Molecular Basis for the Formation of Lamina-Specific Thalamocortical
6. Conclusion
Our findings in in vitro preparations have demonstrated that TC axonal targeting involves axonal termination and branching processes. Evi-dence further indicates that these processes are primarily regulated by the cell surface molecules and/or ECM molecules that are expressed in a lamina-specific manner in the developing cortex, although secreted fac-tors such as neurotrophins also play a role in these axon behaviors. Our extensive molecular screening has further shown that some membrane-associated factors including unc5h4 are expressed specifically in layer 4, the target layer. A future study would be to reveal the role of the candidate molecules and their regulatory mechanisms.
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