM /!1 ! 5' / - &
$ ! Q 1Y ! 9 -G
' AV •G
#-5 9 65 f ' 45di -&
O! = :' - & & 12 &
#0
!
&
& 1V 2 [
• 1& ! 3 !1& T - - !1\! #! 5&
5d dT _ ! r 1V
(CC 1:
1 Q/! !
-/- / … ! & # -<
Pg 1:
1
! !
l $ z5:V / … !
PP 1:
1 !1\! !
15b 1$G9 12 #! G & / 5 5 - - dT _ !
[ 5
I ! 12 G Q56
$ :T & $\ /
gnPg CSn8P ±
- 12
Rn8 Cgn(±
- &
[ !1\! ! E/ 1 ! g
_5? # V
$\12 f/1$ ! l/!1 -
[ -M 8
& # V !
f>$G >d !-i -Z \ T T -
[ T T
# V M
$BT (P++
>5Z
"
(P++rpm
,
=- &
(+
1 - - ` 5:/1$ >5Z -/ 12 !- # V ! #0
[
1 5I'
T T - M & EL 9
(++
5%>' - & 7/1\
8+
$ f>$G #!1I' & !12
6 / 0 -/ 12
- . 7 -. ! ` T G /!
g+
$ 6 !12
- - !
[
•w
#!75 1Y !
IL-19
491 ! !7/W! 459 ! :$ ! &
R&D
& ./1 0
- - 1& !7/W! •/ - t [
GI -. NJV! $5 9 N \ ` 1
-
/ <' #! . 7 h-
491 ! •5 !1\!
!- dT _ -G$
[ 1$G9 12 !1\! ' !
4/ i
$9
$\12 dT _ Q/! 491 4I -
[
- / 491 dT _ Q/! !1\! 491
? 15o '
4 !- !1\! Q/! # t16 [
. -08 J ;L < *:\ S<
H E5\!12 = <B
f ' 45di f - 12
=J5<?'
9 # 0 & @$ ! 45di
%/ >
- [ 1 y_
IL-19
&
x L 5 = O
]/ !
! 12 -
%/ > ! 0 # 0 & dT _ -
[
1$ 9 1/ >
+n+P Gd y_ #! Gd&
1Y !
$\12 - [
1 *
! 8*)
#! ! 1:
mG / 5 5 9 5 ?'
! !
1I 9 - & / - =J.
()Rg
!
# $ !
#! 4 J ]/ ]/ & z $B
= # I:O!
- - &
888 l/!1 & ' & 1:
! dT _ ! r 1V dT _
- - 1i M [
/ / 5 5 I !
$ :T & $\ / 1&
/
>
5G& -G&
/ / 5 5 12 T Z
l $ z5:V
Pg 1 -/- (CC G9 1 PP
# -& T 1
!
1& - 12 ! I
!1Z -G$\12 [
Q59 T1$G/! y_ 1&
(*
/ =J. & / 5 5 #! 1
*
- 9 _
( - Q56 5
O -
FVC
] 9 12 FEV1
$\ / 4 !
5$
4 %
# 5
#0
FEV1/FV
155@'
!-GL 1.
4 ! [
B<%A (
j A C I 1 < a Q* 1 >
1 *
1 C CWTC =
> j P L
FVC (%) P8nS
(gnR8
FEV1 (%) C(n+C
(gnRR
FEV1/FVC (%) gCnR8
8+nC8
K/
12 / 5& Q/1' 5'1' &
E5' 0 45 1&
"
)*n) ,u 45T 5 1&
u"
)Cn(
,
Q 7 45 1&
u"
8*n*
, -G &
-/ 1$ 9 75: 0
- 4 ! [
1$G/! 1 4Y b Q56 5
Q59 T (*
12
I !
$\ / ()Rn8(
8)+nRS± 1$G9 12
(*8ngC 8SRnSS±
- &
[
1 y_ 5 Q56 5
1$G/!
Q59 T (*
I ! 12 ! 1'W & - 12
$\ /
I ! 12
z5:V $\ /
! 1'W & l $ –
I ! -/- $\ / 0 1Y ! = :' Q/! T - &
Gd
! [
"
- 8
,
B<%A (
> CT 17* 46;_ + =
Z
< ] > = A C I
% < ] < 1 *
p-value2 p-value1
IL-19 (pg/ml)
IC* = *
9C z ' B< z ' P L > j %
8SgnCR (S*nC+ 8+CnRR (*8nCC 8SRnSS PP %
+ng8) 8g)n*+ (*SnC+ 8+(n8* 8++nPS 8CSn(C Pg u C1–E W!
+nSgS +n(R* 8C*n)S (PPnP8 (*gnS8 (()n+g 88PnSC (CC %*%
P-value1
H 1$G9 12 & %/ >
P-value2
H z5:V 12 Q5& %/ >
-/- l $
Gd a ' ! 0 ‚ ?T !
1 y_ Q5& !
1$G/!
Q59 T (*
Q &
FVC
12 FEV1
I ! !- $\ / [
Q59 T1$G/! 1 y_ Q5& !
(*
FEV1/FVC
a ' ! $\ / I ! 12
Gd
! !
[
"
+n+88
|
P-value
, /1i # 0
# Q 15w ! 6$%
:G a ' ! Q/! 9 !
]/!7\! & - &
FEV1/FVC
1 y_
Q59 T1$G/!
(*
!-5 ] 9 -G9
[
"
- )
,
Q59 T1$G/! 1 y_ Q5&
(*
5&
Q 7 45 1& 45T 5 1&
0 45 1&
E5'
0 75: 0 $. 1&
6G' / G5& G5& 5&
!1' I ! 12 & 1$G9 12 Q5&
& $\ / 12 Q5
I ! / 5& & $\ / a ' ! / 5& # -&
Gd 0 ‚ ?T ! ! 4 !-
[ Q56 5 y_
Q59 T1$G/! 1 (*
I ! !1\!
Q5/ $\ / 1'
!
I ! !1\! - 12
& & $\ /
1$ 9 / 5
I ! !1\! ! / 5& # -& $\ /
"
6G' 7 &
!1' , Gd 0 ‚ ?T ! 9 - &
! - &
[
B<%A (
46;_ + =
> CT 17*
Z
A C < ]
> = 1 * FVC
4+ <FEV1 FEV1/FVC
IL-19 (pg/ml)
+n+S+ Pearson Correlation
Q
+n)R) P-value
8() !-d'
+n+S( Pearson Correlation
FVC (%)
+nC(S P-value
(g* !-d'
+n++* Pearson Correlation
FEV1 (%)
+n*+) P-value
(g* !-d'
+n(g( Pearson Correlation
FEV1/FVC (%)
+n+88 P-value
(g* !-d'
I ! 12
$\ / Q56 5
1 y_ 5
1$G/!
Q59 T (*
]/!7\! &
FVC
& ]/!7\! FEV1
]/!7\!
FEV1/FVC
] 9 1Y ! ! -& /
0
Gd
! [
#! . 1:Gcb &
(+
\ 1 < hL=
I ]
$ 2
„ 7&
&1Z Q/1' I mG 1V! ! 152
& ! 4 !
"
) [, (*R)
(*RR Q/!
5 N!1 /` l ' / 5 5
!1/! # 2-G
!1Z :$ ! 4\12
"
C ,[
f E/ $ :T
5.T0 2 / & Z -GG9 E5%9 ' $/
4 ! E5 ` ' E5 ` G5 9 Q/! $5%5%9 ' 9
'
- AB ]5 #1Z E/ ! !
4 !
"
P S ,[
' =J.
K/ 9 4 L / 15V
Q/1'
# 2 ! 152
4 ! / 5 5 Q5 -<
"
(+
* ,[
%5 . 45T d\ 16 5&
; I$T! G /!
- &
"
(8 ((
,[
= !72
#
& 3 ' 9 -
$ :T
1 1. J$V! † & - ! '
T ! G /! $%5
"
() ,[
# = dT _
K/ 9 -
$\12 c Q/1'
4 ! / =- ! / 5 5 Q5 -<
"
(C ,[
1
5 \
IL-10
f Q/ 9 $/ ! !
! 4
IL10/19/20/22/26/28/29
[
& ! V Q/! c !
f 9-GL = O
-GG9
"
88 8+
,[
Q59 T1$G/!
(*
! V Q/! ! -/- c
= dT _ 1}9! 9 - &
]5 Q59 $/ E/ #! G & #! !
& I$T!
"
)R
)) 88 8+
, -i = dT _ ! V1&
& I$T!
"
)*
,
1&
- [ ]>
IL-19
&
5T ! = O
•/ / %
5&
$V G E/`1T0 -
4 !
"
8+
,[
dT _
1$G/! 1 y_ 1i M
9 T Q5 (*
Q5 -<
I ! / 5 5 $ :T & $\ /
& %/ >
-& - !1\!
$\12 !1Z 1& I ! # 4 !
[
dT _ Q/!
8gg I ! !1\! ! 1 /
$\
I !
- 12 $\ 5
z5:V / / 5 5
5 l $
-G$\12 !1Z 1& -/- / / 5
1$G/! 1 y_
Q59 T (*
!7/W! •/ - t &
!- !
- 152
[
Q/ 9 $/ dT _ / 5 5 Q5 -< & I$T!
4 1 8+
• 1V 2 & I ! ! l '
# #! . 1:Gcb
!
Q/! y_ 9 -
Q/ 9 $/
/ 5 5 Q5 -<
Y$ ! ŠJV1&
] 9
& I$T!-i Q/ 9 $/ y_ $\ /
IL-10
]/!7\!
4 ! $\ /
"
C+
Cg ,[
dT _ /! /
9 !
8++*
! !
"
CC ,
#
y_ !
1
/ Q/ 9 $ ]5
& I$T!
TNF IL-1 IL-1 IL-1Ra
&
YMJ f& Z
I ! 12 !
1V 2 & $\ /
12 & 4 % 0 1Y ! 9 & 1$ 9 1$G9
a ' !
Gd 4 }
1 y_ Q5& ! C
/ N \ Q/ 9 $
I ! 12 1
4 ! 1$G9 $\ /
[
Q5G‹
! 1\ dT _ 8++*
# !
"
C) ,
Q/ 9 $/ 1 y_ #!75
& I$T!
IL-8 IL-6
&
f& Z
… ! & / 5 5 Q5 -< I '
/ =- W
4 1 / 5 5 #!
8+
12 & %/ > 1V 2 & I ! ! • 4 ! ] 9 1$G9
] 9 Q/! !
eJ & ' !
•: 6G' 15Y /
7$
Q 7 \1 l V
$\ / / G/ d
"
f9!19
! 7/
, 75
1$ 15w ! 1$ ! 4 !-
[
= dT _ Q/!
! # Q5G‹
9 - ! 1 y_
Q/ 9 $/
& I$T!
RANTES/CCL5 IL-8/CXCL8
12
I !
$\ / $ :T &
1$G9 12 & %/ >
Gd ] 9
$ ! !
4 !
1 y_
FRACTALKINE/CXCL1
I ! 12 Q5&
$\ /
Gd ŠJ$V! 1$G9
4 !- !
[ 1 y_ ]/!7\!
MCP-1/CCL2
-i ]> 16 5&
#!75 ] 9 & I$T!
RANTES/CCL5 IL-8/CXCL8
` T /75\ ' 16 5&
%5 .
=- W =!1o! 1& f5V = :$
2 / 5 5 #! 1& 1V - &
"
C+
,[
Z dT _ #! .
8++*
- # 5&
4 !
1 y_
TNF IL-1
& IL-6
f& Z I '
#! 12
Q5/ 1$G9 12 & 4 % / 5 5 1'
&
"
CS ,[
#! . 1:Gcb
Q5G‹
# ! - 9
y_
-i Q59 $/
& I$T!
1$G/!
Q59 T (+
/ K/
4 9
& / 5 5 Q5 -< V
Gd ]/!7\! / 5 5 15b 12 & 4 % !
$\ / 4 !
"
CR ,[
Q59 T1$G/! y_ 1&
(*
/ =J. & / 5 5 #! 1 ((
-/ dT _ Q/!
9 -
1 y_ 5 Q56 5
1$G/!
Q59 T (*
12 I ! 12 ! 1'W & -
$\ /
I ! 12
\ /
z5:V $
! 1'W & l $ –
I ! -/- $\ /
# 5& 9 - &
& -G9 ]/!7\!
Q59 T1$G/! y_ / … ! =-
(*
!-5 ] 9
]5 ]> 1& ! W $M! 9 -G9 Q/! & I$T!
Q59 $/
dT _ 3 !1& !1/ - &
Z = y_
Q59 $/
$T!
] 9 / 5 5 Q5 -< & I
-& / [
I ! 12
$\ /
1 y_ 5 Q56 5
1$G/!
Q59 T (*
]/!7\! &
FVC
& ]/!7\! FEV1
]/!7\!
FEV1/FVC
] 9 1Y ! ! -& /
0
Gd
& dT _ 1i M M !
$& 9 !
#!
%/ > #0 & ! U/ $ Q/!
! 19 -
4 ! [ 1&
3 !
U/ $ Q/!
1$I& & 9 4:2 #! ' / 19 9 #-
1&
1$ 15w ! 3 ! Q59 T1$G/! y_
(*
]/!7\!
!-5 19 4 ! [
4 1 ^1 #! . 1:Gcb = dT _
8+
# 5& $ & I ! ! • -GG9
Q/! b 9
#! 1V 2 =- ' 9 =!1o! 1& = dT _
# / 5 5
! -
{ 9 4 !
$%5 & I$T!
G /!
]/!7\! & I ! &
1Y & ! -& /
I ! !1\! -
! 9 $ :T & $\ /
… !
=- !
U #0
-G 9
1 y_
$/
Q/ 9 ] 9 & I$T!
1 y_
Q59 $/
-i
!-5 ]/!7\! & I$T!
-GG9 [
d\ &
Q59 $/ E/ #- 0
{ ! &
/!
[
Q. ; _ { /! 4I L12!
5 $/ I 4 ! - & Q59 $/ Q/-GL 152 -G
[
Q59 $/ ! !-91 1. #-5 I\
# 0 #!-GL
]> !1/ 4%5
#0
#0 -GG9-5T ' & $%&
45T d\ G /! { \ Š- # 2 !
# - ! '
- & = :$
[ Q59 $/ ! 5%& 4>5>M
]5 ]>
- ! & I$T!-i & I$T!
"
8+
,
1$G/!
Q59 T (*
4%5 G}$% - Z Q/! ! 75 [
dT _
9 !
8++g
!
# !
!
Q59 $/ #!75
& I$T!
IL-8 IL-1beta IL-6
TNF-alpha
K/
& J$ / 5 5 #! BAL
$ :T & I ! ! $. 1&
! & %/ >
Gd ]/!7\! - 12 T !1\
4 ! !
"
C*
,[
& dT _ Q5G‹
8++g
# Q59 T1$G/! 9 ! R
K/
BAL
Q5 -<
I ! / 5 5 1 5\ & J$ $ :T & $\ /
Gd ]/!7\! 75 /
# !
-
"
P+
,[
= :'
Q/! 9 4 ! Q/! = dT _ & 1i M dT _
1 ! dT _
1& 4I :$ !
- 4 !
1$G/!
Q59 T (*
]5 $9 \ E/ # L
4 ! & I$T!
W &
4 ! Y$ ! ; I$T! Ki #0 # &
!
Gd ]/!7\! #! 5& Q/! 1 - ! '
!
$ !- - &
[
dT _
Sheng-chin
#! . 8++C
# !
1 y_
IL-19
&
#! 5
E5' 0
Q5GL
t
BALB/c
1&!1& E5' 0 & 1$G9 12
W & 1 y_ & #! 5&
IL-19
1 y_
IL-4
IL-13
-G$ ! /W &
[ B%
! 1&
IL-19
/
t ]/!7\! E5' 0
!-5 19
"
)P , U/ $ & Q/! 9
# 5& 9 1i M dT _
y_ Q56 5 -G9
1
Q59 T1$G/!
(*
I ! !1\!
Q5/ $\ / 1'
- 12 !
I ! !1\!
!1\! ! 1$ 9 / 5& & $\ /
! I
# -& $\ / / 5&
9 ! =1/ @ - &
Q.
%5 . 4 & 4 !
= :$ ./` T /75\ '
I ! !1\!
- & $\ / [
dT _
Fei huang
#! . 8++*
# !
5& /! ! 5 $5 ! 1/ & 4 % E5' 0 #!
5&
! 1'W & #!75 /
IL-19
75 !
]/!7\!
IL-19
4 9
- T
-/ 12
# Q5GL
! -
# 5&
IL-19
5 $5 !
! 5 1& ƒ9!1' Q59 $/ l ' /!
Th2 (IL-
4 IL-13) IL-17A
5YG' Q/! 5$
9
%/`1G5 =!1o!
IL-4 IL-17A IL-13
# 5&
IL-19
#! . 1:Gcb &
(8
! 5 $5 !
Q. /!
]> 4 ! I
$ ! 0 ` T /75\ ' -G &
"
P(
, dT _ = :'
M 9 4 ! Q/! dT _ Q/! & 1i
! dT _ Q/!
:$ ! 1& 4I 1 -
4 ! Q. 4 !
1$G/! 1 =!155@' Q59 T
(*
=!155@' $ !
- #0 di
[
1Y & Q/!1& G&
- -
Gd = :'
!
1$G/!
Q59 T (*
I ! 12 Q5& 1 I ! $\ /
$\ 5 1 y_ ! .G/! b
Q59 T 1$G/!
(*
&
-5/ ' ! $ :T & I ! 19 5& E/ #! G f E/ #! Gd& Q59 $/ Q/! ]/!7\! T -G9
4 9 - !
%5 . /! ; I$T! Ki
! & I$T!
1$ 5& = dT _ 4 ! 1i -G9
15V ' … ! =- & #0 a ' ! 1& 4I / &
!- ! / -G ; I$T! Ki #0 y_ 152 L
f d& 4 -/0 [
)= 7
1. Ghotbi L, Hassan Z. The Immunostatus of natural killer cels in people exposed to sulfur mustard. International Immuniopharmacology.
2002; 2:981-5.
2. Ghabili K, Agutter PS, Ghanei M, Ansarin K, Panahi Y, Shoja MM. Sulfur mustard toxicity:
history, chemistry, pharmacokinetics, and pharmacodynamics. Crit Rev Toxicol. 2011;
41(5):384-403.
3. Le HQ, Knudsen SJ. Exposure to a First World War blister agent. Emerg Med J. 2006; 23(4):296- 9. 4. Ghanei M, Aslani J, Khateri S.Public health status of the Civil population of Sardasht 15 years following large-scale wartime exposure to sulfur mustard. J Burns & Surg Wound Care.
2003;2(1):7-10
5. Dacre JC, Goldman M. Toxicology and pharmacology of the chemical warfare agent sulfur mustard. Pharmacol rev. 1995; 48(2); 289-326.
6. Ghanei M, Vosoghi AA. An epidemiologic study to screen for chronic myelocytic leukemia in war victims exposed to sulfur mustard gas.
Enviromental Health perspectives. 2002;
110(5):519-521.
7. Bobb AJ, Arfsten Dp.N-acetyl-Lcycteine as prophylaxis against sulfur mustard. Mil Med.
2005; 17(1):52-6.
8. Kehe K, Szinics L.Medical aspect of sulfur mustard poisoning. Toxicology. 2005; 214(3):198- 209.9. Balali-Mood M, Hefazi M. comparison of early and early and late toxic effects of sulfur mustard In Iranian veterans. Basic Clin.
Pharmacol Toxicol. 2006; 99(4):273-82.
10.Khateri S, Ghanei M, Keshavarz S, Soroush M. incidence of lung ,eye and skin lesions as late complications in 34000 Iranians with wartime exposure to mustard agent. J occup Environ Med. 2003; 45(11):1136-43.
11. Javadi MA, Yazdani S, Sajjadi H, Jadidi K.Chronic and delayed-onset of keratitis: report
of 48 patients and review of literature.
Ophtalmology. 2005; 112(4):617-S25.
12. Vosoughi AA, Bagheri AM, Esmaeeili A. Type IV skin test reaction in mustard gas exposed patients. Iranian journal of medical sciences.2000;
25(3-4):105-108.
13. Ishida H, Ray R, Ray P. Sulfur mustard downregultes iNOS expressionto inhibit wound healing in human keratinocyte model. J Dermatol Sci. 2008;49(3):207-216
14. Balali-Mood M, Hefazi M, mahmoudi M, Jalali E. longterm complications of sulfur mustard poisoning in severe intoxicated Iranian veterans.
Fundam Clin Pharmacol. 2005; 19(6):713-21.
15.Pourfarzam S, Ghazanfari T, Ghanei M,Ghasemi H. Long-term pulmonaty complications in sulfur mustard victims of Sardasht, Iran. Toxin Review. 2009;28(1):8-13 16. Ghanei M, Harandi AA. Long term consequences from exposure to sulfur mustard: a review. In hal Toxicol. 2007; 19(5):451-6.
17.Emad A, Rezaian Gr. The diversity of the effects of sulfur mustard gas inhalation on respiratory system 10 years after a single, heavy exposure: analysis of 197 cases. Chest. 1997;
112:734-73
18. Balali-mood M, Hefazi M, Attaran D, Mahmoudi M. Late respiratory complications of mustard gas poisoning in Iranian veterans. Inhal Toxicol. 2005; 17(11):587-92
19.Arroyo CM, Schafer RJ, Kurt EM, Carmichael AJ. Response of normal human keratinocytes to sulfur mustard(HD):cytokine release using a non- enzymeatic detachment procedure. Human ExpToxicol. 1999; 18(10):1-11.
20. Scott Commins M, John W. The extended IL- 10 superfamily: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, IL-28, and IL-29. Jurnal of allergy and clinical Immunology. 2008;125(2): 1108-1111 21. Conti P, Kempuraj D , Frydas S. IL-10 subfamily members: IL-19, IL-20, IL-22, IL-24
Q59 T1$G/! y_ 1&
(*
/ =J. & / 5 5 #! 1 ()
and IL-26.Immunology Letters.2003; 88(3):171- 174 22. Helmut F, Simon H, Heide K. The interleukin- 10 family of cytokines.Trendes of Immunology.
2002; 23(2): 89-96
23.Morel F, Boniface K, Guignouard E. A role for Th17-Derived IL-22 in Psoriatic Skin Inflammation. Cytokine.2007; 39(1): 28-29
24.Chung H, Mei-Yi H, Wei-Yu C. Induction of Interleukin-19 and Interleukin-22 after Cardiac Surgery with Cardiopulmonary Bypass. The Annals of Thoracic Surgery. 2006; 81(6) :2196- 2201
25. Shinichiro W, Philip T. Potentiation of IL-19 expression in airway epithelia by IL-17A and IL- 4/IL-13: Important implications in asthma. Journal of Allergy and Clinical Immunology. 2008;
121(6):1415-1421
26.Shomyseh S, Lauren Z, Masahito K. Anti- inflammatory and pro-inflammatory roles of TGF- , IL-10, and IL-22 in immunity and autoimmunity. Current Opinion in Pharmacology.2009;9( 4) :447-453
27. Haruo H, He Chang, Hui Liu. The Effect of IL- 22-Ig Fusion Protein for Rat Experimental Autoimmune Myocarditis. Journal of Cardiac Failure. 2005; 11(9):284-86
28.Hikami K, Ehara Y, Hasegawa M. Association of IL-10 receptor 2 (IL10RB) SNP with systemic sclerosis. Biochemical and Biophysical Research Communication. 2008; 373( 3): 403-407
29.Wei C, Chen W, Yo-Ching W. Detection of IL- 20 and its receptors on psoriatic skin. Clinical Immunology. 2005; 117(1): 65-72
30.Blumberg H, Conklin D, WenFeng Xu.
Interleukin 20: Discovery, Receptor Identification, and Role in Epidermal Function. Cell. 2001;
104(1): 9-19.
31. Balali-Mood M, Hefazi M.The pharmacology ,toxicology and medical treatment of sulfur mustard poisoning .Fundam Clin Pharmacol.2005;19(3):297-315
32. Hassan ZM,Ebtekar M,Ghanei M,Ghazanfari T.Immunobiological consequences of sulfur mustard contamination . Iran J Allergy Asthma Immunol.2006;5(3):101-8
33.Yuan-Chun L,Wei-Guang L,Feng-Wei C.IL-19 induces production of IL-6 and TNF- alpha and results in cell apoptosis through TNF- alpha.J Immunol.2002 ;169 :4288-4297
34. Kerstin W, Stefanie K, Khusru A.Cutting edge:
Immune cells as sources and targets of IL-10 family members?The Journal of Immunology .2002;168:5397-5402
35.Sheng-Chin L,Yung-Chih C,Yo-Ching W,Sang-Ming Y.IL-19 induced Th2 cytokines and was up –regulated in asthma patients.J Immunol.2004;173:6712-6718
36.Changsoo C, Eugenia Mn Serguei K[ Crystal Structure of Interleukin-19 Defines a New Subfamily of Helical Cytokines[ THE JOURNAL
OF BIOLOGICAL CHEMISTRY. 2003;
278(5):3308-3313
37.Hongyan Z, Yuzhi W, Luiz B.A2B adenosine receptors induce IL-19 from bronchial epithelial cells, resulting in TNF-alpha increase. American Journal of Respiratory cells and Molecular Biology. 2006;35:587-592
38.William J,Joyce E,Michele B.Human IL-19 regulates immunity through auto-induction of IL-19 and production of IL-10.European Journal of Immunology .2005;35:1576-1582 39.Ying T, Laura J, anthong C.Expression and suppressive effects of IL-19 on vascular smooth muscle cells pathophysiology and development of intimal hyperplasia. The American Journal of Pathology [2008;3(173):901- 90940. Ghazanfari T, Yaraee R, Kariminia A.Alterations in the serum level of chemokines 20 years after sulfur mustard exposure: sardasht–Iran cohort study. InternationaImmunology. 2009
;9:1471-1476
41.Relationship between Serum levels of mmp-9 and late ocular complications in Iranian Journal of War and Public Health[ 2009; 1 (3): 1-16[
42. Ghazanfari Tooba, Yaraee Roya, KiaSalari Zahra, Hedayati Fateme, Ghasemi Hassan, PourFarzam Shahriar . Evaluation of serum levels of nitric oxide in chemical victims of Sardsht 20 years after sulfure mustard exposure Iranian Journal of War and Public Health[ 2009; 1 (2) :9- 23
43. Pour farzam Sh,Ghazanfari T,Yaraee R.Serum level of IL-8 and IL-6 in the long term pulmonary complications induce by sulfur mustard:sardasht – Iran cohort study.International Immunology.2009;9:1482-1488
44. Yaraee R, Ghazanfari T, Ebtekar M.Alteration in serum levels of inflammatory cytokines (TNF, IL-1 alpha, IL-1 beta and IL-1 Ra) 20 years after sulfur mustard exposure: sardasht–Iran cohort study. International Immunology. 2009;9:1466- 1470
45.Yaraee R, Ghazanfari T, Faghih zade S.
Alterations in the serum level of soluble L, P and E selectin 20 years after sulfur mustard exposure:
Sardasht–Iran Cohort Study. International Immunology. 2009;9:1477-1481
46. Ghasemi H, Ghazanfari T, Yaraee R.Evaluation of relationship between the serum level of inflammatory mediators and ocular injuries induced by sulfur mustard: sardasht – Iran cohort study. International Immunology. 2009; 9:1494- 1498
47.Amiri S, Ghazanfari T, Yaraee R.Serum level of GM-CSF 20 years after sulfur mustard exposure: sardasht–Iran cohort study. International Immunology. 2009; 9: 1499-1503
48. Ghazanfari T, Faghihzadeh S, Aragizadeh H, Soroush MR. Sardasht-Iran Cohort Study of
#! . 1:Gcb &
(C
Chemical Warfare Victims:Design and Methods.
Arch Iranian Med. 2009; 12 (1): 5 – 14
49. Emad A, Emad Y.levels of cytokine in bronchoalveolar lavage (BAL) fluid in patients with pulmonary fibrosis due to sulfur mustard gas inhalation. J Interferom cytokine Res. 2007;
27(1):39-43.
50.Emad A,Rezaian GR.Characteristics of bronchoalveolar lavage fluid in patients withmustard gas induced asthma or chronic bronchitis.Am J Med.2000;106(6):625-8
51. Fei H, Shinichiro W,Philip T.Airway epithelia up-regulate IL-19 in response to IL- 17A / IL-13.J Allergy Clin Immunol.
2009;6(121):1415-1421
