Dung thuoc chen calci cao h u y e i ^ , tim m^ch
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flng calci di vdo nfli bdo, dfl trQ d bdo tfltfng vd gdy ra sfl co ctf, co mach. Khi cd thdnh mach hodc cd tim co qud mflc can thifi^t, se gay nfin bfnh cao huyet dp hodc benh tim. Thufl'c chen calci do chdng lai hifin tfldng co cd nen ldm gian thdnh mach hodc ldm giam sfl co bdp tim. Loai thufl'c Ou tien chen dong calci of thanh mach se chong sy CO that mach, dung chfla cao huylt dp. Loai thud'c uu tien chen dflng calci d tim se lam thfl gian ctf tim, dung chfla henh tim.Thuoc chen calci co nhieu the' h f
The'hf 1: Bao gim diltiazem, verapamin, nifedipin, nicarin. Chung hoat hfla than kinh the dich, khdi phat hieu Iflc ra't nhanh, cfl ldi khi dQng cdp cflXi, song CO hai gdy tut huyet dp dot ngflt. d cdc nfli5c, thfldng dung cd'p ctiu nfli vifin, khong cho dung tai nha, bdi vi khi dung tai nhd de bi tut huylt dp dft ngflt; nfi'u mufl'n trdnh tdc dung khflng mong mufl'n nay phai dung nhilu lin, biS; tifn. Cflng vi tac dung khflng mong mudn nay, khong nen diing chung cho ngfldi loan ndng that trdi hay vQa trai qua cdn nhdi mdu Cd tim.
NhQng thufl'c trfin dfldc bdo chf d dang tdc dyng keo ddi, hifu Iflc khdi phat chgm nhflng k6o ddi, khflng gay tut huyft dp dflt ngft. Dung rat an todn, tien Itfi.
The hf 2: La cdc ddn chd't dyhydropyridin, bao gdm: nisodipin, manidipin, nitendipin. Chting co tinh chgn lpc cao vdi mfl mach mdu nen hifu Iflc keo ddi, it c6 tdc dung khflng mong mudn (qua trung gian gian mach), it anh hfl&ig d i n d i n truyin nhi - that, it Qc chfl' CO bdp ctf tim nhip tim; tuy nhien c6 gay kich hoat than kinh giao cam; hifu lyc ha huyet dp thfldng dao df ng, CO khi khflng phong thich hoat chd't 100% nen sinh kha dung khong dat mQc to'i da.
The hf 3: G6m cac thufl'c: amlordipin, lacidipin.
Dilu dac bift, chung Id cdc chat Ua lipid, rieng lacidipin la ehl't Qa hpid manh, co he so' phan bo tren mang cao nhat trong nhdm c6 nguon go'c tfl dyhydropyridin. Dieu nay giup chung ling sau vdo thdnh mach mdu, dy trfl tai do, khuech tdn vdo ldp mdng kep chQa kenh calci ldm khdi phdt hifu Iflc ha THUdc & SLfC KHOE sd515 (01.01.2015)
huyit dp tfl tfl, keo ddi, khong dao df ng, mfli ngdy chi can dung mflt l i n ; thufl'c khflng ldm tdng hoat dgng t h i n kinh giao cam d tim vd ngoai hien. Ddy la flu dilm vfltft troi cua the hf nay. Thudc co gay dfl phQng mat, nhflc diu, phu co chdn nhe song khflng CO hai. Ltfi dung tac dung khflng mong muon ndy de danh gid kha ndng dung nap tinh an todn thuoc.
Ngfldi cao huye't dp kfim suy tim man dung thuoc ndy rat an todn,
Dieu can hta y k h i dung n h o m c h e n calci - Ddnh gid diing tdc dung khong mong mudn:
Trfldc day trong nghifin cflu ngau nhifin, thay thuoc chen calci gay bat thfldng v l dpng mach, bat thfldng ve tam that trdi, suy tim, dft quy, bfnh ly tim mach khac, xuat huye't dfldng tifiu hoa.. cuS^i cung Id ty If tfl vong cao htfn dung cdc nhom thuS^c khdc... ddn d^n thai do e de miin ciidng khi dung. Sau ndy nghien cihi bang cdch so sanh trfle tifi'p nhom dung chen It
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ia tra cua thUC pham mau xanh den, tim
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rong t h i gidi thyc pham muon mdu sac, chung ta khong chi nhin thay nhflng loai rau trai con sac xanh non td hodc chin ^ * Qng vang do, ma thi thodng ldc dac van co sfl hien dien cija nhiJng gam mdu ndi bgt nhfl xanh den, tim.. Cdc thfle pham nhfl quen thuoc hdng ngdy chflng ta v i n sQ dung nhfl nho, dau xanh, ddu den, khoai lang tim (khoai lang daang ngpc), ca tim, ddu den xanh long, d^u phflng.,. cd chfla nhilu gid tri dinh dfldng md chung ta it ngd tdi.Cdc l o a i thfle p h ^ m chfla resveratrol - anthocyanidin thfldng hifn difn d nhflng cu, qua mdu xanh den, tim,. co nhieu chflc ndng trong vifc chfl'ng oxy hoa, cdi thifn sflc nhin, chflc nang cua tim va dong mach.
R e s v e r a t r o l Id m d t l o a i polyphenol dang dfldc n g h i i n cflu vl tac dung phdng chdng ung thfl da va rudt gid, ung thfl mdu..
Nghifin cQu tren chuot cua tdc gia Baur, J. A. vd cflng sy da dang trfin tap chi Nature ndm 2006 phdt hien rdng mac du resveratrol
khong ngan ngQa bfnh beo phi, nhflng lai giam thieu dflpc cdc benh lien quan dfi'n beo phi va duy t li tuli thg. Ddc bift, vdi dac tinh khfl dgc, resveratrol cfl kha nang bao vfi tim mach, chong ung thfl cung nhfl bao vfi chflc ndng gan.
Vd gid ddy nhdm Baur va cgng sfl mgt lan nfla cung cip dan chQng cho thdy resveratrol cd kha ndng ngan ngfla dang ke nhflng ton thfldng d gan do chfi' dd an gidu dinh dadng gay ra.
Anthocyanidin la m o t loai sac tfl" den ty nhifin trong thyc vat khdng dfldng, thudc nhdm
-fr BSCKI. DAO TH! YEN THUY flavonoid. Anthocyanidin cd tac
dung chfl'ng oxy hfla manh, gitjp dd trong cugc chifi^n chfl'ng lai cdc gdc tfl do dflpc tao ra bdi tdc hai cua anh mdt trdi.
Cac go'c tfl do dfldc cho Id gdy ra sfl xua't hifn cua lao hda da vd cdc bfinh mdn tinh khdc. Ngfldi ta tin rdng cac sac to' thfle vdt ndy cd t h i dfltfc hifiu qua hdn vitamin C vd vitamin E. Cdc nghifin cQu cung dd cho thdy anthocyanidin cd tdc dpng tich cflc dfi^n collagen bdo vf. Dilu ndy quan trgng bdi vi collagen la mot protein dli ddo trong ctf t h i ngfldi, collagen la mft thdnh phan ciaa mau, mfl mim vd day chang. Cdc nhd nghien cfl!u lac quan v l vific sQ dung cdc sdc td' trong dieu tri vifim khdp, chong gidn tinh mach, tri va cdc loai vifim sflng.
Nhfl vgy, tfl gid trd di, mSi khi sQ dung cdc thfle p h i m cd mdu xanh, tim, den... thi ban hay bilt rkng cd the ban se dfldc bao vf vdi cac chait chd'ng osy hda tuyet vdi.
Hay dung da dang thyc pham mdu sdc d l nhdn dfldc nhilu logi chat dinh dfldng t h i l t yeu. i^
D^calci (amlordipin) va nhdm dung flc che' men chuyen (lisinopril) deu cd tai bifi'n stf cd'p nhfl nhau. Cac nghien cihi ndy da minh oan cho sy nghi ngd tinh an toan cua thud'c chen calci keo ddi dai dang htfn 10 ndm.
- So sdnh nhdm chen calci vd cdc nhdm khdc: Dung thufl'c Idem sodt cao huyfit dp Id de ha thdp sd do huyet dp, quan trgng hcfn la ngan ngQa nguy cd bien chflng ctf quan dich (tim mach). Tat ca cae nhdm thud'c diu cd kha ndng ha thap so do huye't dp tfldng dfldng. M6i nhdm thufl'c cd flu va nhflrfc diem trong viec ngan ngfla nguy ctf bien chiifng cd quan dich nhQng khflng nhdm nao hodn hao htfn han nhdm khac. Chang hgn: nhdm
chen beta thua kdm chen calci trong de phdng dflt quy nhOng nhdm chen beta lai htfn nhdm chen calci (vd cdc nhdm khdc) trong d l phdng suy tim. Nhdm ltfi tilu ra't cd ich khi cao huyfi^t dp kem thfim suy tim xung huye't, nhiftig nhdm Qc che' men chuyln lai tfi^t htfn nhdra ltfi tieu trong ngan ngQa nhdi mdu cd tim.
Vi vdy, khi cao huylt dp cd kem theo bfnh tim mach, vific chpn dung nhdm nao la can cQ vdo vifc ddnh gid lAi diem cua tiftig nhdm. Hfldng dan dilu tri cua H^i Huyet dp chau Au (2008) khdng dat ra vific liu tien nhdm nao trong 5 nhdm thufl'c chfla cao huye't dp. Yah d l lfla chgn do thay thudc quyfit dinh, dfla vdo bfinh
canh ldm sdng cua tittig ngfldi. ^ THUOC &SLfC KHOE sd'515 (01.01.2015)
