Abdassah, M. 2009, Nanopartikel dengan gelasi ionik, Farmaka, 15(1): 45 – 52. Adi, L.T. 2008, Tanaman obat dan jus untuk mengatasi penyakit jantung,
hipertensi, kolestrol, dan stroke, PT. Agromedia Pustaka, Jakarta,
Indonesia.
Agnihotri, S.A., Mallikarjuna, N.N. & Aminabhavi, T.M. 2004, Recent advances on chitosan-based micro and nanoparticles in drug delivery, J Controlled
Release, 100(1): 5 – 28.
Agustina, S., Swantara, I.M.D. & Suartha, I.N. 2015, Isolasi kitin, karakterisasi, dan sintesis kitosan dari kulit udang, Jurnal Kimia, 9(2): 271 – 278.
Ahkam, M. 2011, ‘Sintesis dan karakterisasi membran nanozeolit Y untuk aplikasi pemisahan gas metanol-etanol’, Skripsi, S.Si., Program Studi Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Indonesia, Depok, Indonesia.
Ali, A.K., Prajapati S., Devendra, S., Brajesh, K. & Kausar, S. 2012, Enhanced bioavailability of drugs via intranasal drug delivery system, Int Research
Journal of Pharmacy, 3(7): 68 – 74.
Anderson, H. 2015, Transmission electron microscope, diakses pada tanggal 15 Mei 2017, <http://www.microscopemaster.com/transmission-electron-microscope.html>.
Andrew. 2016, ‘Preparasi dan karakterisasi submikro partikel
Poly(Lactic-Co-Glycolic-Acid) pembawa roksitromisin dengan stabilizer Poly(Vinyl Alcohol)’, Skripsi, S.Farm., Program Studi Farmasi, Fakultas Matematika
dan Ilmu Pengetahuan Alam, Universitas Sriwijaya, Inderalaya, Indonesia. Anggrahini, S., Safitriani, R.R. & Santoso, U. 2007, Pengaruh penutupan dengan kain hitam dan konsentrasi etanol terhadap kandungan kurkuminoid dan aktivitas antioksidan ekstrak simplisia temulawak (Curcuma xanthorrhiza),
Jurnal Teknol Dan Industri Pangan, 18(2): 102 – 108.
AOAC Official Methods of Analysis. 2012, Guidelines for Dietary Supplements and Botanicals, Appendix, 1 – 32.
Astriani, F. 2011, ‘Preparasi kitosan-tripolifosfat sebagai eksipien dalam sediaan tablet enterik’, Skripsi, S.Farm., Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Indonesia, Depok, Indonesia.
Avadi, M.R., Sadeghi, A.M.M., Mohammadpour, N., Abedin, S., Atyabi, F., Dinarvand, R., et al. 2010, Preparation and characterization of insulin nanoparticles using chitosan and arabic gum with ionic gelation method,
114
Ayucitra, A., Indraswati, N., Mulyandasari, V. & Dengi, Y.K. 2011, Potensi senyawa fenolik bahan alam sebagai antioksidan alami minyak goreng nabati, Widya Teknik, 10(1): 1 – 10.
Azevedo, M.A., Bourbon, A.I., Vicente, A.A. & Cerqueira, M.A. 2014, Alginate/chitosan nanoparticle for encapsulation and controlled release of vitamin B2, International Journal of Biological Macromolecules, 2014. Bankar, P.V., Kalkotwar, Ankita, P., Swati, T. & Jadhav. 2012, Evaluation and
quality control of nasal spray. J Drug Delivery & Therapeutics, 2(4): 1 – 4. Bhattacharyya, B. & Majumdar, D.K. 1999, A modified ostwald viscometer, J
Chem Edu, 50(3): 194.
Bhumkar, D.R. & Pokharkar, V.B. 2006, Studies on effect of pH on cross-linking of chitosan with sodium tripolyphosphate: a technical note, AAPS
PharmSciTech, 7(2): E1 – E6.
Cacabelos, R. 2007, Donepezil in Alzheimer’s disease: From conventional trials to pharmacogenetics, Neuropsychiatric Disease and Treatment, 3(3): 303 – 333.
Carageorgiou, H., Tzotzes, V., Sideris, A., Zarros, A. & Tsakiris, S. 2005, Cadmium effects on brain acetylcholinesterase activity and antionxidant status of adult rats: modulation by zinc, calsium and l-cysteine co-administration, Basic & Clinical Pharmacology & Toxicology, 97: 320 – 324.
CDER. 2002, Nasal spray and inhalation solution, suspension, and spray drug
products - chemistry, Office of Training and Communications Division of
Drug Information, Manufacturing, and Controls Documentation, Rockville, U.S.
Chauhan, M. B. & Chauhan, N. B. 2015, Brain uptake of neurotherapeutics after intranasal versus intraperitoneal delivery in mice, J Neurol Neurosurg, 2(1): 1 – 19.
Chhajed, C., Sangale, S. & Barhate, S.D. 2011, Advantageous nasal drug delivery system: a review, IJPSR, 2(6): 1322 – 1336.
Dahlia, A.A. & Hasnawati. 2012, Antioksidan ekstrak etanol daun jambu mete (Anacardium occidentale L.), Jurnal Fitofarmaka Indonesia, 1(1): 24–30. Dangi, R.S. & Shakya, S. 2013, Preparation, optimization, and characterization of
plga nanoparticle, IJPLS, 4(7): 2810 – 2818.
Dehgan, M.H.G. & Amitav, S.A. 2008, An overview to the recent trends in nasal drug delivery systems, diakses pada tanggal 31 Mei 2017, < http://www.pharmatutor.org/articles/overview-to-recent-trends-in-nasal-drug-delivery-systems>.
Depkes RI. 1995, Farmakope Indonesia, edisi ke-4, Departemen Kesehatan, Jakarta, Indonesia.
115
Depkes RI. 2000, Parameter standar umum tanaman obat, Departemen Kesehatan, Jakarta, Indonesia.
Desmiaty, Y., Rahmat, D. & Afifah, H. 2017, Research journal of pharmaceutical, biological and chemical sciences preparation of nanoparticles containing soursop (Annona Muricata L.) leaves extract using gelation ionic method and determination of its antioxidant activity, RJPBCS, 8(1): 275 – 279. Deviarny, C., Lucida, H. & Safni. 2012, Uji stabilitas kimia natrium askorbil fosfat
dalam mikroemulsi dan analisisnya dengan HPLC, Jurnal Farmasi Andalas, 1(1): 1 – 6.
Dewi, N.L., Bahri, S. & Hardi J. 2016, Penggunaan berbagai tekanan dan waktu hidrolisis pada produksi glukosamin hidroklorida dari kitosan cangkang bekicot (Achantian fulica), Kovalen, 2(1): 22–32.
Dewandari, K.T., Yuliani, S. & Yasni, S. 2013, Ekstraksi dan karakterisasi nanopartikel ekstrak sirih merah (Piper crocatum), J Pascapanen, 10(2): 58 – 65.
Dounighi, M., Mehrabi, N., Avadi, M., Zolfagharian, M.R. & Rezayat, H. 2015, Preparation, characterization, and stability investigation of chitosan nanoparticles loaded with the Echis carinatus snake venom as a novel delivery system, Archives of Razi Institute, 70(4): 269 – 277.
Elnaggar, Y.S.R., Etman, S.M., Abdelmonsif, D.A. & Abdallah, O.Y. 2015, Intranasal piperine-loaded chitosan nanoparticles as brain-targeted therapy in Alzheimer’s disease : optimization, biological efficacy, and potential toxicity, J Pharm Sci, 104(10): 3544 – 3556.
Ermolin, M.S. & Fedotov, P.S. 2016, Separation and characterization of environmental nano- and submicron particles, Environmental Nano-and
Submicron Particles, 1 – 15.
Estanqueiro, M., Conceicao, J., Amaral, M.H., Santos, D., Silva, J.B. & Lobo, J.M.S. 2014, Characterization and stability studies of emulsion systems containing pumice, Braz J Pharm Sci, 50(1): 361 – 369.
Fatimah. 2017, 6 Manfaat dan khasiat kulit petai untuk kesehatan, diakses pada tanggal 26 Maret 2017, <http://www.khasiat.co.id/kulit/kulit-petai.html/>. Gaskell, E.E., Hobbs, G., Rostron, C. & Hutcheon, G.A. 2008, Encapsulation and release of α-chymotrypsin from Poly(glycerol adipate-co-ωpentadecalactone) microparticles, J Microencapsul, 25(3): 187 – 195. Gazori, T., Reza, M.R., Azizi, E., Yazdizade, P., Nomani, A. & Haririan, I. 2009,
Evaluation of alginate/chitosan nanoparticles as antisense delivery vector : formulation, optimization and in vitro characterization. Carbohydrate
Polymers, 77(3): 599 – 606.
Ghori, M.U., Mahdi, M.H., Smith, A.M. & Conway, B.R. 2015, Nasal drug delivery systems: an overview, Am J Pharmacol Sci, 3(5): 110 – 119.
116
Gulati, N., Nagaich, U. & Saraf, S.A. 2013, Intranasal delivery of chitosan nanoparticles for migraine therapy, Scientia Pharmaceutica, 81(3): 843-854.
Guntarti, A., Sholehah, K., Irna, N. & Fistianingrum, W. 2015, Penentuan parameter non spesifik ekstrak etanol kulit buah manggis (Garcinia
mangostana) pada variasi asal daerah. Farmasains, 2(6): 259 – 263.
Guo, C. & Doub, W.H. 2006, The influence of actuation parameters on in vitro testing of nasal spray products, J Pharm Sci, 95(9): 2029 – 2039.
Guthrie, W., Filliben, J. & Heckert, A. 2012, Box-Behnken design, diakses pada tanggal 20 Oktober 2017, <http://www.itl.nist.gov/div898/hand-book/pri/section3/pri3362.htm>.
Harahap, Y. 2012, ‘Preparasi dan karakterisasi nanopartikel kitosan dengan variasi asam’, Skripsi, S.T., Program Studi Teknik Kimia, Fakultas Teknik, Universitas Sriwijaya, Depok, Indonesia.
Harunrasheed, S., Haribabu, R., Vineela, J., Raviteja, A., Ravikishore, P., Gajavalili, S., et al. 2011, Transdermal drug delivery system-simplified medication regimen, RJPBCS, 2(4): 223 – 238.
Hikmat. 2017, Fungsi asetilkolin, diakses pada tanggal 14 April 2017, <http://kliksma.com/2015/04/fungsi-asetilkolin.html>.
Hong, S.C., Yoo, S.Y., Kim, H. & Lee, J. 2017, Chitosan-based multifunctional platforms for local delivery of therapeutics, Marine Drugs, 15(3): 1–16. Hu, K. & McClements, D.J. 2014, Fabrication of surfactant-stabilized zein
nanoparticles: A pH modulated antisolvent precipitation method, Food
Research International, 64(2014): 329 – 335.
International Conference on Harmonisation. 2003, ICH harmonised tripartite
guidline: Evaluation for stability data, Switzerland, UK.
InterPro. 2005, Acetylcholine receptors, diakses pada tanggal 28 Agustus 2017, < https://www.ebi.ac.uk/interpro/potm/2005_11/Page2.htm>.
Irianto, H.E. & Muljanah, I. 2011, Proses dan aplikasi nanopartikel kitosan sebagai penghantar obat, Jurnal Squalen, 6(1): 1 – 8.
Jebarus, A.R. 2015, ‘Uji aktivitas antibakteri ekstrak etanol kulit buah petai (Parkia
speciosa Hassk.) terhadap Staphylococcus aureus dan Escherichia coli’, Skripsi, S.Farm., Program Studi Farmasi, Fakultas Farmasi, Universitas
Sanata Dharma, Yogyakarta, Indonesia.
Jiang, S., Li, Y., Zhang, C., Zhao, Y., Bu, G., Xu, H. & Zhang, Y.W. 2014, M1 muscarinic acetylcholine receptor in Alzheimer’s disease. Neuroscience
Bulletin, 30(2): 295 – 307.
Jubran, A.S. & Al-Mashhedy, L.A.M. 2012, Influence of noise pollution on oxidative stress parameters and acetylcholinesterase in gas electric stations,
117
Kafshgari, M.H., Khorram, M., Khodadoost, M. & Sahar, K. 2011, Reinforcement of chitosan nanoparticles obtained by an ionic cross-linking process, Iranian
Polymer Journal, 20(5): 445 – 456.
Kakad, J.K., More, P.K., Gondkar, S.B. & Saudagar R.B. 2015, A recent review on nasal drug delivery system, WJPR, 4(2): 269 – 281.
Kamisiah, Y., Othman, F., Qodriyah, H.M.S. & Jaarin, K. 2013, Parkia speciosa Hassk.: A potential phytomedicine, ECAM, 2013: 1 – 9.
Kant, A.R., Vijay, J. & Nitin, K. 2015, Preparation of Carbamazepine Chitosan Nanoparticles for Improving Nasal Absorption. JDDT, 5(3): 101 – 108. Katas, H., Hussain, Z. & Ling, T.C. 2012, Chitosan nanoparticles as a percutaneous
drug delivery system for hydrocortisone, Journal of Nanomaterials, 1 – 11. Kemenkes RI. 2016, Menkes: Lansia yang sehat, lansia yang jauh dari demensia,
diakes pada tanggal 15 Januari 2017,
<http://www.depkes.go.id/article/print/16031000003/menkes-lansia-yang-sehat-lansia-yang-jauh-dari-demensia.html>.
Kencana, A.L. 2009, ‘Perlakuan Sonikasi Terhadap Kitosan : Viskositas Dan Bobot Molekul Kitosan’, Skripsi, S.Si., Program Studi Fisika, Fakultas Matematika dan Ilmu Pengetahuan Alam, Institut Pertanian Bogor, Bogor, Indonesia.
Kalliola, S., Repo, E., Srivastava, V., Heiskanen, J. P., Antti, J., Liimatainen, H. & Sillanpaa, M. 2017, Colloids and surfaces b: biointerfaces the ph sensitive properties of carboxymethyl chitosan nanoparticles cross-linked with calcium ions, Colloids and Surfaces B: Biointerfaces, 153: 229 – 236. Klafki, H.W., Staufenbiel, M., Kornhuber, J. & Wiltfang, J. 2006, Therapeutic
approaches to Alzheimer’s disease, Journal about Brain, 129: 2840 – 2855. Khalil, I.R., Burns, A.T.H., Radecka, I., Kowalczuk, M., Khalaf, T., Adamus, G. et
al. 2017, Bacterial-derived polymer Poly-γ-Glutamic Acid (γ-PGA)-based
micro/nanoparticles as a delivery system for antimicrobials and other biomedical applications. Int J Mol Sci, 18: 1 – 18.
Khom, T.C., Yadav. H.K.S., Raizaday, A., Manne, N., Kumar, H.S. & Kumar, S.N. 2014, Development of mucoadhesive nanoparticulate system of ebastine for nasal drug deliery, Trop J Pharm Res, 13(7): 1013 – 1019.
Korolev, I.O. 2014, Alzheimer’s disease: a clinical and basic science review, MSRJ, 4: 24 – 33.
Kurniawan, E. 2012, ‘Preparasi dan karakterisasi nanopartikel sambung silang kitosan-natrium tripolifosfat dalam gel verapamil hidroklorida’, Skripsi, S.Farm., Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Indonesia, Depok, Indonesia.
118
Laili, H.N., Winarti, L., Oktora, L. & Kumala, R. 2014, Preparasi dan karakterisasi nanopartikel kitosan-naringenin dengan variasi rasio massa kitosan-natrium tripolifosfat, Jurnal Pustaka Kesehatan, 2(2): 308 – 313.
Leadley, D. 2010, Transmission Electron Microscopy (TEM), diakses pada tanggal 15 Mei 2017, <https://www2.warwick.ac.uk/fac/sci/physics/current-/postgraduate/regs/mpags/ex5/techniques/structural/tem/>.
Leblanc, G.E., Secco, R.A. & Kostic, M. 1999, Viscocity Measurement, CRC Press, Boca Raton, USA.
Leelapornpisid, P., Leesawat, P., Natakarnkitkul, S. & Rattanapanadda, P. 2010, Application of chitosan for preparation of abutin nanoparticles as skin whitening, Journal of Metals, Materials and Minerals, 20(3): 101-105. Li, P., Dai, Y.N., Zhang, J.P., Wang, A.Q. & Wei, Q. 2008, Chitosan-alginate
nanoparticles as a novel drug delivery system for nifedipine, IJBS, 4(3): 221-228.
Liu, S. & Ho, P.C. 2017, Formulation optimization of scutellarin-loaded HP-β-CD/chitosan nanoparticles using response surface methodology with Box– Behnken design, AJPS, 12(4): 378 – 385.
MalvernInstrument. 2015, Ten ways to control rheology by changing particle properties (size, zeta potential and shape), Whitepaper, 1–7.
Manish, K. & Kulkarni. 2013, Development and process optimization of variables for preparation of novel polymeric nanoparticles containing cromolyn sodium, IJPT, 1(1): 5089 – 5099.
Marliana, S.D., Suryanti, V. & Suyono. 2005, Skrining fitokimia dan analisis kromatografi lapis tipis komponen kimia buah labu siam (Sechium edule
Jacq. Swartz.) dalam ekstrak etanol, Biofarmasi, 3(1): 26 – 31.
Martien, R., Adhyatmika, Irianto, I.D.K., Farida, V. & Sari, D.P. 2012, Perkembangan teknologi nanopartikel dalam sistem penghantaran obat,
Majalah Farmaseutik, 8(1): 133 – 144.
Medina, L.S., Gomez, A.G., Ortega, F.R., Sousa, I. M.O., Queiroz, N.C.A., Jorge, M.P., et al. 2015, Chitosan–tripolyphosphate nanoparticles as arrabidaea chica standardized extract carrier: synthesis, characterization, biocompatibility, and antiulcerogenic activity, Int J Nanomedicine, 10: 3897 – 3909.
Mohanraj, V. & Chen, Y. 2006, Nanoparticles–a review tropical, J Pharm Res, 5(1): 561 – 573.
Montgomery, D.C. 2001, Design and analisis of experiments, 5th edition, John Wiley & Sons Inc, New York, USA.
Murthy, P.N. Devi, M.V., Sahoo, S.K., Mahapatra A.K. & Khandai, M. 2015, Evaluation of sedimentation stability in paracetamol suspensions with plantago ovata mucilage as suspending agent using near-infrared transmission measurements, Scholars Research Library, 7(7): 85 – 96.
119
Nahumury, F.E. 2009, ‘Rekayasa nanofluida berbasis TiO2 sebagai media pendingin pada sistem penukar kalor’, Skripsi, S.T., Program Studi Teknik Kimia, Fakultas Teknik, Universitas Indonesia, Depok, Jakarta.
Nanda, R.K., Patil, S.S. & Navathar, D.A. 2012, Chiotsan nanoparticles loaded with thiocolchicoside, Der Pharma Chemica, 4(4): 1619 – 1625.
Naveed, S., Qamar, F., Abbas, S.S., Safdar, S., Ameer, S. & Idrees, U. 2015, Estimation and analysis of mefenamic acid suspension: a proportional investigation, SOJ Pharmacy & Pharmaceutical Sciences, 3(2): 1 – 3. Narhi, L. O., Schmit, J., Bechtold-Peters, K. & Sharma, D. 2011, Classification of
protein aggregates, J Pharm Sci, 101(2): 93 – 498.
Niewiadomska, G., Pazera, M.B. & Riedel, G. 2009, The septo-hippocampal system, learning and recovery of function, Progress in
Neuro-Psychopharmacology and Biological Psychiatry, 33(5): 791 – 805.
Nisa, G.K., Nugroho, W.A. & Hendrawan, Y. 2014, Ekstraksi daun sirih merah (Piper crocatum) dengan metode microwave assisted extraction (MAE).
Jurnal Bioproses Komoditas Tropis, 2(1): 72 – 78.
Nugroho, A.K., Binnarjo, A., Hakim, A.R. & Ermawati, Y. 2014, Compartmental modeling approach of losartan transdermal transport in vitro, Indonesian
J.Pharm, 25(1): 31 – 38.
Nurmaya, U.M., Sunaryo, S., Irhamah & Akbar, M.S. 2013, Optimiasasi multirespon dengan menggunakan metode hybrid fuzzy goal programming dan genetic algorithm, Prosiding Seminar Nasional Manajemen Teknologi
XVIII, 1 – 11.
Nurmiah, S., Syarief, R., Sukarno, Peranginangin, R. & Nurtama, B. 2012, Aplikasi response surface methodology pada optimalisasi kondisi proses pengolahan alkali treated cottonii (ATC), JPB Kelautan dan Perikanan, 8(1): 9 – 22. Octavia, M.D., Halim, A. & Indriyani, R. 2012, Pengaruh ukuran partikel terhadap
sifat-sifat tabelt metronidazol, Jurnal Farmasi Higea, 4(2): 74 – 92. Pal, S.L., Jana, U., Manna, P.K., Mohanta, G.P. & Manavalan, R. 2011,
Nanoparticles–an overview of preparation and characterization, JAPS, 1(6): 228 – 234.
Patel, J.K. & Jivani, N.P. 2009, Chitosan based nanoparticles in drug delivery.
IJPSN, 2(2): 517 – 522.
Patil, P. & Bhoskar, M. 2014, Optimization and evaluation of spray dried chitosan nanoparticles containing doxorubicin, International Journal of Current
Pharmaceutical Research, 6(2): 7 – 15.
Pawar, N. & Chaudhary, H. 2015, Non-pressurized topical spray of diclofenac diethylamine, IJAP, 4(4): 40 – 48.
Petros, R.A. & Desimone, J.M. 2010, Strategies in the design of nanoparticles for therapeutic applications, Nature Reviews, 9(7): 615 – 627.
120
Phaniendra, A., Jestadi, D.B. & Periyasamy, L. 2015, Free radicals: properties, sources, targets, and their implication in various diseases. Indian Journal of
Clinical Biochemistry, 30(1): 11 – 26.
Pramod, K., Tahir, M.A., Charoo. N.A., Ansari. S.H. & Ali, J. 2016, Pharmaceutical product development: A quality by design approach, Int J Pharma Investig, 6(3): 129 – 138.
Pratiwi, E. 2010, ‘Perbandingan metode maserasi, remaserasi, perkolasi, dan reperkolasi dalam ekstraksi senyawa aktif andrographolide dari tanaman sambiloto (Andrographis paniculata (Burm.f.) Nees)’, Skripsi, S.Agr., Program Studi Agroteknologi, Fakultas Teknologi Pertanian, Institut Pertanian Bogor, Bogor, Indonesia.
Pires, A., Fortuna, A., Alves, G. & Falcao, A. 2009, Intranasal drug delivery:how, why, and what for?, J Pharm Pharm Sci, 12(3): 288-311.
Prasetyo & Inoriah, E. 2013, Pengelolaan budidaya tanaman obat-obatan
(simplisia), Percetakan Fakultas Pertanian UNIB, Bengkulu, Indonesia.
Prisiska, F. 2012, Pengaruh kitosan terhadap sifat elongasi dan kekuatan regang biomembran penutup luka, Farmasains, 1(5), 252 – 259.
Putri, D.D., Nurmagustina, D.E. & Chandra, A.A. 2014, Kandungan total fenol dan aktivitas antibakteri kelopak buah rosela merah dan ungu sebagai kandidat feed additive alami pada broiler, Jurnal Penelitian Pertanian Terapan, 14(3): 174 – 180.
Qiu, P., Cui, M., Kang, K., Park, B., Son, Y., Khim, E., et al. 2014, Application of Box-Behnken design with response surface methodology for modeling and optimizing ultrasonic oxidation of arsenite with H2O2, Central European
Journal of Chemistry, 12(2): 164 – 172.
Ramadhan, L.O.A.N., Radiman, C.L., Wahyuningrum, D., Suendo, V., Ahmad, L.O. & Valiyaveetil, S. 2010, Deasetilasi kitin secara bertahap dan pengaruhnya terhadap derajat deasetilasi serta massa molekul kitosan,
Jurnal Kimia Indonesia, 5(1): 17 – 21.
Rani, A.P., Sivannarayana, P., Abbulu, K. & Saikishore, V. 2014, Design and charecterisation of anastrazole loaded chitosan nanoparticles by ionic gelation method, RJPBCS, 5(2069): 2069 – 2078.
Roessiana, D.L., Setiyadi & Sandy, B.H. 2014, Model persamaan faktor koreksi pada proses sedimentasi dalam keadaan free settling, Jurnal Sains Dan
Teknologi Lingkungan, 6(2): 98 – 106.
Rowe, R.C., Sheskey, P.J. & Quinn, M.E. 2009, Handbook of pharmaceutical
excipients, 6th edition, Pharmaceutical Press, London, UK.
Ruby, J.J. & Pandey, V.P. 2014, Chitosan nanoparticles as a nasal drug delivery for memantine hydrochloride, Int J Pharm Pharm Sci, 7(1): 34 – 37.
Sachan, A.K. & Singh, S. 2014, Nanoparticles: Nasal delivery of drugs, IJPRS, 3: 33 – 44.
121
Saifudin, A., Rahayu, V. & Turena, H.Y. 2011, Standarisasi bahan obat alam, Graha Ilmu, Yogyakarta, Indonesia.
Sa’adah, H. & Nurhasnawati, H. 2015, Perbandingan pelarut etanol dan air pada pembuatan ekstrak umbi batang tiwai (Eleutherine americana Merr) menggunakan metode maserasi, Jurnal Ilmiah Manuntung, 1(2): 149 – 153. Sapri, Fitriani, A. & Narulita, R. 2014, Pengaruh ukuran serbuk simplisia terhadap
rendemen ekstrak etanol daun sirsak (Annona muricata L.) dengan metode maserasi, Jurnal Nasional Kimia, 3(1):1 – 4.
Saputra, D.A., Rahman, A. & Kusumawati, I. 2015, Aktivitas penghambat asetilkolinesterase ekstrak etanol 96% daun Syzygium cumini, Syzygium
aromaticum, Syzygium polyanthum dan Syzygium aquaeum, Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, 2(1): 31 – 33.
Shah, B.M., Misra, M., Shishoo, C.J. & Padh, H. 2013, Nose to brain microemulsion-based drug delivery system of rivastigmine: Formulation and ex-vivo characterization, Journal Drug Delivery, 22(7): 918 – 930. Shargel, L., Wu-Pong, A. & Yu, A.B.C. 2012. Biofarmasetika & farmakokinetika
terapan, edisi ke-5, Percetakan Universitas Sriwijaya, Surabaya, Indonesia.
Shukla, J.B. & Patel, S.J. 2010, Formulation and evaluation of self micro emulsifying system of candesartan cilexetil, Int J Pharm Pharm Sci, 2(4): 2 – 5.
Singh, R. & Liliard, J.W.L. 2009, Nanoparticle-based targeted drug delivery,
National Institutes of Health, 86(3): 215 – 223.
Sjahfirdi, L., Aldi, N., Maheshwari, H. & Astuti, P. 2015, Aplikasi Fourier
Transform Infrared (FTIR) dan pengamatan pembengkakan genital pada
spesies primata, lutung jawa (Trachypithecus auratus) untuk mendeteksi masa subur, Jurnal Kedokteran Hewan, 9(2): 156 - 160.
Sood, S., Jain, K. & Gowthamarajan, K. 2013, Curcumin-donepezil–loaded nanostructured lipid carriers for intranasal delivery in an Alzheimer’s disease model, Alzheimer’s Dement, 9(4): P299.
Stoica, R., Somoghi, R. & Ion, R. 2013, Preparation of chitosan-triplyphosphate nanoparticles for the encapsulation of polyphenols extracted from rose hips,
Dig J Nanomater Bios, 8(3): 955 – 963.
Subaktyo, B. 2013, Terapi pete untuk kesehatan, kehidupan, kebahagian, dan
kesejahteraan, PT. Agromedia Pustaka, Jakarta, Indonesia.
Sugita, P., Ambarsari, L. & Farichah, F. 2013, Increasing amount and entrapment efficiency of chitosan-ketoprofen nanoparticle using ultrasonication method with varied time and amplitude, IJRRAS, 14(3):612-618.
Sugiyono. 2006, Metode penelitian kuantitatif, kualitatif, dan R&D, PT. Alfabeta, Bandung, Indonesia.
122
Sunena, Mishra, D., Singh, S.K. & Kumar, A. 2016, Development and characterization of zolmitriptan loaded thiolated chitosan nanoparticles for intranasal drug delivery, The Pharma Innovation Journal, 5(7): 19 – 23. Suyudi, S.D. 2014, ‘Formulasi gel semprot menggunakan kombinasi karbopol 940
dan hidroksipropil metil selulusa (HPMC) sebagai pembentuk gel’, Skripsi, S.Farm., Program Studi Farmasi, Fakultas Kedokteran dan Ilmu Kesehatan, UIN Syarif Hidayatullah, Jakarta, Indonesia.
Syaefudin, Juniarti, A., Rosiyana, L., Setyani, A. & Khodijah, S. 2016, Nanoparticles of Selaginella doederleinii leaf extract inhibit human lung cancer cells A549, IOP Science, 31: 1 – 5.
Thal, D.M., Sun, B., Feng, D., Nawaratne, V., Leach, K., Felder, C.C., et al. 2016, Crystal structures of the M1 and M4 muscarinic acetylcholine receptors,
Nature, 531(4): 1 – 8.
Thorat, S. 2016, Formulation and product development of nasal spray: An overview. SJAMS, 4(8D): 2976 – 2985.
Taurina, W., Sari, R., Hafinur, U., Wahdaningsih, S. & Isnindar. 2017, Optimasi kecepatan dan lama pengadukan terhadap ukuran nanopartikel kitosan-ekstrak etanol 70 % kulit jeruk siam (Citrus Nobilis L .Var Microcarpa) optimization of stirring speed and stirring time toward, Traditional
Medicine Journal, 22(1): 16–20.
Tian, X., Nejadnik, M.R., Baunsgaard, D., Henriksen, A., Rischel, C. & Jiskoot, W. 2016, A comprehensive evaluation of nanoparticle tracking analysis (nanosight) for characterization of proteinaceous submicron particles, J
Pharm Sci, 1 – 10.
Trows, S., Wuchner, K., Spycher, R. & Steckel, H. 2014, Analytical challenges and regulatory requirements for nasal drug products in europe and the U.S.,
Pharmaceutics, 6(2): 195 – 219.
Tsai, M., Fu, Y., Lin, Y., Huang, Y. & Wu, P. 2014. Modified franz diffusion cell, diakses pada tanggal 2 Oktober 2017, <https://figshare.com/ articles/Modified_Franz_diffusion_cell_/1120086>.
Tuppo, E.E. & Forman, L.J. 2001, Free radical oxidative damage and Alzheimer’s disease, Journal Am Osteopath Assoc, 101(12): 11-15.
United States Pharmacopeial (USP) Convention. 2009, United States
pharmacopeia and national formulary: Description and solubility, 32nd
edition, United States Pharmacopeial, Amerika Serikat.
United States of Agriculture. 2016, Parkia speciosa Hassk., diakses pada tanggal
15 Januari 2017, <https://www.plants.usda.gov/core/profile?sym-bol=PASP15>.
ValTech Diagnostics. 2014, Ethyl ethanol 70%, diakses pada tanggal 1 September 2017, < http://www.labchem.com/tools/msds/msds/VT270.pdf>
123
Vij, N. 2012, Pulmonary nanomedicine diagnostics, imaging, and therapeutics, CRC Press, Boca Raton, UK.
Vyjayanthimala T., Bharathi, D., Radhika, G.L., Mallamma, T. & Dinesh, R. 2014, Formulation and evaluation of zidovudine loaded, International Journal of
Biopharmaceutics, 5(1): 1 – 4.
Wang, X., Chi, N. & Tang, X. 2008, Preparation of estradiol chitosan nanoparticles for improving nasal absorption and brain targeting, Eur J Pharm Biopharm, 70(3): 735 – 740.
Wulan, P.P. 2012, Identifikasi pengaruh variabel proses dan penentuan kondisi optimum dekomposisi katalitik metana dengan metode respon permukaan.
Seminar Nasional Kimia Dan Pendidikan Kimia, 1(1): 443 – 452.
Xiao, Z., Xu, Z., & Zhu, G. 2017, Production and characterization of nanocapsules encapsulated linalool by ionic gelation method using chitosan as wall material. Journal A Food Science and Technology, 1(1): 1 – 7.
Yan, Q. & Fong, S.S. 2015, Bacterial chitinase: Nature and perspectives for sustainable bioproduction. Bioresources and Bioprocessing, 2(1): 1 – 9. Yeh, T.H., Hsu, L.W., Tseng, M.T., Lee, P.L., Sonjae, K., Ho, Y.C. et al. 2011,
Mechanism and consequence of chitosan-mediated reversible epithelial tight junction opening, Biomaterials, 32(26): 6164 – 6173.
Yosri, M. 2007, Pokok petai, diakses pada tanggal 25 Maret 2017, <https://ms.wikipedia.org/wiki/Pokok_Petai/>.
Yu-Shin, L., Kiran, S., Kurt, M.L., Jyuhn, H.J., Long, F., Han, Y. et al. 2008, Multi-ion-crosslinked nanoparticles with ph-responsive characteristic for oral delivery of protein drugs, J. Cont Rel, 132: 141 - 149.
Zaini, N.A. & Mustaffa, F. 2017, Review: Parkia speciosa as valuable, miracle of nature, AJMHR, 2(3): 1 – 9.
Zhou, W., Su, M. & Cai, X. 2017, Advances in nanoparticle sizing in suspensions: dynamic light scattering and ultrasonic attenuation spectroscopy, KONA
