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Neutralizing antibody responses and viral evolution in a longitudinal cohort of HIV subtype C infected antiretroviral-naïve individuals.

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Academic year: 2024

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Figure 1.1. Global distribution of HIV-1 subtypes and recombinants in 2004. The colour key on the left-hand side of the figure represents the different HIV-1 subtypes (adapted from Hemelaar et al., 2011).
Figure 1.2. Schematic of the HIV-1 envelope spike interacting with its cellular receptors on a target cell
Figure 1.3. HIV-1 replication cycle divided into the early and late phase. The early phase involves the CD4 receptor and CCR5/CXCR4 coreceptor binding and includes the generation of provirus
Figure 1.4. Schematic of the gp120 core as a ribbon representation of the template subtype C (CAP210) core gp120 structure from the Protein Data Bank (PDB) with variable loops and other features highlighted
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The Neutralizing Human Monoclonal Antibodies (Nmabs) Envelope Clones Analyzing Results Heterogeneity Of Diversity In Env In Slow Progressors And Progressors For The B ACKGROUND N EUTRALIZING AND N ON - NEUTRALIZING A NTIBODIES F UTURE D IRECTIONS

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