DATA ENTRY FORM FOR RENAL FAILURE STUDY

ct scan date access contrast volume angiogram

CTSCAN1:

1. preradiology date access contrast volume

serum creatinine serum urea serum cystatin LFT

urine GST urine albumin urine creatinine

2. day 1

3. day 7

4. day 14

ANGIOGRAM 2:

1. preradiology

serum creatinine serum urea serum cystatin LFT

urine GST urine albumin urine creatinine serum creatinine serum urea serum cystatin urine GST urine albumin urine creatinine serum creatinine serum urea serum cystatin urine GST urine albumin urine creatinine

serum creatinine serum urea serum cystatin LFT

urine GST urine albumin urine creatinine

2. day 1 serum creatinine serum urea serum cystatin LFT

urine GST urine albumin urine creatinine

3. day 7 serum creatinine

serum urea serum cystatin urine GST urine albumin urine creatinine

4. day 14 serum creatinine

serum urea serum cystatin urine GST urine albumin urine creatinine SURGERY

1. preoperation serum creatinine

serum urea serum cystatin c urine GST urine albumin urine creatinine

2. pre clamp serum creatinine

serum urea serum cystatin c urine GST urine albumin urine creatinine 3. pre clamp removal serum creatinine

4.2hrs post clamp removal serum creatinine

serum urea serum cystatin c urine GST urine albumin urine creatinine

serum cystatin c LFT

urine GST urine albumin urine creatinine 5 jay 4 serum creatinine

serum urea serum cystatin c urine GST urine albumin urine creatinine

7 (j^ay 7 serum creatinine

serum urea serum cystatin c urine GST urine albumin urine creatinine

APPENDIX F

Data for patients undergoing surgery (n= 35). Coordinate points for the ROC Curve for baseline serum creatinine and cystatin C * baseline GFR < 72 ml/min

Area Under the Curve baseline serum creatinine * outcome GFR <

72ml/min Test Result Variable(s): slcreats

Area .917

Std. Erroi3

.047

Asymptotic Sig.b

.000

Asymptotic 95% Confidence Interval

Lower Bound .824

Upper Bound 1.009 The test result variable(s): slcreats has at least one tie between the positive actual state group and the negative actual state group. Statistics may be biased.

a. Under the nonparametric assumption b. Null hypothesis: true area = 0.5

Coordinates of the Curve baseline serum creatinine in micromol/l "outcome GFR < 72 ml/min Test Result Variable(s): sicreats

Positive if Greater Than or Equal Toa

62.0000 66.0000 71.5000 76.5000 82.0000 86.5000 88.5000 90.0000 91.5000 93.0000 94.5000 96.5000 99.0000 100.5000 101.5000 103.0000 106.0000 108.5000 109.5000 111.0000 114.0000 116.5000 117.5000 120.5000 128.5000 138.0000 142.5000 153.5000 179.0000 250.5000 308.0000

Sensitivity 1.000 1.000 .962 .962 .962 .923 .923 .923 .923 .885 .808 .808 .769 .731 .692 .654 .615 .538 .500 .462 .423 .346 .308 .269 .231 .192 .154 .115 .077 .038 .000

1 - Specificity 1.000

.889 .889 .667 .556 .556 .444 .333 .222 .222 .222 .111 .000 .000 .000 .000 .000 .000 .000 .000 .000 .000 .000 .000 .000 .000 .000 .000 .000 .000 .000

The test result variable(s): sicreats has at least one tie between the positive actual state group and the negative actual state group.

a- The smallest cutoff value is the minimum

observed test value minus 1, and the largest cutoff value is the maximum observed test value plus 1.

All the other cutoff values are the averages of two consecutive ordered observed test values.

Area Under the Curve baseline serum cystatin C * outcome GFR < 72 ml/min

Test Result Variable(s): slcystc

Area .808

Std. Error3

.074

Asymptotic S i qb

.007

Asymptotic 95% Confidence Interval

Lower Bound .662

Upper Bound .953

a- Under the nonparametric assumption

D Null hypothesis: true area = 0.5

Coordinates of the Curve baseline serum creatinine in micromol/l * Outcome GFR < 72 ml/min Test Result Variable(s): slcystc

Positive if Greater Than

or Equal Toa

-.8300 .2150 .2900 .4600 .6500 .7050 .7350 .7650 .7800 .8000 .8150 .8550 .8950 .9350 .9800 1.0100 1.0350 1.0500 1.1000 1.1450 1.1700 1.2100 1.2500 1.2950 1.3350 1.4350 1.5550 1.6500 1.9650 2.4800 3.7400

Sensitivity 1.000 .962 .962 .923 .923 .885 .846 .808 .769 .769 .769 .769 .769 .769 .769 .692 .654 .615 .577 .538 .462 .423 .385 .346 .308 .269 .231 .192 .077 .038 .000

1 - Specificity 1.000 1.000 .889 .889 .778 .778 .778 .778 .778 .667 .556 .444 .333 .222 .000 .000 .000 .000 .000 .000 .000 .000 .000 .000 .000 .000 .000 .000 .000 .000 .000

a- The smallest cutoff value is the minimum

observed test value minus 1, and the largest cutoff value is the maximum observed test value plus 1.

All the other cutoff values are the averages of two consecutive ordered observed test values.

APPENDIX G

Data for patients undergoing surgery (n= 35). 2x2 Tables for baseline variables * outcomes (For each variable 0 = no, 1 = yes)

Baseline serum creatinines 20 micromol/l * Creatinine rise>25% Crosstabulation

Count

Baseline serum 0 creatinine>120

micromol/l Total

serum creatinine rise

>25%

0 19

2 21

1 9 5 14

Total 28

7 35

Baseline serum creatinine > 120 micromol/l * serum creatinine rise > 44micromol/l Crosstabulation

Count

Baseline serum 0 creatinine > 120

micromol/l Total

serum creatinine rise >

44 micromol/l 0

23 2 25

1 5 5 10

Total 28

7 35

Baseline serum creatinine > 120 micromol/l * serum cystatin C rise > 37% Crosstabulation

Count

Baseline serum 0 creatinine > 120

micromol/l Total

Serum cystatin C rise >

37%

0 20

2 22

1 8 5 13

Total 28

7 35

Baseline serum creatinine > 120 micromol/l * Dialysis Crosstabulation

Count

Baseline serum 0 creatinine > 120

micromol/l Total

DIALYSIS 0

26 4 30

1 2 3 5

Total 28

7 35

Baseline serum cystatin C > 1.24 mg/l * serum creatinine rise > 25%

Crosstabulation Count

Baseline serum cystatin 0

C > 1.24 mg/l 1 Total

Serum creatinine rise

>25%

0 17

4 21

1 8 6 14

Total 25 10 35

Baseline serum cystatin C > 1.24 mg/l * serum creatinine rise > 44 micromol/l Crosstabulation

Count

Baseline serum cystatin 0

C > 1.24 mg/l 1 Total

serum creatinine rise >

44 micromol/l 0

20 5 25

1 5 5 10

Total 25 10 35

Baseline serum cystatin C > 1.24 mg/l * serum cystatin C rise > 37%

Crosstabulation

Count

Baseline serum cystatin 0

C > 1.24 mg/l 1 Total

Serum cystatin C rise >

37%

0 17

5 22

1 8 5 13

Total 25 10 35

Baseline serum cystatin C > 1.24 mg/l * Dialysis Crosstabulation

Count

Baseline serum cystatin 0

C > 1.24 mg/l 1 Total

DIALYSIS 0

24 6 30

1 1 4 5

Total 25 10 35

APPENDIX H

Data for patients undergoing surgery (n=35). Coordinate points for ROC Curve baseline calculated creatinine clearance/ serum creatinine/ serum cystatin C * outcome dialysis

Area Under the Curve Baseline Creatinine clearance Test Result Variable(s): ccrsl

Area .913

Std. Error3

.059

Asymptotic Sig.b

.003

Asymptotic 95% Confidence Interval

Lower Bound .797

Upper Bound 1.030 a- Under the nonparametric assumption

b. Null hypothesis: true area = 0.5

o c

•a c

rea

O o

£ •55 in re CO

£

<t-

rve

o 0) -4-»

•*- o

(A V)

re Q

0 )

E o u

* E b

b c o c

s

In'

riable

« ^*+-

1 - Specifici

-*—

Sensitiv

o o o

-* CM o o o

o o

^—

O Q

o o

• * •

oo en

O O

o o

0 0

CO CO

o o

CD O

r-- co o

o o

o o CD

CD 0 0

o o

CM CO

r-- co

CO o

oo r~-

o o oo

r--

o o CM

oo o

0 0 T—

CO CO CM

O CO o

co CM

O O

0 0 CO

h - CO CM

o o o

0 0 CO

o o CO

s o

r-~

CO CO CO CO

o o o

CO t ^

r-co

o o o

T —

o o o "t

o o o

.<—

X—

CO CO

o o o

CO I - -

r--

( 0

• *

o o o

-3- CM

o en LO

o o ©

LO ( M

CO CO LO

o o o

CO f -

r~-

CO LO

r--

o p CD

o o Q

CO CO CD

o o o

0 0

r--

CO CO

o o o

f~- T—

o o

h~.

o o o

• *

CO CO

r«-

r-- r- to r~

o o o

• *

o o 0 0

• *

CM CO CO CO

O O O

LO CM

r-~

o o o

CD OO

o o 0 0

o o o

CO 0 0

CO CO

o o o

h -

r- o

CD O

o> o

o o o o o o

CO O CO 0 0

minimum sthe

= 5

;utoff<

• 4 — •

smalles utof

d the large

1,a

Ul 3 C

value

•**

erved te

in - I

test value

T l

erve

o F

aximu

E e is the two

4 —

( )

e averages

aret san

utoff v

he other sst values.

.#—»

rderec

secutive

Area Under the Curve Baseline Serum Creatinine

Test Result Variable(s): slcreats

Area .853

Std. Error3

.086

Asymptotic Sig.b

.012

Asymptotic 95% Confidence Interval

Lower Bound .686

Upper Bound 1.021

a- Under the nonparametric assumption b- Null hypothesis: true area = 0.5

ft

8 £

i?

c o

CD a; CD o o

CD O

3 *

Q . <

CD *

$ 3

CD CD

a ..

< s

QJ^ CD

c 3

CD C O co CD

CO O ^

iii

in

f! ¹

5 8

w M

cn cn o o

M N - »

» O N cn o i b i

o o o o o o o o o

O) * . - ^

in b b o o o o o o o o o

o o o co oo o>

cn cn b o o o o o o o o o

o o ->• o

CD CD

b cn cn b o o o o o o o o o o o o

CD CD CO CD -b- CO cn en b o o o o o o o o o

CD CO 0 0 OO - i O CO (Jl

cn cn o o o o o o

0 0 --4 ~«l N> 05 - » • b cn cn o o o o o o o

s

I

2 9 -n

mil

1 CD

-i 3" =;

o 9J

O IO M O O O O O O

NJ 44. CD O O O O O O

CD CD 00 O O O O O O

00 00 00

o o o o o o

00 00 00

o o o o o o

00 00 O O

o o o o o o o o

o o o o o o o o o

o o o o o o o o o o o o

O O O O Q O ->•

O O W CD CD CD O O O W ^ 1 ^ 1 -vl O

- » - " - > N N U U * * * * 0 l 0 l Q l O > l > l > I O « » ( D W W C D W O J O W O W C D O J O C D O C D O W C D O W C D W C 0 W ^ I W ^ 4 O W O W - v l - ^ O ~ ~ I O - s l O W - v l O W - v l C 0

CO O CD O

^ o

• a CD o

H CD W

i - * -

X I CD cn c

Var lab

0) O

3 a) s-</>

o 3

rt^ oi 3 CD 3 3 licr omol/l

O o

i

•£

_B.

o u o m a.

3 0)

ff (0

the o Curve

^ i

o m

CD CA elin

CD (A

| £ w 3

Area Under the Curve Baseline Serum Cystatin C Test Result Variable(s): sicystc

Area .773

Std. Error3

.149

Asymptotic Sig.b

.053

Asymptotic 95% Confidence Interval

Lower Bound .482

Upper Bound 1.065 The test result variable(s): sicystc has at least one tie between the positive actual state group and the negative actual state group. Statistics may be biased.

a. Under the nonparametric assumption b. Null hypothesis: true area = 0.5

Coordinates of the Curve for Baseline serum cystatin C in mg/l * Outcome Dialysis Test Result Variable(s): sicystc

Positive if Greater Than

or Equal Toa

Sensitivity 1.000 1.000 1.000 1.000 1.000 .800 .800 .800 .800 .800 .800 .800 .800 .800 .800 .800 .800 .800 .800 .800 .800 .800 .800 .800 .800 .600 .600 .600 .200 .000 .000

1 - Specificity 1.000

.967 .933 .900 .867 .867 .833 .800 .767 .733 .700 .667 .633 .600 .533 .467 .433 .400 .367 .333 .267 .233 .200 .167 .133 .133 .100 .067 .033 .033 .000

The test result variable(s): sicystc has at least one tie between the positive actual state group and the negative actual state group.

a- The smallest cutoff value is the minimum

observed test value minus 1, and the largest cutoff value is the maximum observed test value plus 1.

All the other cutoff values are the averages of two consecutive ordered observed test values.

Area Under the Curve Baseline Urine Albumin:Creatinine Test Result Variable(s): slalbc

Area .621

Std. Error9

.130

Asymptotic Siq.b

.395

Asymptotic 95% Confidence Interval

Lower Bound .366

Upper Bound .875

a- Under the nonparametric assumption

D- Null hypothesis: true area = 0.5

Coordinates of the curve for Baseline Urine Albuminxreatinine in mg/mmol * Outcome Dialysis

Test Result Variable(s): slalbc Positive if

Greater Than or Equal Toa

-.8647 .4020 .7102 .7768 .8340 .9322 1.1178 1.3524 1.5358 1.6080 1.8802 2.2681 2.6163 2.9283 3.1859 3.4121 3.5833 3.9701 4.4029 4.7815 5.1002 5.3645 5.6132 5.8818 6.2756 7.6633 12.3248 19.4817 23.3031 25.4299 32.2149 38.3971 68.2535 197.2848 298.8304

Sensitivity 1.000 1.000 1.000 1.000 1.000 1.000 1.000 .800 .800 .800 .800 .800 .800 .800 .800 .800 .800 .800 .600 .600 .600 .600 .400 .400 .200 .200 .200 .200 .200 .200 .200 .200 .200 .200 .000

1 - Specificity 1.000

.966 .931 .897 .862 .828 .793 .793 .759 .724 .690 .655 .621 .586 .552 .517 .483 .448 .448 .414 .379 .345 .345 .310 .310 .276 .241 .207 .172 .138 .103 .069 .034 .000 .000

a- The smallest cutoff value is the minimum

observed test value minus 1, and the largest cutoff value is the maximum observed test value plus 1.

APPENDIX I

Data for patients undergoing surgery (n=35). Coordinate points for ROC Curves for T2 urine albumin:creatinine and aGSTrcreatinine * outcome dialysis

ROC Curve.

T2 Urine albuminxreatinine

Outcome dialysis

.75

.50-

f .-

$ 0.00

0.00 75 1.00

1 - Specificity

Area Under the Curve for T2 Urine albuminxreatinine Test Result Variable(s): s2albc

Area .612

Std. Error3

.173

Asymptotic S i gb

.473

Asymptotic 95% Confidence Interval

Lower Bound .273

Upper Bound .951

a- Under the nonparametric assumption b- Null hypothesis: true area = 0.5

8 £ ^{> <}92.

= c

=T CD cn en _ 5 CD

5 <D CD o o 3 3 E. °>

V-L i—f w

( D O S .

**3 * i**

Q. < C o ^ 3

ST s S-

CD ® tn 3 w CD

<D 3 -

° - rt. CD CD CD r-

^r s co

92. 5 <

c a> 92.

CD CQ c en CD CD

a¥

l - " *

a -i

CT I T cn CD CD 3 o .test value 92. lest cutoff

_, <

II

^eist

US 1, !

92 CD

! i . 5 = ^mu

n e lar 197

- g M O l

o o

o o o

135

—*. -4 cn CD

o o

o oi

-&.

Ol M

•vl

bl O l O l O l

o o

o Ol

O l

*>.

o 0 0 CO

O l

o Ol CD

t O -vl

o -*

cn o o

o O l CD

-si CO

A CO

o oi

O l

o o

_ i

o CO O l O l

bi o

• N

• & .

o o

— X

0 0 0 0

O l O l

bo M

0 0

bi o o

_ i

~ v |

t O 0 1 M

oo O l

bi o o

M O -si

O l CO

2 •fe.

O l

O O

• & •

—*

O l O 0 0

k O 0 0

O O

I O

"v|

O l CO CO

bi CO O l 0 0

bi o o

—v

0 0 O l O l 0 0 -vl CO

bi o o

O l

*. cn

^ o

0 0 M

bi o o

CO -vl CO

ro 0 0

_*.

bi o o

• & .

— i .

*•

to -vl

ro 0 0

ro O l

bi o o

*. • I * 0 0

O l

b CO CO CO

bi o o

*•

0 0 O l

*. '^

CO CO O l

bi o o

— V

-vl

ro ro

CO O l CD

bi o o

O l O l

to ro o

v j CO 0 0 CD

bi o o

O l 0 0 O l

bo 0 0 0 0 - J

- 4 O l

0 0 O l

O l

0 0

cn -vl

v j O l

O l

ro —h 0 0

bi oo cn ro

- j O l

O l O l

cn ro

o CD

^vl O l

O l CD

o ro io o o o

^ cn

-vl

ro -t^

—* 4*.

- & •

'-vl O l

~ j O l CO

o bi o oo ro

^ cn O

-vl CO O l

CO CO - v |

•vl O l

v j

cn o

oo ro

0 0 0 0

ro — i . O l -vl

b o o

0 0

ro 0 0 O l

bi O l -vl

o o

0 0 O l

• t -

bi O l O l 0 0

o o

0 0 CO -vl

CO O l O l O l

o o

CD O l

0 0 —^

O l 0 0

"vl

o o

CO O l O l

o O l 0 0

o o

_ j .

o o o

Positiv Greater or Equa

— — 1 CD

—1 2r —.

0> 13

CD 3 cn itiv 5T

1-S

•a eci ficil

. - • -

(U U)

01 01

u CD in

2al

CT O

0 )

t r

Lun

3 0)

a. ₃

3 CD

C Q

3 3 o

n o o a ina S Ul

y, r+

3 "

o c

rve for

-\ to C rine

ROC Curve.

T2 Urine GSTcreatinine Outcome dialysisi

1 - Specificity

Area Under the Curve for T2 urine GSTxreatinine Test Result Variable(s): s2gstc

Area .357

Std. Error3

.133

Asymptotic Sig.b

.362

Asymptotic 95% Confidence Interval

Lower Bound 9.615E-02

Upper Bound .618

a- Under the nonparametric assumption

D- Null hypothesis: true area = 0.5

Coordinates of the Curve for T2 urine GSTxreatinine in microgram/mmol Test Result Variable(s): s2gstc

Positive if Greater Than

or Equal Toa

-.8578 .2702 .4122 .4316 .4675 .5041 .5102 .5247 .5770 .6508 .7644 .8462 .8661 .9821 1.1009 1.1380 1.1911 1.2882 1.5127 1.7756 1.9167 2.0269 2.1405 2.6540 3.3421 3.9297 5.0167 6.0049 6.4488 7.4006 10.1278 16.3124 21.5479

Sensitivity 1.000 1.000 1.000 .750 .750 .750 .750 .750 .750 .750 .750 .500 .250 .250 .250 .250 .250 .250 .250 .250 .250 .250 .250 .250 .000 .000 .000 .000 .000 .000 .000 .000 .000

1 - Specificity 1.000

.964 .929 .929 .893 .857 .821 .786 .750 .714 .679 .679 .679 .643 .607 .571 .536 .500 .464 .429 .393 .357 .321 .286 .286 .250 .214 .179 .143 .107 .071 .036 .000

a- The smallest cutoff value is the minimum

observed test value minus 1, and the largest cutoff value is the maximum observed test value plus 1.

All the other cutoff values are the averages of two consecutive ordered observed test values.

APPENDIX J

Data for patients undergoing surgery (n= 35). Coordinate points for RIC Curves for peak serum creatinine/ peak cystatin C post op * outcome dialysis

Area Under the Curve Peak serum creatinine * outcome dialysis Test Result

Area .980

Vanable(s):

Std. Error3

.023

Deak scr Asymptotic

S i gb

.001

Asymptotic 95% Confidence Interval

Lower Bound .935

Upper Bound 1.025

a- Under the nonparametric assumption b- Null hypothesis: true area = 0.5

Coordinates of the Curve Peak serum creatinine (S) in micromol/l Test Result Variable(s): peak scr

Positive if Greater Than or Equal Toa

77.0000 81.0000 85.5000 88.0000 90.5000 93.0000 96.0000 98.5000 102.5000 107.0000 108.5000 109.5000 112.0000 115.0000 117.0000 119.0000 120.5000 122.5000 125.5000 128.5000 130.5000 137.5000 145.0000 149.0000 153.5000 162.0000 180.0000 231.5000 287.5000 334.5000 397.5000 447.0000 466.0000

Sensitivity 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 .800 .800 .800 .600 .400 .200 .000

1 - Specificity 1.000

.967 .933 .900 .867 .833 .767 .733 .700 .667 .633 .600 .567 .533 .500 .467 .433 .400 .367 .333 .300 .267 .233 .200 .167 .100 .100 .033 .000 .000 .000 .000 .000

a- The smallest cutoff value is the minimum

observed test value minus 1, and the largest cutoff value is the maximum observed test value plus 1.

All the other cutoff values are the averages of two consecutive ordered observed test values.

Area Under the Curve Peak serum cystatin C * outcome dialysis Test Result Variable(s): Peak S Cyst C

Area .943

Std. Error3

.039

Asymptotic Sig.b

.002

Asymptotic 95% Confidence Interval

Lower Bound .867

Upper Bound 1.020 The test result variable(s): Peak S Cyst C has at least one tie between the positive actual state group and the negative actual state group.

Statistics may be biased.

a. Under the nonparametric assumption b- Null hypothesis: true area = 0.5

Coordinates of the Curve Peak serum cystatin C in mg/l Test Result Variable(s): Peak S Cyst C

Positive if Greater Than

or Equal Toa

-.2800 .7900 .8700 .9050 .9500 .9900 1.0150 1.0300 1.0500 1.0950 1.1450 1.1800 1.2050 1.2200 1.2500 1.3200 1.3850 1.4400 1.4850 1.5100 1.5350 1.5500 1.6050 1.6700 1.7750 1.9150 2.1350 2.6150 3.0700 3.4400 4.2150 5.7600

Sensitivity 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 .800 .600 .600 .600 .400 .200 .200 .000

1 - Specificity 1.000

.967 .933 .867 .833 .800 .733 .700 .667 .633 .600 .567 .533 .500 .467 .433 .400 .367 .300 .267 .233 .200 .167 .133 .100 .100 .067 .033 .033 .033 .000 .000

The test result variable(s): Peak S Cyst C has at least one tie between the positive actual state group and the negative actual state group.

a- The smallest cutoff value is the minimum

observed test value minus 1, and the largest cutoff value is the maximum observed test value plus 1.

All the other cutoff values are the averages of two consecutive ordered observed test values.

Dalam dokumen Risk assessment for renal injury post aortic surgery using new and more sensitive markers of renal injury. (Halaman 138-165)

£

s

ft

i?

iii

in

f! 1

s

I

mil

i

•£

f .-

3 * i

a¥

II

f! ¹

**3 * i**