Future perspective - General conclusions and future perspectives

CHAPTER 4. General conclusions and future perspectives

4.3 Future perspective

Active collaborations between clinics and academic research are necessary for clinical validation of new technologies for liquid biopsy. In this thesis, we suggest a robust device for CTC isolation which can be expected to expand the ability to utilize CTC based liquid biopsy in clinical routine and longitudinal surveillance of cancer therapy. If it is applied to run multicenter-large scale clinical trials, FAST disc can serve to clarify the clinical utility of CTCs in clinical routine.

For improving precision medicine, common implementation of single-cell analysis about CTC heterogeneity in clinical routine will be feasible with accompanying development of the technologies which can solve the problem of existing methods for molecular analysis, such as high cost and time- consuming process. Actualization of single-cell analysis will contribute to make affordable precision medicine for many patients.

On the other side, study about the relationship with other liquid biopsy markers, such as ctDNA and extracellular vesicle, allow better understanding of cancer progression and metastasis mechanism.

For clinical applications, complementary use of multi-markers may be beneficial to improve the predictive accuracy in diagnostic and prognostic and to enhance the sensitivity and specificity of liquid biopsy.

References

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Dalam dokumen CIRCULATING TUMOR CELLS ENRICHMENT AND SINGLE CELL ANALYSIS (Halaman 108-123)