DO TIN CAY CUA THANG DO STRESS AT BENH NHAN BENH MAN TiNH
PHAM PHUONG T H A O - 0?( h^c Y Du-gv TP. Hi Chf Minh
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Thang do stress, vi dc thang do chuydn bidt nhw hinh vi, dm xOc, sinh li, nh$n thCrc, hi sd tin c$y Alpha Cmnbach cho thang do chung vi h$ s6 tin c$y cho timg nhdm, timg du tmng ndi bd thang do r.Alpha. Hd s6 twang ^uan bat cip (tau) ding tin ciy tmng chin dbdn stress (hdng qua cic thang do chuydn bidt tmng bdi dnh hidn nay a Viet Nam.
Gldl THIEU
Xu hadng bdnh tdt t h i gidi cung nha Vidt Nam dang thay doi: n i u tnj-de day nhu-ng b d n h e l p tinh, bdnh Idy nhidm nha dich hgch, s i t ret, n h i l m k h u i n ede ioai hay gdp thi hien nay cdc bdnh man tinh ndi ehung vd ddc bidt Id ede bdnh nha tim mgch, ddi thao dadng, tang huyet ap ngay cang nhilu, gdy ra gdnh ndng vd t i n kem eho cd nhdn vd cdng d i n g . (6-8)
B i n h mgn tinh Id b i n h t i i n triin keo dai hoac hay tdi phdL d i i u tn khdng ddt, thdi gian bdnh Id t d ba thdng trd Idn Bdnh man tinh hien nay Id nguyen nhdn gdy t d vong vd tdn tdt chinh tren the gidi.
Hiin nay ehya ed thang do dde hidu stress eho bdnh nhdn bdnh mgn tinh. Chinh vi II do ndy chdng tdi xdy dyng vd c h u l n hda thang do stress cho benh nhdn bdnh mgn tinh.
Ddi tu-p-ng, phaang phdp, thidt kd nghidn cd-u Thiit ke nghien cdu md ta eat ngang Phyang phdp: s d dung phaang phdp phong v l n trac tiep vdi benh nhdn.
- Quan li vd phdn tich so lieu: Sd- di,ing p h i n mlmnhap lieu : epidata 3.1, phan tich d d lieu R.3.1, cae packages dyp-c s d dung Hmise, epieale, psych (phin m i m m l i n phi).
Phyang phdp tinh d i l m bang hdi
- Khao sat 335 bdnh nhan benh man tinh da dape bde sT chuydn khoa chan dodn g i m benh tim mach, tdng huyit dp, dai thdo dydng tai benh vidn Cha Rly, bdnh vidn Qudn 2, Qudn Thd Ddc, Qudn 9.
- M i i cdu hoi trong thang do daae d i o diem:
Khdng ddng: 0 diem. Dung phan nao: i a i m , Ddng p h i n nhieu : 2 d i l m , R i t ddng : 3 d i i m .
- Thang do chuydn biet tap tnjng vao ITnh v y c phO hp-p nhlt vdi tinh trgng stress tdm li bdnh nhdn.
Chdng tdi m u i n tdng kha ndng phdt hien s y thay doi stress (dd ddi khi r i t nhd).
- D i ed d y p c mpt thang do hdu ieh thi thang do ndy khdng nhdng phai eo gid trj. phd hpp, dang tin cdy, d l giai thich md cdn phai dan gian, hodn thanh mdt cdch nhanh chdng, dd tinh diem vd cung e l p nhdng d d ildu hdu ieh cho ldm sdng. Manea vd cs (2012) dd dya ra cdc b y d c de c6 t h i chpn mdt thang do stress phd h&p. (5)
N$l dung vd k i t cdu eua bdng hoi Cdc phyang phdp tinh d i l m bdng cdu hoi stress dypc xdy dyng dya trdn cde hydng ddn td- edc k i t qua do Iydng tdm ly - gido dgc trong edc nghien edu eua Hidp h i i Tdm ly Hoa Ky, Hidp hdi nghidn c d u
gido due Hoa KJ vd Oy ban q u i c gia v i lopng gid c h i t lu-png gido dye Hoa Ky.
Phaang phdp ndy gid t^nh t i t ca cde edu hoi trong cdng m i t ttiang do cd tinl k i t hpp lai md khdng c i n d i i u kidn c h u l n hda hay hd s i hda cde cdu hdi dd. D i trdnh vide c h u l n hda edc cdu h i i , cac tdc g l l chpn lya cde cdu h i i cd d i l m s i trung binh vd dd lech c h u l n tu-ang d i i b i n g nhau. T y a n g t y , nhlm khdng thyc hi$n vide hd s i trpng s i hda edc cdu hdi, cac nha nghi&n edu s d dgng ede cdu h i i ed cdng mdc dp lidn quan vdi thang dp taang d-ng.
Tinh gid trj vd d i tin cdy eda thang do stress quan trpng trong nghidn cdu cdng nha chan doan ca nhdn bj stress.
Thang do Stress (DASS-21) b i n g ngdn ngO- tilng Anh dype s d dyng r i n g rdi trong cdng d i n g sd dyng tieng Anh. Nd d y p c c h u l n hod, tin cdy vd gia trj cao trong phat hidn r i i logn stress. (1, 2, 4, 9) Mdt s l nadc trdn t h i gidi dd c h u l n hod thang do nay eho ngdn ngO eda nadc dd nha: Trung Quie, M i i n Tdy Kenya, _ENREF_5An D i , Canada. C h u l n hod thang do theo ngdn n g d b i n Q\a q u y l t <^nh d i n gid trj vd dd tin cdy trong e h l n dodn Idm sdng hay trong linh vyc do Iydng tdm ly.
0 Vi$t Nam, mdt s i tdc g l l cd c h u l n hda thang do DASS-21 trdn phy n d ndng thdn phia Blc.fSJ chdng tdi d y a trdn 14 cdu do Iydng stress trong DASS-21, tham khdo bang djch t i l n g Vidt eua Vidn sdc khde tdm t h i n Q u i c Gia (10)
Ktl QUA
Bang 1. D i i m trung binh vd d i Idch c h u l n eda thang do
Tiiang do Sinli Li H^nli vi Cam xOc Nii^n tilirc Stress
n 335 335 335 335 335
TB (OLC) 7.98 (5.77) 6.17 (5.78) 4.99 (5.29) 8,40 (4,62) 7,65(8,51) Trong 335 bdnh nhSn b i n h mgn tinh. d i l m trung binh eda thang do stress Id 7.65±8,51. D i l m trung binh cda thang do nhdn thd-c cao n h l t 8.40i4,52, dilm tmng binh t h i p n h l t Id thang do cam xdc 4,99±5,29.
Bi^u d i 1: Hd s i taang quan T ki4m d|nh pearson gida cdc thang do
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K i l m djnh tu-ang quan r (pearson) eho ede b i i n s i
^nh lapng, cy t h i trong thang do sinh li, cdm xde, hdnh vi, nhdn thdc, vd stress eda bdnh nhdn benh man tinh. Cd t h i nhdn t h i y s y taang quan manh me gida cac thang do chuydn bidt vdi nhau vd vdi stress.
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Sinh li vdi hdnh vi, he s i taang quan b i t c | p tau = 0,470
- Sinh I! vdi cam xuc. hd s i taang quan b i t cdp tau = 0,502
Sinh li v d i nhdn thdc, hd s i taang quan b i t cap tau =0,214
- Stress vdi cam xdc, he s i taang quan b i t cdp tau = 0,565
Trong dd hd s i lien quan t h i p n h l t Id gida nhdn thdc vdi sinh li (tau=0.21), nhdn thdc vdi stress (tau=0,37). Tuy nhidn kiem <Snh Kendall - b i t cdp eho thay hidu lye. tin cay cua thang do c h i p nhdn, vd s d dung tot trong bdnh nhdn benh man tinh.
BiSu d6 2. Hd s i tirang quan "tau" bit cdp (kendall) giu-a cdc thang do
Bang 2: Dd tin cdy eua thang do edm xdc N$i dung Cam thSy io l^ng/ lo iSnq nliiSu llori Cam gidc bu6n/ ciiSn nan/ tiiSt vpnq/ tri tre
Cam giSc cSng titSng Cam gicic mgc cam do b$nh t^t Trir n6n da ngiii/ i<ii6ng tin tifong a ngu'di kii^c
Cam giic rai bdi/ kiiflng i<iem so^t difffc Cam thiy minii i<ii6ng giup icii di^iyc niiieu Clio qia dinti Dh bi l<ich thicil hon/ d^ gian dCr/ dS xOc dpng/ dg n6i cdu
TB 0,91 0,81 0,75 0,61 0,31 0,40 0,69 0,51
BLC 1,01 1,00 0,97 0,86 0,66 0,74 0,93 0,84
Alpha 0,876 0,862 0,862 0,879 0,878 0,874 0,873 0,877
r (Alpha) 0,637 0,768 0,761 0,694 0,627 0,661 0,656 0,618 Bdng 3 : Dd tin cdy cda thang do hdnh vi
N$i dung Giam hi^u qua cdng viec
Dfe gay/ xay ra tai nan An nhiSu/ho$c an it hon
GiSc ngu bi thay doi (ngu it/ kM ngu hoSc ngu rat nhieu) Qua ban rdn/ Khonq the nghi nqoi
Khd bat tay vao cdng viec Ndi nhiSu hoac khdng mudn ndi
Khd kiem scat diroc hanh vi Khdng bde Id cam xdc difc^c Na tranh ti^p xdc ngif di khac (k^ ca ngu'di thdn, quen)
TB 0,79 0,42 1,05 1,25 0,47 0,48 0,68 0,39 0,33 0,30
DLC 1,04 0,78 0,83 0,89 0,79 0,81 1,03 0,79 0,72 0,72
Alpha 0,857 0,857 0,866 0,869 0,868 0,849 0,851 0,861 0,868 0.863
r (Alpha) 0,637 0,645 0,610 0,479 0,485 0,736 0,700 0,660 0,640 0,558 Bdng 4: Dd tin cdy cua thang do nhdn thdc
Ndi dung Khdng biet phai idm gi
Khdnq thi dirong 6aul d'ng phd duQC vdi nhi>nq khd khan hien tai Mat kha ndng phan ddan trong nhcnq viec binh thu'dng hang ngay
Kha nang ddnh qia cdng viec cua tdi bi giam sut dang k i C6 gang vif(?t ian cam xuc/ suy nqht tieu c^rc
Tin tl/dng rdng minh se khoi banh Cudc sdng cua tdi gap vdn de (ric roi) idn Khdng thi suv nghT iiin mdt mach/ suy nghT mdt cdch chinh xdc
Cdm thiy rang moi ngi^di khdng than thien va khdnq thich tdi Khdng th^FC sy quan tim den moi ngu'di
Khd difa ra quyet dinh, khdnq tip tmng Sc/ phdi lim nhO'ng viic mdi. dii l i nhOng viic mdi rit binh thifdnq
TB 0.42 0,52 0,41 0,63 2,00 1,99 0,84 0,60 0,26 0,21 0,37 0,36
BLC 0,84 0,88 0,76 0.80 1,08 1.15 1,11 0,79 0,69 0,64 0,66 0,68
Alpha 0,867 0,866 0,871 0,869 0,874*
0,881' 0,874 0,870 0,886 0,886 0,880 0,876
r (Alpha) 0,724 0,730 0,666 0,706 0,619 0,546 0,630 0,680 0,376 0,333 0,498 0,694 (') D i i m dd dypc ma hda Igi trydc khi tinh h i s i tin cdy
Y HQC THVC H A N H (931) - S 6 9/2014
Bang 5. Dd tin cdy eda thang do sinh li Ndi dung
Ddnh trdng ngu'c/ tim ddp nhanh, manh/ hdi hdp Co giat /run tay/ run chdn Dau nhdc todn than (cd/diu/vai)/ Mit moi/ Yiu chdn tay
Nhdc ddu nhiiu Tdi phdt binh cu/ di dng cu Tdo bdn/ ho$c tidu chdy/ khd tiiu Chdng m^t/ Chddng vang/ ngit xiu D i bi cam ianh, cam cum ldm khd chiu hon binh thydng
Dd md hdi, du khdng idm viae ndng hay do trdi ndng
TB 1,16 0.92 1.07 1,09 0,43 0,59 1,11 0,70 0,90
DLC 1,07 1,04 1,00 0,96 0.72 0.82 1.01 0.96 1,09
Alpha 0,814 0,813 0,623 0,817 0,842 0,837 0.813 0.815 0.818
r (Alpha) 0,616 0,625 0,637 0,592 0,326 0.396 0.628 0.610 0.586 each d i l n giai k i t qua roi loan stress
Khdng t h i do ladng tare tiip stress md phai do m i t cdch gidn t i i p thdng qua mpt logt cdc edu hdi v i cdc Unh vyc khdc nhau.
Bdng 6. DO tin cdy cda thang do stress Ndi dung
May bdi rdi trddc nhirng viec chdng diu vdo diu Cd xu hudng phan dng thai qua vdi mpi tinh huing
Cam thdy khd thy gidn dyp'c Kha de bl boi roi Dang suy nghT qui nhiiu Khdng thi kidn nhdn dypc khi phai chd ddi
Khd de phdt!/. ty di Thiy khd md thoai mdi dyyc
De cdu kinh, bye bdi Sau khi bi bdi rdi tdi thiy khd m i trin tTnh iai dypc
Khd chap nhin viic dang lim bi gidn ddan Sdng trong tinh trang cang thang Khdng chdp nhdn dydc viae cd cdi gi dd xen vdd can trd viic tdi
dang ldm D i bi kich dpng
TB 0,48 0,44 0,54 0,60 0,85 0,66 0,64 0,66 0,63 0,47 0,48 0,48 0,46 0,46
DLC 0,87 0,79 0,82 0,81 0,91 0,87 0,87 0,88 0,82 0,77 0,78 0,83 0.78 0.80
Alpha 0.930 0,928 0,930 0,927 0,930 0,929 0,930 0,926 0,928 0,926 0.927 0.927 0,926 0,928
r (Alpha) 0,614 0,675 0,612 0,721 0,625 0,656 0,624 0,732 0,679 0,748 0,732 0,711 0,739 0,696 Cd t h i ddnh gid s y thay d i i iSem s i stress lidn quan d i n m i t ITnh v y c hoat ddng chdc ndng hay tde d i n g cda cde b i l n e i x l y ra trong eupc s i n g .
Vide d l i n giai d i l m s i stress ed t h i dya vdo bdnh nhdn thdng qua vide benh nhdn trd Idi trye t i i p edu hdi cda Bde sT, D i i u Dydng v i tinh trang tdm !^ chinh hp.
Chinh vl vdy, vdi bat ky mdt chiin lape ddnh gid stress nao, chdng tdi phai dya ra tidu chi dl§n g i l i k i t qud dilm s i stress thi cdc nha Idm sdng mdi khdng g | p khd khdn khi d l i n g i l i ket qud ndy.
Khi thyc hiin thang do stress, s y didn gidi k i t q u i phdi phd hpp vdi dd nhay vd dd ddc h i i u thang do, NhO-ngmdc dd, d i tin cdy, tinh gid tri thang do p h l i dype xem xdt cd hd t h i n g va tidu ehi rd rdng. Hgn e h i t i i da nhilu vd ede y i u t i cpng hydng trong do Iydng.
Qua k i t qud b i l u d i 3. ed t h i nhdn t h i y ed s y typng quan ed y nghla t h i n g kd gida cdc cdu trcng thang dp stress d bdnh nhdn benh mgn tinh. H l u h i t hd s i tyang quan > 0.50, hidu lye manh.
Tfnh c h i p nhdn: Hcan thanh cae edu h i i eda bdnh nhdn
Tinh hl^u \\jfc: thang do stress dd xdy dyng tinh hpp id. Md ta m i l lidn quan vdi thang do sinh If, hdnh vi, cdm xde, nhdn thdc cda bdnh nhdn bdnh mgn tinh.
Tinh nhay edm v d i thay d d i : Khi so sdnh vdi cdu h i i thadng gpi Id "tidu c h u l n vdng". thang do stress chaa hdn Id tidu c h u l n vdng, nhang dp nhay vd dd ddc h i i u cd t h i sd- dyng d a p c trong d i i tapng Id bdnh nhdn b i n h man tinh, do d y p c dd nhgy cdm vdi thay d i i .
D i h i n g djnh : Thang do stress ed dp tin cdy cap. c l v i dd tin cdy ndi tgt.
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Thang do stress, vd cae thang do chuydn biet nha hdnh vi, edm xdc, sinh 11, nhdn thdc. h i s i tin cdy rAlpha ede cdu hdi eao. H i s i taang quan b i t cdp (tau) dang tin cdy trong c h i n doan stress thdng qua cic thang do chuydn bidt trong b i i c i n h h i i n nay d Vidt Nam.
T A I L I E U THAM K H A O
1. Al-Gelban, K. S. , H. S. Al-Amri, O. A. Mostafa (2009) "Prevalence of Depression, Anxiety and Stress 35 Measured by the Depression, Anxiety, and Stress Scale (DASS-42) among Secondary School Girls in Abha, Saudi Arabia". Sultan Qaboos Univ Med J, 9. (2).
140-7.
2. Hekimoglu, L. , Z. O. Altun, E. Z. Kaya, N.
Bayram, N. Bilgel (2012) "Psychometric properties of the Turkish version of the 42 item Depression Anxiety Stress Seaie (DASS-42) in a clinical sample". Int J Psychiatry Med, 44, (3), 183-98.
3. Tran, T. D. , T. Tran, J, Fisher (2013) "Validation of the depression anxiety stress scales (DASS) 21 as a screening instrument for depression and anxiety in a rural community-based cohort of northern Vietnamese women". BMC Psychiatry, 13, 24.
4. Covic, T. , S. R. Gumming, J. F. Paliant, N.
Manolios, P. Emery, P, G. Conaghan, A. Tennant (2012)
"Depression and anxiety in patients with rheumatoid
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arthritis: prevalence rates based on a comparison of the Depression, Anxiety and Stress Scale (DASS) and the hospital. Anxiety and Depression Scale (HADS)". BMC Psychiatry, 12,6.
5. lulanea. L, , S. Gilbody, D, McMillan (2012)
"Optimal cut-off score for diagnosing depression with the Patient Health Questionnaire (PHQ-9): a meta-analysis", CMAJ. 184, (3), 191-196.
6. WHO (2009) "The psychological impact of infertility and its treatment. Medical interventions may exacerbate anxiety, depression, and stress". Harv Ment Health Lett, 25, {•\^).^-3.
7. WHO, T.W.H.R (2001) "Mental Health: New Understanding, New Hope". World Health Organization.
8. Whooley, M. A. , J. M. Wong (2013) "Depression and cardiovascular disorders". Annu Rev Clin Psychol, 9 327-54.
9. Wood, B. M. , M. K. Nicholas. F. BIyth. A. Asghari, S. Gibson (2010) "The utility of the short version of the Depression Anxiety Stress Scales (DASS-21) in elderly patients with persistent pain: does age make a difference?". PainMed, 11. (12), 1780-90.
10. Vipn. sdc khoe tam than Trung aang (2011).
Thang Dinh gii Lo iu - Trim cam - Stress, http://nimh.gov.vn/home/trac-nghiem-tam-ly/28-eae-tre- nghim/151 -thang-anh-gia-lo-au-trm-cm-stress-dass- 21.html,
Y HOC THUC HANH (931) - S6 9/2014
T H O N G T I N Y H O C
KtT ngp O L A P A R I B V A C E D I R A N I B o\tu T R I UNG THU- B U 6 N G TRIJNG T G T H Q N M^t tfii> nghidm lim sang giai doan 2 hH^ hen giii phip thay thi hda tri lieu, dwdi dang thudc vidn. Cic nhi nghidn ciiu phat hien ra rang kit hgp hai lo^i thuoc olaparib va cediranib cd the di^t cic ti bio ung tiiw twang tw nhw hda tn & nhirng b^nh nhin ung Uiw buong trimg tii phit Bdnh nhin udng hai loai thuoc nay cd the song thdm 18 thing (PFS) so v6i 9 thing & nhirng ngu-di chi uong olaparib.
Theo Trung tdm Kiem sodt va Phdng ngda Bdnh tat Hoa Ky (CDC), ung tha buing tn>ng p h i biin thd 8 trong cac logi ung tha, anh hydng d i n 3% phy nd m l c bdnh ung thy Neu benh daoe phat hidn sdm, ti Id dilu trj thanh cdng cao han. Olaparib dc c h i enzym Poly ADP- ribose polymerase (PARP), sda chda AON bi t i n hai trong ede t i bdo vd do dd gidp tidu didt t i bdo ung thy. Trong khi dd, cediranib can trd s y phat triln eda cac mgch mdu trong khii u. K i t qua la khii ung thy m i t cac chit dinh dadng va dxy c i n thiit dk t i n tai. cae thd nghiem lien quan d i n 90 phy n d bi ung thy buing tn>ng da trd Igi sau khi hp trdi qua hda trj li§u, Phy nd dapc chpn ngiu nhidn ehi sd dyng claparib hPdc k i t hpp vdi cediranib. K i t q u i cho t h i y khdi u thu Igi 80% d nhdng ngadi tham gia sd dyng diiu tri k i t hpp, nhiiu han so vdi 48% d nhdng ngadi tham gia chi ddng olaparib.
Tuy nhidn khi hai thuie nay ket hap cdng nhau, nguy ca x l y ra tac dung phu nhy tidu chay, huyit dp eao vd mdt m i l sd cao han nhang cde nhd nghidn edu cho bilt tdc dyng phy ed the dope gidm thiiu phy thudc vdo Iilu laang thuie bdnh nhdn s d dyng.
Minh Phwang (Theo Medical Daily)
P H A T H I E N G E N M O I LIEN QUAN DtU UNG THU NAO H\tM GAP
Cic nhi nghidn cCru da dat dwgv mdt bw&c ddt phi trong khi nghidn cuv nguydn nhin di truyen cOa u than kinh dfm, mpt benh ung thw hiem g$p vi c6 khi ning giy chit ngw&i & nao, chO yiu gip
&^6emvi thanh Uiieu nien. PhAt hiin niy cd the hd tr^ trong vide phit trien cic phw<yng phip dieu trj bdnh ung thw niy.
Cdc nha nghidn cdu tai Dgi hoc Y khoa Duke phii hpp vdi cdc nhd phdu thudt t h i n kinh vd cdc nha khoa hpe Tfung Quie dd xac dinh dapc mdt ddt b i i n gen lidn quan d i n sy phdt triin vd c h i t eda cdc te bao khii u. cae nha khoa hpc cung phat hidn ra cac dpt b i l n iam che cae khii u khang bde xg, cho phdp hp gid Igi binh nhdn ed ddt b i i n neu khdng xg trj. Phat hidn ndy dope cdng b i trdn Tap chi Nature Genetics. V l ca bdn, u Uiln kinh dpm thdn ndo phdt trien khi cdc t l bdo t h i n kinh ddm Idt bj ung tha. U t h i n kinh d i m d ndo thadng xdy ra d c l u nao, n i l hdnh tOy va d i i thj. Nao kilm sodt hd thing tim mach, hd h i p , cdm gide vd ede ddy t h i n kinh lien quan den nhin, nghe, vdn d i n g va
ndi do vdy nao khi bj anh hadng se gdy t i n hgi nghidm trpng. Khi nghidn cdu cdc t i bdo k h i i u, cdc nha nghidn edu phat hidn ra ddt b i i n xdy ra d gen PPIVI1D, dapc cho Id dao ngoac nhdng t i n hai cua ADN, D i t biin gen ndy Idm cdc te bao nhan Idn vd trdnh gdy chit cae t i bao t y nhidn. Ddt b i l n gen ndy cd lidn quan d i n ung tha buong trdng vd ung thy vd. Tuy nhidn, ede nghidn edu mdi lai eho t h i y nd thdc d l y mgnh me s y phdt trien cda u than kinh d6m thdn ndo.
Bdn cgnh dd. ede nhd nghidn cdu cdng phdt hidn ra khii u cd gen ddt bien PPM1D thi thieu gen ddt biin TP53. Gen TP53 thydng dieu chinh chu k^ t l bdo va ngdn chdn k h i i u. Dot bien PPM1D hoac TP53 gdy ra cdc t l bdo khii u cd kha ndng ehing bde xg. Hieu biit v i d i t b i l n nay cQng ed the gidp phat triln cae logi thuie mdi gidp cdi thipn ty Id s i n g sdt d nhdng bdnh nhdn u t h i n kinh ddm thdn nao.
Hidn. edc nhd nghien cdu dang e i g i n g tim ra loai thuie ed t h i ngdn ehdn ddt b i i n gen PPIU11D nhlm kilm sodt b$nh ung tha.
Dwang Ngoc (Theo Medical Daily)
KtJ Hgp HOA TRI LIEU v A LIEU P H A P GEN T R O N G D I ^ U TRj HIV
Mdt dch tiip can mdi trong dieu tri dn b^nh thi ki HIV/AIDS dang m& ra nhirng hy vgng m&i cho loii ngwdn. Nhdm cic nha nghi&n cCnj Sangamo BioSciences tai Mf da nghidn cOv vi kit Iu0n khi kit hgp hda tri liSu Cytoxan vi li^u phip gen thi khi ning bio ve cOa ca thi tSng Idn.
Lidu phdp ddng thuie ehing vims sao chdp ngypc hidn nay Id phypng phdp ffliu trj chu y i u eho edc b i n h nhdn HIV. Mdt nhdm edc thuie dapc chia thdnh nhiiu logi, thuie khdng vims thadng Idm vide bing cdch ngdn ehdn vims Idy nhidm eho cdc t i bdo mdi s i p sdn sinh, trong khi v l n duy tri hd t h i n g midn djch eda b i n h nhdn. D i i u tn mdi vda thay d i i cdc gen bj vims HIV phd v d vda ket hpp vdi edc thuie hda trj lidu, gidp iam gia tdng kha ndng cda cde t i bdo miln djch khie mgnh trong ea t h i . dp dao lai vims. O l u tidn. cdc nhd khoa hpc l i y ADN t d mdt s i t i bdo cda bdnh nhdn vd thay doi nd. Hp dang tim kilm m i t gen cy t h i nha CCR5, gen bj HIV phd v d d l t i n cdng edc t i bdo miin djch eda ca the (edn gpi Id t i bdo T). Bing cdch n h l m vdo cdc thu the CCR5, cde nhd khoa hpc cd t h i ngdn ehdn s y t i n edng eda virus vd gidp cdc t i bdo khdng bi nhi§m bdnh nda, Nghidn edu cho thiy sy dyng hda trj lidu Cytoxan vdo qud trinh ndy thyc sy dgt k i t qud t i t han. K i t d l l n d i u tien ddng logi thuie mdi nay, hai trong s i ba bdnh nhdn d i l u trj vdi Iilu cao nhlt Cytoxan dd l^dng c^n dung ttiuic ehing vims sao chdp ngypc trong nhieu t u l n . Bdnh nhdn v l n cdn d i u v i t cda HIV trong mdu. tuy nhidn t m y i n d i n Cytoxan ldm g i i m s i lypng t i bap T, cho phdp lidu phdp gen chQ« trj bdnh khi cdc t i bdo dang phdt triln trd Igi. Khi ngdng s y dyng thuie, cdc t i bdo phyc h i i Igi nhanh ehing.
Dwang Nggc (Theo Medical Daily)
Y HOC THirc HANH (931) - S
