Locke, AE (Locke, Adam E.); Kahali, B (Kahali, Bratati); Berndt, SI (Berndt, Sonja I.); Justice, AE (Justice, Anne E.); Pers, TH (Pers, Tune H.); Felix, R (Day, Felix R.);
Powell, C (Powell, Corey); Vedantam, S (Vedantam, Sailaja); Buchkovich, ML (Buchkovich, Martin L.); Yang, J (Yang, Jian); Croteau-Chonka, DC (Croteau-Chonka, Damien C.); Esko, T (Esko, Tonu); Fall, T (Fall, Tove); Ferreira, T (Ferreira, Teresa);
Gustafsson, S (Gustafsson, Stefan); Kutalik, Z (Kutalik, Zoltan); Luan, JA (Luan, Jian'an); Magi, R (Maegi, Reedik); Randall, JC (Randall, Joshua C.); Winkler, TW
(Winkler, Thomas W.); Wood, AR (Wood, Andrew R.); Workalemahu, T (Workalemahu, Tsegaselassie); Faul, JD (Faul, Jessica D.); Smith, JA (Smith, Jennifer A.); Zhao, JH (Zhao, Jing Hua); Zhao, W (Zhao, Wei); Chen, J (Chen, Jin);
Fehrmann, R (Fehrmann, Rudolf); Hedman, AK (Hedman, Asa K.); Karjalainen, J (Karjalainen, Juha); Schmidt, EM (Schmidt, Ellen M.); Absher, D (Absher, Devin);
Amin, N (Amin, Najaf); Anderson, D (Anderson, Denise); Beekman, M (Beekman, Marian); Bolton, JL (Bolton, Jennifer L.); Bragg-Gresham, L (Bragg-Gresham, L.);
Buyske, S (Buyske, Steven); Demirkan, A (Demirkan, Ayse); Deng, GH (Deng, Guohong); Ehret, GB (Ehret, Georg B.); Feenstra, B (Feenstra, Bjarke); Feitosa, MF
(Feitosa, Mary F.); Fischer, K (Fischer, Krista); Goel, A (Goel, Anuj); Gong, J (Gong, Jian); Jackson, AU (Jackson, Anne U.); Kanoni, S (Kanoni, Stavroula); Kleber, ME
(Kleber, Marcus E.); Kristiansson, K (Kristiansson, Kati); Lim, U (Lim, Unhee);
Lotay, V (Lotay, Vaneet); Mangino, M (Mangino, Massimo); Leach, IM (Leach, Irene Mateo); Medina-Gomez, C (Medina-Gomez, Carolina); Medland, SE (Medland, Sarah
E.); Nalls, MA (Nalls, Michael A.); Palmer, CD (Palmer, Cameron D.); Pasko, D (Pasko, Dorota); Pechlivanis, S (Pechlivanis, Sonali); Peters, MJ (Peters, Marjolein J.); Prokopenko, I (Prokopenko, Inga); Shungin, D (Shungin, Dmitry); Stancakova, A (Stancakova, Alena); Strawbridge, RJ (Strawbridge, Rona J.); Sung, YJ (Sung, Yun
Ju); Tanaka, T (Tanaka, Toshiko); Teumer, A (Teumer, Alexander); Trompet, S (Trompet, Stella); van der Laan, SW (van der Laan, Sander W.); van Settee, J (van Settee, Jessica); Van Vliet-Ostaptchouk, JV (Van Vliet-Ostaptchouk, Jana V.); Wang, ZM (Wang, Zhaoming); Yengo, L (Yengo, Loic); Zhang, WH (Zhang, Weihua); Isaacs, A (Isaacs, Aaron); Albrecht, E (Albrecht, Eva); Arnlov, J (Arnlov, Johan); Arscott, GM
(Arscott, Gillian M.); Attwood, AP (Attwood, Antony P.); Bandinelli, S (Bandinelli, Stefania); Barrett, A (Barrett, Amy); Bas, IN (Bas, Isabelita N.); Bellis, C (Bellis, Claire); Bennett, AJ (Bennett, Amanda J.); Berne, C (Berne, Christian); Blagieva, R (Blagieva, Roza); Bluher, M (Blueher, Matthias); Bohringer, S (Bohringer, Stefan);
Bonnycastle, LL (Bonnycastle, Lori L.); Bottcher, Y (Boettcher, Yvonne); Boyd, HA (Boyd, Heather A.); Bruinenberg, M (Bruinenberg, Marcel);
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Caspersen, IH (Caspersen, Ida H.); Chen, YD (Chen, Yii-Der Ida); Clarke, R (Clarke, Robert); Daw, EW (Daw, E. Warwick); de Craen, AJM (de Craen, Anton J. M.);
Delgado, G (Delgado, Graciela); Dimitriou, M (Dimitriou, Maria); Doney, ASF (Doney, Alex S. F.); Eklund, N (Eklund, Niina); Estrada, K (Estrada, Karol); Eury, E
(Eury, Elodie); Folkersen, L (Folkersen, Lasse); Fraser, RM (Fraser, Ross M.);
Garcia, ME (Garcia, Melissa E.); Geller, F (Geller, Frank); Giedraitis, V (Giedraitis, Vilmantas); Gigante, B (Gigante, Bruna); Go, AS (Go, Alan S.); Golay, A (Golay, Alain); Goodall, AH (Goodall, Alison H.); Gordon, SD (Gordon, Scott D.); Gorski, M (Gorski, Mathias); Grabe, HJ (Grabe, Hans-Joergen); Grallert, H (Grallert, Harald);
Grammer, TB (Grammer, Tanja B.); Grassler, J (Graessler, Jurgen); Gronberg, H (Gronberg, Henrik); Groves, CJ (Groves, Christopher J.); Gusto, G (Gusto, Gaeelle);
Haessler, J (Haessler, Jeffrey); Hall, P (Hall, Per); Haller, T (Haller, Toomas);
Hallmans, G (Hallmans, Goran); Hartman, CA (Hartman, Catharina A.); Hassinen, M (Hassinen, Maija); Hayward, C (Hayward, Caroline); Heard-Costa, NL (Heard-Costa, Nancy L.); Helmer, Q (Helmer, Qinta); Hengstenberg, C (Hengstenberg, Christian);
Holmen, O (Holmen, Oddgeir); Hottenga, JJ (Hottenga, Jouke-Jan); James, AL (James, Alan L.); Jeff, JM (Jeff, Janina M.); Johansson, A (Johansson, Asa); Jolley, J (Jolley, Jennifer); Juliusdottir, T (Juliusdottir, Thorhildur); Kinnunen, L (Kinnunen,
Leena); Koenig, W (Koenig, Wolfgang); Koskenvuo, M (Koskenvuo, Markku);
Kratzer, W (Kratzer, Wolfgang); Laitinen, J (Laitinen, Jaana); Lamina, C (Lamina, Claudia); Leander, K (Leander, Karin); Lee, NR (Lee, Nanette R.); Lichtner, P (Lichtner, Peter); Lind, L (Lind, Lars); Lindstrom, J (Lindstrom, Jaana); Lo, KS (Lo,
Ken Sin); Lobbens, S (Lobbens, Stephane); Lorbeer, R (Lorbeer, Roberto); Lu, YC (Lu, Yingchang); Mach, F (Mach, Francois); Magnusson, PKE (Magnusson, Patrik K.
E.); Mahajan, A (Mahajan, Anubha); McArdle, WL (McArdle, Wendy L.); McLachlan, S (McLachlan, Stela); Menni, C (Menni, Cristina); Merger, S (Merger, Sigrun);
Mihailov, E (Mihailov, Evelin); Milani, L (Milani, Lili); Moayyeri, A (Moayyeri, Alireza); Monda, KL (Monda, Keri L.); Morken, MA (Morken, Mario A.); Mulas, A (Mulas, Antonella); Muller, G (Mueller, Gabriele); Muller-Nurasyid, M (Mueller-
Nurasyid, Martina); Musk, AW (Musk, Arthur W.); Nagaraja, R (Nagaraja, Ramaiah); Nothen, MM (Noethen, Markus M.); Nolte, IM (Nolte, Ilja M.); Pilz, S (Pilz,
Stefan); Rayner, NW (Rayner, Nigel W.); Renstrom, F (Renstrom, Frida); Rettig, R (Rettig, Rainer); Ried, JS (Ried, Janina S.); Ripke, S (Ripke, Stephan); Robertson, NR
(Robertson, Neil R.); Rose, LM (Rose, Lynda M.); Sanna, S (Sanna, Serena);
Scharnagl, H (Scharnagl, Hubert); Scholtens, S (Scholtens, Salome); Schumacher, FR (Schumacher, Fredrick R.); Scott, WR (Scott, William R.); Seufferlein, T (Seufferlein, Thomas); Shi, JX (Shi, Jianxin); Smith, AV (Smith, Albert Vernon);
Smolonska, J (Smolonska, Joanna); Stanton, AV (Stanton, Alice V.);
Steinthorsdottir, V (Steinthorsdottir, Valgerdur); Stirrups, K (Stirrups, Kathleen);
Stringham, HM (Stringham, Heather M.); Sundstrom, J (Sundstrom, Johan); Swertz, MA (Swertz, Morris A.); Swift, AJ (Swift, Amy J.); Syvanen, AC (Syvanen, Ann- Christine); Tan, ST (Tan, Sian-Tsung); Tayo, BO (Tayo, Bamidele O.); Thorand, B
55
(Thorand, Barbara); Thorleifsson, G (Thorleifsson, Gudmar); Tyrer, JP (Tyrer, Jonathan P.); Uh, HW (Uh, Hae-Won); Vandenput, L (Vandenput, Liesbeth);
Verhulst, FC (Verhulst, Frank C.); Vermeulen, SH (Vermeulen, Sita H.); Verweij, N (Verweij, Niek); Vonk, JM (Vonk, Judith M.); Waite, LL (Waite, Lindsay L.); Warren,
HR (Warren, Helen R.); Waterworth, D (Waterworth, Dawn); Weedon, MN (Weedon, Michael N.); Wilkens, LR (Wilkens, Lynne R.); Willenborg, C (Willenborg, Christina); Wilsgaard, T (Wilsgaard, Tom); Wojczynski, MK (Wojczynski, Mary K.);
Wong, A (Wong, Andrew); Wrightl, AF (Wrightl, Alan F.); Zhang, QY (Zhang, Qunyuan); Brennan, EP (Brennan, Eoin P.); Choi, M (Choi, Murim); Dastani, Z (Dastani, Zari); Drong, AW (Drong, Alexander W.); Eriksson, P (Eriksson, Per);
Franco-Cereceda, A (Franco-Cereceda, Anders); Gadin, JR (Gadin, Jesper R.);
Gharavi, AG (Gharavi, Ali G.); Goddard, ME (Goddard, Michael E.); Handsaker, RE (Handsaker, Robert E.); Huang, JY (Huang, Jinyan); Karpe, F (Karpe, Fredrik);
Kathiresan, S (Kathiresan, Sekar); Keildson, S (Keildson, Sarah); Kiryluk, K (Kiryluk, Krzysztof); Kubo, M (Kubo, Michiaki); Lee, JY (Lee, Jong-Young); Liang, L (Liang, Liming); Lifton, RP (Lifton, Richard P.); Ma, BS (Ma, Baoshan); McCarroll, SA
(McCarroll, Steven A.); McKnight, AJ (McKnight, Amy J.); Min, JL (Min, Josine L.);
Moffatt, MF (Moffatt, Miriam F.); Montgomery, GW (Montgomery, Grant W.);
Murabito, JM (Murabito, Joanne M.); Nicholson, G (Nicholson, George); Nyholt, DR (Nyholt, Dale R.); Okada, Y (Okada, Yukinori); Perry, JRB (Perry, John R. B.);
Dorajoo, R (Dorajoo, Rajkumar); Reinmaa, E (Reinmaa, Eva); Salem, RM (Salem, Rany M.); Sandholm, N (Sandholm, Niina); Scott, RA (Scott, Robert A.); Stolk, L (Stolk, Lisette); Takahashi, A (Takahashi, Atsushi); Tanaka, T (Tanaka, Toshihiro);
van 't Hooft, FM (van 't Hooft, Ferdinand M.); Vinkhuyzen, AAE (Vinkhuyzen, Anna A. E.); Westra, HJ (Westra, Harm-Jan); Zheng, W (Zheng, Wei); Zondervan, KT
(Zondervan, Krina T.); Heath, AC (Heath, Andrew C.); Arveiler, D (Arveiler, Dominique); Bakker, SJL (Bakker, Stephan J. L.); Beilby, J (Beilby, John); Bergman,
RN (Bergman, Richard N.); Blangero, J (Blangero, John); Bovet, P (Bovet, Pascal);
Campbell, H (Campbell, Harry); Caulfield, MJ (Caulfield, Mark J.); Cesana, G (Cesana, Giancarlo); Chakravarti, A (Chakravarti, Aravinda); Chasman, DI (Chasman, Daniel I.); Chines, PS (Chines, Peter S.); Collins, FS (Collins, Francis S.);
Crawford, DC (Crawford, Dana C.); Cupples, LA (Cupples, L. Adrienne); Cusi, D (Cusi, Daniele); Danesh, J (Danesh, John); de Faire, U (de Faire, Ulf); den Ruijter,
HM (den Ruijter, Hester M.); Dominiczak, AF (Dominiczak, Anna F.); Erbel, R (Erbel, Raimund); Erdmann, J (Erdmann, Jeanette); Eriksson, JG (Eriksson, Johan
G.); Farrall, M (Farrall, Martin); Felix, SB (Felix, Stephan B.); Ferrannini, E (Ferrannini, Ele); Ferrieres, J (Ferrieres, Jean); Ford, I (Ford, Ian); Forouhi, NG (Forouhi, Nita G.); Forrester, T (Forrester, Terrence); Franco, OH (Franco, Oscar H.); Gansevoort, RT (Gansevoort, Ron T.); Gejman, PV (Gejman, Pablo V.); Gieger, C
(Gieger, Christian); Gottesman, O (Gottesman, Omri); Gudnason, V (Gudnason, Vilmundur); Gyllensten, U (Gyllensten, Ulf); Hall, AS (Hall, Alistair S.); Harris, TB
(Harris, Tamara B.); Hattersley, AT (Hattersley, Andrew T.); Hicks, AA (Hicks,
56
Andrew A.); Hindorff, LA (Hindorff, Lucia A.); Hingorani, AD (Hingorani, Aroon D.);
Hofman, A (Hofman, Albert); Homuth, G (Homuth, Georg); Hovingh, GK (Hovingh, G. Kees); Humphries, SE (Humphries, Steve E.); Hunt, SC (Hunt, Steven C.);
Hypponen, E (Hypponen, Elina); Illig, T (Illig, Thomas); Jacobs, KB (Jacobs, Kevin B.); Jarvelin, MR (Jarvelin, Marjo-Riitta); Jockel, KH (Joeckel, Karl-Heinz);
Johansen, B (Johansen, Berit); Jousilahti, P (Jousilahti, Pekka); Jukema, JW (Jukema, J. Wouter); Jula, AM (Jula, Antti M.); Kaprio, J (Kaprio, Jaakko); Kastelein,
JJP (Kastelein, John J. P.); Keinanen-Kiukaanniemi, SM (Keinanen-Kiukaanniemi, Sirkka M.); Kiemeney, LA (Kiemeney, Lambertus A.); Knekt, P (Knekt, Paul);
Kooner, JS (Kooner, Jaspal S.); Kooperberg, C (Kooperberg, Charles); Kovacs, P (Kovacs, Peter); Kraja, AT (Kraja, Aldi T.); Kumari, M (Kumari, Meena); Kuusisto, J
(Kuusisto, Johanna); Lakka, TA (Lakka, Timo A.); Langenberg, C (Langenberg, Claudia); Le Marchand, L (Le Marchand, Laic); Lehtimaki, T (Lehtimaki, Terho);
Lyssenko, V (Lyssenko, Valeriya); Mannisto, S (Mannisto, Satu); Marette, A (Marette, Andre); Matise, TC (Matise, Tara C.); McKenzie, CA (McKenzie, Colin A.);
McKnight, B (McKnight, Barbara); Moll, FL (Moll, Frans L.); Morris, AD (Morris, Andrew D.); Morris, AP (Morris, Andrew P.); Murray, JC (Murray, Jeffrey C.); Nelis, M (Nelis, Mari); Ohlsson, C (Ohlsson, Claes); Oldehinkel, AJ (Oldehinkel, Albertine J.); Ong, KK (Ong, Ken K.); Madden, PAF (Madden, Pamela A. F.); Pasterkamp, G
(Pasterkamp, Gerard); Peden, JF (Peden, John F.); Peters, A (Peters, Annette);
Postma, DS (Postma, Dirkje S.); Pramstaller, PP (Pramstaller, Peter P.); Price, JF (Price, Jackie F.); Qi, L (Qi, Lu); Raitakari, OT (Raitakari, Olli T.); Rankinen, T (Rankinen, Tuomo); Rao, DC (Rao, D. C.); Rice, TK (Rice, Treva K.); Ridker, PM (Ridker, Paul M.); Rioux, JD (Rioux, John D.); Ritchie, MD (Ritchie, Marylyn D.);
Rudan, I (Rudan, Igor); Salomaa, V (Salomaa, Veikko); Samani, NJ (Samani, Nilesh J.); Saramines, J (Saramines, Jouko); Sarzynski, MA (Sarzynski, Mark A.);
Schunkert, H (Schunkert, Heribert); Schwarz, PEH (Schwarz, Peter E. H.); Sever, P (Sever, Peter); Shuldiner, AR (Shuldiner, Alan R.); Sinisalo, J (Sinisalo, Juha); Stolk,
RP (Stolk, Ronald P.); Strauch, K (Strauch, Konstantin); Tonjes, A (Toenjes, Anke);
Tregouet, DA (Tregouet, David-Alexandre); Tremblay, A (Tremblay, Angelo);
Tremoli, E (Tremoli, Elena); Virtamo, J (Virtamo, Jarmo); Vohl, MC (Vohl, Marie- Claude); Volker, U (Voelker, Uwe); Waeber, G (Waeber, Gerard); Willemsen, G
(Willemsen, Gonneke); Witteman, JC (Witteman, Jacqueline C.); Zillikens, MC (Zillikens, M. Carola); Adair, LS (Adair, Linda S.); Amouyel, P (Amouyel, Philippe);
Asselbergs, FW (Asselbergs, Folkert W.); Assimes, TL (Assimes, Themistocles L.);
Bochud, M (Bochud, Murielle); Boehm, BO (Boehm, Bernhard O.); Boerwinkle, E (Boerwinkle, Eric); Bornstein, SR (Bornstein, Stefan R.); Bottinger, EP (Bottinger,
Erwin P.); Bouchard, C (Bouchard, Claude); Cauchi, S (Cauchi, Stephane);
Chambers, JC (Chambers, John C.); Chanock, SJ (Chanock, Stephen J.); Cooper, RS (Cooper, Richard S.); de Bakker, PIW (de Bakker, Paul I. W.); Dedoussis, G (Dedoussis, George); Ferrucci, L (Ferrucci, Luigi); Franks, PW (Franks, Paul W.);
Froguel, P (Froguel, Philippe); Groop, LC (Groop, Leif C.); Haiman, CA (Haiman,
57
Christopher A.); Hamsten, A (Hamsten, Anders); Hui, JN (Hui, Jennie); Hunter, DJ (Hunter, David J.); Hveem, K (Hveem, Kristian); Kaplan, RC (Kaplan, Robert C.);
Kivimaki, M (Kivimaki, Mika); Kuh, D (Kuh, Diana); Laakso, M (Laakso, Markku);
Liu, YM (Liu, Yongmei); Martin, NG (Martin, Nicholas G.); Marz, W (Maerz, Winfried); Melbve, M (Melbve, Mads); Metspalu, A (Metspalu, Andres); Moebus, S (Moebus, Susanne); Munroe, PB (Munroe, Patricia B.); Njolstad, I (Njolstad, Inger);
Oostra, BA (Oostra, Ben A.); Palmer, CNA (Palmer, Colin N. A.); Pedersen, NL (Pedersen, Nancy L.); Perola, M (Perola, Markus); Perusse, L (Perusse, Louis);
Peters, U (Peters, Ulrike); Power, C (Power, Chris); Quertermous, T (Quertermous, Thomas); Rauramaa, R (Rauramaa, Rainer); Rivadeneira, F (Rivadeneira, Fernando); Saaristo, TE (Saaristo, Timo E.); Saleheen, D (Saleheen, Danish); Sattar,
N (Sattar, Naveed); Schadt, EE (Schadt, Eric E.); Schlessinger, D (Schlessinger, David); Slagboom, PE (Slagboom, P. Eline); Snieder, H (Snieder, Harold); Spector, TD (Spector, Tim D.); Thorsteinsdottir, UR (Thorsteinsdottir, Unnu R.); Stumvoll,
M (Stumvoll, Michael); Tuomilehto, J (Tuomilehto, Jaakko); Uitterlinden, AG (Uitterlinden, Andre G.); Uusitupa, M (Uusitupa, Matti); van der Harst, P (van der Harst, Pim); Walker, M (Walker, Mark); Wallaschofski, H (Wallaschofski, Henri);
Wareham, NJ (Wareham, Nicholas J.); Watkins, H (Watkins, Hugh); Weir, DR (Weir, David R.); Wichmann, HE (Wichmann, H-Erich); Wilson, JF (Wilson, James F.);
Zanen, P (Zanen, Pieter); Borecki, IB (Borecki, Ingrid B.); Deloukas, P (Deloukas, Panos); Fox, CS (Fox, Caroline S.); Heid, IM (Heid, Iris M.); O'Connell, JR (O'Connell, Jeffrey R.); Strachan, DP (Strachan, David P.); Stefansson, K (Stefansson, Kari); van Duijri, CM (van Duijri, Cornelia M.); Abecasis, GR (Abecasis, Goncalo R.); Franke, L
(Franke, Lude); Frayling, TM (Frayling, Timothy M.); McCarthy, MI (McCarthy, Mark I.); Visscher, PM (Visscher, Peter M.); Scherag, A (Scherag, Andre); Willer, CJ
(Willer, Cristen J.); Boehnke, M (Boehnke, Michael); Mohlke, KL (Mohlke, Karen L.); Lindgren, CM (Lindgren, Cecilia M.); Beckmann, JS (Beckmann, Jacques S.);
Barroso, I (Barroso, Ines); North, KE (North, Kari E.); Ingelsson, E (Ingelsson, Erik);
Hirschhorn, JN (Hirschhorn, Joel N.); Loos, RJF (Loos, Ruth J. F.); Speliotes, EK (Speliotes, Elizabeth K.)
Abstract
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in upto 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 x 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for similar to 2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous systemin obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
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Sources : NATURE
ISO Source Abbrev : Nature Impact Factor : 38.138
Year : 2015
Volume : 518
Issue : 7538
Pages : 197-U401
DOI : 10.1016/j.icheatmasstransfer.2011.12.002 Cited reference count : 29
Languge : English
Document Type : Article
Reprint Address : Speliotes, EK (reprint author), Univ Michigan, Dept Internal Med, Div Gastroenterol, Ann Arbor, MI 48109 USA.
Publisher : NATURE PUBLISHING GROUP Web of Science Categories : Multidisciplinary Sciences
Research Areas : Science & Technology - Other Topics
Faculty Name : Center of Princess Al-Jawhara for Excellence in Research of Hereditary Disorders
DSR No. : 7109