C.V. of Prof. Mohammed El-Zahabi
NAME
Mohammed Ayman Ali El-Zahabi
POSITION TITLE
Professor of Chemistry and Medicinal Chemistry Faculty of Pharmacy and King Abdulaziz University, Jeddah, Saudi Arabia
EDUCATION TRAINING INSTITUTION AND LOCATION
DEGREE
(if applicable) YEAR(s) FIELD OF STUDY Chiba University, Chiba, Japan
Al-Azhar University, Cairo, Egypt Al-Azhar University, Cairo, Egypt
PhD MS BS
1994 1988 1982
Pharmaceutical Sciences Pharmaceutical Chemistry
Pharmaceutical Sciences
A. Professional Experience:
2009-present Professor of Chemistry and Medicinal Chemistry, Department of Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, KSA.
2003-2009 Associate Professor of Chemistry and Medicinal Chemistry, Department of Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, KSA.
2001-2003 Visiting scholar, Department of Chemistry, The State University of New York, Buffalo, NY, USA.
2000-2001 Associate Professor of Medicinal and Organic Chemistry, Department of Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
1999-20001 Consultant, Chemistry Department, Ministry of Defense, Egypt.
1996-1998 Research Scientist, Medicinal Chemistry Department, Virginia Commonwealth University, Virginia, USA.
1994-2000 Lecturer, Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
1994-1991 PhD research student, Synthetic Chemistry, Dept., Faculty of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
1988-1990 Teaching Assistant, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
1984-1988 Demonstrator, Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
B. Conferences & Symposia attended:
29-31 Mar 1992 The 112th Annual Meeting of Pharmaceutical Society of Japan, Fukuoka, Japan.
8-9 Oct 1992 The Process in Organic Reactions and Synthetic Applications in the Life Sciences, Sapporo, Japan.
Nov 1993 The 24th Congress of Heterocyclinc Chemistry, Osaka, Japan
19-21 Dec 1995 Al-Azhar First International Conference of Pharmacy and Biotechnology, Cairo, Egypt.
15-16 April 2007 The Scientific Committee of the National Conference in |chemistry, Makkah, Saudi Arabia.
19-21 March 2007 The 7th International Pharmaceutical Conference, Riyadh, Saudi Arabia.
22-23 May 1997 The 76th Annual Meeting of Virginia Academy of Science, Blacksburg, USA.
28-29 May 1998 The 76th Annual Meeting of Virginia Academy of Science, Maryland, USA.
14-18 June 1998 The 26th National Medicinal Chemistry Symposium, Virginia, USA.
19-22 Dec 2001 Al-Azhar Second International Conference of Pharmacy and Biotechnology, Cairo, Egypt.
C. Publications:
1. Mohamed A. El-Zahabi1, , Laila M. Gad1, Faida H. Bamanie1, Zohair Al-Marzooki2 and Salah A. Ghareib1 Pharmaceutical Chemistry Department, Faculty of Pharmacy1, Chemistry Department, Faculty of Medicine2, Biochemistry Department, Faculty of Medicine3. King Abdulaziz University, KAU, Jeddah, KSA. Design and Synthesis of Some cyclic and acyclic imides for hypolipidemic activity. Submitted to medicinal Chem. Res.
2. Mohamed A. El-Zahabi1 and Salah A. Ghareib2, 1 Pharmaceutical Chemistry Department, 2 Pharmacology Department, Faculty of Pharmacy, King Abdulaziz, University, Jeddah, Kingdom of Saudi Arabia. Synthesis of Some Novel Naphthalimide Derivatives for Antihyperlipidemic Activity. (Mansoura Journal of Pharmaceutical Sciences) MJPS VOL. 24 (2) 2008, 144-154.
3. Mohamed A. El-Zahabi1, Faida H. Bamanie1, Mohamed A. Moustafa, Salah A. Ghareib1 and Zohair Al-Marzooki2. Pharmaceutical Chemistry Department, Faculty of Pharmacy1, Chemistry Department, Faculty of Medicine2, Biochemistry Department, Faculty of Medicine3. King Abdulaziz University, KAU, Jeddah, KSA. Design and Synthesis of Some new quinazolinone derivatives for hypoglycemic activity. (in preparation).
4. Laila M. Gad1, Mohamed A. El-Zahabi1, Faida H. Bamanie1, Magdy Genenah, Salah A. Ghareib1 and Zohair Al- Marzooki2. Pharmaceutical Chemistry Department, Faculty of Pharmacy1, Chemistry Department, Faculty of Medicine2, Biochemistry Department, Faculty of Medicine3. King Abdulaziz University, KAU, Jeddah, KSA. Design and Synthesis of Some naphthalimide derivatives for hypolipidemic activity. Submitted to medicinal Chem. Res.
5. Mohamed A. El-Zahabi1, Faida H. Bamanie1, Eman Elbendary, Mohamed F. Radwan and Salah A. Ghareib1 Pharmaceutical Chemistry Department, Faculty of Pharmacy1, Chemistry Department, Faculty of Medicine2, Biochemistry Department, Faculty of Medicine3. King Abdulaziz University, KAU, Jeddah, KSA. Design and Synthesis of Some new phthalimide derivatives for hypoglycemic activity. (in preparation).
6. Mohamed A El-Zahabi & David G. Hangauer. A Novel Synthesis of Tetrahydro-pyrrolo[1,2-a]imidazole-2,5-dione Derivatives. Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY 14260.
(Submitted to J.Org. Chem.)
7. Glennon, Richard A.; Young, Richard; Dukat, Malgorzata; Chang-Fong, Jean; El-Zahabi, Mohamed. N-Methyl-1-(4- methoxyphenyl)-2-aminopropane (PMMA) and N-Methyl-1-(3, 4-methylenedioxyphenyl)-2-aminopropane (MDMA) produce non-identical discriminative stimuli in rats. Pharmacology, Biochemistry and Behavior (2007), 86(3), 477- 484.
8. Mohamed A. El-Zahabi1 and Ahmed Mansour2 . 1 Pharmaceutical Chemistry Department, 2 Pharmacology department, Faculty of Pharmacy (Boys' branch), Al-Azhar University, Nasr City, Cairo, Egypt. Synthesis and Screening of Some Diphenimide Derivatives for Antihyperlipidemic Activity. Az. J. Pharm. Sci. (2007), 35, 16-28.
9. Saber E-S. Barakat2, Mohamed A. El-Zahabi2, Ashraf A. Abdel-Rahman2, Ashraf H. Bayomi1, Monir A-S. Amin3 and Hany E. Ali1. Synthesis of some new Dibenz[c,e]azepine-5,7-diones of Expected Antihyperlipidemic Activity.
(Accepted in KAU journal of Medical sciences 2007).
10. Mohamed A. El-Zahabi. Pharmaceutical Chemistry Department,Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo, Egypt. Synthesis and Pharmacophore Exploration of Some Phthalimide Derivatives For Antihyperlipidemic Activity. J. Biological and Pharmceutical Sci. (2006), 4 No.1, 1-15.
11. Hangauer, David G.; Al-Zahaby, Mohamed Ayman. Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY 14260 Methodology for preparing combinatorial libraries based upon a bicyclic scaffold. PCT Int. Appl. (2005), 70 pp, International publication number WO 2005/ 056523 A2.
12. Ramunno, Anna; Dukat, Malgorzata; Lee, Mase; Young, Richard; El-Zahabi, Mohamed; Damaj, M. Imad; Martin, Billy; Glennon, Richard A. 6-(2-Phenylethyl)nicotine: A novel nicotinic cholinergic receptor ligand. Bioorganic &
Medicinal Chemistry Letters (2005), 15(13), 3237-3240.
13. Hangauer D.G. and El-Zahabi M. A. Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY 14260. Addendum To A Novel Synthesis of Tetrahydro-pyrrolo[1,2-a]imidazole-2,5-dione Derivati-ves. Addendum For: University at Buffalo New Technology Disclosure R-5866, Dec. 1, 2003. A summary for complete solution phase Route To Tetrahydro-pyrrolo[1,2-a]imidazole-2,5-dione Derivatives.
14. A.A. El-Helby; M. A. El-Zahabi; M. A. Amin; M.K. Ibrahim, S.G. Andel-Hameed and A.M. Evadí. Dept. of Pharmaceutical Chem. Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt. Design and Synthesis of some new derivatives of Dibez[c,e]azepine-5,7-diones for testing as anticonvulsant agents. Egypt. J. Biomed. Sci. Vol. 11, April, 2003.
15. M. A. El-Zahabi; A.A. El-Helby; M. A. Amin; M.K. Ibrahim and K. El-Adl. Design and synthesis of some new derivatives of 2(3H)-sulfanilbenzoxazole for testing of anticonvulsant (Part 1). Egypt. J. Biomed. Sci. 13, Nov. (2003).
16. A.A. El-Helby; M. A. El-Zahaby; M.F. Radwan. Synthesis and anticonvulsant activity of some new N-substituted 1,8- Naphthalimides. Egypt. J. Biomed. Sci. 11, April. (2003).
17. Dukat, M.; El-Zahabi M.A.; Ferretti, G. Damaj, M. I; Young, R; Glennon, R.A. (-)6-n-Propylnicotine antagonizes the antinoceptive effects of Nicotine. School of Pharmacy, Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA, USA. Bioorganic & Medicinal Chemistry Letters (2002), 12(20), 3005-3007.
18. Malgrozata Dukata, Matthew Dowda, M Imad Damajb, Billy Martinb, Mohamed A.El-Zahabi, Richard A. Glennona,b .a Department of Medicinal Chemistry and b Department of Pharmacology, Virginia Commonwealth University, Richmond, VA 23298-0540, USA. “Synthesis Receptor Binding and QSAR Studies on 6- Substituted Nicotine Derivatives As Cholinergic Ligands”. Eur. J. Med. Chem., 34, 31-40 (1999).
19. Dowd, M. J.; Dukat, M.; Damaj, M. I.; Martin, B. R.; El-Zahabi, M.; Glennon, R. A. Department Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA, USA. Synthesis, Receptor Binding, and QSAR Studies on 6-Substituted Nicotine Analogs. 216th ACS National Meeting, Boston, August 23-27 (1998).
20. Yasuhiro Torisawa, Mohamed Ayman Ali, Fabrice Tavet, Akiko Kageyama, Maki Aikawa, Naoko Fukui, Tohru Hino and Masako Nakagawa. Faculty of Pharmaceutical Sciences, Chiba University, Yayoi-cho, Inage-Ku, Chiba-shi, Chiba 263, Japan. “ Diels-Alder Reaction of The Dihydropyidinones V : Approach to the Ircinal B Core. Heterocycles, 42, No. 2, 677-689 (1996).
21. Yasuhiro Torisawa, Masako Nakagawa, Hideo Takami, Toshiki Nagata, Mohamed Ayman Ali and Tohru Hino.
Faculty of Pharmaceutical Sciences, Chiba University, Yayoi-cho, Inage-ku, Chiba-shi, Chiba 263 Japan” Diels-Alder Reaction of the N-protected 3-Phenylthio-2-(1H)-Dihydropyridinone Derivatives”. Heterocycles, 42, No. 2, 677- 689 (1994).
22. Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY 14260. A Solution Phase Synthesis of Tetrahydro-pyrrolo[1,2-a]imidazole-2,5-dione Derivatives (In Preparation).
23. El-Zahabi M. A., El-Helby A. A, Amin M. A., Ibrahim, M.K., El-Adl K. Design and Synthesis of Some New Derivatives of 2(3H)-Sulfanylbenzoxazole For Testing as Anticonvulsant (Part 1). Egypt. J. Biomed. Sci. Vol. 11, November, 2003.
24. El-Helby A. A, El-Zahabi M.A., Amin M. A., Ibrahim, M.K., Abdelhamid, S.G. and Ebied, A. Pharmaceutical Chem.
Dept, Al-Azhar University, Cairo, Egypt. Design and Synthesis of Some Dibenz[c,e]azepine derivatives for anticonvulsant activity (Egypt. J. Biomed. Sci. Vol. 11, April, 2003).
25. El-Helby A.A., El-Zahaby M.A. and Radwan M.F. Synthesis and anticonulsant activity of some new N- Substituted-1,8-Naphthalimide (Egypt. J. Biomed. Sci. Vol. 11, April, 2003).
26. Saber E.S. Barakata, Mohamed A. El-Zahabib and Mohamed F. Radwanc. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Appliedd Science University , Amman, Jordand, Al-Azhar University, Cairo, Egypt and Al-Azhar Universityb ,(Assiut branch) Assiut, Egyptc. “ Synthesis and Hypolipidemic Activity of Some New Dibenz [c,e] azepine Derivatives. Saudi Pharmaceutical Journal, 8, No.2-3, (2000).
27. Saber E.S.Barakat, Mohamed A. El-Zahabi and Mohamed Fouad Radwan. “Synthesis and Biological Screening of New 2,4-(1H,3H)-Quinazolinones including mercaptoxadiazole and 5- mercaptotriazole Moieties”. Az. J. Pharm. Sci., 23, 36-45 (1999).
28. El-Zahabi, M.A., “Synthesis of Some Natural lactams and Related Compounds for Possible Antimicrobial Activity (Part 1)”. Az. J. Pharm. Sci., 22, 14-21 (1998).
29. Mohamed A. El-Zahabi, Mohamed K. Ibrahim, Ashraf A. Abdel Rahman and Heba S.A. El-Zahabi “Synthesis and Anticonvulsant Activity of Some Novel 4,4`-Dibromo-5H-Dibenz[c,e] azepine-5,7(6H) Diones” Egypt. J. of Pharm.
Sci., 39, No. 4-6, pp. 487-498 (1998).
30. M. A. El-Zahabi, Saber E.S. Barakat, Abdel-Ghani A. El-Helby. ”Synthesis and Anticonvulsant Activity of Some Novel 5H-Dibenz[c,e] Azepine-5,7(6H) Dione Derivatives”. Egypt. J. of Pharm. Sci., 39, No.4-6, pp. 499-507 (1998).
31. A. E. Ossman, A.N. Osman, M. Khalifa and M.A. El-Zahaby. “Synthesis of Dibenz [c,e] Azepine-5,7-Dione Derivatives”. Egypt. J. Chem. 34, No. 1, pp.51-64 (1991).
