Skip Main Navigation Links Jump to Footer
Scopus Preview
Journal of Applied Pharmaceutical ScienceVolume 5, Issue 8, 2015, Pages 1-5
2-methoxy-1,4-naphthoquinone (MNQ) Suppresses Protein Kinase C ßI, δ, and ζ expression in Raji
cells
(Article) Yew, W.T.,
Kitson, L.,
Hock, A.H.S.,
Chiew, G.S.,
Mooi, L.Y.
View Correspondence (jump link)
aDepartment of Pre-Clinical Sciences, Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Lot PT 21144, Jalan Sungai Long, Bandar Sungai Long, Kajang, Selangor, Malaysia
bSchool of Biosciences, Taylor's University, Lakeside Campus 1, Jalan Taylor's, Subang Jaya, Selangor, Malaysia
Abstract
Protein Kinase C (PKC) is widely documented to be involved in the regulation of cancer cell growth, proliferation, survival, inflammation and apoptosis. This study evaluates the capability of 2-Methoxy-1,4-Naphthoquinone (MNQ) in regulating PMA-induced PKC expression in human Burkitt's lymphoma cell line (Raji cells).
MNQ exhibited stronger anti-tumour-promoting activity than genistein based on the inhibitory assay of Epstein-Barr virus (EBV) activation. The IC50 values attained were 2.92 and 7.40 μM, respectively. The suppressive effects of MNQ on PKC expression was determined by using the PepTag® non-radioactive detection of PKC assay. The IC50 values achieved for staurosporine and rottlerin (standard control), and MNQ were 0.01, 6.38, and 13.13 μM, respectively. These preliminary results indicate that MNQ specifically suppressed the expression of PKC ßI, δ, and ζ in a concentration-dependent manner in Raji cells. © 2015 Wong Teck Yew et al.
Author keywords
2-Methoxy-1,4-Naphthoquinone
Antitumour-promoting
Cancer chemoprevention
Protein kinase C
ISSN: 22313354
Source Type: Journal
Original language: English
DOI: 10.7324/JAPS.2015.50801
Document Type: Article
Publisher: Open Science Publishers LLP Inc.
Mooi, L.Y.; Department of Pre-Clinical Sciences, Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Lot PT 21144, Jalan Sungai Long, Bandar Sungai Long, Kajang, Selangor, Malaysia
© Copyright 2015 Elsevier B.V., All rights reserved.
Cited by 0 documents
Inform me when this document is cited in Scopus:
Set citation alert Set citation feed
Related documents
Find more related documents in Scopus based on:
Authors Keywords
About Scopus
What is Scopus
Content coverage
Scopus blog
Scopus API
Privacy matters
Language
日本語に切り替える
切换到简体中文
切換到繁體中文
Русский язык
Customer Service
Help
Contact us
Terms and conditions
Privacy policy
Copyright © 2018 Elsevier B.V. All rights reserved. Scopus® is a registered trademark of Elsevier B.V.
Cookies are set by this site. To decline them or learn more, visit our Cookies page.
