KFMRC Position: Assistant Professor
Research Unit Coordinator
Recombinant DNA Technology Unit Fundamental And Applied Biology Group
Specialty:
Recombinant DNA Technology Degree:
Ph.D. in Molecular Biology
Brief Bio:
Dr. Absarul Haque has been working as an Assistant Professor in King Fahd Medical Research center, King Abdulaziz University Jeddah, Saudi Arabia. Dr. Absarul Haque earned his Ph.D. in Molecular Biology from Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, India. Then he moved to the United States of America to receive his postdoctoral training. During his first post-doctoral training in the Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, KS, USA, he worked on translation, particularly the role of viral nucleocapsid protein (N-protein) in the initiation of translation in viral infected cells. During his last stay as a Research Associate in Wisconsin Institute of Medical Research, in the department of Human Oncology, Wisconsin University, Madison, USA, he was trained in the area of Skin Cancer. His research especially emphasized on ''determining how Ultraviolet radiation treatment to mice skin increases the interaction of Protein kinase C epsilon (PKCε) with Heat shock protein 90 beta (HSP90β)'' (in reference to skin cancer). During his doctoral stint at Jawaharlal Nehru University, New Delhi, India he received a very strong training in the area of Molecular
Dr. Absarul Haque
Email: [email protected]
Biology. He worked on multidrug resistance ABC transporter genes of opportunistic human fungal pathogen Candida albicans.
He has published his research findings in peer reviewed journals. He is the author in more than ten scientific papers. He has also participated in national and international conferences and presented his posters.
Area(s) of Research:
- Currently one of his areas of research interest is on Heat shock protein (HSP90β) as a novel therapeutic target in skin cancer.
- Another dimension is in utilizing DNA Fingerprinting based approach to diagnose Candida species from immunocompromised patients of Saudi Arabia.
- Interested to elucidate azole resistant mechanism in Candida albicans recovered from Saudi immunocompromised patients.
Number of Publications:
1. Mohammad Zubair Alam, Absarul Haque*, Qamre Alam, Mohammad A Kamal, Adel M Abuzenadah (2013). Gut Microbiota Alteration in Type 2 Diabetes and Alzheimer’s Disease Pathogenicity: An Update. Central Nervous System and Neurological Disorders Drug Targets.
(In press).
2. Nedjadi T, Haque A*, Alam Q, Chaudhary G A, Abuzenadah M A, Damanhouri G, Kamal M A (2013). Genomic Linkage between Alzheimer's Disease and Type 2 Diabetes. CNS &
Neurological Disorder-Drug Targets.(In Press)
3. Hussein IT, Cheng E, Ganaie SS, Werle MJ, Sheema S, Haque A, Mir MA.(2012).
Autophagic clearance of Sin Nombre hantavirus glycoprotein Gn promotes virus replication in cells. J Virol. 2012 Jul;86(14):7520-9.
4. Hussein IT, Haseeb A, Haque A, Mir MA. (2011). Recent advances in hantavirus molecular biology and disease. Adv Appl Microbiol.74:35-75.
5. Cheng E, Haque A, Rimmer MA, Hussein IT, Sheema S, Little A, Mir MA. (2011).
Characterization of the interaction between hantavirus nucleocapsid protein(N) and ribosomal protein S19 (RPS19). J Biol Chem . 286(13):11814-24.
6. Haque A, Mir M A. (2010). Interaction of hantavirus nucleocapsid protein with ribosomal protein S19. J Virol. 84(23):12450-3.
7. Mir M A, Sheema S, Haseeb A, Haque A. (2010). Hantavirus nucleocapsid protein has distinct m7G cap- and RNA-binding sites. J Biol Chem. 285(15):11357-68.
8. Haque A, Rai V, Bahal BS, Shukla S, Lattif AA, Mukhopadhyay G, Prasad R. (2007). Allelic variants of ABC drug transporter Cdr1p in clinical isolates of Candida albicans. Biochem Biophys Res Commun. 12;352 (2):491-7.
9. Gupta N, Haque A, Mukhopadhyay G, Narayan RP, Prasad R.(2005). Interactions between bacteria and Candida in the burn wound. Burns. 31(3):375-8.
10. Gupta N, Haque A, Lattif AA, Narayan RP, Mukhopadhyay G, Prasad R. (2004).
Epidemiology and molecular typing of Candida isolates from burn patients. Mycopathologia.
158(4):397-405.
11. Lattif AA, Banerjee U, Prasad R, Biswas A, Wig N, Sharma N, Haque A, Gupta N, Baquer NZ, Mukhopadhyay G.(2004). Susceptibility pattern and molecular type of species-specific Candida in oropharyngeal lesions of Indian human immunodeficiency virus-positive patients.
J Clin Microbiol. 42(3):1260-2.
12. Khyati Kapoor, Shipra Shukla, Absarul Haque, Vipin Yadav, Sudhanshu Shukla, Dominique Sanglard, Gauranga Mukhopadhyay and Rajendra Prasad (2012). ABC Transporter Snq2p of Candida albicans is involved in pleiotropic drug response, prevents hyphal development and is targeted by UPC2. (Under communication).
13. Ganaie S S, Haque A, Cheng E, Bonny S T, Salim N N, Mir M A. (2012). RPS19 binding domain provides key insights into hantavirus N-mediated translation initiation mechanism.
(Communicated in J Virol ).
14. Mohammad Zubair Alam, Absarul Haque*, Qamre Alam, Asif Jiman-Fatani Mohammad A Kamal, Adel M Abuzenadah, Adeel G Chaudhary, Mohammad Akram (2013). Candida
identification: A journey from conventional to Molecular methods. Mycoses (communicated).
15. Qamre Alam, Absarul Haque*, Mohammad ZubairAlam, Sajjad Karim, Mohammad Amjad Kamal, Asif Jiman-Fatani, Ghazi A. Damanhouri, Adel M Abuzenadah1, Adeel G Chaudhary ( 2013). Nanotechnological approach in management of Alzheimer’s Diseases and type 2 diabetes. Central Nervous System and Neurological Disorders Drug Targets (Communicated).
