Interaction of Vitamin D and Calcium With High-Intensity Circuit Training on BDNF and Fat Percentage of Overweight Elderly
Maryam Dalirani 1 , Abbas Ali Gaeini 2 , Mohammad Reza Kordi 3
1. Department of Sport Biosciences, Faculty of Sport Sciences and Health, University of Tehran, Tehran, Iran.
E-mail: [email protected]
2. Corresponding Author, Department of Sport Biosciences, Faculty of Sport Sciences and Health, University of Tehran, Tehran, Iran. E-mail: [email protected]
3. Department of Sport Biosciences, Faculty of Sport Sciences and Health, University of Tehran, Tehran, Iran.
E-mail: [email protected]
Article Info ABSTRACT
Article type:
Research Article
Article history:
Received:
19 February 2022 Received in revised form:
16 August 2022 Accepted:
18 August 2022 Published online:
25 April 2022
Keywords:
Aging, BDNF, Calcium, Circuit Training, Vitamin D.
Introduction: The present study aimed to investigate the interaction effects of vitamin D and calcium, and High-Intensity Circuit Training (HICT) on BDNF and fat percentage of overweight elderly.
Methods: Thirty-two healthy older women were randomly divided into four Training + Supplementation, Training + Placebo, Supplementation, and Control groups. The training protocol performed three sessions per week for eight weeks. The Supplementation groups consumed 1,000 mg of calcium-effervescent tablet daily and 50,000 IU of vitamin D per week.
Results: The results showed that the body fat percentage in the Training + Supplementation group decreased significantly compared with Supplementation (p = 0.001), Control (p = 0.001), and Training + Placebo (p = 0.045) groups. Moreover, the fat percentage in the Training + Placebo group decreased significantly compared with the Control group (p = 0.001). However, there were no significant differences between the Training + Placebo and Supplementation groups in body fat percentage. Moreover, there was a significant decrease in fat percentage in the Supplementation group compared with the Control group (p = 0.047).
BDNF in the Training + Supplementation group had a significant increase compared with the Supplementation (p = 0.002) and Control (p = 0.001) groups but had no significant difference compared with the Training + Placebo (p = 0.085) group. Moreover, there was a significant increase in BDNF in the Training + Placebo group compared with Control (p = 0.003) and Supplementation (p = 0.01) groups. In contrast, no significant difference was observed between Supplementation and Control (p = 0.985) groups.
Conclusion: Overall, the interaction of training and supplementation showed a significant decrease in the body fat percentage and a significant increase in BDNF in overweight elderly.
Cite this article: Dalirani M., Gaeini A.A., & Kordi M.R. Interaction of Vitamin D and Calcium With High-Intensity Circuit Training on BDNF and Fat Percentage in Overweight Elderly. Journal of Sport Biosciences. 2023; 15 (1): 5-20.
DOI: https://doi.org/10.22059/jsb.2022.339399.1517
Journal of Sport Biosciences by University of Tehran Press is licensed under CC BY-NC 4.0.
| Web site: https://jsb.ut.ac.ir/ | Email: [email protected].
© The Author(s). Publisher: University of Tehran Press.
Introduction
The overweight and obesity pandemic poses a global burden, with as many as 1.5 billion people, or roughly 20% of the world population, affected. A 2019 report states that by 2030, 50% of U.S. adults will have obesity. Obesity is often associated with cardiovascular disease risk factors such as hypertension, dyslipoproteinemia, diabetes, and elevated inflammation markers. Hence, while the World Health Organization reports showed that life expectancy in developed countries is nearly 80 years old, debilitation resulting from obesity can begin (and rapidly accelerate) as early as the fifth decade of life.
Therefore, countermeasures to reduce obesity rates continue to be the focus of much scientific research, particularly in the elderly given their relative susceptibility to developing the disease. There is growing evidence that inadequate calcium intake, inadequate vitamin D status, obesity, and chronic non- communicable disease are often in clusters. The present study aimed to investigate the interaction of vitamin D and calcium and high-intensity circuit training on BDNF and fat percentage in overweight elderly.
Methods
In this quasi-experimental study, 32 healthy elderly women of 60 years and older with a BMI between 25 and 29.9 were randomly assigned to four groups:
vitamin D and calcium supplementation + high- intensity circuit training group (D+Ca+T: n =8), high- intensity circuit training + placebo (T+P: n = 8), vitamin D and calcium supplementation (D+Ca: n = 8), and the control group (CON: n = 8). The subjects in D+Ca received vitamin D and Ca supplements at 50,000 IU/wk and 1000 mg/d for eight weeks, respectively; the subjects in training groups exercised three times per week for eight weeks, and the subjects in D+Ca+T participated in both treatments. Subjects in CON were asked to maintain a normal daily lifestyle for the duration of the study. Body fat and BDNF were evaluated at baseline and after the eight weeks of interventions. Fasting blood samples were collected 48 hours before and after the last training session and changes in BDNF values were measured via ELISA method. To determine the percentage of body fat, the skin fold method was used with the caliper. Analysis of covariance and paired t-test at the significant level (P≤0.05) were used to analyze the data of this study.
The results showed that the body fat percentage in the Training + Supplementation group decreased significantly compared with Supplementation (p = 0.001), Control (p = 0.001), and Training + Placebo (p
= 0.045) groups. Moreover, the fat percentage in the Training + Placebo group decreased significantly compared with the Control group (p = 0.001).
However, there were no significant differences between the Training + Placebo and Supplementation groups in body fat percentage. Moreover, there was a significant decrease in fat percentage in the Supplementation group compared with the Control group (p = 0.047). BDNF in the Training + Supplementation group had a significant increase compared with the Supplementation (p = 0.002) and Control (p = 0.001) groups but had no significant difference compared with the Training + Placebo (p = 0.085) group. Moreover, there was a significant increase in BDNF in the Training + Placebo group compared with Control (p = 0.003) and Supplementation (p = 0.01) groups. In contrast, no significant difference was observed between Supplementation and Control (p = 0.985) groups.
Conclusion
Overall, the results showed that high-intensity circuit training and calcium and vitamin D supplementation both had significant effects on fat percentage variables.
However, in the present study, it was shown that these changes in the high-intensity circuit training + supplementation group were more meaningful. Also, the results showed that the supplement alone did not affect BDNF. However, high-intensity circuit training + supplement and high-intensity circuit training + placebo led to a significant increase in BDNF.
Ethical Considerations
Compliance with ethical guidelines: This study followed the ethical standards and was approved by the Ethics Committee of the Sport Sciences and Research Institute with the ethical code: (SSRI.REC- 2109-1274 (R1)).
Funding: This study was extracted from the MSc thesis of the first author. No funding was received for this study
Authors’ contribution: all authors contribute to the study design.
Maryam Dalirani and Mohammad Reza Kordi collected the data.
Abbas Ali Gaeini and Mohammad Reza Kordi revised the final version of the manuscript. All authors read and approved the final manuscript.
Conflict of interest: The authors declare no conflict of interest.
Acknowledgments: We hereby sincerely thank and appreciate all the people who have cooperated in this research.
نا ﺪﻨﻤﻟﺎﺳ ﯽﺑﺮﭼ ﺪﺻرد و BDNF ﺮﺑ ﺪﯾ ﺪﺷ ﯽﻠﯿﺧ ي ا هﺮ ﯾ اد ﻦﯾ ﺮﻤﺗ ﺎﺑ هاﺮﻤﻫ ﻢﯿ ﺴﻠﮐ و ي د ﻦﯿﻣﺎﺘﯾ و ﻞﻣﺎ ﻌﺗ اراد
ي نزو ﻪﻓﺎﺿا
ﻧاﺮﯿﻟد ﻢﯾﺮﻣ ﯽ
، 1
ﻨﯿﺋﺎﮔ ﯽﻠﻌﺳﺎﺒﻋ ﯽ
2
،
رﺪﻤﺤﻣ يدﺮﮐ ﺎﺿ
3
1 يژﻮﻟﻮﯾﺰﯿﻓ هوﺮﮔ . ﺷزرو
ﯽ ، ﺪﮑﺸﻧاد ة مﻮﻠﻋ ﺷزرو ﯽ ﯽﺘﺳرﺪﻨﺗ و هﺎﮕﺸﻧاد ، :ﻪﻣﺎﻧﺎﯾار .ناﺮﯾا ،ناﺮﻬﺗ ،ناﺮﻬﺗ [email protected]
2 . ،لوﺆﺴﻣ هﺪﻨﺴﯾﻮﻧ هوﺮﮔ
ﻓﯿ ﺰﯾ ژﻮﻟﻮ ي ﺷزرو ﯽ ، ﺪﮑﺸﻧاد ة مﻮﻠﻋ ﺷزرو ﯽﺘﺳرﺪﻨﺗ و ﯽ هﺎﮕﺸﻧاد ،
:ﻪﻣﺎﻧﺎﯾار .ناﺮﯾا ،ناﺮﻬﺗ ،ناﺮﻬﺗ [email protected]
3 هوﺮﮔ . ﻓﯿ ﺰﯾ ژﻮﻟﻮ ي ﺷزرو
،ﯽ ﺪﮑﺸﻧاد ة مﻮﻠﻋ ﺷزرو ﯽﺘﺳرﺪﻨﺗ و ﯽ :ﻪﻣﺎﻧﺎﯾار .ناﺮﯾا ،ناﺮﻬﺗ ،
ﻪﻟﺎﻘﻣ تﺎﻋﻼﻃا هﺪﯿﮑﭼ
:ﻪﻟﺎﻘﻣ عﻮﻧ ﯽﺸﻫوﮋﭘ
رﺎﺗ ﯾ ﺦ رد ﯾ ﺖﻓﺎ : 30 / 11 / 1400
:يﺮﮕﻧزﺎﺑ ﺦﯾرﺎﺗ 25
/ 05 / 1401
رﺎﺗ ﯾ ﺦ ﺬﭘ ﯾ شﺮ : 27 / 05 / 1401
رﺎﺗ ﯾ ﺦ رﺎﺸﺘﻧا : 05 / 02 / 1402
ﺪﯿﻠﮐ هژاو :ﺎﻫ
ﻦﯾﺮﻤﺗ ادﯾ هﺮ ا
،ي
،يﺪﻨﻤﻟﺎﺳ ﺴﻠﮐ ﯿ ﻢ،
وﯾ ﻣﺎﺘ ﯿ ﻦ
، D DNF . B فﺪﻫ
: فﺪﻫ زا ﺶﻫوﮋﭘ ﺮﺿﺎﺣ ﺳرﺮﺑ ﯽ و ﻞﻣﺎﻌﺗ ﯾ ﻣﺎﺘ ﯿ ﻦ د ي ﺴﻠﮐ و ﯿ ﻢ ﺮﻤﺗ ﺎﺑ هاﺮﻤﻫ ﯾ
ﻦ اد ﯾ هﺮ ا ي ﺧ ﯿﻠ ﯽ ﺪﺷ ﯾﺪ ﺮﺑ DNF وB
ﯽﺑﺮﭼ ﺪﺻرد اراد ناﺪﻨﻤﻟﺎﺳ
ي نزو ﻪﻓﺎﺿا دﻮﺑ
.
شور ﺶﻫوﮋﭘ : 32 نز ﻢﻟﺎﺳ ﺪﻨﻤﻟﺎﺳ
، ﻪﺑ ﯽﻓدﺎﺼﺗ رﺎﻬﭼ
هوﺮﮔ 1 ﻦﯾﺮﻤﺗ . و
،ﻞﻤﮑﻣ 2 . راد و ﻦﯾﺮﻤﺗ
،ﺎﻤﻧو 3 . ﻞﻤﮑﻣ و 4 .
لﺮﺘﻨﮐ ﻢﯿﺴﻘﺗ ﺮﻤﺗ ﻞﮑﺗوﺮﭘ .ﺪﻧﺪﺷ ﯾﻨ
ﯽ تﺪﻣ ﻪﺑ ﻪﺘﻔﻫ رد ﻪﺴﻠﺟ ﻪﺳ ﺖﺸﻫ
ﻪﺘﻔﻫ دﻮﺑ . ر ،ﻞﻤﮑﻣ هوﺮﮔ ﻪﻧازو
1000 ﻣ ﯿﻠ ﯽ مﺮﮔ
ﺴﻠﮐ صﺮﻗ ﯿ ﻢ و نﺎﺷﻮﺟ 50000 ﺑ ﺪﺣاو ﯿ ﻦ ﻠﻠﻤﻟا ﯽ و ﯾ ﻣﺎﺘ ﯿ ﻦ .ﺪﻧدﺮﮐ فﺮﺼﻣ ﻪﺘﻔﻫ رد ارD
ﯾ ﻪﺘﻓﺎ ﺎﻫ : ) ﻞﻤﮑﻣ ﻪﺑ ﺖﺒﺴﻧ ﻞﻤﮑﻣ+ﻦﯾﺮﻤﺗ هوﺮﮔ رد ﯽﺑﺮﭼ ﺪﺻرد داد نﺎﺸﻧ ﺞﯾﺎﺘﻧ 001
/0 و (P=
ﮐ ) لﺮﺘﻨ 001 /0 و (P=
) ﺎﻤﻧوراد+ﻦﯾﺮﻤﺗ 045
/0 ﯽﺑﺮﭼ ﺪﺻرد ﻦﯿﻨﭽﻤﻫ .ﺖﺳا ﻪﺘﺷاد يرادﺎﻨﻌﻣ ﺶﻫﺎﮐ (P=
+ﻦﯾﺮﻤﺗ هوﺮﮔ رد ﺖﺒﺴﻧ ﺎﻤﻧوراد
ﻪﺑ
) لﺮﺘﻨﮐ 001 /0 ﺎﺑ .ﺖﺷاد يرادﺎﻨﻌﻣ ﺶﻫﺎﮐ (P=
اﯾ ﻦ لﺎﺣ ﺎﻤﻧوراد+ﻦﯾﺮﻤﺗ هوﺮﮔ رد ﯽﺑﺮﭼ ﺪﺻرد ، ﻧ
ﻞﻤﮑﻣ ﻪﺑ ﺖﺒﺴ
) 127 /0 هوﻼﻋ .داﺪﻧ نﺎﺸﻧ ار يرادﺎﻨﻌﻣ توﺎﻔﺗ (P=
ﯽﺑﺮﭼ ﺪﺻرد ،ﻦﯾا ﺮﺑ ﺖﺒﺴﻧ ﻞﻤﮑﻣ هوﺮﮔ رد
ﺑ لﺮﺘﻨﮐ ﻪ ) 047 /0 (P=
.ﺖﺷاد يرادﺎﻨﻌﻣ ﺶﻫﺎﮐ ) ﻞﻤﮑﻣ هوﺮﮔ ﻪﺑ ﺖﺒﺴﻧ ﻞﻤﮑﻣ+ﻦﯾﺮﻤﺗ هوﺮﮔ ردBDNF
002 /0 ) لﺮﺘﻨﮐ و (P=
001 /0 (P=
) ﺎﻤﻧوراد+ﻦﯾﺮﻤﺗ هوﺮﮔ ﻪﺑ ﺖﺒﺴﻧ ﺎﻣا ،ﺖﺷاد يرادﺎﻨﻌﻣ ﺶﯾاﺰﻓا 085
/0 ﺸﻣ يرادﺎﻨﻌﻣ توﺎﻔﺗ (P=
ﻦﯿﻨﭽﻤﻫ .ﺪﺸﻧ هﺪﻫﺎ
ﺮﻤﺗ هوﺮﮔ رد يرادﺎﻨﻌﻣ ﺪﺣ ردBDNF ) لﺮﺘﻨﮐ هوﺮﮔ ﻪﺑ ﺖﺒﺴﻧ ﺎﻤﻧوراد+ﻦﯾ
003 /0 ﻞﻤﮑﻣ و (P=
) 01 /0 ﺶﯾاﺰﻓا (P=
) لﺮﺘﻨﮐ و ﻞﻤﮑﻣ هوﺮﮔ ﻦﯿﺑ يرادﺎﻨﻌﻣ توﺎﻔﺗ ،ﻞﺑﺎﻘﻣ رد .ﺖﺷاد 985
/0 .ﺪﺸﻧ هﺪﻫﺎﺸﻣ (P=
ﺘﻧ ﯿ ﻪﺠ ﮔﯿ ﺮ :ي ،عﻮﻤﺠﻣ رد ﻪﺑ ﻞﻤﮑﻣ و ﻦﯾﺮﻤﺗ ﻞﻣﺎﻌﺗ
ﺶﻫﺎﮐ ﯽﺑﺮﭼ ﺪﺻرد رادﺎﻨﻌﻣ و
ﺎﻨﻌﻣ ﺶﯾاﺰﻓا راد
BDNF د
ر
ﻣ نزو ﻪﻓﺎﺿا ياراد ناﺪﻨﻤﻟﺎﺳ .ﺪﺷ ﺮﺠﻨ
دﺎﻨﺘﺳا
؛ﻢﯾﺮﻣ ،ﯽﻧاﺮﯿﻟد : .ﺎﺿرﺪﻤﺤﻣ ،يدﺮﮐ و ؛ﯽﻠﻌﺳﺎﺒﻋ ،ﯽﻨﯿﺋﺎﮔ
و ﻞﻣﺎﻌﺗ ﯾ ﻣﺎﺘ ﯿ ﻦ د ي ﺴﻠﮐ و ﯿ ﻢ ﺮﻤﺗ ﺎﺑ هاﺮﻤﻫ ﯾ
ﻦ اد ﯾ هﺮ ا ي ﺧ ﯿﻠ ﯽ ﺪﺷ ﯾﺪ ﺮﺑ ﯽﺑﺮﭼ ﺪﺻرد وBDNF
ناﺪﻨﻤﻟﺎﺳ
اراد ي نزو ﻪﻓﺎﺿا . ﺮﺸﻧ مﻮﻠﻋﮥﯾ ﯽﺘﺴﯾز ﺷزرو ﯽ 1402.
؛ ) 1(
15 : 5-20 .
2022.339399.1517
jsb.
/ 10.22059 DOI: https://doi.org/
ﻪﺑ ﯽﺳﺮﺘﺳد اﯾ
ﻦ ﺮﺸﻧ ﯾﻪ ﻤﻠﻋ
،ﯽ ار ﯾ نﺎﮕ ﮑﻟﺎﻣ ﻖﺣ و ﺖﺳا ﯿ
ﺖ ﺮﮑﻓ ي ﻻ سﺎﺳا ﺮﺑ ار دﻮﺧ ﯾ
ﺲﻨﺴ ﺮﮐ ﯾﺘ ﯿﻮ ) ﺰﻨﻣﺎﮐ CC BY-NC 4.0 ﻪﺑ (
ﻮﻧ ﯾ نﺎﮔﺪﻨﺴ ﺖﺳا هدﺮﮐ راﺬﮔاو .
:ﻪﯾﺮﺸﻧ سردآ| /
https://jsb.ut.ac.ir :ﻞﯿﻤﯾا|
.ناﺮﻬﺗ هﺎﮕﺸﻧاد تارﺎﺸﺘﻧا :ﺮﺷﺎﻧ
.نﺎﮔﺪﻨﺴﯾﻮﻧ©
ﻪﻣﺪﻘﻣ ﺷراﺰﮔ ﯽ لﺎﺳ رد 2019 ﺑﯿ نﺎ ﻣ ﯽ ﺪﻨﮐ ﺗ ﻪﮐ لﺎﺳ ﺎ 2030 ، 50 ا نﻻﺎﺴﮔرﺰﺑ ﺪﺻرد ﯾ
تﻻﺎ ﻗﺎﭼ ﻪﺑ هﺪﺤﺘﻣ ﯽ
ﺪﺷ ﺪﻨﻫاﻮﺧ ﻼﺘﺒﻣ )
1 (.
ﻗﺎﭼ ﯽ ﺎﺑ ﺐﻠﻏا
ﻞﻣاﻮﻋ ﺮﻄﺧ ﺑﯿ رﺎﻤ ي ﺒﻠﻗ ﯽ - ﻗوﺮﻋ ﯽ
،ﻻﺎﺑ نﻮﺧ رﺎﺸﻓ ﺪﻨﻧﺎﻣ د
ﺲﯾ ﻟ ﯽﻣﺪﯿﭙﯿ
، دﯾ ﺖﺑﺎ ﺎﻫﺮﮕﻧﺎﺸﻧ و ي
ﺑﺎﻬﺘﻟا ﯽ ﺖﺳا هاﺮﻤﻫ ﻻﺎﺑ )
2 ( ازا . ﯾ ﻦ ور
ﻟﺎﺣرد ﯽ ﻪﮐ شراﺰﮔ ﺎﻫ ي نﺎﻣزﺎﺳ ﻧﺎﻬﺟ ﯽ ﻣ نﺎﺸﻧ ﺖﺷاﺪﻬﺑ ﯽ
ﺪﻫد ﻣا ﻪﮐ ﯿﺪ ﮔﺪﻧز ﻪﺑ ﯽ ﺎﻫرﻮﺸﮐ رد ي
ﻪﻌﺳﻮﺗ ﯾ ﻪﺘﻓﺎ دﺰﻧ ﯾ ﮏ ﻪﺑ 80 ،ﺖﺳا لﺎﺳ
ﻧاﻮﺗﺎﻧ ﯽ ﺷﺎﻧ ﯽ ﻗﺎﭼ زا ﯽ ﻣ ﯽ ﺪﻧاﻮﺗ اوا زا ﯾ ﻞ ﻫد ﮥ ﮔﺪﻧز ﻢﺠﻨﭘ ﯽ
ﺷ عوﺮﺷ هﺪ ﻪﺑ و ﺮﺴﺗ ﺖﻋﺮﺳ ﯾﻊ
دﻮﺷ . اﺮﺑﺎﻨﺑ ﯾ ﻦ ﺮﯿﺑاﺪﺗ اﺮﺑ ي ﺶﻫﺎﮐ ناﺰﯿﻣ ﻗﺎﭼ ﯽ
ﻪﺑ وﯾ هﮋ رد ناﺪﻨﻤﻟﺎﺳ ﺒﺴﻧ داﺪﻌﺘﺳا ﻪﺑ ﻪﺟﻮﺗ ﺎﺑ
ﯽ ﺎﻬﻧآ اﺮﺑ ي ا ﻪﺑ ﻼﺘﺑا ﯾ ﻦ ﺑﯿ رﺎﻤ
،ي نﺎﻨﭽﻤﻫ ﻪﺟﻮﺗ ﺰﮐﺮﻣ ﺴﺑ
ﯿ رﺎ ي ﺶﻫوﮋﭘ زا ﺎﻫ
ي ﻤﻠﻋ ﯽ ﺖﺳا ) 3 .(
ﺪﻫاﻮﺷ اﺰﻓ ﯾ هﺪﻨ ا ي ﻣ نﺎﺸﻧ ﻪﮐ دراد دﻮﺟو ﯽ
ﺪﻨﻫد ﻓﺎﮐﺎﻧ فﺮﺼﻣ ﯽ
ﺴﻠﮐ ﯿ
،ﻢ ﻌﺿو ﯿ ﺖ ﻓﺎﮐﺎﻧ ﯽ و ﯾ ﻣﺎﺘ ﯿ ﻦ ﻗﺎﭼ ،D
ﯽ ﺑ و ﯿ رﺎﻤ ي ﺎﻫ ي ﻏ ﻦﻣﺰﻣ ﯿﺮ
ﮔاو ﯿﺮ راد ﺐﻠﻏا هوﺮﮔ ﮏﯾ رد راد دﻮﺟو
ﻧﺪ ) 3 (.
رﺎﮐوزﺎﺳ ﻢﯿﻈﻨﺗ ،ﻢﯿﺴﻠﮐ ةﻮﻘﻟﺎﺑ ﺖﺧﻮﺳ
زﺎﺳو ﺖﻓﺎﺑ ﯽﺑﺮﭼ ﺶﻫﺎﮐ ،نﺪﺑ ﺖﻈﻠﻏ
نﻮﻣرﻮﻫ ﺪﯿﺋوﺮﯿﺗارﺎﭘ
و 1 و 25 يد ﻦﯿﻣﺎﺘﯾو ﯽﺴﮐورﺪﯿﻫ ﻪﮐ ﺖﺳا D
ﻣ ﯽ ﺪﻧاﻮﺗ ﻊﻧﺎﻣ زا ﺰﻧژﻮﭙﯿﻟ و دﻮﺷ ﺰﯿﻟﻮﭙﯿﻟ ﮏﯾﺮﺤﺗ ار ﺪﻨﮐ
) 4 ( ﺮﮕﯾد . دﺮﮑﻠﻤﻋ
،ﻢﯿﺴﻠﮐ ﺶﯾاﺰﻓا
ﻊﻓد ﯽﺑﺮﭼ هﺮﯿﺧذ رد .ﺖﺳا ﺰﯿﭼﺎﻧ فﺮﺼﻣ ،ﻞﺑﺎﻘﻣ ﻢﯿﺴﻠﮐ
ﻪﺑ ﺶﯾاﺰﻓا ﺖﻈﻠﻏ نﻮﻣرﻮﻫ ﺪﯿﺋوﺮﯿﺗارﺎﭘ رد
نﻮﺧ و 1 و 25 يد ﻦﯿﻣﺎﺘﯾو ﯽﺴﮐورﺪﯿﻫ
ﺮﺠﻨﻣD
ﻣ ﯽ دﻮﺷ ، ازا ﯾ ﻦ ور ﺶﯾاﺰﻓا ﻢﯿﺴﻠﮐ نورد ﻟﻮﻠﺳ ﯽ رد ﺖﻓﺎﺑ ﯽﺑﺮﭼ نﺎﺴﻧا ﻣ ﯽ ﺪﻧاﻮﺗ ﺖﺧﻮﺳ زﺎﺳو ار ﺎﻬﻧآ زا ﻪﺑ ﺰﯿﻟﻮﭙﯿﻟ ﺰﻧژﻮﭙﯿﻟ
ﺮﯿﯿﻐﺗ ﺪﻫد ) 5 (.
ﻦﯿﻣﺎﺘﯾو دﻮﺟﻮﻣ ﻢﯿﺴﻠﮐ بﺬﺟ D
رد نﻮﺧ ار ﺶﯾاﺰﻓا ﻣ ﯽ ﺪﻫد زا .
،ﯽﯾﻮﺳ دﻮﺒﻤﮐ ﻦﯿﻣﺎﺘﯾو
، D
ﺎﻬﺘﺷا ار ﺶﯾاﺰﻓا و يژﺮﻧا ﺰﻫ ﯾ ﻪﻨ ا ي ار زا هار
ﮏﯾﺮﺤﺗ ﺪﯿﺘﭙﭘورﻮﻧ و Y
ﻒﻗﻮﺗ ﺮﯿﺴﻣ ﺶﻫﺎﮐ ﻦﯿﺗرﻮﮐﻮﻧﻼﻣﻮﯿﭘاوﺮﭘ ﻣ
ﯽ ﺪﻫد ) 6 (.
ﻪﺑ ناﺪﻨﻤﻟﺎﺳ ﺖﻣﺎﺨﺿ ﺶﻫﺎﮐ ،هﺮﻣزور ﺖﯿﻟﺎﻌﻓ ﺶﻫﺎﮐ ﻞﯿﻟد
بﺬﺟ تﻻﻼﺘﺧا ،ﺖﺳﻮﭘ هدور
ا ﺒﮐ تﻻﻼﺘﺧا ،ي ﻦﯿﻣﺎﺘﯾو دﻮﺒﻤﮐ ضﺮﻌﻣ رد ﺮﺘﺸﯿﺑ تﺎﯿﻨﺒﻟ فﺮﺼﻣ ﺶﻫﺎﮐ و يﻮﯿﻠﮐ و ﺪ
.ﺪﻧراد راﺮﻗ ﻢﯿﺴﻠﮐ و D
ﻦﯿﻣﺎﺘﯾو دﻮﺒﻤﮐ عﻮﯿﺷ دوﺪﺣ نﺎﻬﺟ ناﺪﻨﻤﻟﺎﺳ رد D
50 ﺖﺳا هﺪﺷ دروآﺮﺑ ﺪﺻرد )
7 ( . ﻣﯿ ناﺰ ﺴﻠﮐ فﺮﺼﻣ ﯿ
ﻢ و و ﯾ ﻣﺎﺘ ﯿ ﻦ ﺪﺣاو ﻖﺒﻃ D
ﺑﯿ ﻦ ﻠﻠﻤﻟا ﯽ اﺮﺑ ي ﻻﺎﺑ نﺎﻧز ي 50 ﻨﭽﻤﻫ و لﺎﺳ ﯿ
،ﻦ ﻤﻫ ﮥ ﻐﻟﺎﺑ ﺎ ن ﻻﺎﺑ ي 60 ﻪﺑ لﺎﺳ ﺗﺮﺗ ﯿ ﺐ 1000 ﺎﺗ 1500 ﻣ ﯿﻠ ﯽ مﺮﮔ ﺴﻠﮐ ﯿ ﻢ ﻞﻗاﺪﺣ و زور رد
800 ﺮﺜﮐاﺪﺣ و 2000
ﺑ ﺪﺣاو ﯿ ﻦ ﻠﻠﻤﻟا ﯽ و ﯾ ﻣﺎﺘ ﯿ ﻦ ﺖﺳا زور ردD
) 27 .(
ﻪﻌﻟﺎﻄﻣ رد ا
ي
، ﺴﻠﮐ ﻞﻤﮑﻣ ﯿ
ﻢ نزو ﺶﻫﺎﮐ رد ﯽﻗﺎﭼ و نﺪﺑ
، ﺆﻣ ﺖﺳا هدﻮﺑ ﺮﺛ )
8 ( نﺎﺸﻧ . ﺖﺳا هﺪﺷ هداد ﺶﯾاﺰﻓا
رد ﻢﯿﺴﻠﮐ رﺎﻨﮐ
ﻦﯾﺮﻤﺗ
ﯽﺘﻣوﺎﻘﻣ و ﺖﯾدوﺪﺤﻣ
،يژﺮﻧا ﭻﯿﻫ ﺖﯾﺰﻣ ﻪﻓﺎﺿا يا رد ﺶﻫﺎﮐ ﯽﺑﺮﭼ ﯾ زا ﻞﺒﻗ نزو ﻪﻓﺎﺿا ياراد نﺎﻧز رد نﺪﺑ ﮕﺴﺋﺎ
ﯽ دراﺪﻧ ) 9 (.
صﻮﺼﺧ رد
ﻞﻤﮑﻣ فﺮﺼﻣ ﺎﺑ ﻦﯾﺮﻤﺗ ﺮﯿﺛﺄﺗ ﻦﯿﻣﺎﺘﯾو
) ﺶﻧارﺎﮑﻤﻫ و سرداد ،D
2018 +ﻦﯾﺮﻤﺗ هوﺮﮔ رد ار ﯽﺑﺮﭼ ﺪﺻرد و نزو ﺮﯾدﺎﻘﻣ ﺶﻫﺎﮐ ﻦﯾﺮﺘﺸﯿﺑ (
ﻞﻤﮑﻣ شراﺰﮔ هدﺮﮐ ﺪﻧا ) 10 (،
ﻟﺎﺣرد ﯽ ﻪﮐ ﻦﯾﺪﻠﺳ ) نارﺎﮑﻤﻫ و1
2017 ﺪﻧداد نﺎﺸﻧ ( ﻪﻧ
ﺑﺮﭼ ﺪﺻرد ﻪﻧ وBMI
ﯽ ﺎﺑ نﺪﺑ ﺮﯾدﺎﻘﻣ و ﯾ ﻣﺎﺘ ﯿ ﻦ
D
ﺪﻧراﺪﻧ يرادﺎﻨﻌﻣ طﺎﺒﺗرا )
11 ( . ﺞﯾﺎﺘﻧ ﺶﻫوﮋﭘ ﺎﻫ ي مﺎﺠﻧا ﻪﺘﻓﺮﮔ ﻪﺑ رﻮﻈﻨﻣ رﺎﺛآ ﯽﺑﺎﯾزرا ﻣ
ﻞﻤﮑ ﻢﯿﺴﻠﮐ ﺎﺑ ﺎﯾ نوﺪﺑ ﻦﯿﻣﺎﺘﯾو ﺮﺑ ،D
لﺮﺘﻨﮐ نزو نﺪﺑ و
ﯽﺑﺮﭼ ﺪﺻرد زﻮﻨﻫ
ﺚﺤﺑ ﮕﻧاﺮﺑ ﯿﺰ ﯽﻗﺎﺑ هﺪﻧﺎﻣ
،ﺖﺳا ﻪﺑ رﻮﻃ ي ﻪﮐ تﺎﻌﻟﺎﻄﻣ ﯽﺧﺮﺑ
،ﯽﻧﺎﺴﻧا طﺎﺒﺗرا ﻦﯿﺑ ﯽﻔﻨﻣ فﺮﺼﻣ
دﺎﯾز ﻢﯿﺴﻠﮐ و لﻼﺘﺧا ﺎﻫ ي
ﺖﺧﻮﺳ زﺎﺳو ي ﻪﺘﺴﺑاو ﻪﺑ نﺎﺸﻧ ار ﯽﻗﺎﭼ هداد
ﺪﻧا ) 12 .(
ﺮﯾﺎﺳ تﺎﻌﻟﺎﻄﻣ طﺎﺒﺗرا ﯽﺳﻮﮑﻌﻣ ار
ﻦﯿﺑ فﺮﺼﻣ ﻢﯿﺴﻠﮐ و نزو و نﺪﺑ ﺮﻄﺧ قﺎﭼ نﺪﺷ
نﺎﺸﻧ هداد ﺪﻧا ) 8 ( ﻦﯿﻣﺎﺘﯾو و ﻢﯿﺴﻠﮐ فﺮﺼﻣ ﻦﯿﺑ طﺎﺒﺗرا ﻦﯾاﺮﺑﺎﻨﺑ.
ﻪﺑ ﯽﺷزرو ﻦﯾﺮﻤﺗ رﺎﻨﮐ ردD
ﻘﺤﺗ ﯿ تﺎﻘ نﺎﻨﯿﻤﻃا ﺎﺑ ناﻮﺘﺑ ﺎﺗ دراد زﺎﯿﻧ يﺮﺘﺸﯿﺑ
.دﺮﮐ ﺚﺤﺑ يﺮﺘﺸﯿﺑ ﻞﻣاﻮﻋ زا ﯽﮑﯾ ،ﯽﯾﻮﺳ زا ﺪﺷر
هداﻮﻧﺎﺧ ﻦﯿﺑ رد ﯽﺒﺼﻋ
،ﯽﺒﺼﻋ ﺪﺷر ﻞﻣاﻮﻋ ﺰﻐﻣ زا ﻖﺘﺸﻣ ﮏﯿﻓوﺮﺗورﻮﻧ ﻞﻣﺎﻋ
ﺖﺳا2
ﻪﮐ رد ﮏﯿﮑﻔﺗ
ﯽﻧورﻮﻧ ،3
ﻞﮑﺷ ﮔﯿ ﺮ ي گﺮﯾﻮﻣ گﺮﯾﻮﻣ زا ﺪﯾﺪﺟ يﺎﻫ يﺎﻫ
ﯽﻠﺒﻗ رد4
يﺰﮐﺮﻣ ﯽﺒﺼﻋ هﺎﮕﺘﺳد ﻞﮑﺷ ،5
ﺬﭘ ﯾﺮ ي ﯽﺴﭘﺎﻨﯿﺳ
6، ﻪﻣﺎﻧﺮﺑ گﺮﻣ رﯾ
ﺰ ي ﺪﺷ ة
،ﯽﻟﻮﻠﺳ ﺖﺧﻮﺳ و اﺬﻏ بﺬﺟ
،زﺎﺳو و ﻪﻈﻓﺎﺣ و يﺮﯿﮔدﺎﯾ
ﺎﻫدﺮﮑﻠﻤﻋ ي
دراد ﺶﻘﻧ يرﺎﺘﻓر )
13 ، 14 ( ﺖﻈﻠﻏ . و ﯽﻟﻮﻠﺳ ﺮﯾدﺎﻘﻣ رد BDNF
جرﺎﺧ
،ﯽﻟﻮﻠﺳ ﺶﻫﺎﮐ ﻦﺳ ﺶﯾاﺰﻓا ﺎﺑ ﻣ
ﯽ ﯾ ﺪﺑﺎ داﺪﻌﺗ ﺶﻫﺎﮐ ﺎﺑ ﻪﮐ نورﻮﻧ
ﺎﻫ هوﻼﻋ .ﺖﺳا ﻂﺒﺗﺮﻣ ﭗﻤﮐﻮﭙﯾﺎﻫ ﻢﺠﺣ و ﺶﻫﺎﮐ ﺮﯾدﺎﻘﻣ ﺮﺑ
،ﻪﺘﻓﺎﯾ
ﮔﯿ ﻧﺮ هﺪ ﺎﻫ ﺶﻫﺎﮐ ،ﺪﻧراد ﺮﻤﯾاﺰﻟآ يرﺎﻤﯿﺑ ﻪﮐ ﯽﯾﺎﻬﻧآ و ﻢﻟﺎﺳ ناﺪﻨﻤﻟﺎﺳ رد ﻦﺳ ﺶﯾاﺰﻓا ﺎﺑ ﺰﯿﻧ نآ ي ﻣ
ﯽ ﯾ ﺪﺑﺎ ) 15 ( ﺪﻨﻣدﻮﺳ رﺎﺛآ زا ،ﻪﺠﯿﺘﻧ رد ﻪﮐ
1. Seldeen
2 . Brain-Derived Neurotrophic Factor (BDNF)
3 . Neuronal differentiation
4 . Angiogenesis
5 . Central Nervous System (CNS)
6 . Synaptic Plasticity
ﻌﺗ و ﻞﻣﺎ ﻦﯿﻣﺎﺘﯾ د ي ﺴﻠﮐ و ﻢﯿ ﺎﺑ هاﺮﻤﻫ ﺮﻤﺗ ﻦﯾ اد ﯾ هﺮ ا ي ﯽﻠﯿﺧ ﺪﺷ ﺪﯾ ﺮﺑ ﯽﺑﺮﭼ ﺪﺻرد وBDNF
اراد ناﺪﻨﻤﻟﺎﺳ ي
نزو ﻪﻓﺎﺿا
9
ﻪﺘﺳﺎﮐ يدﺎﯾز راﺪﻘﻣ ﻪﺑ BDNF
ﻣ ﯽ دﻮﺷ ﺮﯾدﺎﻘﻣ ﺶﻫﺎﮐ . ﺎﯾ BDNF
ﮔﯿ هﺪﻧﺮ ﺎﻫ نآ ي ﻣ ﯽ ﺪﻧاﻮﺗ ﻞﮑﺷ ﺬﭘ ﯾﺮ و ﯽﺴﭘﺎﻨﯿﺳ ي نورﻮﻧ
رد ﯽﯾاز
رﻮﺼﺗ .ﺪﻫد ﺶﻫﺎﮐ ار ﭗﻤﮐﻮﭙﯾﺎﻫ ﻣ
ﯽ دﻮﺷ ﻞﮑﺷ ﺬﭘ ﯾﺮ نورﻮﻧ و ﯽﺴﭘﺎﻨﯿﺳ ي ﻪﻈﻓﺎﺣ و يﺮﯿﮔدﺎﯾ ﮥﻨﯿﻣز ﻪﮐ ﺪﻨﺘﺴﻫ ﯽﻧورﻮﻧ يﺎﻫﺪﻨﯾآﺮﻓ ﯽﯾاز
ﻞﮑﺷ ار ﭗﻤﮐﻮﭙﯾﺎﻫ ﻪﺑ ﻪﺘﺴﺑاو ﻣ
ﯽ ﺪﻨﻫد ) 16 ( د رد ﯽﺷزرو ﺖﯿﻟﺎﻌﻓ . ﯽﻄﯿﺤﻣ و يﺰﮐﺮﻣ ﯽﺒﺼﻋ هﺎﮕﺘﺳ
mRNA BDNF
ﺶﯾاﺰﻓا ار ﻣ
ﯽ ﺪﻫد زا .
ﻪﮐ ﯽﯾﺎﺠﻧآ ﺮﻤﺗ
ﯾ ﻦ ﺎﻫ يﺮﺘﺸﯿﺑ ﺰﻐﻣ زا ﻖﺘﺸﻣ ﮏﯿﻓوﺮﺗورﻮﻧ ﻞﻣﺎﻋ ﺪﯿﻟﻮﺗ ﺐﺟﻮﻣ ﻻﺎﺑ تﺪﺷ ﺎﺑ بوﺎﻨﺘﻣ ي ﻣ
ﯽ ﺪﻧﻮﺷ ﻦﯾا زا ﺖﺳا هﺪﺷ ﻪﯿﺻﻮﺗ ،
تﺎﻨﯾﺮﻤﺗ ﻪﺑ ناﻮﻨﻋ نﺎﯿﺑ ﺶﯾاﺰﻓا و ﺰﻐﻣ دﺮﮑﻠﻤﻋ ﮥﻌﺳﻮﺗ ياﺮﺑ ﺪﯿﻔﻣ ﯽﺷور دﻮﺷ هدﺎﻔﺘﺳاBDNF
) 17 .(
ﺮﺑ هار ﻪﺳ زا ﻻﺎﺑ تﺪﺷ ﺎﺑ ﯽﺑوﺎﻨﺗ ﻦﯾﺮﻤﺗ
ﺪﯿﻟﻮﺗ ﺮﯿﺛﺄﺗ ﺰﻐﻣ رد BDNF
ﻣ ﯽ دراﺬﮔ : 1 ﺖﻈﻠﻏ و يرﺪﻨﮐﻮﺘﯿﻣ ﺖﯿﻟﺎﻌﻓ . ﺶﯾاﺰﻓا ار نورﻮﻧ رد ROS
ﻣ ﯽ ﺪﻫد ﻪﮐ ﯽﺴﯾﻮﻧور ﺚﻋﺎﺑ ROS
Creb-Bdnf
ﻣ ﯽ دﻮﺷ ؛ 2 ﻪﺑ و نورﻮﻧ رد ﻢﯿﺴﻠﮐ نﻮﯾ ﺖﻈﻠﻏ . ﺖﯿﻟﺎﻌﻓ نآ لﺎﺒﻧد
CaMKII
ﺶﯾاﺰﻓا ار ﻣ
ﯽ ﺪﻫد ﮓﻨﯿﻟﺎﻨﮕﯿﺳ ﺐﺟﻮﻣ و
APK/
ERK/ MSK
ﯽﺴﯾﻮﻧور ندﺮﮐ لﺎﻌﻓ ياﺮﺑ
Creb-Bdnf
ﻣ ﯽ دﻮﺷ ﯽﻟﻮﻠﺳ ﻞﺧاد ﻢﯿﺴﻠﮐ ،ﯽﯾﻮﺳ زا . ﻣ
ﯽ ﺪﻧاﻮﺗ ﺪﯿﻟﻮﺗ رد ROS
نورﻮﻧ ﺎﻫ ار
؛ﺪﻫد ﺶﯾاﺰﻓا 3
ﺶﯾاﺰﻓا ار نﻮﺧ تﺎﺘﮐﻻ ﺖﻈﻠﻏ . ﻣ
ﯽ ﺪﻫد ةﺪﻧﺮﯿﮔ ﺖﯿﻟﺎﻌﻓ ﺖﯾﻮﻘﺗ ﺐﺟﻮﻣ ﻪﮐ ﻢﯿﺴﻠﮐ نﻮﯾ ﺖﻈﻠﻏ ﺶﯾاﺰﻓا ياﺮﺑNMDA
ﻞﺧاد نورﻮﻧ رد ﯽﻟﻮﻠﺳ ﻣ
ﯽ دﻮﺷ ) 18 .(
ﺖﺳا هﺪﺷ هداد نﺎﺸﻧ ،ﯽﯾﻮﺳ زا 16
ﺮﺑ يﺮﯿﺛﺄﺗ ﺪﯾﺪﺷ ﯽﻠﯿﺧ ﯽﺑوﺎﻨﺗ ﻦﯾﺮﻤﺗ ﻪﺘﻔﻫ نادﺮﻣ ﯽﻣﺮﺳBDNF
ﺖﺳا ﻪﺘﺷاﺪﻧ )
19 .(
هوﻼﻋ ،هﺪﺷدﺎﯾ رﺎﺛآ ﺮﺑ ﺶﻘﻧBDNF
ﺬﭘﺎﻧرﺎﮑﻧا ﯾﺮ رد ﺰﯿﻧ ي ﺖﺧﻮﺳ
زﺎﺳو دراد يژﺮﻧا )
20 .(
رد ﻘﺤﺗ ﯿﻘ يزاﻮﻫ ﻦﯾﺮﻤﺗ ﺖﺳا هﺪﺷ هداد نﺎﺸﻧ ﯽ
ﻦﯿﻣﺎﺘﯾو ﻞﻤﮑﻣ و ﺮﯾدﺎﻘﻣD
ﺪﺣ رد ارBDNF
ﺎﺷ ﯾ نﺎ ﻪﺑ ﻦﯿﻣﺎﺘﯾو ﺎﯾ ﻦﯾﺮﻤﺗ هوﺮﮔ ﻪﺑ ﺖﺒﺴﻧ ﯽﻬﺟﻮﺗ ما نارﺎﻤﯿﺑ رد ﯽﯾﺎﻬﻨﺗ
ﯽﻣ دﻮﺒﻬﺑ سا ﺪﺸﺨﺑ
) 21 ( ﺮﺘﻨﯾا ﻦﯾﺮﻤﺗ ﺖﺳا هﺪﺷ هداد نﺎﺸﻧ ،ﯽﯾﻮﺳ زا . ﻪﺑ ﻪﺘﻔﻫ ﺶﺷ تﺪﻣ ﻪﺑ لاو
ﻦﯿﻣﺎﺘﯾو هاﺮﻤﻫ تاﺮﯿﯿﻐﺗ D
ﺮﯾدﺎﻘﻣ رد يرادﺎﻨﻌﻣ
BDNF
ﺖﺳا ﻪﺘﺷاﺪﻧ )
22 .(
هزوﺮﻣا
،ﯽﻗﺎﭼ زا ﻪﻠﻤﺟ ﺶﻟﺎﭼ ﺎﻫ ي ﯽﻤﻠﻋ ﻪﺑ بﺎﺴﺣ ﻣ ﯽ آﯾ ﺪ زا.
،ﯽﯾﻮﺳ ﯽﺷزرو ﺖﯿﻟﺎﻌﻓ ﻪﻠﻤﺟ زا
شور ﺎﻫ ﯽﯾ ﺳا ﺖ ﺶﻫﺎﮐ ﻪﺑ ﻪﮐ ﺪﺻرد
ﯽﺑﺮﭼ
نزو و نﺪﺑ ﯽﻣ ﺮﺠﻨﻣ دﻮﺷ ﻦﯾﺮﻤﺗ.
اد ﯾ هﺮ ا زا هدﺎﻔﺘﺳا ﺎﺑ ﻪﮐ ﺖﺳا نﺪﺑ ﯽﻓﺎﺿا ﯽﺑﺮﭼ ﺎﯾ نزو ﺶﻫﺎﮐ ياﺮﺑ ﺮﺛﺆﻣ و ﻊﯾﺮﺳ ﯽﺷور ﻻﺎﺑ تﺪﺷ ﺎﺑ ي
ﺳا رادرﻮﺧﺮﺑ اﺮﺟا ياﺮﺑ يﺮﺘﺸﯿﺑ ﺖﻟﻮﻬﺳ زا ﯽﺷزرو ﻦﯾﺮﻤﺗ لﺎﮑﺷا ﺮﯾﺎﺳ ﻪﺑ ﺖﺒﺴﻧ و ﺖﺳاﺮﺟا ﻞﺑﺎﻗ تﺎﻧﺎﮑﻣا ﻪﺑ زﺎﯿﻧ نوﺪﺑ و نﺪﺑ نزو .ﺖ
ﻦﯿﻨﭽﻤﻫ ﻪﺑ
وﯾ هﮋ ﻪﺑ ﺪﻨﻤﻟﺎﺳ داﺮﻓا ياﺮﺑ تاﺰﯿﻬﺠﺗ دﻮﺒﻧ و ﺖﻗو دﻮﺒﻤﮐ ﻞﯿﻟد
ﺖﺳا ﯽﺑﻮﺧ ﻦﯾﺰﮕﯾﺎﺟ )
23 .(
درﻮﻣ ﺖﯿﻌﻤﺟ ﻪﺑ ﻪﺟﻮﺗ ﺎﺑ ،ﻦﯾاﺮﺑﺎﻨﺑ
ﺳرﺮﺑ .ﺖﺳا رادرﻮﺧﺮﺑ هدﺎﻔﺘﺳا ياﺮﺑ يﺮﺘﺸﯿﺑ ﺖﯿﻤﻫا زا ﻦﯾﺮﻤﺗ ﻞﮑﺗوﺮﭘ زا ﻞﮑﺷ ﻦﯾا ،ﺪﻨﺘﺴﻫ نزو ﻪﻓﺎﺿا ياراد ناﺪﻨﻤﻟﺎﺳ ﻪﮐ ﯽ زا
ﺮﺑ ،ﯽﯾﻮﺳ
ﺧﺮﺑ ،تﺎﻋﻼﻃا سﺎﺳا ﯽ
ﻘﺤﺗ ﯿ تﺎﻘ ﻪﺑ ﺎﻬﻨﺗ ﺳرﺮﺑ ﯽ رﺎﺛآ ﺴﻠﮐ ﻞﻤﮑﻣ ﻢﯿ
) 8 ، 24 ( ﺎﯾ و و ﻦﯿﻣﺎﺘﯾ D
) 11 ، 25 ، 33 ( ﻪﺘﺧادﺮﭘ نزو ﺶﻫﺎﮐ ﺮﺑ .ﺪﻧا
ﺴﺑ داﺪﻌﺗ رﺎﯿ ﻤﮐ ﯽ رﺎﺛآ ﺴﻠﮐ نﺎﻣﺰﻤﻫ ﻢﯿ
و و ﻦﯿﻣﺎﺘﯾ هدﺮﮐ ﻪﻌﻟﺎﻄﻣ ارD
ﺪﻧا ) 3 ، 34 ، 35 ( ا ﺎﺑ . ﻦﯾ ﺎﺘﻧ ،لﺎﺣ ﺞﯾ ﻀﻗﺎﻨﺘﻣ ﯽ ﺧﺮﺑ رد ﯽ شراﺰﮔ تﺎﻌﻟﺎﻄﻣ
ا هﺪﺷ ﺖﺳ ﻮﺳ زا . ي د
،ﺮﮕﯾ تﺎﻘﯿﻘﺤﺗ ﻤﮐ
ﯽ رﺎﺛآ ﻞﻤﮑﻣ نﺎﻣﺰﻤﻫ ﺎﻫ
ي ﺴﻠﮐ ﻢﯿ و و ﻦﯿﻣﺎﺘﯾ وD
ﯾﺮﻤﺗ ﻦ ) 35 ( ﺘﺳد رد ار ﯽﺑﺎﯿ ﻬﺑ نزو ﺶﻫﺎﮐ ﻪﺑ ﻪﻨﯿ
ﺳرﺮﺑ ﯽ هدﺮﮐ .ﺪﻧا ﺶﻘﻧ ﻪﺑ ﻪﺟﻮﺗ ﺎﺑ ﻦﯿﻨﭽﻤﻫ ردBDNF
ﺖﺧﻮﺳ زﺎﺳو يژﺮﻧا ) 20 ( ﺮﯿﺛﺄﺗ و ﻦﯿﻣﺎﺘﯾو ﺮﯾدﺎﻘﻣ ﺮﺑD
)BDNF
36 - 39 (
، مﺎﺠﻧا
ﯽﺸﻫوﮋﭘ ﺎﺑ ﯽﺷزرو ﺖﯿﻟﺎﻌﻓ ﺐﯿﮐﺮﺗ و
ﻞﻤﮑﻣ ﺎﻫ ي ﯽﯾاﺬﻏ ﻢﯿﺴﻠﮐ و ﻦﯿﻣﺎﺘﯾو ﻪﮐ D
رد ﯽﺸﻫوﮋﭘ هﺪﻫﺎﺸﻣ هﺪﺸﻧ
،ﺖﺳا ﻪﺑ ﺮﻈﻧ ﻣ ﯽ ﺪﺳر ﺮﯿﺛﺄﺗ ﺪﻧاﻮﺘﺑ
و ﯽﺑﺮﭼ ﺪﺻرد ﺮﺑ يزرﺎﺑ .ﺪﺷﺎﺑ ﻪﺘﺷاد نزو ﻪﻓﺎﺿا ياراد ناﺪﻨﻤﻟﺎﺳ BDNF
ازا ﯾ ﻦ ور ﺶﻫوﮋﭘ زا فﺪﻫ ﯽﺳرﺮﺑ ﺮﺿﺎﺣ
ﻞﻣﺎﻌﺗ ﺮﯿﺛﺄﺗ ﺴﻠﮐ
ﻢﯿ و
و ﻦﯿﻣﺎﺘﯾ د ي رﺎﻨﮐ رد ﺮﻤﺗ ﻦﯾ اد ﯾ هﺮ ا ﺪﯾﺪﺷ ﯽﻠﯿﺧ ي ﺮﺑ
ناﺪﻨﻤﻟﺎﺳ ﯽﺑﺮﭼ ﺪﺻرد وBDNF
اراد ي و ﻪﻓﺎﺿا .ﺖﺳا نز
32 ﻢﻟﺎﺳ ﺪﻨﻤﻟﺎﺳ نز 60
ﻻﺎﺑ ﻪﺑ لﺎﺳ
ﻦﯿﺑ نﺪﺑ ةدﻮﺗ ﺺﺧﺎﺷ ﺎﺑ 25
ﺎﺗ 9/
29
ﺎﻤﻧوراد +ﻦﯾﺮﻤﺗ هوﺮﮔ =داﺪﻌﺗ)
8( 8( =داﺪﻌﺗ)ﻞﻤﮑﻣ هوﺮﮔ 8( =داﺪﻌﺗ)ﻞﻤﮑﻣ +ﻦﯾﺮﻤﺗ هوﺮﮔ 8( =داﺪﻌﺗ)لﺮﺘﻨﮐ هوﺮﮔ
ﺶﯿﭘ نﻮﻣزآ - ﻠﺧاﺪﻣ ﮥ و ﯽﻨﯾﺮﻤﺗ
اﺬﻏ ) ﯽﯾ 8 (ﻪﺘﻔﻫ - ﺲﭘ
نﻮﻣزآ 8 ) ﯽﯾاﺬﻏ ﮥﻠﺧاﺪﻣ- نﻮﻣزآﺶﯿﭘ
(ﻪﺘﻔﻫ - ﺲﭘ
نﻮﻣزآ و ﯽﻨﯾﺮﻤﺗﮥ ﻠﺧاﺪﻣ- نﻮﻣزآﺶﯿﭘ
) ﯽﯾاﺬﻏ 8 (ﻪﺘﻔﻫ - ﺲﭘ
نﻮﻣزآ نﻮﻣزآﺲﭘ- نﻮﻣزآﺶﯿﭘ
نﻮﺧ يﺮﯿﮔ 48 ﺖﻋﺎﺳ ﺶﯿﭘ زا
ﻦﯾﺮﻤﺗ مﺎﺠﻧا و ﻞﻤﮑﻣ فﺮﺼﻣ
ﻪﺑ ﯽﻓدﺎﺼﺗ ﻢﯿﺴﻘﺗ رﺎﻬﭼ
هوﺮﮔ
شور ﺳﺎﻨﺷ ﯽ ﺶﻫوﮋﭘ
ﺶﻫوﮋﭘ حﺮﻃ ﻞﮑﺷ رد ﺶﻫوﮋﭘ ﯽﻠﮐ حﺮﻃ 1
.ﺖﺳا هﺪﺷ هداد نﺎﺸﻧ
ﻞﮑﺷ 1 ﺶﻫوﮋﭘ حﺮﻃ ﯽﻠﮐ ﮏﯿﺗﺎﻤﺷ .
ﻧدﻮﻣزآ ﯽ ﺎﻫ
مﺮﻧ زا هدﺎﻔﺘﺳا ﺎﺑ ﻪﻧﻮﻤﻧ ﻢﺠﺣ راﺰﻓا
G-POWER
هزاﺪﻧا ﺎﺑ اﻮﻧآ نﻮﻣزآ ياﺮﺑ ﮔﯿ
ﺮ ي ﺎﻫ ي ناﻮﺗ ﺎﺑ ،يراﺮﮑﺗ 9/
0 زاﺪﻧا و ة ﺮﺛا 25 /0 يﺎﻄﺧ ﺢﻄﺳ و
ﺮﺑاﺮﺑ ﺎﻔﻟآ 05 /0 ، 2 3 ﻦﯿﯿﻌﺗ ﺮﻔﻧ ﺷ
ﺪ ) 40 ، 41 ( . 32 ﺪﻨﻤﻟﺎﺳ نﺎﻧز زا ﺮﻔﻧ ﻢﻟﺎﺳ
60 لﺎﺳ ﺎﺑ ﻻﺎﺑ ﻪﺑ ﻦﯿﺑBMI
25 ﺎﺗ 9/
29 زا ﻌﻣﺎﺟ ﮥ رﺎﻣآ زا ﺲﭘ ي
.ﺪﻧﺪﺷ ﺶﻫوﮋﭘ ﮥﻧﻮﻤﻧ ﻪﻧﺎﺒﻠﻃواد ،ﯽﺘﻣﻼﺳ ﮥﻣﺎﻨﺸﺳﺮﭘ ﻞﯿﻤﮑﺗ ﻧدﻮﻣزآ
ﯽ ﺎﻫ ﺮﮔ رﺎﻬﭼ ﻪﺑ ﯽﻓدﺎﺼﺗ ﻪﺑ هدﺎﺳ ﯽﻓدﺎﺼﺗ شور رد .ﺪﻧﺪﺷ ﻢﯿﺴﻘﺗ هو
زا ﮏﯾﺮﻫ ﻧدﻮﻣزآ
ﯽ ﺎﻫ ةرﺎﻤﺷ 1 ﺎﺗ 32 داﺪﻋا ﺲﭙﺳ ،ﺪﺷ هداد 1
- 8 داﺪﻋا ،ﻞﻤﮑﻣ و ﻦﯾﺮﻤﺗ هوﺮﮔ رد 9
- 16 داﺪﻋا ،ﺎﻤﻧوراد و ﻦﯾﺮﻤﺗ هوﺮﮔ رد 17
-
24 داﺪﻋا و ﻞﻤﮑﻣ هوﺮﮔ رد 32
- 25 ﭻﯿﻫ .ﺪﻨﺘﻓﺮﮔ راﺮﻗ لﺮﺘﻨﮐ هوﺮﮔ رد زا ﮏﯾ
ﻧدﻮﻣزآ ﯽ ﺎﻫ اد ﺎﯾ ﯽﺷزرو ﻞﻤﮑﻣ زا ﺶﯿﭘ هﺎﻣ ﮏﯾ ﺎﺗ ﯽﺻﺎﺧ يور
زا ﻦﯿﻨﭽﻤﻫ .ﺪﻧدﺮﮑﻧ هدﺎﻔﺘﺳا ﺶﻫوﮋﭘ ةرود عوﺮﺷ زا ﺎﻬﻧآ
ﺪﺷ ﻪﺘﺳاﻮﺧ ﻫﯿ
ﭻ ﻪﻧﻮﮔ ﻦﯾا .ﺪﻨﻨﮑﻧ فﺮﺼﻣ ﺶﻫوﮋﭘ ةرود رد ﯽﯾوراد ﺎﯾ ﯽﯾاﺬﻏ ﻞﻤﮑﻣ
ةرﺎﻤﺷ ﻪﺑ ﯽﺷزرو مﻮﻠﻋ و ﯽﻧﺪﺑ ﺖﯿﺑﺮﺗ ةﺪﮑﺸﻫوﮋﭘ قﻼﺧا ﮥﺘﯿﻤﮐ رد ﺶﻫوﮋﭘ
SSRI.REC-2109-1274(R1)
.ﺖﺳا هﺪﺷ ﺖﺒﺛ وﯾ
ﮔﮋ ﯽ ﺎﻫ ي
ﻮﻣزآ ﻧد ﯽ ﺎﻫ لوﺪﺟ رد 1
.ﺖﺳا هﺪﺷ شراﺰﮔ
نﻮﺧ يﺮﯿﮔ 48 ﺖﻋﺎﺳ ﺲﭘ زا
ﺎﺠﻧا و ﻞﻤﮑﻣ فﺮﺼﻣ ﻦﯾﺮﻤﺗ م
نﺪﺑ ﯽﺑﺮﭼ ﺪﺻرد ﻦﯿﯿﻌﺗ
ﻌﺗ و ﻞﻣﺎ ﻦﯿﻣﺎﺘﯾ د ي ﺴﻠﮐ و ﻢﯿ ﺎﺑ هاﺮﻤﻫ ﺮﻤﺗ ﻦﯾ اد ﯾ هﺮ ا ي ﯽﻠﯿﺧ ﺪﺷ ﺪﯾ ﺮﺑ ﯽﺑﺮﭼ ﺪﺻرد وBDNF
اراد ناﺪﻨﻤﻟﺎﺳ ي
نزو ﻪﻓﺎﺿا
11
لوﺪﺟ 1 ﻣ. ﻦﯿﮕﻧﺎﯿ
،نزو ﻦﺳ و ﺪﻗ ،نﺪﺑ ةدﻮﺗ ﺺﺧﺎﺷ ﻧدﻮﻣزآ
ﯽ ﺎﻫ هوﺮﮔ رﺎﻬﭼ رد
ﻞﮑﺗوﺮﭘ ﻦﯾﺮﻤﺗ
ﻞﮑﺗوﺮﭘ ﻦﯾﺮﻤﺗ اد ﯾ هﺮ ا ي ﻪﺳ ﺪﯾﺪﺷ ﯽﻠﯿﺧ ﻪﺴﻠﺟ
رد تﺪﻣ ﻪﺑ ﻪﺘﻔﻫ ﺖﺸﻫ
مﺎﺠﻧا ﻪﺘﻔﻫ ﺖﻓﺮﮔ
. ﻧ ﺮﯾز ﯽﻨﯾﺮﻤﺗ تﺎﺴﻠﺟ يژﻮـﻟﻮﯾﺰﯿﻓ ﺺـﺼﺨﺘﻣ ﺮﻈ
مﺎﺠﻧا ﺺﺼﺨﺘﻣ ﮏﺷﺰﭘ و ﯽﺷزرو ﺖﻓﺮﮔ
. اﺪﺘﺑا
، ﻧدﻮﻣزآ ﯽ ﺎﻫ ﺞﻨﭘ ﻪﻘﯿﻗد و لﺎﻌﻓ ﯽﺸﺸﮐ تﺎﮐﺮﺣ و مارآ يود ﻤﺗ هﺎﮕﻧآ
ﻦﯾﺮ اد ﯾ هﺮ ا ي ﺪﯾﺪﺷ ﯽﻠﯿﺧ
ﻞﻣﺎﺷ ار 12 دﺮﺳ ﺲﭙﺳ ،ﺪﻧداد مﺎﺠﻧا ﺖﮐﺮﺣ ندﺮﮐ
تﺪﻣ ﻪﺑ ﺞﻨﭘ و مارآ يود ﺎﺑ ﻪﻘﯿﻗد تﺎﮐﺮﺣ
ﯽﺸﺸﮐ ﻏﯿ لﺎﻌﻓﺮ مﺎﺠﻧا ﺷ ﺪ .
ﻞﻣﺎﺷ ﻞﮑﺗوﺮﭘ ﻦﯾا رد هﺮﯾاد ﺖﺑﻮﻧ ﮏﯾ 12
حﻼـﺻا يﺪﺋﻮﺳ يﺎﻨﺷ ،راﻮﯾد ﻪﺑ ﺖﺸﭘ ﻦﺘﺴﺸﻧ ،ﻪﻧاوﺮﭘ :ﺖﮐﺮﺣ و ﻻﺎـﺑ ،ﯽﻤﮑـﺷ ﭻﻧاﺮـﮐ ،هﺪـﺷ
ﻪﺳ ﭗﯾد ،تﺎﮑﺳا ،ﻪﻠﭘ زا ﻦﺘﻓر ﻦﯿﯾﺎﭘ دﻮـﺑ ﯽﺒﻧﺎـﺟ ﮏـﻧﻼﭘ و سﻮـﮑﻌﻣ ﮏـﻧﻼﭘ ،ﺞـﻧﻻ ،ﺎﺟ رد نﺪﯾود و ﺪﻨﻠﺑ ﻮﻧاز ،ﺎﺘﺴﯾا ﮏﻧﻼﭘ ،وزﺎﺑ ﺮﺳ
) 23 (
لوﺪﺟ) 2 .(
اﺮﺑ ي لﺮﺘﻨﮐ ﻣﺎﻧﺮﺑ تﺪﺷ ﮥ
ﻣ زا ﯽﻨﯾﺮﻤﺗ سﺎﯿﻘ
حﻼﺻا ﺪﺷ ة رﺎﺸﻓ كرد گرﻮﺑ
ﺪﺷ هدﺎﻔﺘﺳا1
. ﺖـﺳا يراﺰـﺑا ،گرﻮﺑ رﺎﺸﻓ كرد سﺎﯿﻘﻣ
ﺋارا ﺖﻬﺟ ﻪﮐ ﮥ
كاردا ﯽﻨﻫذ زﺎﯿﺘﻣا ﮏﯾ هدﺎﻔﺘﺳا ﻦﯾﺮﻤﺗ تﺪﺷ زا دﺮﻓ ﻂﺳﻮﺗ هﺪﺷ
ﻣ ﯽ دﻮﺷ زا ار ﻦﯾﺮﻤﺗ تﺪﺷ ﻪﮐ 0
ﺎﺗ 10 ﯽﻫدزﺎﯿﺘﻣا ﻣ
ﯽ ﺪﻨﮐ ﻪﮐ
0 و ﻦﯾﺮﺘﻤﮐ 10
ﺖﺳا هﺮﻤﻧ ﻦﯾﺮﺗﻻﺎﺑ ﺮﻤﻧ ﺎﺗ ﻪﮐ
ة 7 ﺎﺗ 8 ﺮﻤﺗ ﺮﮕﻧﺎﯿﺑ .ﺖﺳا ﺪﯾﺪﺷ ﯽﻠﯿﺧ ﻦﯾ
زا ﮏـﯾﺮﻫ زا ﺪـﻌﺑ سﺎﯿﻘﻣ ﻦﯾا ﺖـﮐﺮﺣ هدزاود
ﯽـﻃ
ﻠﺣﺮﻣ ﮥ ﺖﺒﺛ ﻦﯾﺮﻤﺗ ﺪﺷ
) 42 (.
لوﺪﺟ 2 . ﻦﯾﺮﻤﺗ ﻞﮑﺗوﺮﭘ
ﻪﺴﻠﺟ ﺎﻫ ي
ﻦﯾﺮﻤﺗ ﺮﺟا نﺎﻣز
ﺮﻫ يا (ﻪﯿﻧﺎﺛ) ﺖﮐﺮﺣ ﺮﻫ ﻦﯿﺑ ﺖﺣاﺮﺘﺳا نﺎﻣز
(ﻪﯿﻧﺎﺛ) ﺖﮐﺮﺣ ﺮﻫ ﻦﯿﺑ ﺖﺣاﺮﺘﺳا نﺎﻣز
(ﻪﻘﯿﻗد) ﺖﺑﻮﻧ داﺪﻌﺗ
ﺖﺑﻮﻧ ﻦﯾﺮﻤﺗ ﻞﮐ نﺎﻣز تﺪﻣ
(ﻪﻘﯿﻗد)
1 و 2 30
30 2
ﺎﺗ 3 1
5/
11
3 30
30 2
ﺎﺗ 3 2
25 ﺎﺗ 26
4 30
25 2
ﺎﺗ 3 2
23 ﺎﺗ 24
5 30
25 2
ﺎﺗ 3 3
34 ﺎﺗ 35
rating of perceived exertion modified borg scale
. 1
ﺮﯿﻐﺘﻣ هوﺮﮔ
ﺎﻫ ﭘﯿ
ﺶ نﻮﻣزآ ﺲﭘ
نﻮﻣزآ
نزو (مﺮﮔﻮﻠﯿﮐ) ﻞﻤﮑﻣ و ﻦﯾﺮﻤﺗ
ﺎﻤﻧوراد و ﻦﯾﺮﻤﺗ ﻞﻤﮑﻣ لﺮﺘﻨﮐ 59
/
±37 1/
78 37 /
±25 2/
77 69 / 87
± 2/
76 29 / 12
± 2/
78 65
/
±25 2/
73 75 /
±25 1/
74 54 / 37
± 3/
75 00 / 00
± 2/
78
نﺪﺑ ةدﻮﺗ ﺺﺧﺎﺷ /مﺮﮔﻮﻠﯿﮐ) (ﻊﺑﺮﻣﺮﺘﻣ
ﻞﻤﮑﻣ و ﻦﯾﺮﻤﺗ ﺎﻤﻧوراد و ﻦﯾﺮﻤﺗ
ﻞﻤﮑﻣ لﺮﺘﻨﮐ 02
/ 81
± 1/
29 93 /
±27 0/
24 13 / 18
± 1/
28 75 / 72
± 1/
27 65
/ 46
± 2/
27 06 /
±81 2/
28 04 / 12
± 1/
27 04 / 78
± 2/
27
ﺪﻗ ) ﺘﻧﺎﺳ ﯽ ﺮﺘﻣ ( ﻞﻤﮑﻣ و ﻦﯾﺮﻤﺗ
ﺎﻤﻧوراد و ﻦﯾﺮﻤﺗ ﻞﻤﮑﻣ لﺮﺘﻨﮐ 23
/ 12
± 2/
163 74 /
±00 3/
161 28 /
±25 5/
165 20 / 00
± 3/
168 -
-
- -
ﻦﺳ (لﺎﺳ) ﻞﻤﮑﻣ و ﻦﯾﺮﻤﺗ
ﺎﻤﻧوراد و ﻦﯾﺮﻤﺗ ﻞﻤﮑﻣ لﺮﺘﻨﮐ 59
/ 37
± 1/
65 24 /
±00 4/
61 42 /
±62 3/
63 16 / 75
± 4/
60 -
- - -
6 و 7 30
20 2
ﺎﺗ 3 3
31 ﺎﺗ 32
8 و 9 30
15 2
ﺎﺗ 3 3
28 ﺎﺗ 29
10 ﺎﺗ 24 30
10 2
ﺎﺗ 3 3
5/
25 ﺎﺗ 5/
26
ﻞﻤﮑﻣ فﺮﺼﻣ
صﺮﻗ ﺴﻠﮐ ﯿ ﻢ نﺎﺷﻮﺟ و ﺎﻤﻧوراد ي آ ن ﺎﺑ ﺶﺷﻮﭘ ﺎﻫ ي
ًﻼﻣﺎﮐ ﻪﺑﺎﺸﻣ و نزو ﯾ نﺎﺴﮑ ﺪﻧرادﺮﺑرد ة ﺖﮐﺮﺷ ﻂﺳﻮﺗ ﯽﮐارﻮﺧ ﻦﯿﻓارﺎﭘ و زﻮﺘﮐﻻ
يزﺎﺳوراد ﺮﯿﺴﮐا
)
،دﺮﺟوﺮﺑ اﯾ ناﺮ ( و ﻞﻤﮑﻣ و ﯾ ﻣﺎﺘ ﯿ ﻦ و D راد ﺎﻤﻧو ي نآ ﻪﮐ ﻞﮑﺸﺘﻣ زا ﮥﺘﺳﺎﺸﻧ ترذ و ﻦﯿﻟﺎﺘﺴﯾﺮﮐوﺮﮑﯿﻣ) ﻞﺴﯾوآ (ﺰﻟﻮﻠﺳ
و
ًﻼﻣﺎﮐ ﻪﺑﺎﺸﻣ ﻦﯿﻣﺎﺘﯾو ﺖﺳا D
، ﻂﺳﻮﺗ ﺖﮐﺮﺷ زﺎﺳوراد ﺮﯿﺴﮐا ي )
،دﺮﺟوﺮﺑ اﯾ ناﺮ ( ﻪﺘﺧﺎﺳ ﺪﺷ . هوﺮﮔ ﻞﻤﮑﻣ رد لﻮﻃ رود ة ﺮﻈﻧ ﺎﺑ ﺶﻫوﮋﭘ
،ﮏﺷﺰﭘ ﻪﻧازور 1000 ﻣ ﯿﻠ ﯽ مﺮﮔ صﺮﻗ ﻢﯿﺴﻠﮐ نﺎﺷﻮﺟ ) 43 ( ﻪﺑ ار ﺐﺷ مﺎﮕﻨﻫ و
50000 ﺪﺣاو ﺑﯿ ﻦ ﻠﻠﻤﻟا ﯽ ﻦﯿﻣﺎﺘﯾو )D 34 ( ﺎﺑ هاﺮﻤﻫ ﻪﺘﻔﻫ رد ار
فﺮﺼﻣ ﺮﻬﻇ مﺎﮕﻨﻫ ﻪﺑ اﺬﻏ ﺪﻧدﺮﮐ
هوﺮﮔ . +ﻞﻤﮑﻣ ﻦﯾﺮﻤﺗ ﻦﯿﻤﻫ هﻮﯿﺷ ار اﺮﺟا
،دﺮﮐ ﻪﺑ هوﻼﻋ ﻪﺳ ﻪﺴﻠﺟ ﻦﯾﺮﻤﺗ اد ﯾ هﺮ ا ي ﯽﻠﯿﺧ ﺪﯾﺪﺷ ﺰﯿﻧ رد
ﻪﺘﻔﻫ ﺪﻧداد مﺎﺠﻧا و
هوﺮﮔ لﺮﺘﻨﮐ ﻫﯿ ﭻ ﻪﻧﻮﮔ ﯽﻠﻤﮑﻣ ﺖﻓﺎﯾرد و ﺪﻧدﺮﮑﻧ ﻦﯾﺮﻤﺗ
ﯽﺷزرو ار ﺰﯿﻧ مﺎﺠﻧا ﺪﻧداﺪﻧ و هاﺮﻤﻫ هوﺮﮔ ﺎﺑ ﻞﻤﮑﻣ و +ﻞﻤﮑﻣ
ﻦﯾﺮﻤﺗ 48 ﺖﻋﺎﺳ ﭘﯿ ﺶ و ﺲﭘ زا فﺮﺼﻣ ﻞﻤﮑﻣ و مﺎﺠﻧا ﻦﯾﺮﻤﺗ ﯽﺷزرو ﻪﻧﻮﻤﻧ ﺎﺘﺷﺎﻧ ﯽﻧﻮﺧ زا
ﺎﻬﻧآ .ﺪﺷ ﻪﺘﻓﺮﮔ ﺎﺷ
ﯾ نﺎ ﺮﮐذ ناﺰﯿﻣ ﺖﺳا
ﻧازور فﺮﺼﻣ ﮥ
ﺴﻠﮐ ﯽﯾاﺬﻏ ﻢﯾژر رد ﯽﻌﯿﺒﻃ يد ﻦﯿﻣﺎﺘﯾو و ﻢﯿ ﻧدﻮﻣزآ
ﯽ ﺎﻫ ﺖﺳا هﺪﺸﻧ لﺮﺘﻨﮐ .
ﺶﺠﻨﺳ ﺺﺧﺎﺷ ﺎﻫ ي نﻮﺧ ﯽﯾﺎﯿﻤﯿﺷﻮﯿﺑ
ﯽﻣﺮﺳ ﺮﯾدﺎﻘﻣ ﯽﺑﺎﯾزرا ياﺮﺑ زا BDNF
ﻧدﻮﻣزآ ﯽ ﺎﻫ زا ﺲﭘ ﺪﺷ ﻪﺘﺳاﻮﺧ 12
تﺎﻋﺎﺳ ﻦﯿﺑ ﯽﯾﺎﺘﺷﺎﻧ ﺖﻋﺎﺳ 8
ﺎﺗ 9 ﻪﻌﺟاﺮﻣ هﺎﮕﺸﯾﺎﻣزآ ﻪﺑ ﺢﺒﺻ
راﺪﻘﻣ ﯽﻧدﻮﻣزآ ﺮﻫ زا .ﺪﻨﻨﮐ 5
ﻣ ﯿﻠ ﯽ ﻟﯿ ﺮﺘ و زا نﻮﺧ ﻪﺘﻓﺮﮔ نﻮﺧ .ﺪﺷ ﻪﺘﻓﺮﮔ ﯽﯾوزﺎﺑ ﺪﯾر
ﻟﻮﻟ نورد ،ﺪﯾرو زا هﺪﺷ ﮥ
ﺲﭙﺳ و ﺪﺷ ﻪﺘﺨﯾر ﺶﯾﺎﻣزآ
ﻖﺒﻃ ﻞﻤﻌﻟارﻮﺘﺳد ﺎﻫ
ﻏ ﺖﻈﻠ مﺮﺳ BDNF
ا شور ﻪﺑ ﻻ
ﺪﻧﺎﺳ عﻮﻧ زا اﺰﯾ و
ﯽﺘﺑﺎﻗر ﯽﭽﯾ ﺎﺑ
هدﺎﻔﺘﺳا زا يرﺎﺠﺗ ﺖﯿﮐ Kit ELISA
) Persongen Human
ﺖﮐﺮﺷBDNF Boster
رﺎﻤﺷ (نﺎﻤﻟآ ؛ ة
ﺮﮔﻮﻟﺎـــﺗﺎﮐ 01
- 00752 SK
ﯿﺳﺎﺴﺣ :ﺖ 063 /0 ﯽﻠﯿﻣ /مﺮﮔﻮﻧﺎﻧ ،ﺮﺘﯿﻟ
ﻨﻣاد ﮥ :ﺺﯿﺨﺸﺗ 20
- 325 /0 ﯽﻠﯿﻣ /مﺮﮔﻮﻧﺎﻧ ﺮﺘﯿﻟ
.ﺪﺷ هﺪﯿﺠﻨﺳ
ﻌﺗ ﻦﯿﯿ ﺑﺮﭼ ﺪﺻرد ﯽ
نﺪﺑ
ﺮﭙﯿﻟﺎﮐ ﮏﻤﮐ ﻪﺑ ﺪﻟﻮﻓ ﻦﯿﮑﺳا شور زا نﺪﺑ ﯽﺑﺮﭼ ﺪﺻرد ﻦﯿﯿﻌﺗ ياﺮﺑ نﺪﻨﭘرﺎﻫ لﺪﻣ
ﻧﺎﭙﻤﮐ زا ﯽ نﺎﺘﺴﻠﮕﻧاBATY
) British Indicators-
ﺑ .ﺪﺷ هدﺎﻔﺘﺳا (UK ﺪ
ﻦﯾ ﺮﻫ ﻪﮐ ﺐﯿﺗﺮﺗ ﺶﺠﻨﺳ
د ﻞﺻاﻮﻓ ﺎﺑ و رﺎﺑ و 15
ﻧﺎﺛ ﯿﻪ ا ي طﺎﻘﻧ رد ﻪﺳ قﻮﻓ ،ﯽﯾوزﺎﺑ ﺮﺳ هﺮﺻﺎﺧ
يا و ﻧار ﯽ ﯽﺑﺮﭼ ﺖﻣﺎﺨﺿ
ﯽﺘﺳﻮﭘﺮﯾز ﻧدﻮﻣزآ
ﯽ ﺎﻫ هﺪﯿﺠﻨﺳ لﻮﻣﺮﻓ زا هدﺎﻔﺘﺳا ﺎﺑ ﺲﭙﺳ و ﺪﺷ ﻪﺳ
ﻪﻄﻘﻧ نﻮﺴﮑﺟ يا -
نﺪﺑ ﯽﺑﺮﭼ ﺪﺻرد كﻻﻮﭘ ﻧدﻮﻣزآ
ﯽ ﺎﻫ ﻪﺒﺳﺎﺤﻣ .ﺪﺷ
1 لﻮﻣﺮﻓ ( )
× X 0/0001392 (
- ) 2
×SSF 0/0000023 SSF) + (
× 0/0009929 (
-
=1/0994921 DB
SSF=ﻪﻄﻘﻧ ﻪﺳ رد ﯽﺘﺳﻮﭘﺮﯾز ﯽﺑﺮﭼﺖﻣﺎﺨﺿعﻮﻤﺠﻣ ،X =ﯽﻧدﻮﻣزآ
ﺰﺠﺗ شور ﯾﻪ
ﻠﺤﺗو ﯿ ﻞ هداد ﺎﻫ
ياﺮﺑ ﺰﺠﺗ ﯾﻪ ﻠﺤﺗو ﯿ ﻞ هداد ﺎﻫ زا ﺶﻫوﮋﭘ ي شور
ﺎﻫ .ﺪﺷ هدﺎﻔﺘﺳا ﯽﻃﺎﺒﻨﺘﺳا و ﯽﻔﯿﺻﻮﺗ يرﺎﻣآ ي زا
ﮕﻧﺎﯿﻣ ﮥﺒﺳﺎﺤﻣ ياﺮﺑ ﯽﻔﯿﺻﻮﺗ رﺎﻣآ و ﻦﯿ
دراﺪﻧﺎﺘﺳا فاﺮﺤﻧا هداد
ﺎﻫ ﻪﺴﯾﺎﻘﻣ ياﺮﺑ ﯽﻃﺎﺒﻨﺘﺳا رﺎﻣآ زا و هوﺮﮔ
ﺎﻫ ﻨﭽﻤﻫ .ﺪﺷ هدﺎﻔﺘﺳا ﻢﻫ ﺎﺑ ﯽﺳرﺮﺑ ياﺮﺑ ﻦﯿ
دﻮﺑ لﺎﻣﺮﻧ ﻊﯾزﻮﺗ ن
هداد ﺎﻫ زا
.ﺪﺷ هدﺎﻔﺘﺳا ﮏﻠﯾووﺮﯿﭘﺎﺷ نﻮﻣزآ ﻪﺴﯾﺎﻘﻣ ياﺮﺑ
ﻣﯿ ﮕﻧﺎ ﯿ ﻦ ﺎﻫ نورد ي ﯽﺗ يرﺎﻣآ شور زا ﯽﻫوﺮﮔ رد ﻪﺘﺴﺑاو
) يرادﺎﻨﻌﻣ ناﺰﯿﻣ 05
/0
P<
(
هدﺎﻔﺘﺳا زا هوﺮﮔ رﺎﻬﭼ ﮥﺴﯾﺎﻘﻣ ياﺮﺑ .ﺪﺷ نﻮﻣزآ
ﻪﻫاﺮﮑﯾ ﺲﻧﺎﯾراو ﺰﯿﻟﺎﻧآ .ﺪﺷ هدﺎﻔﺘﺳا
ﻞﯿﻠﺤﺗ ياﺮﺑ داد
ه ﺎﻫ زا مﺮﻧ راﺰﻓا
21
ﻢﺳر ياﺮﺑ و SPSS
زا ﺎﻫرادﻮﻤﻧ مﺮﻧ
راﺰﻓا
2013 Exell
.ﺪﺷ هدﺎﻔﺘﺳا
ﻌﺗ و ﻞﻣﺎ ﻦﯿﻣﺎﺘﯾ د ي ﺴﻠﮐ و ﻢﯿ ﺎﺑ هاﺮﻤﻫ ﺮﻤﺗ ﻦﯾ اد ﯾ هﺮ ا ي ﯽﻠﯿﺧ ﺪﺷ ﺪﯾ ﺮﺑ ﯽﺑﺮﭼ ﺪﺻرد وBDNF
اراد ناﺪﻨﻤﻟﺎﺳ ي
نزو ﻪﻓﺎﺿا
3 1
ﯾ ﻪﺘﻓﺎ ﺎﻫ ﺶﻫوﮋﭘ ي
مﺎﻤﺗ ﻧدﻮﻣزآ ﯽ ﺎﻫ ار تﻼﺧاﺪﻣ و ﻞﯿﻤﮑﺗ ار ﺶﻫوﮋﭘ ﺪﻨﯾاﺮﻓ ﻞﮐ ﻪﺑ
رﻮﻃ ﺮﮐ اﺮﺟا ﻞﻣﺎﮐ ﻣزآ ﺞﯾﺎﺘﻧ .ﺪﻧد
راو ﻞﯿﻠﺤﺗ نﻮ ﻫاﺮﮑﯾ ﺲﻧﺎﯾ
ﻦﯿﺑ داد نﺎﺸﻧ ﻪ
رد ﯽﺸﻫوﮋﭘ هوﺮﮔ رﺎﻬﭼ ﭘﯿ
ﺶ نﻮﻣزآ ﺮﯿﻐﺘﻣ فﻼﺘﺧاBDNF
رادﺎﻨﻌﻣ ) دراﺪﻧ دﻮﺟو ي 0681
/0
=
هوﻼﻋ .(P
ﺲﻧﺎﯾراو ﻞﯿﻠﺤﺗ نﻮﻣزآ ﺞﯾﺎﺘﻧ ،ﻦﯾا ﺮﺑ
ﮏﯾ رد ﯽﺸﻫوﮋﭘ هوﺮﮔ رﺎﻬﭼ ﻦﯿﺑ داد نﺎﺸﻧ ﻪﻫار ﺲﭘ
نﻮﻣزآ ﺮﯿﻐﺘﻣ فﻼﺘﺧاBDNF
رادﺎﻨﻌﻣ راد دﻮﺟو ي ) د
001 /0
=
،P
68 /0
= 2 ηp
.(
ﺞﯾﺎﺘﻧ
،داد نﺎﺸﻧ ﯽﮐﻮﺗ ﯽﺒﯿﻘﻌﺗ نﻮﻣزآ هوﺮﮔ رد BDNF
) ﻞﻤﮑﻣ هوﺮﮔ ﻪﺑ ﺖﺒﺴﻧ ﻞﻤﮑﻣ+ﻦﯾﺮﻤﺗ 002
/0
=
) لﺮﺘﻨﮐ و (P
1 00 /0
=
ﺶﯾاﺰﻓا (P
) ﺎﻤﻧوراد+ﻦﯾﺮﻤﺗ هوﺮﮔ ﻪﺑ ﺖﺒﺴﻧ ﺎﻣا ،ﺖﺷاد يرادﺎﻨﻌﻣ 085
/0
=
ﻦﯿﻨﭽﻤﻫ .ﺪﺸﻧ هﺪﻫﺎﺸﻣ يرادﺎﻨﻌﻣ توﺎﻔﺗ (P DNF
ﺎﻤﻧوراد+ﻦﯾﺮﻤﺗ هوﺮﮔ ردB
ﺖﺒﺴﻧ ) لﺮﺘﻨﮐ هوﺮﮔ ﻪﺑ 003
/0
=
ﻞﻤﮑﻣ و (P
) 01 /0
=
ﺎﻨﻌﻣ توﺎﻔﺗ ،ﻦﯾا دﻮﺟو ﺎﺑ .ﺖﺷاد يرادﺎﻨﻌﻣ ﺶﯾاﺰﻓا (P
ﻞﻤﮑﻣ هوﺮﮔ ﻦﯿﺑ يراد لﺮﺘﻨﮐ و
) 985 /0
=
.ﺪﺸﻧ هﺪﻫﺎﺸﻣ (P
ﺮﯾدﺎﻘﻣ ﻦﯿﺑ ،ﺞﯾﺎﺘﻧ ﻪﺑ ﻪﺟﻮﺗ ﺎﺑ ﭘﯿ
ﺶ نﻮﻣزآ و ﺲﭘ نﻮﻣزآ هوﺮﮔ BDNF
ﺗ ) ﻞﻤﮑﻣ + ﻦﯾﺮﻤ 001
/0
=
هوﺮﮔ و (P
ﺎﻤﻧوراد + ﻦﯾﺮﻤﺗ )
02 /0
=
توﺎﻔﺗ (P
ﺮﯾدﺎﻘﻣ ﻦﯿﺑ ﺎﻣا .دراد دﻮﺟو يرادﺎﻨﻌﻣ ﭘﯿ
ﺶ نﻮﻣزآ و ﺲﭘ نﻮﻣزآ ﻞﻤﮑﻣ هوﺮﮔ BDNF
) 786 /0
=
و (P
) لﺮﺘﻨﮐ 098 /0 ﻞﮑﺷ) دراﺪﻧ دﻮﺟو يرادﺎﻨﻌﻣ توﺎﻔﺗ (P=
2 .(
رد ﯽﺸﻫوﮋﭘ هوﺮﮔ رﺎﻬﭼ ﻦﯿﺑ داد نﺎﺸﻧ ﻪﻫاﺮﮑﯾ ﺲﻧﺎﯾراو ﻞﯿﻠﺤﺗ نﻮﻣزآ ﺞﯾﺎﺘﻧ ﭘﯿ
ﺶ نﻮﻣزآ ﺮﯿﻐﺘﻣ رد ﯽﺑﺮﭼ ﺪﺻ ﻼﺘﺧا
ف رادﺎﻨﻌﻣ دﻮﺟو ي
) دراﺪﻧ 085 /0 .(P=
هوﻼﻋ ﺸﻫوﮋﭘ هوﺮﮔ رﺎﻬﭼ ﻦﯿﺑ داد نﺎﺸﻧ ﻪﻫاﺮﮑﯾ ﺲﻧﺎﯾراو ﻞﯿﻠﺤﺗ نﻮﻣزآ ﺞﯾﺎﺘﻧ ،ﻦﯾا ﺮﺑ رد ﯽ
ﺲﭘ نﻮﻣزآ ﺻرد ﺮﯿﻐﺘﻣ ﯽﺑﺮﭼ ﺪ
فﻼﺘﺧا رادﺎﻨﻌﻣ ) دراد دﻮﺟو ي 001
/0
=
،P
74 /0
= 2 ηp
،داد نﺎﺸﻧ ﯽﮐﻮﺗ ﯽﺒﯿﻘﻌﺗ نﻮﻣزآ ﺞﯾﺎﺘﻧ .(
ﯽﺑﺮﭼ ﺪﺻرد د
هوﺮﮔ ر ﺴﻧ ﻞﻤﮑﻣ+ﻦﯾﺮﻤﺗ ﺖﺒ
) ﻞﻤﮑﻣ هوﺮﮔ ﻪﺑ 001
/0
=
ﮐ و (P
) لﺮﺘﻨ 001 /0
=
) ﺎﻤﻧوراد+ﻦﯾﺮﻤﺗ و (P
045 /0
=
.ﺖﺳا ﻪﺘﺷاد يرادﺎﻨﻌﻣ ﺶﻫﺎﮐ (P
ﻦﯿﻨﭽﻤﻫ ﺪﺻرد
ﭼ ﯽﺑﺮ رد
) لﺮﺘﻨﮐ هوﺮﮔ ﻪﺑ ﺖﺒﺴﻧ ﺎﻤﻧوراد+ﻦﯾﺮﻤﺗ هوﺮﮔ 001
/0 ﯽﺑﺮﭼ ﺪﺻرد ،ﻦﯾا دﻮﺟو ﺎﺑ .ﺖﺷاد يرادﺎﻨﻌﻣ ﺶﻫﺎﮐ (P=
د ﺎﻤﻧوراد +ﻦﯾﺮﻤﺗ هوﺮﮔ ر ﺖﺒﺴﻧ
) ﻞﻤﮑﻣ هوﺮﮔ ﻪﺑ 127
/0 .داﺪﻧ نﺎﺸﻧ ار يرادﺎﻨﻌﻣ توﺎﻔﺗ (P=
ﻪﺑ هوﻼﻋ ﻧ ﻞﻤﮑﻣ هوﺮﮔ رد ﯽﺑﺮﭼ ﺪﺻرد ، لﺮﺘﻨﮐ هوﺮﮔ ﻪﺑ ﺖﺒﺴ
) 047 /0 ﺰﯿﻧ (P=
ﺮﯾدﺎﻘﻣ ﻦﯿﺑ ،ﺞﯾﺎﺘﻧ ﻪﺑ ﻪﺟﻮﺗ ﺎﺑ .ﺖﺷاد يرادﺎﻨﻌﻣ ﺶﻫﺎﮐ ﭘﯿ
ﺶ نﻮﻣزآ و ﺲﭘ نﻮﻣزآ ﮔ ﯽﺑﺮﭼ ﺪﺻرد ) ﻞﻤﮑﻣ + ﻦﯾﺮﻤﺗ هوﺮ
001 /0 و (P=
هوﺮﮔ
ﺎﻤﻧوراد + ﻦﯾﺮﻤﺗ )
001 /0 ﺮﯾدﺎﻘﻣ ﻦﯿﺑ ﺎﻣا .دراد دﻮﺟو يرادﺎﻨﻌﻣ توﺎﻔﺗ (P=
ﭘﯿ ﺶ ﻣزآ نﻮ و ﺲﭘ نﻮﻣزآ ﻞﻤﮑﻣ هوﺮﮔ ﯽﺑﺮﭼ ﺪﺻرد )
089 /0 و (P=
) لﺮﺘﻨﮐ 147 /0
=
ﻞﮑﺷ) دراﺪﻧ دﻮﺟو يرادﺎﻨﻌﻣ توﺎﻔﺗ (P
3 .(
ﻞﮑﺷ 2 . ﺛﺄﺗ ﯿﺮ ﻦﯾﺮﻤﺗ ﺎﺑ هاﺮﻤﻫ ﻢﯿﺴﻠﮐ و يد ﻦﯿﻣﺎﺘﯾو ﻞﻣﺎﻌﺗ اد
ﯾ هﺮ ا تاﺮﯿﯿﻐﺗ ﺮﺑ ﺪﯾﺪﺷ ﯽﻠﯿﺧ ي BDNF
ﻪﻓﺎﺿا ياراد ناﺪﻨﻤﻟﺎﺳ .نزو
نﺎﺸﻧ# فﻼﺘﺧا ةﺪﻨﻫد رادﺎﻨﻌﻣ
ﻦﯿﺑ ﮔ ﯽﻫوﺮ ) 05 /0 P≤ (
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