DANH GIA KET QUA PHOI HOP CHIEU LASER He TRONG DIEU TRI BENH ZONA TAI KHOA DA LIEU BENH VIEN DA KHOA TRUNG I/ONG THAI NGUYEN
Nguyen Quy Thai Tncdng DH Y Dugc - DH Thdi Nguyen
TOMTAT
Muc tieu nghien cuu: Danh gia ket qua phdi hgp chieu tia Laser He trong dilu trj benh Zona tai Khoa Da lieu - Benh vien Da khoa Trung uong Thai Nguyen tu 10/2007 dkn 10/2009.
Doi tirmg vd phuong phdp: Thiet ke nghien cuu md ta can thiep lam sang cd ddi chung. Ky thuat nghien cuu dugc tien hanh tren hai nhdm benh nhan: Nhdm can thiep (nhdm I) dugc dieu tri theo phac dd thdng thudng (thudc khang virus + chong viem + giam dau) ddng thdi ket hgp vdi chieu tia Laser He tai chd, va nhdm chi dieu tri theo phac dd thong thudng lam ddi chdng (nhdm II).
Ket qud nghien cuu: Sau 7 ngay dieu tri ty le benh nhan lanh ton thuong d nhdm can thiep la 87,9% cao hon nhdm chdng 62,9%, vdi p<0,05. Sau 5 ngay dieu trj mdc do dau nang d nhdm can thiep giam 24,2%, cao hon nhdm chung 5,1%, vdi p<0,05. Sau 7 ngay mdc do dau nang d nhdm can thiep giam 33,3%o, cao hon nhdm chdng 11,4%, vdi p<0,05. Ty le khdi benh dat muc Tot d nhom can thiep la 81,7% cao hon nhdm chung 57,1%), vdi p<0,05. Tac gia khuyen nghi cd the ap dung ap dung rdng rai chieu tia Laser He phdi hgp vdi phac dd thdng thudng trong dieu trj benh Zona gop phan nhanh khdi benh va giam dau sau Zona.
Tu- khoa: Zona, Laser He, virus, khdng viem, hgng nuoc DAT VAN DE
Zona (hay Herpes Zoster) Id mdt benh cdp linh do mdt loai virus gdy viem da, hach than kinh (cd ten Varicella Zoster Virus - VZV).
Benh cd xu hudng lang nhanh trong nhung nam gdn day, tu mdt benh it gap nay dd trd thanh kha phd bien vd chiem ty le 5% - den
10% Irong tdng sd benh nhdn da lieu nam dieu tri ndi trd lai benh vien [1], [6]. Mac du hien nay viec chdn dodn vd dieu tri benh Zona khdng khd khan, nhung neu benh nhdn khdng dugc dieu tri tdt se de nhiem trung gay seo xdu anh hudng tdi thdm mT, nghiem trgng hon la benh cd the de lai cdc di chung ndng ne nhu giam thi luc, teo co. tdn thii-ang mdt sd co- quan ndi tang, nhdl Id dau sau Zona. Thdm chi ngudi benh sau khi tdn thuong da da ldnh, trieu chung dau vdn cdn keo ddi nhieu thdng, nhieu nam, cd khi keo ddi den tan cudi ddi [3], [8], [10]. Hien nay cd nhieu phuong phdp dieu tri Zona nhu dung thudc khdng virus, dieu bien mien dich, phong be thdn kinh, lieu phap corticoide vd chdng dau. dieu tri vat ly ' Tel: 0913313147
(chieu lia tu ngoai, hdng ngoai, lia laser) [10].
Tuy nhien d Viet Nam viec nghien cuu ddnh gid hieu qud phdi hgp vira dung thudc khdng virus ket hgp chieu tia laser ngoai mach nhdm ndng cao hieu qud hon nua trong dieu tri Zona cdn thdy it dugc de cap tdi. Vi vdy chdng tdi tien hanh de lai nay nhdm muc tieu: Bitrfc ddu ddnh gid ket qua phdi hgrp chieu Laser He trong dieu tri benh Zona tgi Khoa Da lieu - BVDKTlf Thdi Nguyen.
DOI TU'ONG v A PHU'ONG P H A P NGHIEN CU'U
a) Doi tirgng
Dugc lien hdnh tren cdc benh nhan dugc chan dodn Zona vd dirge dieu tri ndi tru tai Khoa Da lilu - BVDKTW Thdi Nguyen tu 10/2007 den 10/2009.
Tieu chitdn chdn dodn: dua vdo trieu chung lam sang kinh dien: Thuc the: Tdn thuong cd mun nirdc hoac bgng nude tap trung lung chum xen lan cdc ddm dich tiet hoac vdy tiet tren nen da dd, phu ne. Vi tri tdn thuong khu tru d mgl ben co the, cd the cd bach cue bg tai tdn Ihuong. Co- ndng: benh nhan cd dau rat [10].
Nguyen Quy Thai Tap chi KHOA HOC & CONG NGHE 81(05): 147- 152 Tieu chudn lira chon:
Dugc ehan dodn lam sang Id Zona vd cd thai gian phdi benh trong 72 gid ddu, do ludi >I2.
Benh nhdn chua dugc dieu Iri gi vd chap nhdn tham gia nghien euu.
Tieu chudn loai trir:
Benh nhdn mac cdc benh ndi khoa phdi hgp (tim mach, hd hdp, gan, than...).
Benh nhan dang ed thai, eho con bu hoac benh nhdn cdn dugc theo ddi cap cuu, ngoai khoa, hoac cd tdn thuong d giac mac va dau d u d d i d m d t , HlV/AlDS,...
b) Phuong phap nghien ciru
- Thiet ke nghien cini: Nghien cdu md td can thiep lam sdng ngdu nhien cd ddi chirng, lien hdnh tren hai nhdm benh nhdn: nhdm dugc dieu tri theo phdc dd thdng thudng cd kel hgp vdi chieu tia laser ngoai mach tai chd
( N H O M I), va nhdm chi dieu tri theo phdc dd thdng thudng khdng can thiep laser (NHOM II) lam ddi chung. So sdnh kel qua sau dieu tri giua hai nhdm nghien cuu.
- Cd mdu vd chon mdu nghien cint:
+ Cd mdu thuan tien; Benh nhan Zona dieu trj ndi trd tai khoa, du kien n > 30.
+ Chgn mdu: Cdc benh nhan Zona du tieu chuan lira chgn vdo nghien cuu dugc phdn ngdu nhien lam hai nhdm vd ggi nhdm I - theo sd le va nhdm II - sd chdn (dua theo sd hd so benh an). Benh nhdn d nhdm I (can thiep laser):
dieu tri phdc do thdng thudng + Laser ngoai mach; nhdm II (chdng): Phdc do thdng thudng.
- Ky thudl nghien cint;
+ Nhdm can thiep: Dieu tri phdc do thdng thu-dng kel hgp Laser He [1], [5]:
Phdc do thdng thudns dieu tri Zona:
Tai cho: Tdn thuong tay dd chua cd mun nude, bgng nude: bdi md, kem Acyclvir 2%.
Tdn thuong dap vd chdy dich: bdi tai chd dung dich Methylen, tim Gentian...
Toan than:
- Acyclovir 800mg/lan x 5 Idn/ ngdy x 7-10 ngdy.
- Corticoide: lieu trung binh (» 60mg/ngay), khdng sinh, gidm dau, an than.
148
Kit hap Laser He:
Ngodi dieu trj theo phdc dd tren, benh nhan dugc dp dung tia Laser He chieu ngoai tai vung tdn thuong Zona: Day la loai Laser cdng xuat thap 20 - 30 mw, budc sdng 632,8 nm, tia mdu dd, vdi dau quang dan sgi (Model D579), khodng each chieu tia Id Im tu vdng tdn thuong, thdi gian 15 phut, mdi ngay 1 lan.
-I- Nhdm chung: Dieu tri theo phdc dd thdng thudng.
- Chi tieu theo doi vd ddnh gid ket qud:
-I- Muc do dau: Dua vdo thang do do dau VAS (Visual Analogue Scale), ehia do dau tu 0 -
10, quy ude md ta eae muc do dau [trich tu 9]
va phdn ra 3 muc sau:
Khong dau: tuong ung 0 diem (benh nhan khdng cdm thay bat ky mdt dau ddn khd chiu ndo. ngu dugc).
Dau nhe: tuong ung diem dau tu I -3 diem (dau nhe hoi khd chju, thdy khd ngu nhung van ngu dugc).
Dau vira: 3 < diem dau < 7 diem (dau rat kho chiu, khdng the nam yen, phdi trd minh, nghieng qua nghieng lai hoac phan xa keu ren).
Dau nang: tuong ung diem dau 7 - 1 0 (dau vat va qudn quai, lodl md hdi , dau tdt dinh va cd the chodng).
-I- Ldnh tdn thuong: la loan bd tdn thuong ldnh seo, bet mun nudc/bgng nude, bet tiel djch, khdng cdn vay tiet, da het dd, het phu ne.
•f Ddnh gid kel qud chung: dugc chia lam 4 muc dd nhu sau:
Tot: Da ldnh tdn thuong, het dau (VAS = 0), di chung: khdng, loan than; khdng sdt, khdng sung hach.
Khd: Da Idnh Idn thuong, dau gidm nhieu hoac dau nhe (VAS < 3 diem), di chung:
khdng, khdng sdt, khdng sung hach.
Trung binh: Da ldnh tdn thuong, dau giam it (3 < VAS < 7 diem), di chung: khdng, khdng sdt, khdng sung hach.
Kem: Tdn thuong da chua lanh sau 2 tuan dieu tri, cdn dau nhieu hoac dau tang (VAS >
7 diem), cd the cd di chung: liet mat, teo ca...
hoac khdng, toan than cd sdt, cd sung hach hoac khdng.
- Xit ly sd lieu: theo pbuong phdp thdng ke y hgc, su dung test x" de kiem dinh khi so sanh 2 ty le %, su khde biet cd y nghTa thong ke khi gid tri p<0,05.
KET QUA NGHIEN CU'U VA BAN L U A N
Bang 1. Phan bd benh nhan theo gidi tinh cua 2 nhdm nghien cuu
^~~~ l^^l6rn Gioi tinh ^~~~~~----__
Nam NCr Tdng sd
-_ SL 17 16 33
Nhdm 1
% 51,5 48,5 100
SL 20 15 35
Nhom H
% 57.1 42,9 100
P
>0,05
>0,05
Nhdn xet: Sd benh nhdn dugc chgn vdo nghien cuu gdm nhdm I (can thiep): 33 , nhdm II (chdng): 35. Su phdn bd benh nhdn theo gidi tinh ve ty le nam vd nu giua hai nhdm khdng cd su khac biet (p>0,05).
Bang 2. Phan bd benh nhan theo tudi Tuoi
-—-NMm
< 5 0 5 0 - 5 9 6 0 - 6 9
> 7 0 Tdng sd
_ SL 10
7
6
10 33
Nhdm I
% 30,3 21,2 18,2 30,3 100
SL 12 6 8 9 35
Nhom 11
% 34,3
17,1 22,9 25,7 100
P
>0,05
>0,05
>0,05
>0.05
NhCin xet: Ty le benh nhdn phdn bd theo cdc nhdm ludi giua hai nhdm nghien cdu deu khdng cd sir khde biet (p>0,05).
Bang 3. Phan bd benh nhan theo vi tri tdn thuong
^ — N J i o m
Vj tri T T ^ — ^ - ^ ^ ^ Nguc - canh tay
Dau - mat - cd That lung Vung cung cut Cac vung khac
Tdng sd
SL 14
10 5 2
2 33
Nhom 1
% 42,4 30,4 15,2 6,0
6,0
100
SL 16 11 4 2 2 35
Nhom II
% 45,7 31,4 11,4 5,7 5,7 100
P
>0,05
>0,05
>0,05
>0,05
>0,05
NhCin xet: Qua bdng 3 ta thdy: vi tri Idn thuong Zona d cd hai nhdm chu yeu gap d ngirc - cdnh lay vd dau mat cd (chiem tren 70%). Ty le benh nhan phdn bd theo vi tri tdn thuong giua hai nhdm deu khdng thdy cd su khde biet (p>0,05).
Bang 4. Phan bd benh nhan theo muc do dau
^ IVdidm Muc do d a u ^ — - _
Nhe Vua Nang Tdng sd
-_ SL 8 12 13 33
Nhom 1
% 24,2 36,4 39,4 100
SL 11 12 12 35
Nhom II
%>
31,4 34,3 34.3
too
P
>0,05
>0,05
>0,05
Nhdn xet: Muc dd dau tren benh nhdn dugc phdn bd deu d ca 3 mirc (nhe, vua vd nang). Ty le benh theo muc do dau giua 2 nhdm chua cd su khde biet (p>0,05).
Kel qud nghien cuu d cac bdng I, 2, 3, 4 cua chdng tdi phu hgp vdi cdc ldc gid khde (Dang Van Em, Vu Nggc Vuong,...) [2], [3], [4], [7]. Vdi sir phdn bd cdc lieu thirc nghien cuu d hai nhdm nhu tren cd the ndi la khd luong dong vd nhu vdy se gdp phdn ldm cho viec ddnh gid cdc chi lieu ket qua sau can thiep mdt each khdch quan hon.
Nguyen Quy Thai Tap chi KHOA HOC & CONG NGHE 81(05): 147- 152 Bang 5. Cac ddu hieu lam sang khac
Nhdm ll(n = 35)
SL %
22,9 60.0
>0.05
>0,05 Nhdn xit: Ty le cd hach tai cho d 2 nhdm ddu chiSm tdi 60%, tiep den Id sdt (18,2 - 22,9%).
Bang 6. So sanh kk qua dilu trj theo thdi gian Idm lanh tdn thuong
——J^didm
Ket qua ^ — - ^ Sau 5 ngay
Sau 7 ngay Tdng sd
Nh.
SL 2 29 31
dm l ( n = = 33)
% 6,0 87,9 93,9
Nhdm SL
2 22 24
II (n = 35)
% 5,7 62,9 68.6
P
>0,05
<0,05
<0,05 Nhdn xet: Sau 5 ngdy dilu tri IS le benh nhdn ldnh tdn thuong d 2 nhdm chua cd su khde biet.
Nhung sau 7 ngdy ty le benh nhan ldnh tdn thuong d nhdm I Id 87,9% eao hon so vdi nhdm chdng 62,9%; sir khde biet cd y nghTa thdng ke (vdi p<0,05).
Kit qud cua chung tdi phu hgp vdi nghien cuu eua Usik vd Gostrev (thai gian ldnh tdn thuang gidm) [5]. Dieu ndy theo chung tdi la hgp ly do co che tdc dung cua tia Laser He chieu tai ton thuong cd tdc dung lam tang tudn hodn, kich thich phdn chia te bdo, tang phdt trien Id chuc hat de tai tao bilu md, nhanh ldnh seo va sach mu [5]. Nhu vdy ddi vdi nhung vung da ed dd phu ne, bgng nude tiet dich vd bdi nhiem nhu trong Zona thi viec chieu tia Laser He len vung tdn thuong cd tdc dung gidm nhanh thdi gian ldnh tdn thuong la hgp ly .
Bang 7. Su thay ddi muc do dau- theo chieu hudng gidm sau 3 ngdy dieu trj
(Nhii; het dau; Vita; het dau hoac giam xudng mitc nhe; Nang; hit dau, hoac gldm vita, nhe)
'~~~-—JVJJidm
Ket qua — ^ ^ Nhe
Vua Nang Tdng sd
Nhdm SL
5 3 2 10
I ( n = _ 1 -1 \
% 15,2
9,1 6,1 30,3
Nhdm SL
6 2 1 9
II (n = 35)
%) 17,1
5,7 2,9 25,7
P
>0,05
>0,05
>0.05
>0,05 Nhdn xit: Sau 3 ngdy dieu trj mdc do gidm dau d ede muc nhe, vira vd ndng chua thay cd sir khac biet giu'a hai nhdm (p>0.05....).
Bang 8. Su thay ddi muc do dau- theo chieu hudng gidm sau 5 ngay dieu tri Nhdm l(n = 33)
Ket qua
Nhdm II(n = 35)
SL SL %
Nhe Vua Nang Tdnsj sd
21.2 24,2 24,2 69.6
6 6 2 14
17.1 17,1 5,7 40,0
>0.05
>0.05
<0.05
<0.05 Nhdn .Kit: Sau 5 ngdy dieu tri su thay ddi dd dau d muc nang d nhdm I da gidm dugc 24.2%.
nhieu bon so vdi chirng 5,7%), sir khde biet cd y nghTa thdng ke (p<0,05).
Bang 9. Su thay ddi muc do dau- theo chieu hudng gidm sau 7 ngdy dieu tri
^ ^ ^ - ^ ^ - N J i d m
Ket qua ^ ^ — - ^ _ Nhe
Vua Nang Tdng sd
Nhdm _ SL
8 12 II 31
I(n = _ -> -» \
% 24.2 36,4
" » - > - N
J J , J
93.9
Nhdm SL
l i 11
4 26
11 (n = 35)
% 3 1 , 4 31.4 11.4 74.3
P
>0,05
>0,05
<0,05
<0,05 150
Nhfin xit: Sau 7 ngdy dieu tri su thay ddi muc dd dau d muc nhe vd vua giua hai nhdm chua thdy cd su khac biet (p>0,05,...). Nhung d muc do dau nang thi nhdm I da gidm dugc vdi ty le Id 33,3%), nhieu hon so vdi nhdm chung 11,4%), sir khac biet cd y nghTa thdng ke (p<0,05). Tdng sd benh nhdn chung cd cai thien trieu chung gidm dau d nhdm I gidm 93,9%) cao bon nhdm chung 74,3%), su khac biet cd y nghTa thdng ke (vdi p<0,05).
Bang 10. So sanh ket qua chung cua hai nhdm nghien cuu sau tri lieu
~—-~-N]i6m
Ket qua ^~~~—-..^
Tdt Kha Trung binh
Kem Tdng sd
SL 27 5 1 0 33
Nhom I
% 81,8 15,2 3,0 0,0 100
SL 20 10 5 0 35
Nhom II
% 57,1 28,6
P
<0,05
>0,05
>0,05
Nhdn xit: Qua bdng 10 ta thdy sau dieu tri ket qud chung nhdm 1 dat d muc tdt la 81,8%o cao ban nhdm chdng 57,1%, su khac biet cd y nghTa thdng ke (p<0,05). Ty le dat ket qud d muc khd vd trung binh giu'a hai nhdm chua thdy cd sir khac biet (p>0,05); chua phdt hien Irirdng hgp ndo sau dieu Iri d bai nhdm vdn cdn tinh trang benh d mdc kem.
Tac dung khong mong muon if hai nhdm trong thdi gian dieu trj:
Trong qua trinh thuc hien de ldi chdng tdi chua gap bat ky tdc dung khdng mong mudn nao d nhdm nghien cuu cung nhu nhdm ddi chung (Ndn - budn ndn, chodng - chdng mat.
ngua, ban dd, bdi nhiem).
Kel qua d cdc bdng (8, 9, 10) cho thay dau (mdc do nang) cung nhu kel qud chung dat tot sau dieu trj d nhdm nghien cuu deu dat ly le cao hon so vdi nhdm chung, su khde biet cd y nghTa thdng ke (vdi p<0,05, ... vd p<0,05). Kel qua eua chdng ldi phd hgp vdi nghien cuu vd nhdn xel cua Benh vien Trung Y Hoai An (Trung Qudc), vdi Gorbashiko:
chieu Laser He cd tac dung gidm phu ne rd ret, giam dau nhanh (nhdl Id gidm dau sau Zona), benh nhanh khdi [5]. Theo nguyen ly chung ve tdc dung cua Laser cdng xudl thdp nhu Laser He ngodi tdc dung quang bod vd nhiet (tang luan hodn, dinh dudng...) thi nd cdn cd khd ndng gdy ddp ung sinh bgc [5]
nhu: ldm thay ddi sdm mirc phdn tu, thay ddi d mirc te bao (kich thich sinh tdng hgp protein, nhdn vd phdn chia le bdo) vd ddp ung cda td chdc vd co' the (gidi phdng morphin ndi sinh. dn djnb ndi mdi, dieu chinh he mien dich dac hieu vd khdng dac hieu, tac ddng den h? thdng dieu hod boat ddng te bdo).
Vd vdi CO- che tdc dung cua Laser He cdng xudl thdp nhu tren viec phdi hgp chieu tia Laser He song song vdi duy tri phac dd dieu trj thdng thudng cda chung tdi cho kel qua chung d mdc tot Id 81.7% cao hon so vdi nhdm chdng chi dugc dieu tri theo phac do thdng thudng 57.1%, su khac biet cd y nghTa thdng ke (vdi p<0,05) Id phu hgp. Nhir vdy viec dp dimg phdi hgp chieu tia Laser He cung vdi dieu tri todn thdn theo phdc dd thdng thudng (thudc khdng virus) trong dieu trj Zona la cd co- sd vd cd the dugc cbi dinh mgl each rdng rdi.
KET L U A N V A K I E N NGH!
Qua nghien cdu phdi hgp chieu tia Laser He tren benh nhdn Zona tai Khoa Da lieu - BVDKTW Thdi Nguyen chung ldi cd mgl sd kel ludn sau:
- Thdi gian Idnh tdn thuo-ng: Sau 7 ngdy dieu trj ty le benh nhdn ldnh tdn thuong d nhdm can thiep (chieu tia Laser He) Id 87,9%o cao bon nhdm chung 62,9%o, vdi p<0,05.
- Thay ddi muc do dau: Sau 5 ngdy dieu tri muc do dau nang d nhdm can thiep giam 24.2%). cao ban nhdm chdng 5.7% (p<0,05).
Sau 7 ngdy mirc do dau ndng d nhdm can thiep gidm 33,3%o, cao bon nhdm chung
ll,4%'(p<0,05).
- Kel qua chung: ty le khdi benh dat mirc Tot d nhdm can thiep la 81,7% cao bon nhdm chung 57,1% (p<0,05).
Nguyen Quy Thai Tap chi KHOA HOC & CONG NGHE 81(05): 147-152 Khuyen nghj:
Cd the dp dung dp dung rdng rai phdi hgp chieu lia Laser He vdi phdc dd thdng thudng dilu tri Zona gdp phdn nhanh lanh tdn thuong va gidm dau sau Zona.
TAI LIEU THAM KHAO
[l],Nguyln Thi Dao (1999), "Vdn dl dau sau Zona", Ndi san Da lieu so 2, Hdi Da lieu Viet Nam, HaNdi.tr 1 0 - 1 3 .
[2].Dang Van Em, Ngd Xuan Nguyet (2005),
"Nghien cdu mdt sd tinh hinh va dac diem lam sang benh Zona dieu tri ndi trd taiu Khoa Da lieu, Benh vien Trung uong Quan ddi 108", Tgp chi Y hgc thuc hdnh (3), tr 27 - 29.
[3].Dd Xuan Khoat (2001), "Nghien curu dich ll hgc lam sang, can lam sang va dieu tri Zona", Ndi san Da lieu sd 1, Hdi Da lieu Viet Nam, tr 18 - 22.
[4].Nguyln Thj Lai (2005), "Nghien cuu mot s6 dac dilm cda Zona d ngudi cao tudi va hieu qua cda Acyclovir trong dieu tri Zona", Tgp chi Y hoc thitc hdnh sd 525 (10) tr 2 3 - 2 6 .
[5].Nguyen Huu Sdu (2005), U'ng dung Laser trong dieu tri mdt sd benh Da lieu, Bdi giang Sau dai hpc, Bg mdn Da lilu - Trudng Dai hgc Y Ha Ndi.
[dj.NguyIn Xuan Son (2000), "Kien thdc cap nhat vl Zona", Ndi san Da lieu sd 2, Hdi Da lieu Viet Nam, HdNdi, ir 1 1 - 1 2 .
[7].Nguyin Van Thdng (1997), "Zona", Ndi san Da liiu so 2, Hdi Da lilu Viet Nam, Ha Ndi, tr 49 - 51.
[8]. Pham Thi Thuy, Nguyin Xuan Son (1999), "Mot sd nhan xet ve lam sdng vd dieu trj Zona", Ndi san Da liiu sd 2, Hdi Da lieu Viet Nam, tr 32 - 37.
[9].Nguyln Van Ut (2002), Benh Da lilu, Trudng Dai hgc Y Dugc Thdnh phd Hd Chi Minh, Nha xudt ban Y hgc, tr 274 - 278
[10]. Vu Nggc Vuong (2006), Budc ddu ddnh gld tdc dung ciia dien chdm trong dieu tri Zona, Luan van Thac sT Y hgc, Trudng Dai hgc Y Ha Ngi.
SUMMARY
EVALUATION OF COMBINED TREATMENT RESULTS WITH LASER He IN THERAPY FOR ZONA AT DERMATOLOGY DEPARTMENT
IN THAI NGUYEN CENTRAL GENERAL HOSPITAL
Nguyen Quy Thai College of Medicine - Pharmacology - TNU
Object: To evaluate a combined treatment with Laser He in therapy for Zona
Subjects and methods: Patients treating at Dermatology & Venereology Dept. The study design is a controlled - clinical trial - descriptive study. The study conducted in 2 patient group: Group I treated with a conventional regime (antivirus + anti inflammation + pain relief drugs) combined with local Laser He), Group II treated with a conventional regime (antivirus + anti inflammation + pain relief drugs) only.
Results and conclusion: Comparison of results in 2 groups after 7 treatment days, we revealed that the rate of patients with recovered lesions in the group I was 87.9%) and higher than the control 62.9% ( p<0.05). After 5 treatment days, the serious level of pain in the group I decreased 24.2% and higher than the control 5.7% (p<0.05). After 7 treatment days, the serious level of pain in the group I decreased 33.3% and higher than the control 11.4%) (p<0.05). The rate of recovery reaching at a good level in the group I was 81.7% and higher than the control 57.l%o ( p<0.05). \t was recommended that this combined regime can widely be used for therapy of zona and can contribute to a fast recovery and a pain relief after zona.
Key words: Zona, Laser He, virus, antl-lnflamatlon, bullous
Tel: 0913313147 152
