DOI TOONGSO-eO TUOI CO ROI LOAN LIPID MAU
Nguyen Xucin Ninh', Nguyen Do Viin Anli^, Nguyen Anh Tiidn^, Nguyen Thi Ldm'
120 doi tugng, 30-60 tuoi, c6 roi loan lipids mau (RLLPM) dugc udng vien toi-folate (4 vien/ngay) hang ngay trong thdi gian 3 thang, Ket qua cho thay nhom uong vien toi/folate (Can thiep - CT) da CO mpt so hieu qua tich cue: giam co y nghTa nong do cholesterol mau toan phan va LDL- eholestrol so vdi tmde can thiep va so vdi nhom chimg (CTR); co xu hudng giam nong dp tryg- lycerid mau va HDL-cholesterol, tuy nhien su khac biet chua co y nghia thong ke. Hieu qua can thiep Clia vien toi/folate trong viec giam roi loan lipids mau la 21,%, 28,2%, 33,7%, va 4,5%
tuong ung vdi triglycerid, cholesterol TP, LDL cholesterol va HDL cholesterol.
Tii- khoa: roi lognlipids mdu, toi-folate, ngudi triarng thdnh, Hd noi
DAT VAN DE
Rdi loan lipid mau la mdt trong nhirng van dS thdi su dugc y hge thS gidi quan tam, do su lien quan chat che vdi benh ly tim mach, huySt ap. Rdi loan lipid mau cdn liSn quan mat thiSt vdi thua can - beo phi ngay cang gia tang d cae nudc, trong dd cd Viet Nam [1-5]. Phdng chong RLLPM, bao gdm viec thay doi chS do an, luyen tap thS due, phdi hgp vdi su- dung thudc.. ..tuy nhiSn gia thanh ciia cac loai thudc cdn cao, gay nhiSu biSn chirng cho ngudi bSnh[ll].
Su dung toi trong phdng chdng rdi loan lipid mau va benh tim mach da dugc mdt sd tac gia cdng bd [6,7]. Mdt sd tac dung Clia tdi dugc nhac dSn nhu tac nhan chdng nhiSm trung, chdng tae nghen
' PGS, TS - Vien Dinh du-dng
^ThS, BS ~ Vien Dinh dirang
^ BS - Vien Dinh dirong
" B S -TTYTDPHaNoi
mach mau, uc che qua trinh dxy hda lipid, giam cac thanh phan lipid mau [8]. Vai tro ctia acid folic va ndng do homcysteine mau vdi benh tim mach cdng dugc gidi khoa hgc quan tam. Rat nhiSu nudc trSn the gidi da tiSn hanh tang cudng folate bat bugc vao bdt my ngoai muc dich giam di dang dng than kinh d tre sinh ra, cdn phdng chdng cac rdi loan liSn quan dSn benh tim mach cua cdng ddng [9].
Tdi la mdt thuc pham gia vj, dugc trdng va su dung rat phd bien d Viet Nam, cdng dung cua tdi va liSu dung hau nhu chl dua trSn kinh nghiSm dan gian. Gan day, mpt sd chS pham dugc san xuat tir toi dudi dang viSn nang, viSn nen da xuat hien trSn thi trudng trong nudc. Tuy nhiSn tai Viet Nam, eho dSn nay chua cd nghiSn
ciiu khoa hoc nao cong b6 hieu qua cua su dung toi-folate trSn ngudi benh cd rdi loan chuyen hda lipid mau.
Muc tieu: Danh gia hieu qua eiia sir dung viSn toi - folate ddi vdi tinh trang RLLPM trSn ddi tugng rdi loan lipids mau.
II. DOI TUONG VA PHUONG PHAP
Thiet he nghien cuu: Thu nghiSm ean thiep lam sang, ngau nhiSn cd ddi chimg.
Ddi tupng nghien cuu: ngudi truong thanh tir 30-60 tuoi sdng trong dja ban 05 phudng Ndi thanh Ha Ndi (Hang Bac, Nga Tu Sd, Tuang Mai, Truong Djnh, Dien BiSn), cd rdi loan lipids mau, dugc can thiep bang udng viSn tdi-folate trong thdi gian 3 thang (12 tuan, tir 9/2008-
11/2008)
Tieu chudn chpn lua: Ngudi trudng thanh 30-60 tu6i
Co roi loan lipid mau: dua vao 2 chi tiSu chinh [10]: triglycerid mau >2,26 dSn 5mmol/L hoac/va cholesterol toan phan
>5,2 mmol/L dSn 7 mmol/L, chua hoac khdng diing thudc diSu trj RLLPM 2 tuan tardc khi xet nghiSm, tu nguySn khdng diing thuoc ha md mau trong 3 thang nghien ciru, khdng dimg thSm rugu toi hoac an toi dSu dan hang ngay vdi muc dich dieu trj benh.
Chl tiSu phu khac: cd tang huySt ap do 1 hoac huySt ap binh thudng, khdng diing thuoc dieu trj tang huySt ap trong thdi gian nghiSn cim; cd hoac khdng thira can beo phi (neu cd thi BMI tu 23-29,0);
CO thS cd tang dudng mau khi ddi nhung chua dat muc dai thao dudng rd (Glucose mau trong khoang 6,2 - <7 mmol/L) .
Tieu chudn logi trir: Dj tat bam sinh hoac
mac phai nhu gu, veo cpt sdng mac cac benh cap tinh; phu nu- cd thai, phu nu cho con bit; md mau d mirc cao phai diSu trj bang thudc ha md mau.
Chpn mdu
- Cd mdu: ap dung cdng thirc n = 2 x [ [ ( Z a + Z p ) a ] / [ ^ , - M 2 ] ] -
Trong do: Za=l,96, vdi a=0,05; Z|3 = 1,28 vdi (^=0,1; 8=0.6 la do lech chuan ude lugng dua vao nghiSn ciru trudc[12]; p j - P2'^0'35: chSnh lech trung binh mong mudn vS ndng do lipid mau giira hai nhdm nghiSn cim, thSm 15% du phdng bd cuge, n=60/nhdm.
Tai mdi phudng, lap danh sach mdi khoang 200 ddi tugng tir 30-60 tudi, cd nguy ca bj rdi loan md mau, mdi cd thS tdi tram y tS phudng kham benh.
Ddi tugng cd rdi loan lipid mau, dat tiSu chuan chgn lua, dugc mdi nghe giai thich vS muc dich nghiSn cu'u, ky giay cam kSt ddng y tham gia nghien cuu, sau dd dugc chia ngau nhiSn ra 2 nhdm nghien cim.
Phdn nhdm ngau nhien: Lap khung mau cac ddi tugng dugc chgn; dung may tinh phan nhdm ngau nhiSn theo timg block 6 ddi tugng, sir dung 2 code ma so 1 va 2, nhirng ddi tugng mang sd 1 dugc ngau nhiSn chgn vao nhdm can thiep, nhii-ng ddi tugng mang sd 2 dugc chgn vao nhdm ddi chiing cho den khi du 60 ddi tugng cho mdi nhdm nghiSn cuu.
* Nhdm can thiep gdm 60 ddi tugng, dugc uong viSn nang toi -folat, liSu 4 viSn/ngay, chia 2 lan/ngay trong thdi gian 12 tuan.
* Nhdm doi chii-ng gdm 60 ddi tugng, khdng dimg vien tdi, chi diing viSn placebo.
Che phdm vien tdi/Folate:
Thanh phan: Bot tot kho (do am<6%) 200 mg; Acid Folic 0,1 mg; Vi- tamin B6 0,4mg; Vitamin B12 0,5 mg;
Aerosil 4 mg; Tinh bdt my (do am <3,5%) 100 mg; Nang 80 mg.
Hai loai chS pham (viSn tdi-folate that va viSn gia dugc), cd hinh dang, kich cd, mau sac gidng het nhau, dugc dung trong cimg mdt loai lg cd nhan mac nhu nhau, loai lg dung vien tdi -folate that dugc bdi thSm mdt vach vang trSn nhan mac. Cac ddi tugng nghiSn ciru khdng dugc biSt vS thdng tin nay. Cac ddi tu-gng dugc giai thich la sii- dung viSn vi chat dinh dudng vdi nhung thanh phan khac nhau, khdng cd thanh phan nao cd hai cho sire khde.
ChS pham dugc ddng lo 100 viSn, du dung trong 25 ngay, kem theo hudng dan sir dung rd rang chi tiet. Mdi thang, ddi tugng dugc phat 01 Ip, 3 lg trong 3 thang. Moi ddi tugng udng 6 ngay/tuan
Quy trinh va ham lugng cua vien tdi/folate dugc Vien Dinh Dudng va Xi nghiep dugc Hau Giang phdi hgp ngliiSn cuu san xuat.
Phuffng phdp thu thdp so lieu
Phong vdn true tiep: cac thdng tin chung ciia ddi tugng tham gia nghien cim; thdi quen an udng va sinh hoat;
tiSn su benh tat; kien thirc vS RLLPM
Cdn do cdc chi tieu nhdn trdc hao gom: Can nang, chiSu cao, BMI;
vong eo; vdng mdng, ty IS vdng eo/vdng mdng theo ky thuat chuan hoa ciia Vien Dinh dudng. Cac chi tieu nay duge danh gia vao liic bat dau va khi kSt thiic nghiSn ciru.
Do ty le % miy ca the: dua trSn nguySn ly do dien trd sinh hpc eua ca thS, su dung OMRON HBP 306 (Japan), vdi dp chinh xac 0,1 %.
Do huyet dp: diing may huySt ap ke thiiy ngan, do 2 lan va lay kSt qua trung binh 2 lan do, khi kSt qua giua 2 lan chSnh nhau >10mmHg thi do lai lan 3 va lay kSt qua ciia 2 lan c6 gia trj gan nhau nhat.
Xet nghiem sinh hoa mdu truac vd sau nghien ciru: Lay 5ml mau tinh mach vao budi sang, khi ddi. Djnh lugng glucose mau toan phan bang phuang phap GOD- PAP; Cholesterol toan phan huySt thanh- phuang phap CHOD-PAP; Triglyceride- huySt thanh- phuang phap GPO-PAP;
HDL-C huySt thanh - phuang phap ket tua cua LDL,VLDL, chylomicrons.
Chi tieu ddnh gid
- Danh gia RLLPM theo WHO (2000) [14]: Cholesterol toan phan >5,2 mmol/1 (200mg/dl), hoac HDL-C <
0,9 mmol/1 (35mg/dl), hoac LDL-C
>3,38 mmol/1 (130mg/dl), hoac Triglycerid huySt thanh >2,26 mmol/1 (130mg/dl)
- Danh gia TTDD: Chi so BMI= Can ndng (kg)/Chieu cao-(m): TTDD binh thudng: BMI 18,5-22,9; Thiia can: BMI >23; TiSn beo phi: B.MI 23-24,9; Beo phi do 1: BMI 25-29,9;
Beo phi do II: BMI >30; Beo bung khi ty sd VE/VM vugt qua 0,9 o nam gidi va 0,8 a nu gidi.
Ty le md co the cao khi gia trj do dugc >30%) doi vdi nu va >25"/o ddi vdi nam.
Tang huySt ap: Khi HA tam thu (HATT) >140mmHg va/hoac HA tam truang (HATTr) >90mmllg;
Roi loan glucose mau khi ddi: glu- cose mau > 6,1 mmol/1, dai thao dudng; glucose mau > 7mtnol/l.
Gidm sdt sir dung thudc: hang tuan nghien ciru viSn gii-i va thu phieu theo ddi, ghi chep lai tinh hinh sue khde chung, tac dung phu, sd viSn thudc su dung (theo mau phiSu djnh san). Nghien ciru vien cting gap ngau nhiSn va phdng van true tiSp viee su- dung thudc cua mdt sd ddi tugng.
Phdn tich sd lieu:
Sd lieu dugc nhap vao phan mem EPI data, sau dd dugc chuySn sang SPSS 10.0 dS xu ly. Sd lieu nhan trac dugc kiSm djnh phan bd chuan khi so sanh thdng kS. Chi nhii-ng ddi tugng su- dung til- 85% sd viSn thudc duge phat (tir 255 viSn trd len), cd xet nghiSm mau 2 lan tru'dc va sau nghiSn ciru mdi dugc dua vao tinh toan danh gia
Bang 1: Cac chi so nhan trac va
hieu qua cua can thiep.
Ill- KET QUA
Kham sang lgc 686 doi tugng thudc 5 phudng; tudi tmng binh 48,5±7,9 tudi. Ty IS rdi loan triglycerid (27,4%)), cholesterol toan phan (31,9%)), LDL cho- lesterol (24%,); tang huyet ap 12%), thii-a can beo phi (BMI >23) la 45%, dai thao dudng 15,5%.
Khi bat dau can thiep cd 120 ddi tugng (60 cho mdi nhdm) dugc chgn. KSt thuc nghiSn cim co 56 ddi tugng d nhdm chirng (49 nii-, 7 nam) va 55 ddi tugng d nhdm can thiep (50 nii, 5 nam) dii diSu kien dua vao tinh toan thdng ke. Cd 9 ddi tugng bj loai khdi nghiSn cim vdi mpt sd ly do: khdng xet nghiSm lan 2 (3 ngudi), udng <85%) sd vien thudc (4 ddi tugng), ban cdng viec khdng tham gia tiSp (2 ngudi).
3.1- Dgc diem 2 nhdm nghien ciiru khi bdt ddu can thiep
Bang 1&2 cho thay khdng cd su khac biet cd y nghTa thdng kS vS cac chi sd nhan trac, huySt ap, lipid mau khi bat dau nghiSn cuu giira 2 nhdm chirng (CTR) va nhdm bd sung -viSn tdi/folate (CT).
huyet ap khi bat dau nghien cii-u
Tuoi (nain) Chieu cao (cm) Can nang (kg) BMI
Ty le md ("-i)) Ty so vong eo/mong HA-iam ilui (mmHg) HA- Tam inrang (mmHg)
C l R (n=56) 49,7±7,9 1:^7,2-5,8
5H,6±7,1 2.\8±1,9 3(i,08±:4,02
O.S7T:(),04
120,1 ±15,4 7,S.3t.9,5
C T (n=55) 50,1 ±8,1 157,1 ±6,5
58,4±8,3 23,6±2,3 29,83±5,21
(i,88±0,04 121,4±15,8
"8,1±10,0
p (t test) NS NS NS NS NS NS NS NS Mean '-Sl > NS. p>0.05 giira 2 nhom nghiin eini
3.2-Hieu cpid can thiep
Bang 2: Cac chi so lipid mau khi bat dau va k^t thiic n"hien cii-u
Triglycerid, mir
Cholesterol TP
LDL, mmol/1
H D L , mmol/1 ol/l
mmoL'l
Ih oi d i e m TO T3 TO T3 TO T3 TO T3
C F R (11=56) 2.82 : 1,97 2 , ^ 5 - 1,66
>,:'5 -11,71 5,''>:'l,95 4.07:11,51 4,17-i),79 1,22:0,26 1,1911,23
C r (n=55)
2 . 7 3 . 1,97 2.66:11.85 5 , 7 9 t 0 , 8 2
5 , 4 8 J : 0 . 9 2
4,03±0,51 3,46*0,71
1 , 2 2 ± 0 , 2 7 1 . 2 2 ± 0 . 2 4
p (1 test) NS N S NS 0.05 NS 0.01 NS NS
TO: khi bdt ddu, T3: kit thiic 3 thdng ho sung NS. p> 0.0 5 giil a 2 nhom nghien ciiu
Khi kSt thiic nghiSn cu-u (bang 2):
chi sd triglycerid mau ed xu hudng giam nhe d ca 2 nhom, tuy nhiSn khdng cd su- khac biet y nghTa giii-a 2 nhdm; chi sd cho- lesterol toan phan d nhdm CT ed xu hudng giam nhieu han y nghia (p<0,05) so vdi nhdm CTR; tuang tu chi sd LDL- cholesterol ciing giam nhiSu ban y nghTa (p<0,01); trong khi dd chi sd HDL-cho- lesterol khdng ed su khac biet giua 2 nhdm ca trudc va sau can thiep.
Bang 3 cho thay hieu sd (gia trj khi kSt thiic - gia trj khi bat dau can thiep) tang hoac giam cua cac chi sd nhan trac, huySt ap, lipid mau:
Bang 3: Thay d6i (T3-T0) cac chi
So vdi tRidc nghiSn eii-u, hai chi so cholesterol toan phan va LDL ciia nhdm can thiep da giam co y nghTa (p<0,01 va<0,05)
So vdi nhdm doi chu-ng, hai chi so nay cua nhdm ean thiep ciing giam nhiSu han cd y nghTa (p<0,OI), theo hudng cd lgi cho tinh trang sire khoe ciia ngudi benh.
Cac chi sd khac vS nhan trac, huyet ap, % md, BMI, ty sd vdng eo/\6ng mdng,,. khdng thay cd su thay doi y nghTa trudc va sau can thiep, ciing nhu so sanh giiia 2 nlidm cimg thcri diem.
so nhan trac, lipid mau
Tang can (kg) BMI
Tang % m a Ty .so eo/mong H A - T a m thu ( m m H g ) HA T a m triro-ng ( m m H g ) Triglycerid (mmol/L) Cholesterol T P ( m m o l L) H D L (mmol/L)
LDL (mmol/L)
C T R (n=56) 0,2511), 15 0.01--0,45 0 , 1 5 . 0 , 1 4 0,00 U 0,015
- 1 , 5 4 - 1 , 0 9 - 0 . 4 5 : 0 , 8 2
0 . 1 1 T O , 1 2
0.04iO,()9 0,02-: 0,03 - 0 . 0 9 : 0 , 0 8
C T ( n = 5 5 ) 0,24^0,15 0.()8r0,45
0 , 3 7 . T 0 , 1 6
0,003 t:0,001 0,29 ::0.95 -1.36^0,92 0.01 -0.09 -0.31 r 0 . 0 8 * *
-0.01 t 0 . 0 3 -0,41 : 0 , 0 5 *
p ( t t e s t ) NS NS NS NS NS NS NS ' 0 , 0 1
NS
• 0.01
Mean ±SE (Hieu sd sau - truin' can thiep)
*p- I).05. **, p'l) 111 vs trudc • cin thiep. ciing nhom ( t ghep cd/>)
Bang 4: Chi so hieu qua c Chi so lipid
Triglycerid (>2,26 mmol/L)
Cholesterol ri' (>5,2mmol/L)
LDL cholesterol (>3,38 mmol/L)
HDL cholesterol (<0,9mmc)|/L)
Thoi diem Tl T3 CSHQ
Tl T3 CSHQ
Tl T3 CSHQ
Tl T3 CSHQ
C I R ( n=56)
56.9 65,5 -15.1 79.3 74,1 6,6 89,3 79,3 10,0 8,6 6,9 19,8
CT (n=55)
52.6
4 i ) . l 6.7 80.7 52.6 34,8 87,3 45,6 41.7 7.0 5.3 24,3
Hieu qua can thiep
21,8"„
28,2%
3 1.7%
4,5%
Bang 4 cho thay hieu qua ean thiep viSn tdi/folate dSu cao hon so vdi nhdm chung, tuy nhien chi so hieu qua va hieu qua can thiep ro nhat vdi chi sd LDL-cho- lesterol (31,7%), Cholesterol toan phan (28,2%), triglycerid (21,8%), va sau ciing la HDL cholesterol (4,5%)). Nhdm chu-ng ciing cai thien mgt sd ty IS nhu-ng it han so vdi nhom can thiep.
* M()t si) yen td lien quan khac: Khau phan an cua doi tugng dugc phong van vao thdi diSm kSt thiic nghiSn ciru. KSt qua cho thay khdng cd su khac biet giira 2 nhdm nghien eiru. Tuy nhien \ u thS ehung la eac doi tu-gng cua ca 2 nhom deu tiSu thu nang lugng thap han nhu cau, ty IS Ca/P chua hgp ly, nang lugng do glu- cid cung cap dat ty IS 72-73%, thugc loai cao, xu the an thjt va md giam di va nang lugng dl) protid, lipid cung cap chi dat xung quanh I VI4%). Sd lieu theo ddi vS sii- dung thuix. cung nhu benh tat khac ciing cho tha\ khdng cd su khac biet y nghTa giua 2 nhdm. ' ''-'-' ' '• •
m thiep den cac chi so lipid mau
IV- BAN LUAN
NghiSn cuu cua ehiing tdi da chi ra rang su dung vien tdi/folate trong thdi gian 3 thang cho nhii-ng benh nhan cd roi loan md mau, da cai thien y nghTa ndng do cholesterol mau toan phan ciing nhu ndng do L D L - cholesterol .
Ket qua nay phii hgp vdi mdt sd nghiSn cu-u khac da cong bd cho thay tdi cd tac dung lam giam cholesterol mau, giam nguy ca mac benh tim mach, lam tang cudng chuc nang miSn djch... thdng qua vai trd chdng oxy hda [6,7,8,12,13].
Ca chS giam cholesterol toan phan va LDL cholesterol cd hai cua tdi va chirc nang chong oxy hoa dugc nhiSu nghiSn eiru nhac dSn. Qua trinh oxy hda lipid, dac biet la LDL tham gia vao ca che sinh benh tim mach va mach mau nao. Oxy hda LDL lam tang cudng su phat triSn cua cac mang xa vii-a d thanh mach mau. Hoat tinh chdng oxy hda cua toi ire che va lam thay ddi qua trinh oxy hoa ciia lipid LDL lam giam lugng LDL va san pham choles- terol trong eac dja thuc bao, ea tran va thanh mach mau, ket qua la ire chS qua trinh xa viia dgng mach h.~']. Hieu qua irc chS ngung tap tiSu eau cua toi cting tham gia vao ca chS chong nhiSm trimg, chong tae nghen mach mau [7].
van dS khau phan an va tap thS due ciing la nhu-ng yeu to anh huo-ng dSn ndng do md mau, cac chi sd nay ciing dugc theo doi trong thdi gian nghiSn cim. KSt qua cho thay khong cd sir thay doi dang kS Cling nhu khae biet guia 2 nhom ve tiSu thu thuc pham. Mot diic diem chung la
khau phan ciia cac ddi tugng c6 mirc nang lugng thap, chua dap u-ng nhu cau khuyen nghj, nguySn nhan co thS lien quan den kiSn thirc chung ciia ngudi dan tai cac quan nay co hiSu biet nhat djnh vS phdng chdng thira can beo phi, md mau, dac biet la van de giam an, giam can...
VS dac tinh cam quan, miii vj khd chiu cua viSn tdi: tuy la sir dung phuang phap mil vdi viSn placebo, tuy nhien miii vi dac trirng cua toi van cd thS phat hien de dang. NhiSu ddi tugng phan nan ve mill vj khd chju sau khi udng, tuy nhiSn khi dugc giai thich ky vS tac dung cua thudc, dai da sd cac ddi tugng van su- dung dat ySu cau >85% sd vien. Tac dung phu nay dSu dugc phat hien vdi cac san pham viSn tdi tren thjt trudng hien nay.
Viec cai tiSn ky thuat chS biSn trong tuang lai dS che dau miii vj nay can dugc tiSp tuc nghien cuu.
VS gia thanh ciia san pham, ham hrgng cac chat trong viSn tdi: qua kiSm nghiem cho thay ham lugng Folate cd xu hudng giam trong thdi gian bao quan (sau san xuat, 3 thang, 6 thang), do vay cac ham lugng chinh can dugc theo doi trong thdi gian dai ban. Vdi gia thanh tinh tam thdi khoang 30.000 ddng/lg 100 viSn, su- dung trong 25 ngay, gia nay cd thS chap nhan dugc vdi da sd cac tang ldp binh dim, gia ciing thap ban so vdi nhiSu vien toi trSn thj tmdng hien nay.
KET LUAN
Bd sung vien toi/folate trong thdi gian 12 tuan trSn ddi tugng rdi loan lipid mau da CO mdt sd hieu qua tich cue:
Lam giam cd y nghTa ndng do choles-
terol mau toan phan va LDL- eholestrol so vdi trudc can thiep va so vdi nhdm chiing.
Cd xu hudng lam giam ndng do tryg- lycerid mau va HDL-cholesterol, tuy nhiSn su khae biet chua cd y nghTa thdng kS.
Hieu qua can thiep cua viSn tdi/folate trong viec giam rdi loan lipid mau la 21,8%, 28,2%o, 33,7%), va 4,5% hrang img vdi triglycerid, cholesterol TP, LDL cho- lesterol va cudi ciing la HDL cholesterol.
KHUYEN NGHI
can cd nhirng nghiSn cuu sau hon vS san xuat, danh gia tinh dn djnh cua vien tdi/folate, cung nhu danh gia hieu qua vdi thdi gian nhiSu ban dS khang djnh hieu qua cua su dung viSn toi/folate.
TAI LIEU THAM KHAO
1. Pham Gia Khai, Nguyen Lan Viet, Do Qudc Hung, Nguyen Bach Yen (2002),
"Nhan xet ve mot so roi loan dinh dirdng va chuyen hda d ngudi tang huyet ap", Y hoc thuc hdnh 418:11-18.
2. Le Bach Mai, Nguyen Cong Khan va cs (2004), "Thuc trang thira can beo phi d ngudi 30-59 tuoi tai noi thanh Ha Ndi nam 2003", Tgp chi Y hoc thuc hdnh, s6418,tr. 76-81.
3. Quach Huu Trung, Ho Khai Hoan (2007), -'Nghien cim Hoi chirng chuyen hda o benh nhan tang huyet ap", Hoi nghi khoa hoc todn quoc chuyen ngdnh noi tiet vd chuyen hoa ldn thii 3, NXB Y hpc. Ha Npi, tr229-234.
4. Tran Dinh Toan (2003), "Tinh trang thira can beo phi, mot so chi deu sinh hoa cua can bg vien chirc den kham
benh vien Huu N'gh; nam 2002", Y hoc Viet Nam 22,S, 229 (O, |0)/2003;92-99.
Dzoan Thi Tudng \ i . Pham Quang Cu 10.
(2006), "Ty le tang huyet ap va moi lien quan giua tinh trang dinh dud-ng d ngudi trudng thanh 20-70 tudi tai benb vicn 19-8 nam 2()0n-2()0r', Tap chi
dinh duong vd ihiii phdm, 2(3-1-4), tr ]]
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ABSTRACT: EFFEC IS OF THE GARLIC/FOLATE CAPSULE IN SUBJECTS AGED 30-60 YEARS OLD WITH HYPERLIPIDEMIA
Hundred and twenty subjects aged 30-60 years old suffering from hyperlipidemia, received 4 capsules of garlic-foliate day for 12 weeks (3 months). The results indicates that the garlic'folate group have some positive results on lipid metabolism: significantly reduced the cholesterol total, and LDL cholesterol comp.ircd with the beginning ofthe study and with the control group received placebo; while no significantly reduced on triglyceride and HDL-cholesterol, The effect index of garlic/folate capsule supplementation in reducing the hyperlipidemia case are 2 1 % , 28.2%, 33,7%, and 4,5% respectively for triglycendc, cholesterol TP, LDL cholesterol and HDL choles- terol.
Keys works: hyperlipuleinia, garllc-folate, adult person, Hanoi.
