MOC 기초연구실 정기세미나
주관: 인하대학교 바이오융합시스템 연구실 후원: 한국연구재단 기초연구실 사업
지원: 인하대학교 바이오시스템융합학과
제 6 회
2022.03.31.일 오전 10시
인하대학교 온라인 강연
방석호 교수님 / 성균관대학교
제목
초록
약력
2013 이전 Georgia Tech. 박사 후 연구원
2013-2015 서울대학교 화학생물공학부 BK 조교수 2015-2019 성균관대학교 화학공학/고분자공학부 조교수 2019-현재 성균관대학교 화학공학/고분자공학부 부교수
경력
Upregulating therapeutic efficacy of stem cell-based therapy using photobiomodulation and co-spatial patch for treating ischemic diseases
In this presentation, two strategies will be introduced in terms of low-level light therapy (LLLT) and co-spatial cell patch. LLLT is a safe and noninvasive technique that has drawn
attention as a new therapeutic method to treat various diseases. A blue organic light-emitting diode (bOLED) as a safe and effective light source that could generate a low amount of heat and luminance compared to conventional light sources will be introduced. Phototoxicity of bOLED light with different light fluences to human adipose-derived stem cells (hADSC) and underlying molecular mechanisms involved in the therapeutic efficacy of bOLED for
enhancing angiogenic properties of hADSC will be discussed. Next, a new aspect of
fibroblast-based cell therapy will be introduced. 3D fibroblasts exhibit unique angiogenic and inflammation-manipulating properties that are not present in 2D forms. However, the
therapeutic effect of 3D fibroblasts in tissue regeneration has not been fully elucidated. Later part of this presentation will discuss a biocompatible flat patch with specifically designed holes that form a spheroid-incorporated human dermal fibroblast sheet to mediate the activity of inflammatory cytokines for M2 polarization and increase angiogenic efficacy.
